FI111251B - Menetelmä säteilyltä suojaavien polyamiinitiolien valmistamiseksi - Google Patents
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- FI111251B FI111251B FI920271A FI920271A FI111251B FI 111251 B FI111251 B FI 111251B FI 920271 A FI920271 A FI 920271A FI 920271 A FI920271 A FI 920271A FI 111251 B FI111251 B FI 111251B
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- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 125000005543 phthalimide group Chemical group 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- ISHLCKAQWKBMAU-UHFFFAOYSA-N tert-butyl n-diazocarbamate Chemical compound CC(C)(C)OC(=O)N=[N+]=[N-] ISHLCKAQWKBMAU-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- VOVUARRWDCVURC-UHFFFAOYSA-N thiirane Chemical compound C1CS1 VOVUARRWDCVURC-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Materials For Medical Uses (AREA)
- Polyurethanes Or Polyureas (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Polyethers (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64481091 | 1991-01-23 | ||
| US07/644,810 US5217964A (en) | 1991-01-23 | 1991-01-23 | Polyamine thiols as radioprotective agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI920271A0 FI920271A0 (fi) | 1992-01-22 |
| FI920271A FI920271A (fi) | 1992-07-24 |
| FI111251B true FI111251B (fi) | 2003-06-30 |
Family
ID=24586432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI920271A FI111251B (fi) | 1991-01-23 | 1992-01-22 | Menetelmä säteilyltä suojaavien polyamiinitiolien valmistamiseksi |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5217964A (de) |
| EP (1) | EP0497202B1 (de) |
| JP (1) | JP3203582B2 (de) |
| KR (1) | KR100195420B1 (de) |
| AT (1) | ATE127785T1 (de) |
| AU (1) | AU647570B2 (de) |
| CA (1) | CA2059817C (de) |
| DE (1) | DE69204698T2 (de) |
| ES (1) | ES2079695T3 (de) |
| FI (1) | FI111251B (de) |
| IE (1) | IE67961B1 (de) |
| IL (1) | IL100698A (de) |
| NO (1) | NO179003C (de) |
| NZ (1) | NZ241347A (de) |
| PT (1) | PT100045B (de) |
| ZA (1) | ZA92360B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677351A (en) * | 1986-12-02 | 1997-10-14 | University Of Florida Research Foundation, Inc. | Sterically hindered tetraamines and method for their production |
| US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
| US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5354782A (en) * | 1991-01-17 | 1994-10-11 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
| US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
| JPH08509699A (ja) * | 1993-02-23 | 1996-10-15 | メレルダウ ファーマスーティカルズ インコーポレイテッド | 放射線防護剤としてのポリアミン誘導体類 |
| CN1124483A (zh) * | 1993-05-26 | 1996-06-12 | 默里尔多药物公司 | 作为放射保护剂的n-烷硫基多胺衍生物 |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| WO2002038105A2 (en) * | 2000-11-08 | 2002-05-16 | Slil Biomedical Corporation | Novel polyamine analog-amino acid conjugates useful as anticancer agents |
| WO2000066175A2 (en) * | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Conjugates as therapies for cancer and prostate diseases |
| EP1698629A3 (de) | 1999-04-30 | 2006-11-29 | Cellgate, Inc. | Polyamine und ihre therapeutische Verwendung |
| US6489312B1 (en) * | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| WO2001085142A1 (en) * | 2000-05-05 | 2001-11-15 | Wisconsin Alumni Research Foundation | Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy |
| US7053072B2 (en) | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
| US7045550B2 (en) * | 2001-08-07 | 2006-05-16 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| AU2002364539A1 (en) | 2001-12-07 | 2003-06-23 | Cellgate, Inc. | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
| EP1478618A1 (de) * | 2002-02-07 | 2004-11-24 | Wisconsin Alumni Research Foundation | Polyaminverbindungen und zusammensetzungen zur verwendung im zusammenhang mit einer krebstherapie |
| US7314959B2 (en) * | 2003-08-07 | 2008-01-01 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| US7754463B2 (en) * | 2006-06-20 | 2010-07-13 | Dana-Farber Cancer Institute | Inhibitors of USP1 Deubiquitinating Enzyme Complex |
| CA2797719C (en) | 2010-04-30 | 2019-11-26 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| TWM528362U (zh) * | 2016-04-15 | 2016-09-11 | Calendar Entpr Co Ltd | 無繩式電動節能捲簾結構改良 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2901503A (en) * | 1956-08-28 | 1959-08-25 | Campbell Pharmaceuticals Inc | Dialkylaminophenyl esters of thiophosphoric acids |
| US3368972A (en) * | 1965-01-06 | 1968-02-13 | Mobil Oil Corp | High molecular weight mannich bases as engine oil additives |
| AU602186B2 (en) * | 1987-02-03 | 1990-10-04 | Merrell Dow Pharmaceuticals Inc. | Novel polyamine derivatives |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
-
1991
- 1991-01-23 US US07/644,810 patent/US5217964A/en not_active Expired - Fee Related
-
1992
- 1992-01-17 ZA ZA92360A patent/ZA92360B/xx unknown
- 1992-01-17 AU AU10304/92A patent/AU647570B2/en not_active Ceased
- 1992-01-19 IL IL10069892A patent/IL100698A/en not_active IP Right Cessation
- 1992-01-21 NZ NZ241347A patent/NZ241347A/en unknown
- 1992-01-22 NO NO920283A patent/NO179003C/no unknown
- 1992-01-22 ES ES92101017T patent/ES2079695T3/es not_active Expired - Lifetime
- 1992-01-22 PT PT100045A patent/PT100045B/pt not_active IP Right Cessation
- 1992-01-22 IE IE920189A patent/IE67961B1/en not_active IP Right Cessation
- 1992-01-22 AT AT92101017T patent/ATE127785T1/de not_active IP Right Cessation
- 1992-01-22 KR KR1019920000836A patent/KR100195420B1/ko not_active IP Right Cessation
- 1992-01-22 EP EP92101017A patent/EP0497202B1/de not_active Expired - Lifetime
- 1992-01-22 FI FI920271A patent/FI111251B/fi active
- 1992-01-22 CA CA002059817A patent/CA2059817C/en not_active Expired - Fee Related
- 1992-01-22 DE DE69204698T patent/DE69204698T2/de not_active Expired - Fee Related
- 1992-01-23 JP JP03128092A patent/JP3203582B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3203582B2 (ja) | 2001-08-27 |
| CA2059817A1 (en) | 1992-07-24 |
| NO179003C (no) | 1996-07-17 |
| IL100698A0 (en) | 1992-09-06 |
| FI920271A0 (fi) | 1992-01-22 |
| AU1030492A (en) | 1992-07-30 |
| IE67961B1 (en) | 1996-05-15 |
| EP0497202B1 (de) | 1995-09-13 |
| KR100195420B1 (ko) | 1999-06-15 |
| FI920271A (fi) | 1992-07-24 |
| IL100698A (en) | 1998-08-16 |
| ES2079695T3 (es) | 1996-01-16 |
| NO179003B (no) | 1996-04-09 |
| DE69204698D1 (de) | 1995-10-19 |
| NO920283D0 (no) | 1992-01-22 |
| NO920283L (no) | 1992-07-24 |
| DE69204698T2 (de) | 1996-02-15 |
| EP0497202A1 (de) | 1992-08-05 |
| PT100045B (pt) | 1999-10-29 |
| PT100045A (pt) | 1993-03-31 |
| AU647570B2 (en) | 1994-03-24 |
| JPH04334362A (ja) | 1992-11-20 |
| ATE127785T1 (de) | 1995-09-15 |
| KR920014772A (ko) | 1992-08-25 |
| IE920189A1 (en) | 1992-07-29 |
| ZA92360B (en) | 1992-11-25 |
| NZ241347A (en) | 1994-04-27 |
| CA2059817C (en) | 2003-07-15 |
| US5217964A (en) | 1993-06-08 |
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