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ES384735A1 - Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES384735A1
ES384735A1 ES384735A ES384735A ES384735A1 ES 384735 A1 ES384735 A1 ES 384735A1 ES 384735 A ES384735 A ES 384735A ES 384735 A ES384735 A ES 384735A ES 384735 A1 ES384735 A1 ES 384735A1
Authority
ES
Spain
Prior art keywords
mineral
reaction medium
metal salt
derivatives
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES384735A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DE ROVIRALTA ROCAMORA
Original Assignee
DE ROVIRALTA ROCAMORA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DE ROVIRALTA ROCAMORA filed Critical DE ROVIRALTA ROCAMORA
Priority to ES384735A priority Critical patent/ES384735A1/en
Priority to CH932371A priority patent/CH527825A/en
Publication of ES384735A1 publication Critical patent/ES384735A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for obtaining pyrazolidine derivatives with therapeutic action, particularly acidic pyrazolidine derivatives with antirheumatic action (phenylbutazone, monophenylbutazone, p-hydroxyphenylbutazone, ketobutazone, etc.) neutralized with bases of also known anti-inflammatory, antipyretic, analgesic and myorelaxant (benzidamine or other)., characterized by reacting the metal salt formed therein or outside the reaction medium with the mineral (hydrochloric, sulfuric, etc.) or organic (citric, oxalic, tartaric, etc.) mineral salt of the chosen base of the metal salt of this anion (mineral or organic) remains in the solution of the reaction medium and insolubilized the pyrazolidine compound of the chosen base, operating under conditions such as illumination, temperature and ph that do not compromise the stability of the resulting compound or its constituents, being able of the reaction medium, to be then isolated the co the desired compound is separated from the metal salt by conventional physical means (filtration, centrifugation, decantation, etc.), the desired compound being able to be further purified by dissolution in alcoholic, ketonic, hydroalcoholic or hydrocetonic solutions and reprecipitation by changing medium, and can also be purified by washing with any solvent in which the desired salt is little or very soluble, or respectively soluble or insoluble impurities. (Machine-translation by Google Translate, not legally binding)
ES384735A 1970-10-21 1970-10-21 Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding) Expired ES384735A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES384735A ES384735A1 (en) 1970-10-21 1970-10-21 Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding)
CH932371A CH527825A (en) 1970-10-21 1971-06-25 Multi-activity salts - from antirheumatic pyrazolidines and analgesic bases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES384735A ES384735A1 (en) 1970-10-21 1970-10-21 Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES384735A1 true ES384735A1 (en) 1973-09-01

Family

ID=8457068

Family Applications (1)

Application Number Title Priority Date Filing Date
ES384735A Expired ES384735A1 (en) 1970-10-21 1970-10-21 Procedure for obtaining piazolidinic derivatives with therapeutic action. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
CH (1) CH527825A (en)
ES (1) ES384735A1 (en)

Also Published As

Publication number Publication date
CH527825A (en) 1972-09-15

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