ES427240A1 - Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field - Google Patents
Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical fieldInfo
- Publication number
- ES427240A1 ES427240A1 ES427240A ES427240A ES427240A1 ES 427240 A1 ES427240 A1 ES 427240A1 ES 427240 A ES427240 A ES 427240A ES 427240 A ES427240 A ES 427240A ES 427240 A1 ES427240 A1 ES 427240A1
- Authority
- ES
- Spain
- Prior art keywords
- pinol
- synthesis
- subjected
- sobrerol
- cineole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the synthesis of 2,6-dihydroxyzineol, characterized in that it comprises the following phases from pure overrol, through a pure pinol: A) Pinol epoxide (1: 2: 6: 8-diepoxy-p) is obtained -methane) at 98%, and B) the latter is subjected, as obtained, that is, with about 98%, to hydrolysis, in an aqueous or hydroalcoholic environment, with an acid chosen from among mineral acids, such as hydrochloric, sulfuric, phosphoric and organic acids, such as acetic, tartaric, malic, citric, at a concentration that can vary from traces, suitable for conceiving a pH between 5 and 0.5, at values of 1 - 2%, at a temperature between 10 and 125ºC, depending on the solvent used, at normal pressure and for 6-24 hours; the aqueous (or hydroalcoholic solution obtained) is subjected to salification and extraction with an organic solvent, chosen from ether, chloroform, methylene chloride, and finally the extract is subjected to evaporation and crystallization to isolate 2,6-dihydroxicineol; and characterized by the fact that it operates on an industrial scale. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2512773 | 1973-06-12 | ||
| IT2120574 | 1974-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES427240A1 true ES427240A1 (en) | 1976-09-01 |
Family
ID=26327823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES427240A Expired ES427240A1 (en) | 1973-06-12 | 1976-05-14 | Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5944316B2 (en) |
| AR (2) | AR202410A1 (en) |
| CH (1) | CH605965A5 (en) |
| DE (2) | DE2428039C3 (en) |
| ES (1) | ES427240A1 (en) |
| GB (2) | GB1469921A (en) |
| NL (3) | NL176745C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554366A (en) * | 1982-09-13 | 1985-11-19 | Shell Oil Company | Certain substituted, 7-oxabicyclo[2.2.1]heptan-2-ols and -2-ones as intermediates |
| US4542244A (en) * | 1982-09-13 | 1985-09-17 | Shell Oil Company | Oxabicycloalkane herbicides |
| JPS61181403A (en) * | 1985-02-06 | 1986-08-14 | 島村 ▲てい▼次郎 | Stick |
-
1974
- 1974-05-28 AR AR253955A patent/AR202410A1/en active
- 1974-05-30 GB GB4347676A patent/GB1469921A/en not_active Expired
- 1974-05-30 CH CH746374A patent/CH605965A5/xx not_active IP Right Cessation
- 1974-05-30 GB GB2409074A patent/GB1468758A/en not_active Expired
- 1974-06-11 DE DE2428039A patent/DE2428039C3/en not_active Expired
- 1974-06-11 DE DE2462947A patent/DE2462947C2/en not_active Expired
- 1974-06-12 NL NLAANVRAGE7407862,A patent/NL176745C/en not_active IP Right Cessation
- 1974-06-12 JP JP49066122A patent/JPS5944316B2/en not_active Expired
-
1975
- 1975-04-18 AR AR258428A patent/AR202506A1/en active
-
1976
- 1976-05-14 ES ES427240A patent/ES427240A1/en not_active Expired
-
1984
- 1984-11-14 NL NL8403477A patent/NL8403477A/en not_active Application Discontinuation
- 1984-11-14 NL NL8403481A patent/NL8403481A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CH605965A5 (en) | 1978-10-13 |
| NL176745B (en) | 1985-01-02 |
| AR202506A1 (en) | 1975-06-13 |
| AR202410A1 (en) | 1975-06-06 |
| GB1469921A (en) | 1977-04-06 |
| DE2428039B2 (en) | 1980-10-30 |
| DE2462947C2 (en) | 1986-08-28 |
| DE2428039A1 (en) | 1975-01-09 |
| JPS5035155A (en) | 1975-04-03 |
| DE2428039C3 (en) | 1981-12-24 |
| NL7407862A (en) | 1974-12-16 |
| NL8403481A (en) | 1985-03-01 |
| NL176745C (en) | 1985-06-03 |
| GB1468758A (en) | 1977-03-30 |
| JPS5944316B2 (en) | 1984-10-29 |
| NL8403477A (en) | 1985-03-01 |
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