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ES466794A1 - Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulphoxides and sulphones - Google Patents

Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulphoxides and sulphones

Info

Publication number
ES466794A1
ES466794A1 ES466794A ES466794A ES466794A1 ES 466794 A1 ES466794 A1 ES 466794A1 ES 466794 A ES466794 A ES 466794A ES 466794 A ES466794 A ES 466794A ES 466794 A1 ES466794 A1 ES 466794A1
Authority
ES
Spain
Prior art keywords
dicyclic
sulphones
antiinflammatory
imidazoles
substituted thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466794A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/865,832 external-priority patent/US4159338A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES466794A1 publication Critical patent/ES466794A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The novel compounds having anti-inflammatory activity are of the formula < IMAGE > R1 to R4 and n are defined in Patent Claim 1. The same activity is also exhibited by the pharmaceutically acceptable acid addition salts of the compounds mentioned, in which n has the value 0 or in which at least one of the radicals R2 and R3, independently, represents 3-pyridyl, and the pharmaceutically acceptable metal salts of the compounds mentioned, in which R4 is hydrogen and n has the value 1 or 2.
ES466794A 1977-02-09 1978-02-08 Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulphoxides and sulphones Expired ES466794A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76722077A 1977-02-09 1977-02-09
US05/865,832 US4159338A (en) 1977-02-09 1978-01-05 Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Publications (1)

Publication Number Publication Date
ES466794A1 true ES466794A1 (en) 1979-08-01

Family

ID=27117879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466794A Expired ES466794A1 (en) 1977-02-09 1978-02-08 Antiinflammatory 4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulphoxides and sulphones

Country Status (26)

Country Link
JP (1) JPS53130664A (en)
AR (1) AR219310A1 (en)
AT (1) AT361470B (en)
AU (1) AU517028B2 (en)
CA (1) CA1105024A (en)
CH (1) CH644108A5 (en)
DE (1) DE2805167A1 (en)
DK (1) DK16778A (en)
ES (1) ES466794A1 (en)
FI (1) FI69462C (en)
FR (1) FR2380275A1 (en)
GB (1) GB1564184A (en)
GR (1) GR64142B (en)
HU (1) HU178211B (en)
IE (1) IE46187B1 (en)
IL (1) IL53995A (en)
IT (1) IT1092588B (en)
LU (1) LU79024A1 (en)
MX (1) MX5933E (en)
NL (1) NL7801453A (en)
NO (1) NO148265C (en)
NZ (1) NZ186410A (en)
PH (1) PH13852A (en)
PT (1) PT67626B (en)
SE (1) SE7801467L (en)
YU (1) YU28878A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1302A (en) * 1978-04-11 1985-12-06 Ciba Geigy Ag Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (en) * 1978-10-02 1980-04-03 Du Pont METHOD FOR PREPARING ANTI-INFLAMMATORY 2-SUBSTITUTED 1H-PHENANTRO (9,10) -IMIDAZOLES
AT374198B (en) * 1979-04-10 1984-03-26 Ciba Geigy Ag METHOD FOR PRODUCING NEW 2-SUBSTITUTED MERCAPTOIMIDAZOLE DERIVATIVES, THEIR N-OXYDES AND THEIR SALTS
FI850995L (en) * 1984-03-16 1985-09-17 Ciba Geigy Ag FOERFARANDE FOER FRAMSTAELLNING AV NYA 3-MERKAPTO-1,2,4-TRIAZACYKLOALKADIENDERIVAT.
EP0994858A1 (en) * 1997-06-30 2000-04-26 Ortho-McNeil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE10107683A1 (en) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituted imidazole derivatives and their use in pharmacy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (en) * 1972-07-29 1978-11-24
SE428686B (en) * 1975-08-11 1983-07-18 Du Pont PROCEDURE FOR PREPARING ANTI-INFLAMMATORALLY ACTIVE IMIDAZOLS

Also Published As

Publication number Publication date
YU28878A (en) 1983-01-21
AU517028B2 (en) 1981-07-02
IT7820078A0 (en) 1978-02-07
NO780433L (en) 1978-08-10
FI780428A (en) 1978-08-10
IE46187B1 (en) 1983-03-23
PT67626B (en) 1979-07-17
AT361470B (en) 1981-03-10
NO148265B (en) 1983-05-30
DE2805167A1 (en) 1978-08-10
NL7801453A (en) 1978-08-11
FI69462B (en) 1985-10-31
FI69462C (en) 1986-02-10
ATA86978A (en) 1980-08-15
IL53995A (en) 1982-02-28
SE7801467L (en) 1978-08-10
JPS53130664A (en) 1978-11-14
FR2380275B1 (en) 1982-01-08
GB1564184A (en) 1980-04-02
LU79024A1 (en) 1979-05-25
GR64142B (en) 1980-01-28
IL53995A0 (en) 1978-04-30
CH644108A5 (en) 1984-07-13
FR2380275A1 (en) 1978-09-08
HU178211B (en) 1982-03-28
NO148265C (en) 1983-09-07
DK16778A (en) 1978-08-10
PT67626A (en) 1978-03-01
NZ186410A (en) 1979-12-11
AR219310A1 (en) 1980-08-15
PH13852A (en) 1980-10-22
IE780279L (en) 1978-08-09
CA1105024A (en) 1981-07-14
MX5933E (en) 1984-08-30
AU3309678A (en) 1979-08-16
IT1092588B (en) 1985-07-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202