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ES8607284A1 - Novel production of dextrorotary optical isomer of ym-09730 diastereomer a - Google Patents

Novel production of dextrorotary optical isomer of ym-09730 diastereomer a

Info

Publication number
ES8607284A1
ES8607284A1 ES547696A ES547696A ES8607284A1 ES 8607284 A1 ES8607284 A1 ES 8607284A1 ES 547696 A ES547696 A ES 547696A ES 547696 A ES547696 A ES 547696A ES 8607284 A1 ES8607284 A1 ES 8607284A1
Authority
ES
Spain
Prior art keywords
reaction
isomero
optical
dextrogiro
levogiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547696A
Other languages
Spanish (es)
Other versions
ES547696A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Eli Lilly and Co
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd, Eli Lilly and Co filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES8607284A1 publication Critical patent/ES8607284A1/en
Publication of ES547696A0 publication Critical patent/ES547696A0/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for the production of an optical isomero dextrogiro of the diestereomer a of ester 3- (1-bencilpirrolidin-3-ilico). Is to make reaction an isomero optico levogiro or a racemato of the acid 5- (metoxicarbonil-2,6-dimethyl-4- (m-nitrofenil) -1,4-dihidropiridin-3-carboxilico with an isomero optico levogiro or a racemato de 1-bencil-3-hydroxypirrolidine, in presence, optionally, of a condensing agent (diciclohexilcarbodiimida) the reaction is carried out in organic solvent (methylene chloride, dimethylformamide) and cooling the means of reaction or maintaining it at ambient temperature. The final product, which can be isolated from the reaction mixture by extraction, concentration or by column chromatography, selectively can be obtained as a reaction product, the optical isomero dextrogiro, or a mixture of both optical isomeros dextrogiro and levogram; separated by chromatography in column or by fractionated crystallization. (Machine-translation by Google Translate, not legally binding)
ES547696A 1985-01-24 1985-10-08 Novel production of dextrorotary optical isomer of ym-09730 diastereomer a Expired ES8607284A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1205185 1985-01-24

Publications (2)

Publication Number Publication Date
ES8607284A1 true ES8607284A1 (en) 1986-05-16
ES547696A0 ES547696A0 (en) 1986-05-16

Family

ID=11794796

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547696A Expired ES8607284A1 (en) 1985-01-24 1985-10-08 Novel production of dextrorotary optical isomer of ym-09730 diastereomer a

Country Status (12)

Country Link
JP (1) JPS61267577A (en)
KR (1) KR900002342B1 (en)
CN (1) CN1023483C (en)
AT (1) AT390613B (en)
CA (1) CA1273931A (en)
DK (1) DK468385A (en)
ES (1) ES8607284A1 (en)
FI (1) FI83517C (en)
GR (1) GR852497B (en)
IT (1) IT1221762B (en)
MX (1) MX260A (en)
NO (1) NO166643C (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60134557D1 (en) * 2000-08-01 2008-08-07 Kaneka Corp NEW CARBONYL REDUCTASE, THEIR GENE AND METHOD FOR THE USE THEREOF
KR100939347B1 (en) 2005-07-20 2010-01-29 (주)카이로드 Method for preparing optically pure (S) -3-hydroxy pyrrolidine
CN101643469B (en) * 2008-12-27 2012-11-21 武汉百科药物开发有限公司 Synthesis process of barnidipine hydrochloride
EP4382529A1 (en) 2022-12-07 2024-06-12 Bayer Consumer Care AG A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Also Published As

Publication number Publication date
DK468385D0 (en) 1985-10-14
MX260A (en) 1995-01-31
JPS61267577A (en) 1986-11-27
IT1221762B (en) 1990-07-12
FI853697L (en) 1986-07-25
NO166643B (en) 1991-05-13
NO166643C (en) 1991-08-21
NO854062L (en) 1986-07-25
FI853697A0 (en) 1985-09-26
KR860005637A (en) 1986-08-11
CN1023483C (en) 1994-01-12
FI83517C (en) 1991-07-25
FI83517B (en) 1991-04-15
DK468385A (en) 1986-07-25
GR852497B (en) 1986-02-18
AT390613B (en) 1990-06-11
ES547696A0 (en) 1986-05-16
KR900002342B1 (en) 1990-04-12
IT8522489A0 (en) 1985-10-15
CN85107590A (en) 1986-07-23
ATA297085A (en) 1989-11-15
CA1273931A (en) 1990-09-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051231