FI112080B - 2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti - Google Patents

2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti Download PDF

Info

Publication number: FI112080B
Authority: FI; Finland
Prior art keywords: amino; dihydro; methoxy; hydroxy; oxopurin
Prior art date: 1994-07-28

Application number

FI953592A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI953592A0 (fi

FI953592L (fi

Inventor

John J Nestor

Scott W Womble

Hans Maag

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

1995-07-27

Publication date

2003-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI112080(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-07-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1995-07-27 Publication of FI953592A0 publication Critical patent/FI953592A0/fi

1996-01-29 Publication of FI953592L publication Critical patent/FI953592L/fi

2003-10-31 Application granted granted Critical

2003-10-31 Publication of FI112080B publication Critical patent/FI112080B/fi

Links

-1 2-amino-1,6-dihydro-6-oxopurin-9-yl Chemical group 0.000 title claims description 121
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims abstract description 77
150000003839 salts Chemical class 0.000 claims abstract description 71
150000001875 compounds Chemical class 0.000 claims description 116
239000000203 mixture Substances 0.000 claims description 85
229960002963 ganciclovir Drugs 0.000 claims description 75
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical class CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 54
238000000034 method Methods 0.000 claims description 41
238000002360 preparation method Methods 0.000 claims description 38
125000006239 protecting group Chemical group 0.000 claims description 37
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 30
239000003814 drug Substances 0.000 claims description 24
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 24
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 22
238000011282 treatment Methods 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 18
239000001257 hydrogen Substances 0.000 claims description 16
201000010099 disease Diseases 0.000 claims description 15
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
230000008569 process Effects 0.000 claims description 15
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238000000926 separation method Methods 0.000 claims description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
238000010511 deprotection reaction Methods 0.000 claims description 11
238000001990 intravenous administration Methods 0.000 claims description 11
125000004423 acyloxy group Chemical group 0.000 claims description 8
230000000840 anti-viral effect Effects 0.000 claims description 8
150000002367 halogens Chemical class 0.000 claims description 8
230000007062 hydrolysis Effects 0.000 claims description 8
238000006460 hydrolysis reaction Methods 0.000 claims description 8
230000036961 partial effect Effects 0.000 claims description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 6
KZSNJWFQEVHDMF-BYPYZUCNSA-M L-valinate Chemical compound CC(C)[C@H](N)C([O-])=O KZSNJWFQEVHDMF-BYPYZUCNSA-M 0.000 claims description 6
230000002378 acidificating effect Effects 0.000 claims description 6
125000003118 aryl group Chemical group 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
125000003545 alkoxy group Chemical group 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
125000005905 mesyloxy group Chemical group 0.000 claims description 3
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125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 8
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

FI953592A 1994-07-28 1995-07-27 2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti FI112080B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28
US28189394		1994-07-28

Publications (3)

Publication Number	Publication Date
FI953592A0 FI953592A0 (fi)	1995-07-27
FI953592L FI953592L (fi)	1996-01-29
FI112080B true FI112080B (fi)	2003-10-31

Family

ID=23079211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI953592A FI112080B (fi)	1994-07-28	1995-07-27	2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti

Country Status (33)

Country	Link
EP (1)	EP0694547B1 (nl)
JP (1)	JP3090305B2 (nl)
KR (1)	KR100358626B1 (nl)
CN (1)	CN1045089C (nl)
AT (1)	ATE179173T1 (nl)
AU (1)	AU697107B2 (nl)
BR (1)	BR9503468A (nl)
CA (1)	CA2154721C (nl)
CO (1)	CO4410181A1 (nl)
CY (2)	CY2180B1 (nl)
CZ (1)	CZ290511B6 (nl)
DE (3)	DE69509173T2 (nl)
DK (1)	DK0694547T3 (nl)
ES (1)	ES2083348T3 (nl)
FI (1)	FI112080B (nl)
GR (2)	GR960300021T1 (nl)
HK (1)	HK1012339A1 (nl)
HU (1)	HU216867B (nl)
IL (1)	IL114735A (nl)
LU (1)	LU91136I2 (nl)
MA (1)	MA23631A1 (nl)
MY (1)	MY114393A (nl)
NL (1)	NL300071I2 (nl)
NO (2)	NO312899B1 (nl)
NZ (1)	NZ272652A (nl)
PE (1)	PE32296A1 (nl)
PL (1)	PL180609B1 (nl)
RU (1)	RU2133749C1 (nl)
SA (1)	SA95160158B1 (nl)
TR (1)	TR199500895A2 (nl)
TW (1)	TW434242B (nl)
UY (1)	UY24006A1 (nl)
ZA (1)	ZA956228B (nl)

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US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
AU1543797A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
ES2186127T3 (es) *	1997-02-10	2003-05-01	Medivir Ab	Sintesis de derivados de nucleosidos aciclicos.
CN1130362C (zh) *	1997-08-15	2003-12-10	美迪维尔公司	核苷类似物,这些化合物作为包括乙型肝炎病毒(hbv)的逆转录病毒的逆转录酶及dna聚合酶抑制剂的抗病毒药
WO1999032490A1 (en) *	1997-12-19	1999-07-01	Bristol-Myers Squibb Company	Prodrugs of lobucavir and methods of use
WO1999051613A1 (en) *	1998-04-03	1999-10-14	Medivir Ab	Prodrugs of phosphorous-containing pharmaceuticals
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60313769T2 (de) *	2002-04-23	2008-03-06	Aventis Pharmaceuticals Inc.	3-(pyridinyl-amino)-1h-indol-2-carbonsäure-verbindungen als inhibitoren der interleukin-4 genexpression
ES2534713T3 (es)	2002-10-16	2015-04-27	Takeda Pharmaceutical Company Limited	Preparaciones sólidas estables
ATE398455T1 (de)	2003-01-14	2008-07-15	Gilead Sciences Inc	Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
EP1660499A1 (en) *	2003-08-28	2006-05-31	Ranbaxy Laboratories Limited	Amorphous valganciclovir hydrochloride
JP5563735B2 (ja)	2004-06-16	2014-07-30	タケダファーマシューティカルズユー．エス．エー．インコーポレイティド	Ｐｐｉ多回剤形
CN101027318B (zh) *	2004-07-19	2016-05-25	比奥孔有限公司	胰岛素-低聚物共轭物，制剂及其用途
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
KR20100116165A (ko)	2007-10-12	2010-10-29	다케다 파마슈티칼스 노쓰 어메리카, 인코포레이티드	음식 섭취와 관계없이 위장 장애를 치료하는 방법
CN103562207B (zh) *	2011-05-31	2016-08-17	法尔玛赞公司	用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

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NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
EP0187297B1 (en) *	1984-12-12	1991-08-21	Syntex (U.S.A.) Inc.	Alkoxy methyl ether and alkoxy methyl ester derivatives
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
EP0375329B1 (en) *	1988-12-19	1995-05-31	The Wellcome Foundation Limited	Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-19 EP EP95111319A patent/EP0694547B1/en not_active Expired - Lifetime
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 CA CA002154721A patent/CA2154721C/en not_active Expired - Lifetime
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1998
- 1998-12-15 HK HK98113443A patent/HK1012339A1/xx not_active IP Right Cessation
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I2/el unknown

Also Published As

Publication number	Publication date
IL114735A0 (en)	1995-11-27
CA2154721A1 (en)	1996-01-29
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
EP0694547B1 (en)	1999-04-21
CY2004003I1 (el)	2009-11-04
NL300071I2 (nl)	2002-03-01
HU9502238D0 (en)	1995-09-28
HU216867B (hu)	1999-09-28
RU95113148A (ru)	1997-06-27
ES2083348T1 (es)	1996-04-16
NO312899B1 (no)	2002-07-15
CY2180B1 (en)	2002-08-23
TR199500895A2 (tr)	1996-06-21
PL309812A1 (en)	1996-02-05
DE10299032I2 (de)	2006-06-14
AU697107B2 (en)	1998-09-24
DE69509173T2 (de)	1999-10-21
PE32296A1 (es)	1996-08-07
CO4410181A1 (es)	1997-01-09
SA95160158B1 (ar)	2006-05-20
MY114393A (en)	2002-10-31
LU91136I2 (fr)	2005-07-06
JP3090305B2 (ja)	2000-09-18
CY2004003I2 (el)	2009-11-04
PL180609B1 (pl)	2001-03-30
NL300071I1 (nl)	2002-02-01
ATE179173T1 (de)	1999-05-15
GR960300021T1 (en)	1996-04-30
NO2003001I2 (no)	2007-06-11
MA23631A1 (fr)	1996-04-01
JPH0841061A (ja)	1996-02-13
EP0694547A2 (en)	1996-01-31
KR100358626B1 (ko)	2003-01-14
CZ290511B6 (cs)	2002-08-14
AU2719595A (en)	1996-02-08
DE10299032I1 (de)	2003-01-23
CN1122804A (zh)	1996-05-22
EP0694547A3 (en)	1996-06-05
FI953592A0 (fi)	1995-07-27
UY24006A1 (es)	2001-07-31
NZ272652A (en)	1996-12-20
ES2083348T3 (es)	1999-08-01
IL114735A (en)	1998-06-15
DK0694547T3 (da)	2000-01-03
CA2154721C (en)	2001-01-02
HUT73246A (en)	1996-07-29
BR9503468A (pt)	1996-02-27
CN1045089C (zh)	1999-09-15
TW434242B (en)	2001-05-16
NO952977D0 (no)	1995-07-27
HK1012339A1 (en)	1999-07-30
GR3030678T3 (en)	1999-11-30
CZ193995A3 (en)	1996-02-14
ZA956228B (en)	1996-02-22
KR960004345A (ko)	1996-02-23
NO952977L (no)	1996-01-29
FI953592L (fi)	1996-01-29
RU2133749C1 (ru)	1999-07-27

Publication	Publication Date	Title
FI112080B (fi)	2003-10-31	2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti
US6083953A (en)	2000-07-04	2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
JP7367908B2 (ja)	2023-10-24	標的タンパク質分解化合物、その抗腫瘍応用、その中間体および中間体の応用
AP160A (en)	1991-11-18	Therapeutic acyclic nucleosides.
US9315523B2 (en)	2016-04-19	Cyclic dinucleosides
US5543414A (en)	1996-08-06	Achiral amino acid acyl esters of ganciclovir and its derivatives
EP3919488A1 (en)	2021-12-08	Immunomodulator
EP2865669B1 (en)	2021-04-28	Novel rebamipide prodrug, method for producing same, and usage thereof
KR19990076616A (ko)	1999-10-15	2,7-치환된 옥타하이드로-피롤로[1,2-에이]피라진 유도체
BR112020004495A2 (pt)	2020-09-08	composto, composição, e, método para preparar uma composição.
ES2180923T5 (es)	2005-10-16	Proceso para la preparacion de derivados de purina.
ES2641190T3 (es)	2017-11-08	Procedimiento de síntesis de IB-MECA
EP1891071B1 (en)	2012-02-22	Cyclopropanecarboxylate esters of acyclovir
TW202339766A (zh)	2023-10-16	非環狀硫醇前藥
JPH0834789A (ja)	1996-02-06	ピロロインドールカルボン酸エステル誘導体及びその製造方法
KR20000051515A (ko)	2000-08-16	항바이러스 활성을 가지는 2-아미노퓨린

Legal Events

Date	Code	Title	Description
2004-01-27	SPCF	Supplementary protection certificate application filed	Spc suppl protection certif: L20040001
2014-09-03	SPCE	Application for extension of a supplementary protection certificate [pediatric extension]	Spc suppl protection certif: L20040001
2015-09-02	MA	Patent expired
2015-10-30	SPCP	Extension of a supplementary protection certificate [pediatric extension]	Spc suppl protection certif: 241 Extension date: 20170320