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ES8608536A1 - Procedimiento de preparacion de 21-hidroxi-20-ceto-delta 16-esteroides y nuevos compuestos intermedios formados en este procedimiento - Google Patents

Procedimiento de preparacion de 21-hidroxi-20-ceto-delta 16-esteroides y nuevos compuestos intermedios formados en este procedimiento

Info

Publication number
ES8608536A1
ES8608536A1 ES532031A ES532031A ES8608536A1 ES 8608536 A1 ES8608536 A1 ES 8608536A1 ES 532031 A ES532031 A ES 532031A ES 532031 A ES532031 A ES 532031A ES 8608536 A1 ES8608536 A1 ES 8608536A1
Authority
ES
Spain
Prior art keywords
new
steroids
keto
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532031A
Other languages
English (en)
Other versions
ES532031A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES8608536A1 publication Critical patent/ES8608536A1/es
Publication of ES532031A0 publication Critical patent/ES532031A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 17-(2-ALCOXI-3-OXOZOLIN-4-IL)-DELTA16-ESTEROIDES, DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO, METILO O ESTA AUSENTE; R2 ES HIDROGENO O METILO; R5 ES ALQUILO; R4 PUEDE SER VARIOS TIPOS DE RADICALES; Y LOS ANILLOS A, B, C Y D PUEDEN CONTENER SUSTITUYENTES. CONSISTE EN LA REACCION DE UN 17-(ISOCIANO-SULFONILMETILENO)ESTEROIDE, DE FORMULA (II), EN LA QUE R3 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN ALDEHIDO, TAL COMO FORMALDEHIDO Y UN ALCOHOL ALQUILICO C1-6. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, BAJO CONDICIONES DE TRANSFERENCIA DE FASES. EL COMPUESTO OBTENIDO SE PUEDE HIDROLIZAR AL CORRESPONDIENTE 21-HIDROXI-20-CETO-DELTA16-ESTEROIDE. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA SINTESIS DE MEDICAMENTOS.
ES532031A 1983-04-29 1984-04-28 Procedimiento de preparacion de 21-hidroxi-20-ceto-delta 16-esteroides y nuevos compuestos intermedios formados en este procedimiento Expired ES8608536A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP83200618A EP0123736A1 (en) 1983-04-29 1983-04-29 New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process

Publications (2)

Publication Number Publication Date
ES8608536A1 true ES8608536A1 (es) 1986-07-16
ES532031A0 ES532031A0 (es) 1986-07-16

Family

ID=8190951

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532031A Expired ES8608536A1 (es) 1983-04-29 1984-04-28 Procedimiento de preparacion de 21-hidroxi-20-ceto-delta 16-esteroides y nuevos compuestos intermedios formados en este procedimiento
ES553608A Expired ES8800262A1 (es) 1983-04-29 1986-04-01 Procedimiento de preparacion de 21-hidroxi-20-ceto-delta16-esteroides

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES553608A Expired ES8800262A1 (es) 1983-04-29 1986-04-01 Procedimiento de preparacion de 21-hidroxi-20-ceto-delta16-esteroides

Country Status (18)

Country Link
US (1) US4548749A (es)
EP (2) EP0123736A1 (es)
JP (2) JPS59206400A (es)
KR (1) KR860001470B1 (es)
AT (1) ATE71108T1 (es)
AU (1) AU567934B2 (es)
CA (1) CA1302401C (es)
DE (1) DE3485399D1 (es)
DK (2) DK166544B1 (es)
ES (2) ES8608536A1 (es)
FI (1) FI82059C (es)
GR (1) GR81987B (es)
HU (2) HU203767B (es)
IE (1) IE57392B1 (es)
IL (1) IL71659A (es)
NO (1) NO167512C (es)
NZ (1) NZ207986A (es)
PT (1) PT78504B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
FR2677028B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
WO2001005364A1 (en) * 1999-07-15 2001-01-25 The Procter & Gamble Company Nitrogen-containing steroid compounds and their use to regulate hair growth
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE927029C (de) * 1952-02-12 1955-04-28 Hoechst Ag Verfahren zur Herstellung von 16, 17-Oxydo-20, 21-ketolen der Pregnanreihe
US2963496A (en) * 1957-06-05 1960-12-06 Olin Mathieson 9 alpha-halo-16-dehydro steroids of the pregnane series
US3056730A (en) * 1961-06-14 1962-10-02 Olin Mathieson 21-hydroxylation of steroids
US3281415A (en) * 1963-08-30 1966-10-25 Upjohn Co Steroidal delta16-20 (alpha and beta)-hydroperoxides
NL6801762A (es) * 1967-02-20 1968-08-21
US3493563A (en) * 1968-02-23 1970-02-03 Squibb & Sons Inc Process for the production of intermediates for triamcinolone and related compounds
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2493324B1 (es) * 1980-11-05 1983-01-21 Roussel Uclaf
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
US4460509A (en) * 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
NO167512B (no) 1991-08-05
DK212384D0 (da) 1984-04-27
IL71659A0 (en) 1984-07-31
HU194906B (en) 1988-03-28
JPH053479B2 (es) 1993-01-14
ATE71108T1 (de) 1992-01-15
DK166544B1 (da) 1993-06-07
NO167512C (no) 1991-11-13
HUT34217A (en) 1985-02-28
EP0127216A1 (en) 1984-12-05
DK22292D0 (da) 1992-02-21
FI841680A0 (fi) 1984-04-27
US4548749A (en) 1985-10-22
NO841701L (no) 1984-10-30
ES553608A0 (es) 1987-11-01
EP0123736A1 (en) 1984-11-07
KR860001470B1 (ko) 1986-09-26
ES532031A0 (es) 1986-07-16
IL71659A (en) 1988-11-15
ES8800262A1 (es) 1987-11-01
PT78504A (en) 1984-05-01
CA1302401C (en) 1992-06-02
FI841680A (fi) 1984-10-30
DE3485399D1 (de) 1992-02-13
GR81987B (es) 1984-12-12
FI82059C (fi) 1991-01-10
IE841039L (en) 1984-10-29
DK212384A (da) 1984-10-30
FI82059B (fi) 1990-09-28
NZ207986A (en) 1986-11-12
EP0127216B1 (en) 1992-01-02
AU2713584A (en) 1984-11-01
JPH06287200A (ja) 1994-10-11
DK167443B1 (da) 1993-11-01
JPH0699470B2 (ja) 1994-12-07
PT78504B (en) 1986-05-20
DK22292A (da) 1992-02-21
AU567934B2 (en) 1987-12-10
JPS59206400A (ja) 1984-11-22
IE57392B1 (en) 1992-08-26
KR840008462A (ko) 1984-12-15
HU203767B (en) 1991-09-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506