ES8802234A1 - Un metodo para preparar un peptido o una sal no toxica del mismo - Google Patents
Un metodo para preparar un peptido o una sal no toxica del mismoInfo
- Publication number
- ES8802234A1 ES8802234A1 ES543284A ES543284A ES8802234A1 ES 8802234 A1 ES8802234 A1 ES 8802234A1 ES 543284 A ES543284 A ES 543284A ES 543284 A ES543284 A ES 543284A ES 8802234 A1 ES8802234 A1 ES 8802234A1
- Authority
- ES
- Spain
- Prior art keywords
- phe
- pal
- tyr
- trp
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title 1
- -1 4Cl-D-Phe Chemical compound 0.000 abstract 3
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 210000002149 gonad Anatomy 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- HQMLIDZJXVVKCW-UWTATZPHSA-N (2r)-2-aminopropanamide Chemical compound C[C@@H](N)C(N)=O HQMLIDZJXVVKCW-UWTATZPHSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010062767 Hypophysitis Diseases 0.000 abstract 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical group NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 229940094892 gonadotropins Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 210000003635 pituitary gland Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
LOS PEPTIDOS DE FORMULA X-R1-(W) D-PHE-R3-R4-R5-R6-R7-ARG-PRO-R10, DONDE NO EXCLUSIVAMENTE X ES HIDROGENO, R1 3,4-DESHIDROPROLINA, R3 D-ALANINA, R4 SER, R5 TYR, R6 D-LYS, R7 NORLEUCINA, R10 GLY-NH2 Y W ES CL, F O NO2; SE OBTIENEN POR COPULACION DE AMINOACIDOS O PEPTIDOS CORTOS PARA OBTENER UN INTERMEDIO DEL QUE SE SCINDEN LOS GRUPOS PROTECTORES, TRAS LO CUAL SE OBTIENE UNA DE SUS SALES NO TOXICAS. ESTOS PEPTIDOS INHIBEN EN LOS MAMIFEROS LA LIBERACION DE GONADOTROPINAS POR LA GLANDULA PITUITARIA, LOS CUALES REGULAN LA OVULACION.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/612,072 US4569927A (en) | 1984-02-23 | 1984-05-21 | GnRH Antagonists IV |
| US06/653,867 US4652550A (en) | 1984-05-21 | 1984-09-21 | GnRH antagonists VII |
| US69669985A | 1985-01-31 | 1985-01-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES543284A0 ES543284A0 (es) | 1988-04-16 |
| ES8802234A1 true ES8802234A1 (es) | 1988-04-16 |
Family
ID=27417072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543284A Expired ES8802234A1 (es) | 1984-05-21 | 1985-05-20 | Un metodo para preparar un peptido o una sal no toxica del mismo |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0162575B1 (es) |
| JP (1) | JPH0725795B2 (es) |
| AU (1) | AU580598B2 (es) |
| CA (1) | CA1302650C (es) |
| DE (1) | DE3583964D1 (es) |
| DK (1) | DK166214C (es) |
| ES (1) | ES8802234A1 (es) |
| GR (1) | GR851205B (es) |
| HU (1) | HU198089B (es) |
| IL (1) | IL74827A (es) |
| MX (1) | MX160995A (es) |
| NZ (1) | NZ212124A (es) |
| PH (1) | PH22655A (es) |
| PT (1) | PT80443B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795740A (en) * | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| US5140009A (en) * | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
| JP2673025B2 (ja) * | 1988-02-10 | 1997-11-05 | タツプ・フアーマシユーテイカルズ・インコーポレイテツド | 小さいサイズのｌｈｒｈ類似体 |
| JP2672677B2 (ja) * | 1989-02-09 | 1997-11-05 | タツプ・フアーマシユーテイカルズ・インコーポレイテツド | Ｌｈｒｈ同族体 |
| US5656727A (en) * | 1992-09-15 | 1997-08-12 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
| US5480969A (en) * | 1992-09-15 | 1996-01-02 | The Administrators Of The Tulane Educational Fund | Antagonists of LHRH |
| US6602856B1 (en) * | 1995-01-17 | 2003-08-05 | J. Mark Quillan | Antagonists of alpha-melanocyte stimulating hormone and methods based thereon |
| HU230601B1 (hu) | 2000-12-22 | 2017-02-28 | Ipsen Manufacturing Ireland Limited | Eljárás Trp aminosavat tartalmazó peptid szintézisére |
| KR20050090420A (ko) | 2002-12-26 | 2005-09-13 | 다케다 야쿠힌 고교 가부시키가이샤 | 메타스틴 유도체 및 이의 용도 |
| EP1604682A4 (en) | 2003-03-12 | 2009-06-24 | Takeda Chemical Industries Ltd | AGENTS IMPROVING GONADIC FUNCTION |
| AU2005257484A1 (en) | 2004-06-25 | 2006-01-05 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933782A (en) * | 1974-11-14 | 1976-01-20 | American Home Products Corporation | (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates |
| NZ188987A (en) * | 1977-11-30 | 1982-02-23 | Salk Inst For Biological Studi | Peptide analogues of luteinizing hormone releasing factor |
| US4215038A (en) | 1978-10-16 | 1980-07-29 | The Salk Institute For Biological Studies | Peptides which inhibit gonadal function |
| US4292313A (en) * | 1980-04-15 | 1981-09-29 | The Salk Institute For Biological Studies | LRF Antagonists |
| NZ196558A (en) * | 1980-04-15 | 1984-10-19 | Salk Inst For Biological Studi | Lrf antagonists and pharmaceutical compositions |
| US4409208A (en) * | 1980-04-15 | 1983-10-11 | The Salk Institute For Biological Studies | GnRH antagonists |
| DE3165535D1 (en) * | 1980-06-02 | 1984-09-20 | Andrew Victor Schally | Lh-rh antagonists |
| US4341767A (en) * | 1980-10-06 | 1982-07-27 | Syntex Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| JPS57162562A (en) * | 1981-03-30 | 1982-10-06 | Nec Corp | Delay wave detecting circuit |
| AU9102582A (en) * | 1981-12-10 | 1983-06-16 | David Howard Coy | Lh-rh antagonists |
| ZA829041B (en) * | 1981-12-10 | 1983-09-28 | David Howard Coy | Lh-rh antagonists |
| US4444759A (en) * | 1982-07-26 | 1984-04-24 | The Salk Institute For Biological Studies | GnRH Antagonists II |
| IL70888A0 (en) * | 1983-03-10 | 1984-05-31 | Salk Inst For Biological Studi | Gn rh antagonist peptides and pharmaceutical compositions containing them |
| ZA84912B (en) * | 1983-03-10 | 1984-09-26 | Salk Inst For Biological Studi | Gnrh antagonists |
| US4504414A (en) * | 1983-03-28 | 1985-03-12 | Board Of Regents, The University Of Texas System | Synthetic pyridyl-alanyl decapeptides having antiovulatory activity |
-
1985
- 1985-04-05 IL IL74827A patent/IL74827A/xx unknown
- 1985-04-17 DE DE8585302702T patent/DE3583964D1/de not_active Expired - Lifetime
- 1985-04-17 EP EP85302702A patent/EP0162575B1/en not_active Expired - Lifetime
- 1985-04-19 CA CA000479605A patent/CA1302650C/en not_active Expired - Lifetime
- 1985-05-08 PH PH32241A patent/PH22655A/en unknown
- 1985-05-10 PT PT80443A patent/PT80443B/pt unknown
- 1985-05-14 AU AU42447/85A patent/AU580598B2/en not_active Ceased
- 1985-05-17 JP JP60105745A patent/JPH0725795B2/ja not_active Expired - Lifetime
- 1985-05-17 GR GR851205A patent/GR851205B/el unknown
- 1985-05-20 NZ NZ212124A patent/NZ212124A/xx unknown
- 1985-05-20 ES ES543284A patent/ES8802234A1/es not_active Expired
- 1985-05-21 DK DK224985A patent/DK166214C/da not_active IP Right Cessation
- 1985-05-21 HU HU851920A patent/HU198089B/hu not_active IP Right Cessation
- 1985-05-21 MX MX205358A patent/MX160995A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU198089B (en) | 1989-07-28 |
| EP0162575A3 (en) | 1987-10-07 |
| JPH0725795B2 (ja) | 1995-03-22 |
| ES543284A0 (es) | 1988-04-16 |
| PT80443B (en) | 1986-12-15 |
| EP0162575A2 (en) | 1985-11-27 |
| DK224985D0 (da) | 1985-05-21 |
| AU580598B2 (en) | 1989-01-19 |
| DK166214C (da) | 1993-08-16 |
| IL74827A0 (en) | 1985-07-31 |
| EP0162575B1 (en) | 1991-09-04 |
| PT80443A (en) | 1985-06-01 |
| DK166214B (da) | 1993-03-22 |
| DE3583964D1 (de) | 1991-10-10 |
| NZ212124A (en) | 1989-04-26 |
| CA1302650C (en) | 1992-06-02 |
| MX160995A (es) | 1990-06-29 |
| PH22655A (en) | 1988-10-28 |
| JPS60260594A (ja) | 1985-12-23 |
| DK224985A (da) | 1985-11-22 |
| GR851205B (es) | 1985-11-25 |
| AU4244785A (en) | 1985-11-28 |
| IL74827A (en) | 1989-06-30 |
| HUT37634A (en) | 1986-01-23 |
Similar Documents
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| ES8505335A1 (es) | Un metodo de preparar un peptido que inhibe la liberacion de gonadotropinas por la glandula pituitaria en mamiferos | |
| CA2292846C (en) | Lh-rh peptide analogues, their uses and pharmaceutical compositions containing them | |
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| JPS6434997A (en) | Peptide, manufacture, lhrh antagonistic medicine and manufacture | |
| KR970701730A (ko) | GnRH 길항물질(GNRH ANTAGONISTS) | |
| ES8307720A1 (es) | "un metodo para la preparacion de peptidos antagonistas de una hormona hipotalamica". | |
| ES8504677A1 (es) | Un procedimiento para obtener un peptido o una sal no toxica del mismo. | |
| ES8207510A1 (es) | Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos. | |
| TH1657A (th) | กรรมวิธีการผลิตสารจีเอนอาร์เอช iii | |
| FI933629L (fi) | Antagonistpeptider till hormon som frigoer luteiniserande hormon (lhrh) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |