ES8607284A1 - Un procedimiento para la produccion de un isomero optico dextrogiro - Google Patents
Un procedimiento para la produccion de un isomero optico dextrogiroInfo
- Publication number
- ES8607284A1 ES8607284A1 ES547696A ES547696A ES8607284A1 ES 8607284 A1 ES8607284 A1 ES 8607284A1 ES 547696 A ES547696 A ES 547696A ES 547696 A ES547696 A ES 547696A ES 8607284 A1 ES8607284 A1 ES 8607284A1
- Authority
- ES
- Spain
- Prior art keywords
- reaction
- isomero
- optical
- dextrogiro
- levogiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003287 optical effect Effects 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DE UN ISOMERO OPTICO DEXTROGIRO DEL DIASTEREOMERO A DE ESTER 3-(1-BENCILPIRROLIDIN-3-ILICO). CONSISTE EN HACER REACCIONAR UN ISOMERO OPTICO LEVOGIRO O UN RACEMATO DEL ACIDO 5-(METOXICARBONIL-2,6-DIMETIL-4-(M-NITROFENIL)-1,4-DIHIDROPIRIDIN-3-CARBOXILICO CON UN ISOMERO OPTICO LEVOGIRO O UN RACEMATO DE 1-BENCIL-3-HIDROXIPIRROLIDINA; EN PRESENCIA, OPCIONALMENTE, DE UN AGENTE CONDENSANTE (DICICLOHEXILCARBODIIMIDA). LA REACCION SE LLEVA A CABO EN DISOLVENTE ORGANICO (CLORURO DE METILENO, DIMETILFORMAMIDA) Y ENFRIANDO EL MEDIO DE REACCION O MANTENIENDOLO A TEMPERATURA AMBIENTE. OBTENIENDOSE EL PRODUCTO FINAL; QUE PUEDE AISLARSE DE LA MEZCLA DE REACCION POR EXTRACCION, CONCENTRACION O BIEN POR CROMATOGRAFIA EN COLUMNA. SELECTIVAMENTE PUEDE OBTENERSE COMO PRODUCTO DE REACCION, EL ISOMERO OPTICO DEXTROGIRO, O BIEN UNA MEZCLA DE AMBOS ISOMEROS OPTICOS DEXTROGIRO Y LEVOGIRO; QUE SERAN SEPARADOS POR CROMATOGRAFIA EN COLUMNA O POR CRISTALIZACION FRACCIONADA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1205185 | 1985-01-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES547696A0 ES547696A0 (es) | 1986-05-16 |
| ES8607284A1 true ES8607284A1 (es) | 1986-05-16 |
Family
ID=11794796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547696A Expired ES8607284A1 (es) | 1985-01-24 | 1985-10-08 | Un procedimiento para la produccion de un isomero optico dextrogiro |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS61267577A (es) |
| KR (1) | KR900002342B1 (es) |
| CN (1) | CN1023483C (es) |
| AT (1) | AT390613B (es) |
| CA (1) | CA1273931A (es) |
| DK (1) | DK468385A (es) |
| ES (1) | ES8607284A1 (es) |
| FI (1) | FI83517C (es) |
| GR (1) | GR852497B (es) |
| IT (1) | IT1221762B (es) |
| MX (1) | MX260A (es) |
| NO (1) | NO166643C (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2309082T3 (es) * | 2000-08-01 | 2008-12-16 | Kaneka Corporation | Nueva carbonil reductasa, gen de la misma y metodo para usar la misma. |
| KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법 |
| CN101643469B (zh) * | 2008-12-27 | 2012-11-21 | 武汉百科药物开发有限公司 | 一种盐酸巴尼地平的合成工艺 |
| EP4382529A1 (en) | 2022-12-07 | 2024-06-12 | Bayer Consumer Care AG | A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride |
-
1985
- 1985-09-26 FI FI853697A patent/FI83517C/fi not_active IP Right Cessation
- 1985-10-08 ES ES547696A patent/ES8607284A1/es not_active Expired
- 1985-10-11 CN CN85107590A patent/CN1023483C/zh not_active Expired - Lifetime
- 1985-10-14 MX MX260A patent/MX260A/es unknown
- 1985-10-14 AT AT0297085A patent/AT390613B/de not_active IP Right Cessation
- 1985-10-14 KR KR1019850007554A patent/KR900002342B1/ko not_active IP Right Cessation
- 1985-10-14 DK DK468385A patent/DK468385A/da not_active Application Discontinuation
- 1985-10-14 NO NO854062A patent/NO166643C/no not_active IP Right Cessation
- 1985-10-15 IT IT22489/85A patent/IT1221762B/it active
- 1985-10-15 GR GR852497A patent/GR852497B/el unknown
- 1985-10-15 CA CA000492966A patent/CA1273931A/en not_active Expired
-
1986
- 1986-01-22 JP JP61012358A patent/JPS61267577A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX260A (es) | 1995-01-31 |
| AT390613B (de) | 1990-06-11 |
| IT1221762B (it) | 1990-07-12 |
| KR860005637A (ko) | 1986-08-11 |
| ES547696A0 (es) | 1986-05-16 |
| DK468385A (da) | 1986-07-25 |
| NO854062L (no) | 1986-07-25 |
| CA1273931A (en) | 1990-09-11 |
| KR900002342B1 (ko) | 1990-04-12 |
| IT8522489A0 (it) | 1985-10-15 |
| NO166643C (no) | 1991-08-21 |
| GR852497B (es) | 1986-02-18 |
| DK468385D0 (da) | 1985-10-14 |
| CN85107590A (zh) | 1986-07-23 |
| FI83517B (fi) | 1991-04-15 |
| FI853697L (fi) | 1986-07-25 |
| FI83517C (fi) | 1991-07-25 |
| FI853697A0 (fi) | 1985-09-26 |
| CN1023483C (zh) | 1994-01-12 |
| NO166643B (no) | 1991-05-13 |
| JPS61267577A (ja) | 1986-11-27 |
| ATA297085A (de) | 1989-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051231 |