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AU645799B2 - Hydrazones - Google Patents

Hydrazones

Info

Publication number
AU645799B2
AU645799B2 AU75967/91A AU7596791A AU645799B2 AU 645799 B2 AU645799 B2 AU 645799B2 AU 75967/91 A AU75967/91 A AU 75967/91A AU 7596791 A AU7596791 A AU 7596791A AU 645799 B2 AU645799 B2 AU 645799B2
Authority
AU
Australia
Prior art keywords
independently
hydrogen
another
lower alkyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU75967/91A
Other versions
AU7596791A (en
Inventor
Giorgio Dr. Caravatti
Jorg Dr. Frei
Jaroslav Dr. Stanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU7596791A publication Critical patent/AU7596791A/en
Application granted granted Critical
Publication of AU645799B2 publication Critical patent/AU645799B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Wire Bonding (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which A denotes a direct bond or -(CH2)n-, in which n represents 1, 2 or 3; X represents a -C(=Y)-NR6R7 radical; Y represents NR8, O or S; Z represents NR9, O or S; R1 and R2, independently of one another, denote hydrogen or one or more substituents other than hydrogen; the radicals R3, R4, R6, R8 and R9 independently of one another denote hydrogen or lower alkyl; and R5 and R7 independently of one another represent hydrogen, lower alkyl, hydroxyl, etherified or esterified hydroxyl or unsubstituted or mono- or disubstituted amino; tautomers thereof, and salts thereof. They have useful pharmaceutical properties and are particularly active against tumours. They are prepared in a manner known per se.
AU75967/91A 1990-05-07 1991-04-26 Hydrazones Ceased AU645799B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH153890 1990-05-07
CH1538/90 1990-05-07

Publications (2)

Publication Number Publication Date
AU7596791A AU7596791A (en) 1991-11-07
AU645799B2 true AU645799B2 (en) 1994-01-27

Family

ID=4212764

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75967/91A Ceased AU645799B2 (en) 1990-05-07 1991-04-26 Hydrazones

Country Status (26)

Country Link
EP (1) EP0456133B1 (en)
JP (1) JP2565602B2 (en)
KR (1) KR100203234B1 (en)
AT (1) ATE119878T1 (en)
AU (1) AU645799B2 (en)
CA (1) CA2041832C (en)
CY (1) CY2080B1 (en)
CZ (1) CZ279340B6 (en)
DE (1) DE59104930D1 (en)
DK (1) DK0456133T3 (en)
ES (1) ES2069768T3 (en)
FI (1) FI107916B (en)
GR (1) GR3015574T3 (en)
HK (1) HK1000919A1 (en)
HU (1) HU218221B (en)
ID (1) ID1040B (en)
IE (1) IE66157B1 (en)
IL (1) IL98008A (en)
NO (1) NO175097C (en)
NZ (1) NZ238033A (en)
PT (1) PT97571B (en)
RU (2) RU2057748C1 (en)
SA (1) SA91120283B1 (en)
SK (1) SK279136B6 (en)
TW (1) TW202428B (en)
ZA (1) ZA913391B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395855A (en) * 1990-05-07 1995-03-07 Ciba-Geigy Corporation Hydrazones
RU2081108C1 (en) * 1991-10-16 1997-06-10 Циба-Гейги АГ Additive salts of acids with the base and pharmaceutical composition showing antitumor activity
WO1993020046A1 (en) * 1992-04-03 1993-10-14 Innothera Indan-1,3-dione and indan-1,2,3-trione derivatives, processes for preparation of same and their use as therapeutic agents
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
FR2710639B1 (en) * 1993-10-01 1995-12-22 Innothera Lab Sa Ketone indane derivatives, their process of obtaining, their therapeutic application.
JP3989543B2 (en) * 1995-01-26 2007-10-10 ノバルティス・アクチエンゲゼルシャフト Imidazole derivatives, their preparation and their use as S-adenosylmethionine decarboxylase (= SAMDC) inhibitors
EP1408028A1 (en) * 2002-10-09 2004-04-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-adenosyl methionine decarboxylase inhibition for the treatment of a herpes simplex virus infection
EP1834669A1 (en) * 2006-03-15 2007-09-19 Heinrich-Pette-Institut Use of specific hydrazone compounds for the treatment of viral infections
EP1884515A1 (en) * 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
CN102627593A (en) * 2012-02-23 2012-08-08 河南师范大学 1,4-dihydroxy-2-formyl-9,10 anthraquinone thiosemicarbazone new compound with anticancer activity and preparation method thereof
WO2016001390A1 (en) * 2014-07-02 2016-01-07 Inflectis Bioscience O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4200885A (en) * 1984-05-05 1985-11-07 Bayer Aktiengesellschaft Amidino hydrazones of derivatives of tetralin, chromone, thiochromone and tetrahydroquinoline
AU5024690A (en) * 1988-12-27 1990-08-01 E.I. Du Pont De Nemours And Company Substituted semicarbazone arthropodicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7407469A (en) * 1974-06-01 1975-12-03 Akzo Nv NEW AMIDINOHYDRAZONE COMPOUNDS.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4200885A (en) * 1984-05-05 1985-11-07 Bayer Aktiengesellschaft Amidino hydrazones of derivatives of tetralin, chromone, thiochromone and tetrahydroquinoline
AU5024690A (en) * 1988-12-27 1990-08-01 E.I. Du Pont De Nemours And Company Substituted semicarbazone arthropodicides

Also Published As

Publication number Publication date
AU7596791A (en) 1991-11-07
NO911777L (en) 1991-11-08
IL98008A0 (en) 1992-06-21
KR100203234B1 (en) 1999-06-15
RU2057748C1 (en) 1996-04-10
HUT57183A (en) 1991-11-28
PT97571A (en) 1992-01-31
IE911530A1 (en) 1991-11-20
EP0456133B1 (en) 1995-03-15
TW202428B (en) 1993-03-21
ATE119878T1 (en) 1995-04-15
NO911777D0 (en) 1991-05-06
HU218221B (en) 2000-06-28
DE59104930D1 (en) 1995-04-20
GR3015574T3 (en) 1995-06-30
RU2066311C1 (en) 1996-09-10
CZ279340B6 (en) 1995-04-12
NO175097C (en) 1994-08-31
FI107916B (en) 2001-10-31
SK279136B6 (en) 1998-07-08
JP2565602B2 (en) 1996-12-18
FI912164A (en) 1991-11-08
FI912164A0 (en) 1991-05-03
NO175097B (en) 1994-05-24
SA91120283B1 (en) 2005-12-17
EP0456133A1 (en) 1991-11-13
CA2041832C (en) 2002-09-17
KR910019964A (en) 1991-12-19
HK1000919A1 (en) 1998-05-08
PT97571B (en) 1999-04-30
JPH04225946A (en) 1992-08-14
CS131791A3 (en) 1992-03-18
ZA913391B (en) 1991-12-24
CA2041832A1 (en) 1991-11-08
ES2069768T3 (en) 1995-05-16
NZ238033A (en) 1993-01-27
CY2080B1 (en) 1998-10-16
ID1040B (en) 1996-10-25
DK0456133T3 (en) 1995-05-22
IE66157B1 (en) 1995-12-13
IL98008A (en) 1996-08-04

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