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ES2489191T3 - Nuevos derivados de 5,6-dihidro-4-[(difluoroetil)fenil]-4H-pirrolo[1,2-a][1,4] benzodiacepina y de 4-(difluoroetil)fenil-6H-pirrolo[1,2-a][1,4] benzodiacepina antifúngicos - Google Patents

Nuevos derivados de 5,6-dihidro-4-[(difluoroetil)fenil]-4H-pirrolo[1,2-a][1,4] benzodiacepina y de 4-(difluoroetil)fenil-6H-pirrolo[1,2-a][1,4] benzodiacepina antifúngicos Download PDF

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Publication number
ES2489191T3
ES2489191T3 ES11723445.0T ES11723445T ES2489191T3 ES 2489191 T3 ES2489191 T3 ES 2489191T3 ES 11723445 T ES11723445 T ES 11723445T ES 2489191 T3 ES2489191 T3 ES 2489191T3
Authority
ES
Spain
Prior art keywords
spp
compound
fluorine
difluoroethyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11723445.0T
Other languages
English (en)
Spanish (es)
Inventor
Lieven Meerpoel
Louis Jules Roger Marie Maes
Kelly De Wit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2489191T3 publication Critical patent/ES2489191T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES11723445.0T 2010-06-07 2011-06-01 Nuevos derivados de 5,6-dihidro-4-[(difluoroetil)fenil]-4H-pirrolo[1,2-a][1,4] benzodiacepina y de 4-(difluoroetil)fenil-6H-pirrolo[1,2-a][1,4] benzodiacepina antifúngicos Active ES2489191T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10165076 2010-06-07
EP10165076 2010-06-07
PCT/EP2011/059058 WO2011154298A1 (en) 2010-06-07 2011-06-01 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES

Publications (1)

Publication Number Publication Date
ES2489191T3 true ES2489191T3 (es) 2014-09-01

Family

ID=42294978

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11723445.0T Active ES2489191T3 (es) 2010-06-07 2011-06-01 Nuevos derivados de 5,6-dihidro-4-[(difluoroetil)fenil]-4H-pirrolo[1,2-a][1,4] benzodiacepina y de 4-(difluoroetil)fenil-6H-pirrolo[1,2-a][1,4] benzodiacepina antifúngicos

Country Status (23)

Country Link
US (1) US9637490B2 (xx)
EP (1) EP2576557B1 (xx)
JP (4) JP5922107B2 (xx)
KR (1) KR101886136B1 (xx)
CN (1) CN102947307B (xx)
AP (1) AP3285A (xx)
AR (1) AR081642A1 (xx)
AU (1) AU2011263946B2 (xx)
BR (1) BR112012030895A2 (xx)
CA (1) CA2799634C (xx)
EA (1) EA021220B1 (xx)
ES (1) ES2489191T3 (xx)
HK (1) HK1178152A1 (xx)
JO (1) JO3029B1 (xx)
MX (1) MX2012014271A (xx)
MY (1) MY156731A (xx)
NZ (1) NZ602981A (xx)
PH (1) PH12012502293A1 (xx)
SG (1) SG185650A1 (xx)
TW (1) TWI500619B (xx)
UA (1) UA107963C2 (xx)
WO (1) WO2011154298A1 (xx)
ZA (1) ZA201209246B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2605654B1 (en) * 2010-08-20 2023-09-27 Biotelliga Holdings Limited Epipyrone a as an anti-microbial agent

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013012547A2 (pt) * 2010-11-24 2016-08-09 Janssen Pharmaceutica Nv antifúngicos 5,6-di-hidro-4h-pirrolo][1,4]benzodiazepinas e 6h-pirrolo [1,2-a] [1,4]benzodiazepinas substituídos por derivados de fenila
AU2013204604B2 (en) * 2012-05-30 2016-05-19 Biodiem Limited Method of treating Scedosporium spp. infection
JP6197348B2 (ja) * 2013-04-25 2017-09-20 セントラル硝子株式会社 α，α−ジフルオロ芳香族化合物の保存安定性の向上方法
RU2771019C1 (ru) * 2021-06-29 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392691B1 (en) * 2000-10-23 2009-05-20 Janssen Pharmaceutica N.V. Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a] [1,4] benzodiazepines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2605654B1 (en) * 2010-08-20 2023-09-27 Biotelliga Holdings Limited Epipyrone a as an anti-microbial agent

Also Published As

Publication number Publication date
US20130085136A1 (en) 2013-04-04
KR101886136B1 (ko) 2018-08-07
WO2011154298A1 (en) 2011-12-15
JP5922107B2 (ja) 2016-05-24
CA2799634C (en) 2018-07-10
CA2799634A1 (en) 2011-12-15
US9637490B2 (en) 2017-05-02
JP2013528192A (ja) 2013-07-08
JP2018021060A (ja) 2018-02-08
CN102947307A (zh) 2013-02-27
TWI500619B (zh) 2015-09-21
BR112012030895A2 (pt) 2016-11-08
AP2012006502A0 (en) 2012-10-31
CN102947307B (zh) 2015-03-18
JP2019112460A (ja) 2019-07-11
MY156731A (en) 2016-03-15
EA201291401A1 (ru) 2013-04-30
UA107963C2 (xx) 2015-03-10
HK1178152A1 (en) 2013-09-06
TW201211045A (en) 2012-03-16
JP6208263B2 (ja) 2017-10-04
AR081642A1 (es) 2012-10-10
MX2012014271A (es) 2013-01-24
NZ602981A (en) 2013-11-29
KR20130113922A (ko) 2013-10-16
EP2576557A1 (en) 2013-04-10
JP6505176B2 (ja) 2019-04-24
JP6653036B2 (ja) 2020-02-26
SG185650A1 (en) 2012-12-28
AU2011263946A1 (en) 2012-11-08
EP2576557B1 (en) 2014-05-21
AU2011263946B2 (en) 2014-10-30
PH12012502293A1 (en) 2022-10-05
JO3029B1 (ar) 2016-09-05
ZA201209246B (en) 2015-06-24
JP2016128450A (ja) 2016-07-14
AP3285A (en) 2015-05-31
EA021220B1 (ru) 2015-04-30

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