FI112356B - Tämligt skör pulverformig mannitol och förfarande för dess framställning - Google Patents
Tämligt skör pulverformig mannitol och förfarande för dess framställning Download PDFInfo
- Publication number
- FI112356B FI112356B FI944464A FI944464A FI112356B FI 112356 B FI112356 B FI 112356B FI 944464 A FI944464 A FI 944464A FI 944464 A FI944464 A FI 944464A FI 112356 B FI112356 B FI 112356B
- Authority
- FI
- Finland
- Prior art keywords
- mannitol
- less
- microns
- advantageously
- powdered
- Prior art date
Links
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title claims abstract description 126
- 235000010355 mannitol Nutrition 0.000 title claims abstract description 125
- 229930195725 Mannitol Natural products 0.000 title claims abstract description 122
- 239000000594 mannitol Substances 0.000 title claims abstract description 122
- 238000000034 method Methods 0.000 title claims description 34
- 238000002360 preparation method Methods 0.000 title claims description 10
- 239000002245 particle Substances 0.000 claims abstract description 74
- 238000012360 testing method Methods 0.000 claims abstract description 14
- 235000013305 food Nutrition 0.000 claims abstract description 8
- 239000000654 additive Substances 0.000 claims abstract description 7
- 238000009826 distribution Methods 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 3
- 239000000945 filler Substances 0.000 claims description 21
- 229920005862 polyol Polymers 0.000 claims description 17
- 150000003077 polyols Chemical class 0.000 claims description 17
- 235000000346 sugar Nutrition 0.000 claims description 15
- 239000000725 suspension Substances 0.000 claims description 12
- 238000004090 dissolution Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 238000005469 granulation Methods 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 2
- 238000000889 atomisation Methods 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 abstract description 6
- 239000003765 sweetening agent Substances 0.000 abstract description 6
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 4
- 230000002829 reductive effect Effects 0.000 abstract description 3
- 239000003981 vehicle Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000000126 substance Substances 0.000 description 13
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000005507 spraying Methods 0.000 description 10
- 239000006188 syrup Substances 0.000 description 10
- 235000020357 syrup Nutrition 0.000 description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 9
- 239000000600 sorbitol Substances 0.000 description 9
- 235000010356 sorbitol Nutrition 0.000 description 9
- 229920002472 Starch Polymers 0.000 description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 235000019698 starch Nutrition 0.000 description 8
- 239000005720 sucrose Substances 0.000 description 8
- 229960004793 sucrose Drugs 0.000 description 8
- 239000003826 tablet Substances 0.000 description 8
- 239000011230 binding agent Substances 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- 239000000428 dust Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 239000010419 fine particle Substances 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- 150000008163 sugars Chemical class 0.000 description 6
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 5
- 208000002925 dental caries Diseases 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229960001375 lactose Drugs 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 239000006199 nebulizer Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 229960001021 lactose monohydrate Drugs 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- -1 mannitol Chemical class 0.000 description 2
- 238000002663 nebulization Methods 0.000 description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920002245 Dextrose equivalent Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000534944 Thia Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 229960004977 anhydrous lactose Drugs 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000011362 coarse particle Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- NYPJDWWKZLNGGM-RPWUZVMVSA-N esfenvalerate Chemical compound C=1C([C@@H](C#N)OC(=O)[C@@H](C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-RPWUZVMVSA-N 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 235000012438 extruded product Nutrition 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 229960003082 galactose Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000003262 industrial enzyme Substances 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical class OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000012803 melt mixture Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000011819 refractory material Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/34—Sugar alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/18—Polyhydroxylic acyclic alcohols
- C07C31/26—Hexahydroxylic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Seasonings (AREA)
- General Preparation And Processing Of Foods (AREA)
- Peptides Or Proteins (AREA)
Claims (10)
1. Pulverformig mannitol, kännetecknad därav, att den har: 5. en skörhet pa 40—80 % enligt test I, fördelaktigt 40—68 % och mera fördelaktigt 45—65 %, — en medeltäthet, för en partikelstorlek pä 100—200 mikron, pä mellan 300 och cirka 525 g/1, fördelaktigt 350—510 g/1 och mera fördelaktigt 400—495 g/1, 10 — och mindre än cirka 30 %, fördelaktigt mindre än 25 % och mera fördelaktigt mindre än 15 % av partiklar med en storlek mindre än 75 mikron.
1 I I I » < I | 112356
2. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att den 15 har mindre än 40 %, fördelaktigt mindre än 30 % och mera fördelaktigt mindre än 20. partiklar med en storlek större än 250 mikron.
3. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att enhetligheten av dess partikelstorlekfördelning är approximativt 1—8, fördelaktigt :,i.: 20 1—5 och mera fördelaktigt 1—3 och dessutom en medeldiameter pä mellan 100 och 20 mikron.
• « · * · ·' 4. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att den ’·’ inte har mera än 10 % och mera fördelaktigt inte mera än 5 % partiklar med en 25 storlek pä mindre än 75 mikron. • · · ♦ tl*
5. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att den »· · • · « : ·’ är praktiskt taget fri frän partiklar med en storlek pä mindre än 40 mikron och frän • · · • · partiklar med en storlek större än 315 mikron. • V 30 :.'i
6. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att den har en mannitolrenhet, räknad i förhällande tili mängden socker eller polyoler, som 112356 är större än cirka 90 %, fördelaktigt större än 95 % och mera fördelaktigt större än 98,5 %.
7. Pulverformigmannitolenligtpatentkrav 1, kännetecknad därav, attdess 5 flytbarhet eller Carr-index är mellan cirka 70 och 90, fördelaktigt mellan 75 och 90 och mera fördelaktigt mellan 80 och 90.
8. Pulverformig mannitol enligt patentkrav 1, kännetecknad därav, att den har en upplösningshastighet enligt testet II pä mindre än 30 sekunder, fördelaktigt 10 mindre än 25 sekunder och mera fördelaktigt mindre än 20 sekunder.
9. Förfarande för framställning av pulverformig mannitol enligt patentkrav 1, kännetecknat därav, att det innefattar ett finfördelningssystem av en mannitollösning eller -suspension och ett granuleringssteg medelst en vät rutt av 15 mannitolen som resulterar i nämnda finfördelningssteg.
10. Sammansättningar avsedda för i synnerhet mat och de farmaceutiska branscher-na, kännetecknade därav, att de innefattar pulverformig mannitol enligt patentkrav 1 som används som sötningsämne, struktureringsämne eller fyllnadsämne \i.: 20 som fungerar som tillsatsämne eller transportämne. » · · * I M • * · • I I • · t I · • * I • · · · * f * I » · • · · * « · · III • · • * • I · 1 > · » · · » · • »
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9311513A FR2710637B1 (fr) | 1993-09-28 | 1993-09-28 | Mannitol pulvérulent de friabilité modérée et son procédé de préparation. |
| FR9311513 | 1993-09-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI944464A0 FI944464A0 (sv) | 1994-09-27 |
| FI944464A FI944464A (sv) | 1995-03-29 |
| FI112356B true FI112356B (sv) | 2003-11-28 |
Family
ID=9451298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944464A FI112356B (sv) | 1993-09-28 | 1994-09-27 | Tämligt skör pulverformig mannitol och förfarande för dess framställning |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5573777A (sv) |
| EP (1) | EP0645096B1 (sv) |
| JP (1) | JP3492428B2 (sv) |
| KR (1) | KR100353433B1 (sv) |
| CN (1) | CN1046622C (sv) |
| AT (1) | ATE160676T1 (sv) |
| AU (1) | AU675732B2 (sv) |
| CA (1) | CA2133012C (sv) |
| DE (1) | DE69407123T2 (sv) |
| DK (1) | DK0645096T3 (sv) |
| ES (1) | ES2109635T3 (sv) |
| FI (1) | FI112356B (sv) |
| FR (1) | FR2710637B1 (sv) |
| GR (1) | GR3025720T3 (sv) |
| HU (1) | HU217453B (sv) |
| NO (1) | NO302356B1 (sv) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235947B1 (en) * | 1997-04-14 | 2001-05-22 | Takeda Chemical Industries, Ltd. | D-mannitol and its preparation |
| PL329614A1 (en) † | 1996-04-16 | 1999-03-29 | Bayer Ag | D-mannitoll and method of obtaining same |
| DE19615418A1 (de) * | 1996-04-22 | 1997-10-23 | Merck Patent Gmbh | Polyol-Zusammensetzung |
| DE19617487A1 (de) † | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
| US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| GB9716432D0 (en) * | 1997-08-05 | 1997-10-08 | Cerestar Holding Bv | Tableting of erythritol |
| DE19819012A1 (de) * | 1998-04-29 | 1999-11-25 | Dynamit Nobel Ag | Feuersichere, nicht explosionsfähige, Nitroglycerin und wasserfreie Lactose enthaltende Feststoffmischungen |
| US6296868B1 (en) * | 1998-11-19 | 2001-10-02 | Advanced Technology Pharmaceuticals Corporation | Chewable tablets containing mannitol and aspartame |
| FR2787110B1 (fr) * | 1998-12-11 | 2001-02-16 | Roquette Freres | Sorbitol pulverulent et son procede de preparation |
| US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
| FR2807034B1 (fr) * | 2000-03-29 | 2002-06-14 | Roquette Freres | Mannitol pulverulent et son procede de fabrication |
| CA2342121C (fr) * | 2000-03-29 | 2010-05-25 | Roquette Freres | Mannitol pulverulent et son procede de preparation |
| EP1343518B1 (en) * | 2000-11-07 | 2009-07-22 | Novartis Vaccines and Diagnostics, Inc. | Stabilized interferon compositions |
| CA2439873A1 (en) * | 2001-03-06 | 2002-09-12 | Kyowa Hakko Kogyo Co., Ltd. | Intraorally rapidly desintegrable tablet |
| DE10161402A1 (de) * | 2001-12-13 | 2003-06-18 | Merck Patent Gmbh | Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit |
| US7118765B2 (en) | 2001-12-17 | 2006-10-10 | Spi Pharma, Inc. | Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms |
| US7462232B2 (en) | 2002-05-14 | 2008-12-09 | Fmc Corporation | Microcrystalline cellulose compositions |
| ES2199061B1 (es) * | 2002-06-10 | 2005-02-16 | Laboratorios Vita, S.A. | Comprimidos bucodispersables y procedimiento para su obtencion. |
| US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| US7282217B1 (en) * | 2003-08-29 | 2007-10-16 | Kv Pharmaceutical Company | Rapidly disintegrable tablets |
| WO2007034287A2 (en) * | 2005-09-19 | 2007-03-29 | University Of The Witwatersrand, Johannesburg | Oramucosal pharmaceutical dosage form |
| US7879382B2 (en) * | 2005-09-30 | 2011-02-01 | Fmc Corporation | Stabilizers and compositions and products comprising same |
| JP2009520704A (ja) * | 2005-12-21 | 2009-05-28 | エーディーディー アドバンスト ドラッグ デリバリー テクノロジーズ リミテッド | 水溶性担体を持つコアを含むペレット |
| JP5410290B2 (ja) * | 2006-10-27 | 2014-02-05 | エフ エム シー コーポレーション | 共処理組成物とその製造方法、打錠可能な錠剤処方物、錠剤の製造方法及び錠剤 |
| GB2450498A (en) | 2007-06-26 | 2008-12-31 | Schlumberger Holdings | Battery powered rotary steerable drilling system |
| WO2010021300A1 (ja) | 2008-08-18 | 2010-02-25 | 三菱商事フードテック株式会社 | 新規マンニトール打錠用賦形剤 |
| US20100190739A1 (en) * | 2008-12-15 | 2010-07-29 | Fleming And Company, Pharmaceuticals | Rapidly Dissolving Vitamin Formulation and Methods of Using the Same |
| FR2949296B1 (fr) * | 2009-09-01 | 2011-11-18 | Roquette Freres | Procede de remplacement total ou partiel du talc dans les chewing-gums |
| FR2949462B1 (fr) | 2009-09-01 | 2011-12-16 | Roquette Freres | Poudre de cristaux de mannitol define, son procede de fabrication |
| WO2012049156A1 (en) | 2010-10-12 | 2012-04-19 | Bayer Animal Health Gmbh | Non-starch based soft chewables |
| WO2013052118A1 (en) | 2011-10-05 | 2013-04-11 | Fmc Corporation | Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses |
| CN103842425B (zh) | 2011-10-05 | 2017-05-24 | Fmc有限公司 | 微晶纤维素和羧甲基纤维素的稳定剂组合物、制备方法和应用 |
| BR112014013792B8 (pt) | 2011-12-09 | 2020-11-10 | Dupont Nutrition Usa Inc | composição estabilizadora co-atritada compreendendo carboximetilcelulose de alto grau de substituição e baixa viscosidade, alimento, composição industrial, e, método para fazer a composição estabilizadora |
| BE1021954B1 (nl) | 2014-06-05 | 2016-01-28 | Syral Belgium Nv | Samenstelling van sorbitol met lage friabiliteit |
| FI4233847T3 (fi) * | 2015-02-26 | 2024-09-24 | Takeda Pharmaceuticals Co | Metoksiureajohdannaista ja mannitolihiukkasia käsittävä tabletti |
| FR3038836B1 (fr) | 2015-07-17 | 2017-07-14 | Roquette Freres | Granules de mannitol pour compression directe |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3145146A (en) * | 1961-10-31 | 1964-08-18 | Warner Lambert Pharmaceutical | Modified mannitol for pharmaceutical tablets |
| US3341415A (en) * | 1964-02-12 | 1967-09-12 | Warner Lambert Pharmaceutical | Pharmaceutical tablet excipients of solid particles of a binary solid solution of mannitol with a sugar |
| JPS5536646A (en) * | 1978-09-06 | 1980-03-14 | Arai Pump Mfg Co Ltd | Double mechanical seal |
| US4293570A (en) * | 1979-04-02 | 1981-10-06 | Chimicasa Gmbh | Process for the preparation of sweetener containing product |
| FR2571046B1 (fr) * | 1984-10-03 | 1987-10-16 | Roquette Freres | Procede de preparation de mannitol granulaire directement compressible |
| FR2571045B1 (fr) * | 1984-10-03 | 1987-12-11 | Roquette Freres | Mannitol granulaire directement compressible et son procede de fabrication |
| JPS6185330A (ja) * | 1984-10-04 | 1986-04-30 | Fuji Kagaku Kogyo Kk | 直打用賦形薬の製造法 |
| JPS6185331A (ja) * | 1984-10-04 | 1986-04-30 | Fuji Kagaku Kogyo Kk | 直打用賦形薬の製造法 |
| ES2066092T3 (es) * | 1990-11-29 | 1995-03-01 | Wei Ming Pharmaceutical Mfg Co | Coadyuvante para la formacion directa de comprimidos. |
| JPH06185330A (ja) * | 1992-12-16 | 1994-07-05 | Nissan Motor Co Ltd | エンジンのオイルポンプ支持構造 |
-
1993
- 1993-09-28 FR FR9311513A patent/FR2710637B1/fr not_active Expired - Fee Related
-
1994
- 1994-09-26 US US08/311,791 patent/US5573777A/en not_active Expired - Lifetime
- 1994-09-26 DE DE69407123T patent/DE69407123T2/de not_active Expired - Lifetime
- 1994-09-26 DK DK94402134.4T patent/DK0645096T3/da active
- 1994-09-26 EP EP94402134A patent/EP0645096B1/fr not_active Expired - Lifetime
- 1994-09-26 AT AT94402134T patent/ATE160676T1/de active
- 1994-09-26 ES ES94402134T patent/ES2109635T3/es not_active Expired - Lifetime
- 1994-09-26 AU AU74239/94A patent/AU675732B2/en not_active Expired
- 1994-09-27 CN CN94117872A patent/CN1046622C/zh not_active Expired - Lifetime
- 1994-09-27 HU HU9402773A patent/HU217453B/hu unknown
- 1994-09-27 NO NO943586A patent/NO302356B1/no not_active IP Right Cessation
- 1994-09-27 FI FI944464A patent/FI112356B/sv not_active IP Right Cessation
- 1994-09-27 KR KR1019940024331A patent/KR100353433B1/ko not_active IP Right Cessation
- 1994-09-27 CA CA002133012A patent/CA2133012C/en not_active Expired - Lifetime
- 1994-09-28 JP JP23359994A patent/JP3492428B2/ja not_active Expired - Lifetime
-
1997
- 1997-12-19 GR GR970403367T patent/GR3025720T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI944464A0 (sv) | 1994-09-27 |
| DE69407123D1 (de) | 1998-01-15 |
| JPH07184590A (ja) | 1995-07-25 |
| NO302356B1 (no) | 1998-02-23 |
| DE69407123T2 (de) | 1998-04-23 |
| ES2109635T3 (es) | 1998-01-16 |
| HUT70804A (en) | 1995-11-28 |
| FR2710637A1 (fr) | 1995-04-07 |
| AU7423994A (en) | 1995-04-13 |
| ATE160676T1 (de) | 1997-12-15 |
| AU675732B2 (en) | 1997-02-13 |
| KR950008457A (ko) | 1995-04-17 |
| FR2710637B1 (fr) | 1995-12-08 |
| EP0645096B1 (fr) | 1997-12-03 |
| CA2133012A1 (en) | 1995-03-29 |
| JP3492428B2 (ja) | 2004-02-03 |
| KR100353433B1 (ko) | 2002-12-11 |
| NO943586D0 (no) | 1994-09-27 |
| EP0645096A1 (fr) | 1995-03-29 |
| DK0645096T3 (da) | 1998-05-04 |
| CN1107516A (zh) | 1995-08-30 |
| FI944464A (sv) | 1995-03-29 |
| HU9402773D0 (en) | 1994-12-28 |
| HU217453B (hu) | 2000-01-28 |
| NO943586L (no) | 1995-03-29 |
| US5573777A (en) | 1996-11-12 |
| CN1046622C (zh) | 1999-11-24 |
| CA2133012C (en) | 2006-01-31 |
| GR3025720T3 (en) | 1998-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI112356B (sv) | Tämligt skör pulverformig mannitol och förfarande för dess framställning | |
| US6180157B1 (en) | Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate | |
| US7662799B2 (en) | Powder of amino acids and method for producing the same | |
| JPH0386839A (ja) | ソルビトール結晶小球 | |
| SK132094A3 (en) | Pharmaceutical dosage form | |
| US4973486A (en) | Formulation of lactitol-containing food | |
| CA2521253A1 (en) | Pharmaceutical compositions having reduced bitter taste | |
| US9636307B2 (en) | Oral pharmaceutical composition comprising taste-masked N-acetylcysteine | |
| EP0735042B1 (fr) | Composition de maltitol et son procédé de préparation | |
| KR101409302B1 (ko) | 인도메타신 및／또는 아세메타신을 포함하는 약학적 조성물 | |
| US5114726A (en) | Process for preparing aspartame coated organic acid | |
| MXPA96001193A (en) | Composition of maltitol and process for supreparac | |
| FR2732343A1 (fr) | Composition de maltitol et son procede de preparation | |
| US5989352A (en) | Lactitol composition and process for the preparation thereof | |
| JP3435109B2 (ja) | 瞬溶性顆粒及びその製法 | |
| US20220370368A1 (en) | Oral pharmaceutical composition comprising a melt-agglomerated active ingredient core | |
| JPH10276715A (ja) | 支持物質上のアスパルテーム |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |