FI107916B - Förfarande för framställning av hydrazonderivat - Google Patents
Förfarande för framställning av hydrazonderivat Download PDFInfo
- Publication number
- FI107916B FI107916B FI912164A FI912164A FI107916B FI 107916 B FI107916 B FI 107916B FI 912164 A FI912164 A FI 912164A FI 912164 A FI912164 A FI 912164A FI 107916 B FI107916 B FI 107916B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- indanone
- mmol
- compound
- amidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
- C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
- C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Photolithography (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Wire Bonding (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (4)
1. Förfarande för framställning av terapeutiskt verksamma hydrazonderivat/ deras tautomerer och deras salter, med formeln I X r^V-A-| Rt 4- I -j-R2 (i) z li II N .C. Rs I I R3 r4 där A betecknar en direkt bindning eller en -CH2- grupp, X betecknar en rest -C (=Y) -NR6R7/ Y är NRe, Z är NRg, Ri och R2 betecknar oavsett varandra väte, lägre alkyl eller lägre alkoxi, resterna R3, R4, R6, Ra och R9 betecknar oavsett varandra väte eller lägre alkyl och R5 och Rt betecknar oavsett varandra väte, lägre alkyl eller hydroxi, kännetecknat därav, att a) en förening med formeln II • · · • · • M1 2 : X ='.··! Rl-Q0-R3 dl) .·:·! W, 'w2 • · · där gruppen CWiW2 betecknar karbonyl, funktionellt om- .***. vandlad karbonyl eller skyddad karbonyl och resterna A, • 1 · *.4 X, Ri och R2 har den i samband med formeln I angivna betydelsen, • · ··· • · · 2 m 107916 kondenseras med en amin med formeln III Z H2N^C-n-Rs (i"> I I R3 R4 där resterna Z, R3/ R4 och R5 har den i saraband med formeln I angivna betydelsen, eller b) i en förening med formeln IV W3 R,~UQi m I 1 R3 r4 där W3 betecknar tiokarbamoyl, cyano, bromo eller N-hydroxiamidino och resterna A, Z, Ri, R2, R3, R4 och R5 har den i saraband med formeln I definierade betydelsen, omvandlas resten W3 till gruppen X, och, när sa önskas, • · omvandlas en erhällen förening med formeln I till en *· · ....: annan förening med formeln I, och/eller, när sa önskas, • · : omvandlas ett erhället salt till en fri förening eller • · · • · ....: till ett annat salt, och/eller, när sä önskas, omvandlas • · en erhällen fri förening med formeln I, med saltbildande I I I egenskaper, till ett salt.
• · .***; 2. Förfarande enligt patentkravet 1 för framställning av • « · 4-amidino-l-indanon-2, -amidinohydrazon eller dess farina-ceutiskt godtagbara salt, kännetecknat därav, • m • att motsvarande substituerade utgängsmaterial används. • · • · • 107916
3. Förfarande enligt patentkravet 1 för framställning av 4- amidino-l-indanon-2'-(N-hydroxiamidino)-hydrazon eller dess farmaceutiskt godtagbara sait, kännetecknat därav, att motsvarande substitue-rade utgängsmaterial används.
4. Förfarande enligt patentkravet 1 för framställning av 5- amidino-l-tetralon-2'-amidinohydrazon eller dess farmaceutiskt godtagbara sait, kännetecknat därav, att motsvarande substituerade utgängsmaterial används. • · 1 « · • · · « • « « • · · • 1 · • · • ♦ • » · • · ♦ 9 · • lltt • · • · · * · ♦ s. · · • · · • · ··· ··· ·»·· · · • · • « • · « • · ·
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH153890 | 1990-05-07 | ||
| CH153890 | 1990-05-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI912164A0 FI912164A0 (fi) | 1991-05-03 |
| FI912164A FI912164A (fi) | 1991-11-08 |
| FI107916B true FI107916B (sv) | 2001-10-31 |
Family
ID=4212764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI912164A FI107916B (sv) | 1990-05-07 | 1991-05-03 | Förfarande för framställning av hydrazonderivat |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0456133B1 (sv) |
| JP (1) | JP2565602B2 (sv) |
| KR (1) | KR100203234B1 (sv) |
| AT (1) | ATE119878T1 (sv) |
| AU (1) | AU645799B2 (sv) |
| CA (1) | CA2041832C (sv) |
| CY (1) | CY2080B1 (sv) |
| CZ (1) | CZ279340B6 (sv) |
| DE (1) | DE59104930D1 (sv) |
| DK (1) | DK0456133T3 (sv) |
| ES (1) | ES2069768T3 (sv) |
| FI (1) | FI107916B (sv) |
| GR (1) | GR3015574T3 (sv) |
| HK (1) | HK1000919A1 (sv) |
| HU (1) | HU218221B (sv) |
| ID (1) | ID1040B (sv) |
| IE (1) | IE66157B1 (sv) |
| IL (1) | IL98008A (sv) |
| NO (1) | NO175097C (sv) |
| NZ (1) | NZ238033A (sv) |
| PT (1) | PT97571B (sv) |
| RU (2) | RU2057748C1 (sv) |
| SA (1) | SA91120283B1 (sv) |
| SK (1) | SK279136B6 (sv) |
| TW (1) | TW202428B (sv) |
| ZA (1) | ZA913391B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395855A (en) * | 1990-05-07 | 1995-03-07 | Ciba-Geigy Corporation | Hydrazones |
| RU2081108C1 (ru) * | 1991-10-16 | 1997-06-10 | Циба-Гейги АГ | Аддитивные соли кислот с основанием и фармацевтическая композиция, обладающая противоопухолевой активностью |
| WO1993020046A1 (fr) * | 1992-04-03 | 1993-10-14 | Innothera | Derives d'indane-1,3-dione et d'indane-1,2,3-trione, leurs procedes de preparation et leur application en therapeutique |
| ES2103166B1 (es) * | 1992-08-26 | 1998-04-01 | Ciba Geigy Ag | Procedimiento para la obtencion de amidinohidrazonas biciclicas. |
| FR2710639B1 (fr) * | 1993-10-01 | 1995-12-22 | Innothera Lab Sa | Dérivés d'indane cétoniques, leur procédé d'obtention, leur application thérapeutique. |
| JP3989543B2 (ja) * | 1995-01-26 | 2007-10-10 | ノバルティス・アクチエンゲゼルシャフト | イミダゾール誘導体、その製造およびｓ−アデノシルメチオニンデカルボキシラーゼ（＝ｓａｍｄｃ）阻害剤としてのその使用 |
| EP1408028A1 (en) * | 2002-10-09 | 2004-04-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection |
| EP1834669A1 (en) * | 2006-03-15 | 2007-09-19 | Heinrich-Pette-Institut | Use of specific hydrazone compounds for the treatment of viral infections |
| EP1884515A1 (en) * | 2006-07-31 | 2008-02-06 | Laboratorios del Dr. Esteve S.A. | Substituted indanyl sulfonamide compounds, their preparation and use as medicaments |
| CN102627593A (zh) * | 2012-02-23 | 2012-08-08 | 河南师范大学 | 具有抗癌活性的1，4-二羟基-2-甲酰基-9，10蒽醌缩氨硫脲新化合物及制备方法 |
| WO2016001390A1 (en) * | 2014-07-02 | 2016-01-07 | Inflectis Bioscience | O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7407469A (nl) * | 1974-06-01 | 1975-12-03 | Akzo Nv | Nieuwe amidinohydrazonverbindingen. |
| DE3416695A1 (de) * | 1984-05-05 | 1985-11-07 | Bayer Ag, 5090 Leverkusen | Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE68913706T2 (de) * | 1988-12-27 | 1994-08-04 | Du Pont | Substituierte Semicarbazon-Arthropodizide. |
-
1991
- 1991-04-26 AU AU75967/91A patent/AU645799B2/en not_active Ceased
- 1991-04-30 IL IL9800891A patent/IL98008A/en not_active IP Right Cessation
- 1991-05-02 TW TW080103460A patent/TW202428B/zh not_active IP Right Cessation
- 1991-05-03 NZ NZ238033A patent/NZ238033A/xx unknown
- 1991-05-03 DE DE59104930T patent/DE59104930D1/de not_active Expired - Fee Related
- 1991-05-03 AT AT91107225T patent/ATE119878T1/de not_active IP Right Cessation
- 1991-05-03 FI FI912164A patent/FI107916B/sv active
- 1991-05-03 DK DK91107225.4T patent/DK0456133T3/da not_active Application Discontinuation
- 1991-05-03 CA CA002041832A patent/CA2041832C/en not_active Expired - Lifetime
- 1991-05-03 ES ES91107225T patent/ES2069768T3/es not_active Expired - Lifetime
- 1991-05-03 EP EP91107225A patent/EP0456133B1/de not_active Expired - Lifetime
- 1991-05-06 KR KR1019910007285A patent/KR100203234B1/ko not_active IP Right Cessation
- 1991-05-06 NO NO911777A patent/NO175097C/no not_active IP Right Cessation
- 1991-05-06 SK SK1317-91A patent/SK279136B6/sk not_active IP Right Cessation
- 1991-05-06 IE IE153091A patent/IE66157B1/en not_active IP Right Cessation
- 1991-05-06 RU SU914895338A patent/RU2057748C1/ru active
- 1991-05-06 CZ CS911317A patent/CZ279340B6/cs not_active IP Right Cessation
- 1991-05-06 PT PT97571A patent/PT97571B/pt not_active IP Right Cessation
- 1991-05-06 ZA ZA913391A patent/ZA913391B/xx unknown
- 1991-05-06 HU HU519/91A patent/HU218221B/hu not_active IP Right Cessation
- 1991-05-07 JP JP3101512A patent/JP2565602B2/ja not_active Expired - Fee Related
- 1991-12-17 SA SA91120283A patent/SA91120283B1/ar unknown
-
1992
- 1992-01-30 ID IDP189692A patent/ID1040B/id unknown
- 1992-10-23 RU RU9292004359A patent/RU2066311C1/ru active
-
1995
- 1995-03-30 GR GR950400746T patent/GR3015574T3/el unknown
-
1997
- 1997-11-06 HK HK97102109A patent/HK1000919A1/xx not_active IP Right Cessation
-
1998
- 1998-10-16 CY CY9802080A patent/CY2080B1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI91397C (sv) | Förfarande för framställning av farmaceutiskt verkande arylhydrazoner | |
| HU208811B (en) | Process for producton of biaryl-compounds and pharmaceutical compositions comprising them as medical agent | |
| FI107916B (sv) | Förfarande för framställning av hydrazonderivat | |
| IL187421A (en) | Process for the synthesis of 5-(methyl-1h-imidazol-1-yl)-3-(tri fluoromethyl)-benzeneamine | |
| AU653024B2 (en) | Substituted diaminophthalimides and analogues | |
| FR2846657A1 (fr) | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| JP2002509930A (ja) | ベンゾ複素環ジスタマイシン誘導体、その製造方法および抗腫瘍薬としてのそれの使用 | |
| NZ206823A (en) | N-piperazinylalkanoylanilides and pharmaceutical compositions | |
| US5238941A (en) | Arylhydrazones and pharmaceutical compositions thereof | |
| FI57104B (fi) | Foerfarande foer framstaellning av befruktningshindrande nya s-triatsolo(5,1-a)isokinolinderivat | |
| FI112212B (sv) | Förfarande för framställning av som läkemedel användbara syraadditionssalter av aminoindanoner | |
| CN104447733B (zh) | 1-苄基-2-吡咯啉酮-4-酰胺类化合物及其制备方法与应用 | |
| AU678975B2 (en) | Pyrimidine compounds used in the therapy | |
| FR2665442A1 (fr) | Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant. | |
| JPS62226959A (ja) | ピリジン誘導体、それらの製法および向意識、抗うつ、抗パーキンソン病剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: NOVARTIS AG |