FI104908B - Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus - Google Patents

Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus Download PDF

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Publication number: FI104908B
Authority: FI; Finland
Prior art keywords: cys; leu; ala; ser; somatotropin
Prior art date: 1988-08-24

Application number

FI893963A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI893963A (fi

FI893963A0 (fi

Inventor

Susan Mancini Cady

John Steele Logan

Brian Lee Buckwalter

Gerald W Stockton

Deborah Tardy Chaleff

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-23

Publication date

2000-04-28

1989-08-23 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1989-08-23 Publication of FI893963A0 publication Critical patent/FI893963A0/fi

1990-02-25 Publication of FI893963A publication Critical patent/FI893963A/fi

2000-04-28 Application granted granted Critical

2000-04-28 Publication of FI104908B publication Critical patent/FI104908B/fi

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150000002790 naphthalenes Chemical class 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
235000012149 noodles Nutrition 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
150000002942 palmitic acid derivatives Chemical class 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
239000012169 petroleum derived wax Substances 0.000 description 1
235000019381 petroleum wax Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000004080 punching Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
238000011110 re-filtration Methods 0.000 description 1
238000005215 recombination Methods 0.000 description 1
230000006798 recombination Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000008439 repair process Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000004044 response Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
210000002374 sebum Anatomy 0.000 description 1
150000003355 serines Chemical class 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
229920000260 silastic Polymers 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000002002 slurry Substances 0.000 description 1
238000002791 soaking Methods 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
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UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 1
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
239000013598 vector Substances 0.000 description 1
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PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Toxicology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

FI893963A 1988-08-24 1989-08-23 Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus FI104908B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US23606088A	1988-08-24	1988-08-24
US23606088		1988-08-24
US37269989A	1989-07-03	1989-07-03
US37269989		1989-07-03

Publications (3)

Publication Number	Publication Date
FI893963A0 FI893963A0 (fi)	1989-08-23
FI893963A FI893963A (fi)	1990-02-25
FI104908B true FI104908B (fi)	2000-04-28

Family

ID=26929421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI893963A FI104908B (fi)	1988-08-24	1989-08-23	Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus

Country Status (18)

Country	Link
US (1)	US5891840A (de)
EP (1)	EP0355460B1 (de)
JP (1)	JP2894355B2 (de)
AR (1)	AR245138A1 (de)
AT (1)	ATE198353T1 (de)
AU (1)	AU630105B2 (de)
DE (1)	DE68929273T2 (de)
DK (1)	DK416589A (de)
ES (1)	ES2154627T3 (de)
FI (1)	FI104908B (de)
GR (1)	GR3035608T3 (de)
HU (1)	HU217095B (de)
IE (1)	IE892706A1 (de)
IL (1)	IL91156A (de)
NO (1)	NO893387L (de)
NZ (1)	NZ230342A (de)
PT (1)	PT91512B (de)
YU (1)	YU163289A (de)

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US5089473A (en) *	1988-08-29	1992-02-18	Monsanto Company	Somatotropin variants and their use
US5079230A (en) *	1988-09-12	1992-01-07	Pitman-Moore, Inc.	Stable bioactive somatotropins
US5166322A (en) *	1989-04-21	1992-11-24	Genetics Institute	Cysteine added variants of interleukin-3 and chemical modifications thereof
US5951972A (en) *	1990-05-04	1999-09-14	American Cyanamid Company	Stabilization of somatotropins and other proteins by modification of cysteine residues
ATE163431T1 (de) *	1990-05-04	1998-03-15	American Cyanamid Co	Stabilisierung von somatotropin durch modifizierung von cysteinsresten
DK168790D0 (de) *	1990-07-13	1990-07-13	Novo Nordisk As
US6894023B1 (en)	1990-07-13	2005-05-17	Novo Nordisk A/S	Growth hormone crystals and a process for production of these GH-crystals
US5780599A (en) *	1990-07-13	1998-07-14	Novo Nordisk A/S	Growth hormone crystals and a process for production of growth hormone crystals
US5849694A (en) *	1990-07-16	1998-12-15	Synenki; Richard M.	Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5310882A (en) *	1990-11-30	1994-05-10	American Cyanamid Company	Somatotropins with alterations in the α-helix 3 region
NZ260103A (en) *	1990-11-30	1996-10-28	Bio Technology General Corp	Somatotropin with alterations in the alpha-helix-1 region
GB9100381D0 (en) *	1991-01-09	1991-02-20	Erba Carlo Spa	Human bfgf derivatives,their analogs and process for their production
FR2671554A1 (fr) *	1991-01-11	1992-07-17	Clonatec Sa	Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b.
AU654563B2 (en) *	1991-07-24	1994-11-10	Imperial Chemical Industries Plc	Proteins
ZA936811B (en) *	1992-10-28	1995-03-15	Upjohn Co	Somatotropin modifications
US6753165B1 (en)	1999-01-14	2004-06-22	Bolder Biotechnology, Inc.	Methods for making proteins containing free cysteine residues
US7270809B2 (en)	1997-07-14	2007-09-18	Bolder Biotechnology, Inc.	Cysteine variants of alpha interferon-2
US7153943B2 (en)	1997-07-14	2006-12-26	Bolder Biotechnology, Inc.	Derivatives of growth hormone and related proteins, and methods of use thereof
CN1269805A (zh)	1997-07-14	2000-10-11	博尔德生物技术公司	生长激素和相关蛋白的衍生物
US7495087B2 (en)	1997-07-14	2009-02-24	Bolder Biotechnology, Inc.	Cysteine muteins in the C-D loop of human interleukin-11
US20080076706A1 (en)	1997-07-14	2008-03-27	Bolder Biotechnology, Inc.	Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US8288126B2 (en)	1999-01-14	2012-10-16	Bolder Biotechnology, Inc.	Methods for making proteins containing free cysteine residues
CA2408851C (en)	2000-05-16	2011-07-12	Bolder Biotechnology, Inc.	Methods for refolding proteins containing free cysteine residues
US6878861B2 (en)	2000-07-21	2005-04-12	Washington State University Research Foundation	Acyl coenzyme A thioesterases
US7060442B2 (en)	2000-10-30	2006-06-13	Regents Of The University Of Michigan	Modulators on Nod2 signaling
WO2004022593A2 (en) *	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en)	2004-11-04	2011-08-16	Hanall Biopharma Co., Ltd.	Modified growth hormones
US8329866B2 (en)	2005-10-03	2012-12-11	Bolder Biotechnology, Inc.	Long acting VEGF inhibitors and methods of use
WO2007044382A2 (en)	2005-10-07	2007-04-19	Health Protection Agency	Proteins with improved solubility and methods for producing and using same
EP2102355B1 (de)	2006-12-14	2016-03-02	Bolder Biotechnology, Inc.	Proteine und peptide mit langer wirkung sowie verfahren zu ihrer herstellung und verwendung
BRPI0917000A2 (pt) *	2008-08-06	2016-02-16	Novo Nordisk Healthcare Ag	proteínas conjugadas com eficácia in vivo prolongada
JP5816097B2 (ja)	2009-01-22	2015-11-18	ノヴォ・ノルディスク・ヘルス・ケア・アーゲー	安定な成長ホルモン化合物
CN105963710A (zh)	2009-08-06	2016-09-28	诺沃—诺迪斯克保健股份有限公司	具有延长的体内功效的生长激素
EP2805964A1 (de) *	2009-12-21	2014-11-26	Ambrx, Inc.	Modifizierte Rinder-Somatotropinpolypeptide und deren Verwendungen
MX2012006980A (es) *	2009-12-21	2012-07-17	Ambrx Inc	Polipeptidos de somatotropina porcina modificados y sus usos.
AU2011208620B2 (en)	2010-01-22	2015-04-16	Novo Nordisk Health Care Ag	Stable growth hormone compounds
CN118767116A (zh)	2010-01-22	2024-10-15	诺沃—诺迪斯克保健股份有限公司	体内功效延长的生长激素
TR201910573T4 (tr) *	2012-08-31	2019-08-21	Glaxosmithkline Biologicals Sa	Staphylococcus aureus'a karşı bağışıklık kazandırmak için stabilize edilmiş proteinler.
EP2981282B1 (de)	2013-04-05	2020-11-04	Novo Nordisk Health Care AG	Wachstumshormonverbindungsformulierung
KR20180003677A (ko) *	2016-06-30	2018-01-10	주식회사 크레아플래닛	인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물

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US4443539A (en) *	1980-02-05	1984-04-17	The Upjohn Company	Process for preparing bovine growth hormone
FI82266C (fi) *	1982-10-19	1991-02-11	Cetus Corp	Foerfarande foer framstaellning av il-2 -mutein.
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KR910700264A (ko) *	1989-01-19	1991-03-14	로버트 에이. 아미테이지	소마토트로핀 유사물
EP0456642A1 (de) *	1989-01-31	1991-11-21	The Upjohn Company	Somatotropin-analoge
US5849694A (en) *	1990-07-16	1998-12-15	Synenki; Richard M.	Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof

1989
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 EP EP89113852A patent/EP0355460B1/de not_active Expired - Lifetime
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU4020289A (en)	1990-03-15
HUT51331A (en)	1990-04-28
EP0355460A2 (de)	1990-02-28
HU217095B (hu)	1999-11-29
NO893387D0 (no)	1989-08-23
YU163289A (en)	1992-05-28
DE68929273D1 (de)	2001-02-01
EP0355460B1 (de)	2000-12-27
JPH034797A (ja)	1991-01-10
IE892706A1 (en)	1991-01-16
IE892706L (en)	1990-02-24
FI893963A (fi)	1990-02-25
DK416589D0 (da)	1989-08-23
PT91512B (pt)	1995-05-31
PT91512A (pt)	1990-03-08
NZ230342A (en)	1992-08-26
ES2154627T3 (es)	2001-04-16
NO893387L (no)	1990-02-26
DE68929273T2 (de)	2001-07-05
FI893963A0 (fi)	1989-08-23
AR245138A1 (es)	1993-12-30
US5891840A (en)	1999-04-06
EP0355460A3 (de)	1991-04-03
IL91156A (en)	1995-05-26
DK416589A (da)	1990-02-25
IL91156A0 (en)	1990-03-19
AU630105B2 (en)	1992-10-22
JP2894355B2 (ja)	1999-05-24
ATE198353T1 (de)	2001-01-15
GR3035608T3 (en)	2001-06-29

Publication	Publication Date	Title
FI104908B (fi)	2000-04-28	Rekombinanttiporsassomatotropiini ja menetelmiä sen valmistamiseksi sekä sitä sisältävä koostumus
KR100977744B1 (ko)	2010-08-24	콜라겐과 그 생산방법
DE69128944T2 (de)	1998-06-25	Stabilisierung von Somatotropin durch Modifizierung von Cysteinsresten
LU87772A1 (fr)	1990-12-11	Procede de preparation d'une composition pharmaceutique sous forme de microparticules
AU712445B2 (en)	1999-11-04	Cartilage/bone inducing materials for reparation
IL97232A (en)	1994-04-12	Polypropylene polymer flame retardants and a process for their preparation
CZ294992A3 (en)	1993-04-14	Injectable pharmaceutical preparation with prolonged action and process for preparing thereof
US5801141A (en)	1998-09-01	Implant compositions containing a biologically active protein, peptide or polypeptide
CN117618668A (zh)	2024-03-01	一种基于胶原蛋白和软骨形成蛋白的融合蛋白的水凝胶的制备方法及应用
KR0130969B1 (ko)	1998-04-11	동물의 재조합 소마토트로핀과 그의 응집을 막는 방법 및 그를 포함하는 제약학적 조성물
PL164207B1 (pl)	1994-06-30	Sposób hamowania agregacji zwierzecej somatotropiny rekombinowanej PL PL PL PL PL
Jana et al.	2024	Collagen and Gelatin from Fish Processing By-Products for Biomedical Applications
PL164082B1 (pl)	1994-06-30	S posób hamowania agregacji zwierzecej somatotropiny rekombinowanej PL PL PL PL PL
JP3173858B2 (ja)	2001-06-04	抗菌性ペプチドおよび抗菌剤
CN112516330A (zh)	2021-03-19	丝素蛋白与甲状旁腺激素偶联接枝的方法及其应用
Prus et al.	2018	The influence of collagen from various sources on skin parameters
JP3173857B2 (ja)	2001-06-04	抗菌性ペプチドおよび抗菌剤
JPH02249487A (ja)	1990-10-05	ヒツジ成長ホルモン
JP4651013B2 (ja)	2011-03-16	細胞増殖促進因子
AU2005201970B2 (en)	2008-09-04	Collagen and method for producing same
Kouchakian Sabour et al.	2001	A study on the production of gelatin from sturgeon fish skin

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: AMERICAN CYANAMID COMPANY