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ES2524896T3 - Cristal de compuesto de amida - Google Patents

Cristal de compuesto de amida Download PDF

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Publication number
ES2524896T3
ES2524896T3 ES11795784.5T ES11795784T ES2524896T3 ES 2524896 T3 ES2524896 T3 ES 2524896T3 ES 11795784 T ES11795784 T ES 11795784T ES 2524896 T3 ES2524896 T3 ES 2524896T3
Authority
ES
Spain
Prior art keywords
amide compound
compound crystal
crystal
ylcarbonyl
methoxybutyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11795784.5T
Other languages
English (en)
Inventor
Masato Kitayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2524896T3 publication Critical patent/ES2524896T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un cristal del hidrocloruro de 1-(4-metoxibutil)-N-(2-metilpropil)-N-[(3S,5R)-5-(morfolin-4-ilcarbonil)piperidin- 3-il]-1H-bencimidazol-2-carboxamida que tiene un patrón de difracción de polvo de rayos X que muestra picos característicos en espaciamientos interplanares (d) de aproximadamente 26,43 ± 0,2, 7,62 ± 0,2 y 4,32 ± 0,2 angstroms

Description

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Claims (1)

  1. imagen1
ES11795784.5T 2010-06-16 2011-06-15 Cristal de compuesto de amida Active ES2524896T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010137194 2010-06-16
JP2010137194 2010-06-16
PCT/JP2011/063735 WO2011158880A1 (ja) 2010-06-16 2011-06-15 アミド化合物の結晶

Publications (1)

Publication Number Publication Date
ES2524896T3 true ES2524896T3 (es) 2014-12-15

Family

ID=45348277

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11795784.5T Active ES2524896T3 (es) 2010-06-16 2011-06-15 Cristal de compuesto de amida

Country Status (27)

Country Link
US (1) US9018374B2 (es)
EP (1) EP2583967B1 (es)
JP (1) JP5782438B2 (es)
KR (1) KR20130119903A (es)
CN (1) CN103068816B (es)
AU (1) AU2011266099B2 (es)
BR (1) BR112012032055B8 (es)
CA (1) CA2802483C (es)
CL (1) CL2012003526A1 (es)
CO (1) CO6670573A2 (es)
DO (1) DOP2012000313A (es)
EA (1) EA022094B1 (es)
EC (1) ECSP13012392A (es)
ES (1) ES2524896T3 (es)
GE (1) GEP20146195B (es)
IL (1) IL223562A (es)
MA (1) MA34378B1 (es)
MX (1) MX2012014828A (es)
MY (1) MY163927A (es)
PE (1) PE20130283A1 (es)
PH (1) PH12012502468A1 (es)
SG (1) SG186223A1 (es)
TN (1) TN2012000589A1 (es)
TW (1) TWI511967B (es)
UA (1) UA108888C2 (es)
WO (1) WO2011158880A1 (es)
ZA (1) ZA201300065B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104781226A (zh) * 2012-02-14 2015-07-15 陶氏环球技术有限责任公司 非离子型表面活性剂组合物
US20150011549A1 (en) * 2012-02-15 2015-01-08 Takeda Pharmaceutical Company Limited Tablet
CN103831159B (zh) * 2014-01-20 2016-04-13 华润赛科药业有限责任公司 一种阿齐沙坦微粉化方法
EP3130581A4 (en) * 2014-04-10 2017-11-22 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound
GB2542876B (en) * 2015-04-20 2019-10-23 Johnson Matthey Plc Structure Directing Agent
CN107595842A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种药物复方制剂及在制备治疗高血压合并冠心病的药物中的用途
CN107595853A (zh) * 2017-10-25 2018-01-19 桂林浩新科技服务有限公司 一种用于治疗高血压合并冠心病的药物组合物及其用途

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6944296A (en) 1995-09-13 1997-04-01 Takeda Chemical Industries Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
WO2002006234A1 (en) 2000-07-17 2002-01-24 Takeda Chemical Industries, Ltd. Sulfone derivatives, process for their production and use thereof
US7342117B2 (en) 2001-10-30 2008-03-11 Astellas Pharma Inc. α-form or β-form crystal of acetanilide derivative
PE20040609A1 (es) 2002-11-01 2004-10-29 Takeda Pharmaceutical Compuestos heterociclicos aromaticos como promotores de un factor neurotrofico
CA2505322A1 (en) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Receptor function regulator
AU2003284596A1 (en) 2002-11-22 2004-06-18 Takeda Pharmaceutical Company Limited Imidazole derivative, process for producing the same, and use
CN100343248C (zh) * 2003-04-15 2007-10-17 安斯泰来制药株式会社 溴化物及其晶体
JP3618341B2 (ja) * 2003-04-15 2005-02-09 山之内製薬株式会社 臭化物及びその結晶
WO2004106276A1 (ja) 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited 縮合環化合物
EP1641779A1 (en) 2003-06-18 2006-04-05 AstraZeneca AB 2-substitued 5, 6-diaryl-pyrazine derivatives as cb1 modulator.
WO2005030740A1 (ja) 2003-09-30 2005-04-07 Takeda Pharmaceutical Company Limited チアゾリン誘導体およびその用途
WO2005058823A1 (ja) 2003-12-17 2005-06-30 Takeda Pharmaceutical Company Limited ウレア誘導体、その製造法及び用途
US7456218B2 (en) 2003-12-25 2008-11-25 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl) propanoic acid derivatives
US7585880B2 (en) 2003-12-26 2009-09-08 Takeda Pharmaceutical Company Limited Phenylpropanoic acid derivatives
EP1726580A4 (en) 2004-03-15 2008-02-13 Takeda Pharmaceutical AMINOPHNYLPROPANO ACID DERIVATIVE
WO2005095338A1 (ja) 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited アルコキシフェニルプロパン酸誘導体
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
US8957070B2 (en) 2005-04-20 2015-02-17 Takeda Pharmaceutical Company Limited Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity
JP5044398B2 (ja) 2005-06-09 2012-10-10 武田薬品工業株式会社 固形製剤
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
JP5084503B2 (ja) 2005-07-29 2012-11-28 武田薬品工業株式会社 シクロプロパンカルボン酸化合物
US20090054435A1 (en) 2005-07-29 2009-02-26 Hiroshi Imoto Phenoxyalkanoic Acid Compound
PE20070338A1 (es) 2005-08-10 2007-04-16 Takeda Pharmaceutical Derivados heterociclicos como agentes terapeuticos para diabetes
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CN102731451B (zh) 2006-06-27 2015-07-29 武田药品工业株式会社 稠环化合物
WO2008047821A1 (en) 2006-10-18 2008-04-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP5260507B2 (ja) 2006-10-19 2013-08-14 武田薬品工業株式会社 インドール化合物
WO2008093639A1 (ja) 2007-01-29 2008-08-07 Takeda Pharmaceutical Company Limited ピラゾール化合物
KR20090106660A (ko) 2007-02-09 2009-10-09 다케다 야쿠힌 고교 가부시키가이샤 Ｐｐａｒ-감마의 부분 작용제로서의 축합 고리 화합물
EP2149550A4 (en) 2007-04-27 2010-08-11 Takeda Pharmaceutical NITROGENIC FIVE-GLOSS HETEROCYCLIC COMPOUND
JP2011502958A (ja) 2007-06-19 2011-01-27 武田薬品工業株式会社 グルコキナーゼ活性化インダゾール化合物
JP2010229034A (ja) 2007-07-26 2010-10-14 Dainippon Sumitomo Pharma Co Ltd 二環性ピロール誘導体
KR101207830B1 (ko) 2008-06-19 2012-12-04 다케다 야쿠힌 고교 가부시키가이샤 헤테로시클릭 화합물 및 그의 용도
JP4901849B2 (ja) 2008-12-15 2012-03-21 バブコック日立株式会社 空気清浄機、及び分析室、並びに空気の浄化方法
US8642622B2 (en) 2010-06-16 2014-02-04 Bristol-Myers Squibb Company Piperidinyl compound as a modulator of chemokine receptor activity

Also Published As

Publication number Publication date
TN2012000589A1 (en) 2014-04-01
BR112012032055B1 (pt) 2019-10-22
BR112012032055B8 (pt) 2019-11-12
US20130252954A2 (en) 2013-09-26
MX2012014828A (es) 2013-02-27
WO2011158880A1 (ja) 2011-12-22
EP2583967B1 (en) 2014-10-01
EA022094B1 (ru) 2015-10-30
CA2802483A1 (en) 2011-12-22
JPWO2011158880A1 (ja) 2013-08-19
SG186223A1 (en) 2013-01-30
CA2802483C (en) 2017-10-24
MY163927A (en) 2017-11-15
MA34378B1 (fr) 2013-07-03
AU2011266099B2 (en) 2014-09-11
BR112012032055A2 (pt) 2016-11-08
US20130090337A1 (en) 2013-04-11
TW201206914A (en) 2012-02-16
CN103068816A (zh) 2013-04-24
ECSP13012392A (es) 2013-03-28
HK1179605A1 (en) 2013-10-04
JP5782438B2 (ja) 2015-09-24
CO6670573A2 (es) 2013-05-15
IL223562A (en) 2015-03-31
GEP20146195B (en) 2014-11-10
UA108888C2 (xx) 2015-06-25
KR20130119903A (ko) 2013-11-01
EP2583967A4 (en) 2013-09-04
ZA201300065B (en) 2014-03-26
DOP2012000313A (es) 2013-02-15
CN103068816B (zh) 2015-01-07
EA201291453A1 (ru) 2013-05-30
PH12012502468A1 (en) 2015-05-08
PE20130283A1 (es) 2013-03-25
TWI511967B (zh) 2015-12-11
EP2583967A1 (en) 2013-04-24
CL2012003526A1 (es) 2013-05-31
US9018374B2 (en) 2015-04-28
AU2011266099A1 (en) 2013-01-24

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