[go: up one dir, main page]

ES8607342A1 - Procedimiento para preparar peptidos, utilizables como pro- ductos intermedios en la sintesis de gonadorelina o de sus compuestos analogos - Google Patents

Procedimiento para preparar peptidos, utilizables como pro- ductos intermedios en la sintesis de gonadorelina o de sus compuestos analogos

Info

Publication number
ES8607342A1
ES8607342A1 ES541535A ES541535A ES8607342A1 ES 8607342 A1 ES8607342 A1 ES 8607342A1 ES 541535 A ES541535 A ES 541535A ES 541535 A ES541535 A ES 541535A ES 8607342 A1 ES8607342 A1 ES 8607342A1
Authority
ES
Spain
Prior art keywords
denotes
gonadorelin
intermediates
preparation
obut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541535A
Other languages
English (en)
Other versions
ES541535A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES541535A0 publication Critical patent/ES541535A0/es
Publication of ES8607342A1 publication Critical patent/ES8607342A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PEPTIDOS, UTILIZABLES COMO PRODUCTOS INTERMEDIOS EN LA SINTESIS GONADORELINA O DE SUS COMPUESTOS ANALOGOS, DE FORMULA GENERAL (I), EN LA QUE U SIGNIFICA UN GRUPO PROTECTOR URETANO; A1 SIGNIFICA TRP O D-TRP; A2 SIGNIFICA SER, ALA O THR; A3 SIGNIFICA TYR O PHE; Y V SIGNIFICA OH. CONSISTE EN HACER REACCIONAR UN TRIPEPTIDO DE FORMULA GENERAL (I), EN LA QUE V REPRESENTA OH, MEDIANTE CONDENSACION DE FRAGMENTOS DE PEPTIDOS SEGUN EL ESQUEMA DE CONDENSACION: (1C2)B3 O 1B(2C3), SIENDO BLOQUEADOS EVENTUALMENTE CON CARACTER INTERMEDIO OTROS GRUPOS FUNCIONALES. EL TRIPEPTIDO ASI OBTENIDO SE HACE REACCIONAR, EN CASO DESEADO, CON UN PEPTIDO DE FORMULA GENERAL (II), PARA LA FORMACION DE UN PEPTIDO DE FORMULA GENERAL (I), EN LA QUE V REPRESENTA A4-A5-X. DE APLICACION COMO PRODUCTOS INTERMEDIOS EN LA SINTESIS DE GONADORELINA, HORMONA PROCEDENTE DEL HIPOTALAMO.
ES541535A 1984-03-27 1985-03-25 Procedimiento para preparar peptidos, utilizables como pro- ductos intermedios en la sintesis de gonadorelina o de sus compuestos analogos Expired ES8607342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843411224 DE3411224A1 (de) 1984-03-27 1984-03-27 Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren

Publications (2)

Publication Number Publication Date
ES541535A0 ES541535A0 (es) 1986-05-16
ES8607342A1 true ES8607342A1 (es) 1986-05-16

Family

ID=6231739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541535A Expired ES8607342A1 (es) 1984-03-27 1985-03-25 Procedimiento para preparar peptidos, utilizables como pro- ductos intermedios en la sintesis de gonadorelina o de sus compuestos analogos

Country Status (10)

Country Link
US (1) US4691008A (es)
EP (1) EP0156280B1 (es)
JP (1) JPH0686478B2 (es)
AT (1) ATE50267T1 (es)
CA (1) CA1278650C (es)
DE (2) DE3411224A1 (es)
DK (1) DK170820B1 (es)
ES (1) ES8607342A1 (es)
HU (1) HU197928B (es)
IL (1) IL74703A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608251A (en) * 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
DE3839379A1 (de) * 1988-11-22 1990-05-23 Hoechst Ag Verfahren zur herstellung von tripeptiden
US5191065A (en) * 1988-11-22 1993-03-02 Hoechst Aktiengesellschaft Process for the preparation of tripeptides
DE19527574A1 (de) * 1995-07-28 1997-01-30 Basf Ag Verfahren zur Herstellung vona-(N,N-Dialkyl)-aminocaarbonsäureamiden
AUPO776897A0 (en) * 1997-07-09 1997-07-31 Csl Limited A method of achieving production gains in livestock and agents useful for same
AUPP807399A0 (en) 1999-01-08 1999-02-04 Csl Limited Improved immunogenic lhrh composition and methods relating thereto
DE10333042B4 (de) * 2003-07-21 2005-09-29 Clariant Gmbh Verfahren zur Herstellung von cyclischen Phosphonsäureanhydriden und deren Verwendung
CN112500455A (zh) * 2020-10-12 2021-03-16 湖南津安生物科技有限公司 一种多肽固液组合合成戈那瑞林的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953416A (en) * 1971-12-20 1976-04-27 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
FR2238700B1 (es) * 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
CS180644B2 (en) * 1973-09-29 1978-01-31 Takeda Chemical Industries Ltd Process for preparing nonapeptides
US3915947A (en) * 1974-07-11 1975-10-28 Lilly Co Eli Des-{8 His{hu 2{b ,Gly{hu 10{b {9 -D-Ala{hu 6 {b LHRH ethylamide as an inhibitor of LHRH
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3963691A (en) * 1974-10-07 1976-06-15 Merck & Co., Inc. Synthetic antigens of luteinizing hormone releasing hormone
US4272432A (en) * 1974-11-13 1981-06-09 American Home Products Corporation Claudogenic-interceptive nonapeptide
NL7611963A (nl) * 1975-10-29 1977-05-03 Parke Davis & Co Werkwijze voor het bereiden van nieuwe nonapep- tiden.
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US4101537A (en) * 1977-04-07 1978-07-18 Parke, Davis & Company Octapeptides and methods for their production
DE3020941A1 (de) * 1980-06-03 1981-12-17 Hoechst Ag, 6000 Frankfurt Nonapeptid, verfahren zu seiner herstellung, dieses enthaltendes mittel und seine verwendung
JPS57118563A (en) * 1981-01-14 1982-07-23 Takeda Chem Ind Ltd Indole derivative and preparation of peptide
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists

Also Published As

Publication number Publication date
DE3411224A1 (de) 1985-10-10
IL74703A0 (en) 1985-06-30
DK170820B1 (da) 1996-01-29
DK137085D0 (da) 1985-03-26
JPH0686478B2 (ja) 1994-11-02
ATE50267T1 (de) 1990-02-15
HU197928B (en) 1989-06-28
JPS60218399A (ja) 1985-11-01
HUT37445A (en) 1985-12-28
EP0156280A3 (en) 1987-10-21
EP0156280B1 (de) 1990-02-07
ES541535A0 (es) 1986-05-16
US4691008A (en) 1987-09-01
IL74703A (en) 1988-11-30
CA1278650C (en) 1991-01-02
DE3575931D1 (de) 1990-03-15
EP0156280A2 (de) 1985-10-02
DK137085A (da) 1985-09-28

Similar Documents

Publication Publication Date Title
CA1069888A (en) Peptides having strong lh-rh/fsh-rh activity and process for their manufacture
HU903740D0 (en) Process for the production of new proteins
Rovero et al. Synthesis of cyclic peptides on solid support
YU200083A (en) Process for making hpgrf peptide
MD1652G2 (ro) Proteină cu activitate de tip citochină, ADN recombinant, codificator pentru această proteină, celule şi microorganisme transformate, vector de expresie, procedeu de obţinere a proteinei şi remediu care conţine această proteină
KR870007203A (ko) 펩타이드를 제조하는 방법
EP0467279A2 (en) Polypeptides having c-AMP producing activity
AU5963290A (en) Inhibition of the n-end rule pathway in living cells
ES8607342A1 (es) Procedimiento para preparar peptidos, utilizables como pro- ductos intermedios en la sintesis de gonadorelina o de sus compuestos analogos
NZ198626A (en) Peptides and pharmaceutical compositions
Wang et al. Preparation of protected peptide intermediates for a synthesis of the ovine pituitary growth hormone sequence 96-135
US4491541A (en) Peptides
US3816385A (en) (ile3,leu4)-vasopressin analogs and intermediates
EP0292257A3 (en) Peptides having anf activity
ES2001392A6 (es) Un procedimiento para la preparacion de polipeptidos analogos a superoxidos dismutasa humana.
GB2130590A (en) Peptides
MARTINEZ et al. SYNTHESIS OF ANALOGS OF THE SERUM THYMIC NONAPEPTIDE,“FACTEUR THYMIQUE SERIQUE”(FTS) Part II
US4474765A (en) Biologically active peptides
GB1465235A (en) Process for preparing peptides
EP0015036B1 (en) Psycho-pharmacological peptides, process for their preparation and therapeutical compositions containing them
EP0056274A1 (en) Indole derivatives and a method for production of peptides
Nozaki Synthesis of [2-serine, 8-valine]-human calcitonin.
GB2118190A (en) Peptides with sauvagine-like activity
Procházka et al. Synthesis and properties of analogues of vasopressin with 1-aminocyclopropane-1-carboxylic acid in position 9
GB1486578A (en) Process for preparing somatostatin and derivatives thereo

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060128