[go: up one dir, main page]

ES2166786T3 - Procedimiento i. - Google Patents

Procedimiento i.

Info

Publication number
ES2166786T3
ES2166786T3 ES94929076T ES94929076T ES2166786T3 ES 2166786 T3 ES2166786 T3 ES 2166786T3 ES 94929076 T ES94929076 T ES 94929076T ES 94929076 T ES94929076 T ES 94929076T ES 2166786 T3 ES2166786 T3 ES 2166786T3
Authority
ES
Spain
Prior art keywords
medicinal product
size
screw feeder
themselves
finally divided
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929076T
Other languages
English (en)
Inventor
Eva Trofast
Johan Falk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9303214A external-priority patent/SE9303214D0/xx
Priority claimed from SE9304271A external-priority patent/SE9304271D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2166786T3 publication Critical patent/ES2166786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Control Of Multiple Motors (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Stereophonic System (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Glanulating (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

DE ACUERDO CON LA INVENCION, SE PROPORCIONA UN METODO DE TRATAMIENTO DE UN MEDICAMENTO EN POLVO FINAMENTE DIVIDIDO CON UN TAMAÑO DE PARTICULA MENOR A 10{MI}M Y POBRES PROPIEDADES DE FLUJO PARA FORMAR, DE MANERA CONTROLADA, AGLOMERADOS O BOLITAS QUE FLUYEN LIBREMENTE Y QUE SON CAPACES DE ROMPERSE PARA PROPORCIONAR EL MEDICAMENTO FINAMENTE DIVIDIDO, QUE INCLUYE LOS PASOS DE LA AGLOMERACION DEL MEDICAMENTO EN POLVO, ALIMENTANDO EL MATERIAL A UN ALIMENTADOR DE TORNILLO, DEJANDOLO PASAR A TRAVES DEL MISMO , OBTENIENDO ASI AGLOMERADOS, FORMANDO AGLOMERADOS RESULTANTES EN FORMA DE ESFERA PARA OBTENER AGLOMERADOS MAS ESFERICOS, MAS DENSOS Y COMPACTOS QUE AQUELLOS OBTENIDOS DEL PROCESO DE AGLOMERACION EN EL ALIMENTADOR DE TORNILLO, Y DANDO UN TAMAÑO A LOS MISMOS PARA OBTENER UN TAMAÑO UNIFORME DEL PRODUCTO FINAL. DE ACUERDO CON LA INVENCION, TAMBIEN SE PROPORCIONA UN APARATO PARA LLEVAR A CABO EL METODO.
ES94929076T 1993-10-01 1994-09-29 Procedimiento i. Expired - Lifetime ES2166786T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9303214A SE9303214D0 (sv) 1993-10-01 1993-10-01 Process I
SE9304271A SE9304271D0 (sv) 1993-12-22 1993-12-22 Process I
US08/317,033 US5551489A (en) 1993-10-01 1994-10-03 Agglomeration of finely divided powders

Publications (1)

Publication Number Publication Date
ES2166786T3 true ES2166786T3 (es) 2002-05-01

Family

ID=27355730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929076T Expired - Lifetime ES2166786T3 (es) 1993-10-01 1994-09-29 Procedimiento i.

Country Status (23)

Country Link
US (1) US5551489A (es)
EP (1) EP0721331B1 (es)
JP (1) JP3732508B2 (es)
CN (1) CN1110300C (es)
AT (1) ATE209903T1 (es)
AU (1) AU679789B2 (es)
BR (1) BR9407686A (es)
CZ (1) CZ289214B6 (es)
DE (1) DE69429357T2 (es)
DK (1) DK0721331T3 (es)
EG (1) EG20677A (es)
ES (1) ES2166786T3 (es)
FI (1) FI116364B (es)
HU (1) HU222355B1 (es)
IL (1) IL111080A (es)
NO (1) NO314836B1 (es)
NZ (1) NZ274277A (es)
PL (1) PL175564B1 (es)
PT (1) PT721331E (es)
RU (1) RU2170082C2 (es)
SG (1) SG48049A1 (es)
SK (1) SK283569B6 (es)
WO (1) WO1995009615A1 (es)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404945D0 (en) * 1994-03-15 1994-04-27 Glaxo Group Ltd Pharmaceutical composition
SE9700136D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
SE9700134D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19522899C1 (de) * 1995-06-23 1996-12-19 Hexal Pharmaforschung Gmbh Verfahren zum kontinuierlichen Ersintern eines Granulats
US5826633A (en) * 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
GB9616047D0 (en) * 1996-07-31 1996-09-11 Glaxo Group Ltd Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US6495167B2 (en) 1997-03-20 2002-12-17 Schering Corporation Preparation of powder agglomerates
US6503537B2 (en) 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
IL131640A0 (en) * 1997-03-20 2001-01-28 Schering Corp Preparation of powder agglomerates
EP0876814A1 (en) * 1997-05-07 1998-11-11 "PHARLYSE", Société Anonyme Dry powder inhaler excipient, process for its preparation and pharmaceutical compositions containing it
US6182712B1 (en) 1997-07-21 2001-02-06 Inhale Therapeutic Systems Power filling apparatus and methods for their use
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
JP2002509119A (ja) * 1998-01-13 2002-03-26 アストラゼネカ ユーケイ リミテッド ドーパミン（Ｄ２）レセプターアゴニスト活性を有する化合物およびβ２−アドレナリンレセプターアゴニスト活性を有する化合物（Ｂ）を含有する薬学的組成物
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US8722668B2 (en) * 1998-12-23 2014-05-13 Daryl W. Hochman Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
JP2003507410A (ja) * 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ，インコーポレイテッド 乾燥粉末製剤からの放出調節
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7304750B2 (en) 1999-12-17 2007-12-04 Nektar Therapeutics Systems and methods for non-destructive mass sensing
US6499984B1 (en) * 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
CA2433335C (en) * 2000-12-29 2010-04-20 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
PT1370543E (pt) 2001-02-14 2007-02-28 Tibotec Pharm Ltd Inibidores de protease de vih 2-(amino-substituída)-benzotiazol-sulfonamida de largo espectro
MXPA03009179A (es) 2001-04-09 2004-11-22 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa.
EA009590B1 (ru) 2001-05-11 2008-02-28 Тиботек Фармасьютикалз Лтд. 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
US7182961B2 (en) * 2001-11-20 2007-02-27 Advanced Inhalation Research, Inc. Particulate compositions for pulmonary delivery
WO2003043603A1 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
MXPA04006201A (es) 2001-12-21 2004-12-06 Tibotec Pharm Ltd Sulfonamidas que contienen fenilo sustituido con grupos heterociclicos, inhibidores de la proteasa del vih de amplio espectro.
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
KR100994759B1 (ko) 2002-08-14 2010-11-16 티보텍 파마슈티컬즈 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
EP1417958A1 (en) * 2002-11-08 2004-05-12 Pari GmbH Wet granulation process
US8268885B2 (en) 2003-09-11 2012-09-18 Janssen R&D Ireland Entry inhibitors of the HIV virus
SE528121C2 (sv) * 2004-03-29 2006-09-05 Mederio Ag Preparering av torrpulver för på förhand uppmätt DPI
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AU2005244121B2 (en) 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TW200607503A (en) 2004-05-17 2006-03-01 Tibotec Pharm Ltd 1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones
JP4879889B2 (ja) 2004-05-17 2012-02-22 テイボテク・フアーマシユーチカルズ・リミテツド ４−置換−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
ATE481403T1 (de) 2004-05-17 2010-10-15 Tibotec Pharm Ltd Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2- büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva
TW200710091A (en) 2005-04-11 2007-03-16 Tibotec Pharm Ltd (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
US8003627B2 (en) 2005-10-21 2011-08-23 Universiteit Antwerpen Urokinase inhibitors
US7994187B2 (en) 2006-04-03 2011-08-09 Tibotec Pharmaceuticals Ltd. HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones
DE102007049931A1 (de) 2007-10-18 2009-04-23 Pharmatech Gmbh Vorrichtung und Verfahren zur kontinuierlichen Herstellung von sphärischen Pulveragglomeraten
EP2116236A1 (en) 2008-04-21 2009-11-11 Université de Mons-Hainaut Bisbenzamidine derivatives for use as antioxidant
US20120097160A1 (en) * 2009-04-24 2012-04-26 Schering Corporation Agglomerate formulations including active pharmaceutical agents with targeted particle sizes
KR101794009B1 (ko) 2010-03-02 2017-11-07 주식회사 피에이치파마 Ｒｏｃｋ 저해제로서 헤테로고리 아미드
US20110224229A1 (en) 2010-03-10 2011-09-15 Astrazeneca Ab Novel Crystalline Form
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds
GB201102237D0 (en) 2011-02-09 2011-03-23 Kuecept Ltd Particle formulation
GB201108225D0 (en) 2011-05-17 2011-06-29 Amakem Nv Novel KBC inhibitors
GB201113689D0 (en) 2011-08-09 2011-09-21 Amakem Nv Novel PDE4 inhibitors
GB201114854D0 (en) 2011-08-29 2011-10-12 Amakem Nv Novel rock inhibitors
SG11201400058PA (en) 2011-08-31 2014-03-28 Amakem Nv Novel rock kinase inhibitors
KR20140078710A (ko) 2011-09-30 2014-06-25 온코디자인 에스.에이. 거대고리 flt3 키나제 억제제
PT2760453T (pt) 2011-09-30 2016-08-02 Ipsen Pharma Sas Inibidores macrocíclicos da cinase lrrk2
PL2810198T3 (pl) 2012-01-30 2024-01-22 Universiteit Gent Związki przeciwinwazyjne
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
CA2906262A1 (en) 2013-03-15 2014-09-18 Oncodesign S.A. Macrocyclic salt-inducible kinase inhibitors
US9427376B2 (en) * 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
WO2015150337A1 (en) 2014-04-01 2015-10-08 Amakem Nv Lim kinase inhibitors
WO2016003450A1 (en) 2014-07-01 2016-01-07 The Regents Of The University Of California Pkc-epsilon inhibitors
EP3166955B1 (en) 2014-07-08 2018-05-02 Universiteit Gent Hamamelitannin analogues and uses thereof
EP3194407B1 (en) 2014-09-17 2019-10-23 Oncodesign S.A. Macrocyclic rip2 kinase inhibitors
EA032838B1 (ru) 2014-09-17 2019-07-31 Онкодизайн С.А. Макроциклические ингибиторы lrrk2-киназы
WO2016083490A1 (en) 2014-11-27 2016-06-02 Remynd Nv Compounds for the treatment of amyloid-associated diseases
WO2016146651A1 (en) 2015-03-16 2016-09-22 Oncodesign Sa Macrocyclic activin-like receptor kinase inhibitors
WO2017146994A1 (en) * 2016-02-24 2017-08-31 Merck Sharp & Dohme Corp. Controlled agglomeration of micronized drug or drug-excipient mixtures
WO2017157882A1 (en) 2016-03-14 2017-09-21 Université Catholique de Louvain Serine biosynthetic pathway inhibitors
WO2018065387A1 (en) 2016-10-04 2018-04-12 Universiteit Gent Novel hamamelitannin analogues and uses thereof
EP3544952B1 (en) 2016-11-24 2024-11-06 Universiteit Antwerpen Halogenated benzotropolones as atg4b inhibitors
EP3573608A1 (en) 2017-01-30 2019-12-04 Université de Liège Perk and ire-1a inhibitors against neurodevelopmental disorders
US11548881B2 (en) 2017-05-11 2023-01-10 Remynd N.V. Compounds for the treatment of epilepsy, neurodegenerative disorders and other CNS disorders
US12178805B2 (en) 2017-05-11 2024-12-31 Remynd N.V. Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders
EP3773562A1 (en) 2018-04-05 2021-02-17 Universiteit Hasselt Selective pde4d inhibitors against demyelinating diseases
US12281308B2 (en) 2018-08-29 2025-04-22 University Of Massachusetts Inhibition of protein kinases to treat Friedreich ataxia
CN114206864B (zh) 2019-05-14 2024-05-24 苏州四体康宸医药科技有限公司 喹唑啉-2.4-二酮衍生物作为parp抑制剂
WO2022157381A1 (en) 2021-01-25 2022-07-28 Universiteit Hasselt Phloretin for use in the treatment of neurodegenerative and demyelinating diseases
WO2023021132A1 (en) 2021-08-18 2023-02-23 Katholieke Universiteit Leuven 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
US20250066365A1 (en) 2021-09-23 2025-02-27 Katholieke Universiteit Leuven Ribonucleoside Analogues Against -Sars-Cov-2
WO2023241799A1 (en) 2022-06-15 2023-12-21 Université Libre de Bruxelles Flavanols for use in the treatment of retroviral infections

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2609150A (en) * 1949-11-05 1952-09-02 Union Carbide & Carbon Corp Mechanical pulverization of refrigerated plastics
NL258520A (es) * 1960-03-25 1900-01-01
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
US3802822A (en) * 1972-03-01 1974-04-09 Mars Mineral Corp Pelletizer
GB1520247A (en) * 1974-08-10 1978-08-02 Fisons Ltd Pelletised medicament formulations
GB1569611A (en) * 1976-01-23 1980-06-18 Fisons Ltd Pelletised or granular medicament formulation
US4161516A (en) * 1975-07-25 1979-07-17 Fisons Limited Composition for treating airway disease
US4161526A (en) * 1978-07-20 1979-07-17 Sterling Drug Inc. Zinc salt prevention or removal of discoloration in pyrithione, pyrithione salt and dipyrithione compositions
EP0072046B1 (en) * 1981-07-24 1986-01-15 FISONS plc Inhalation drugs, methods for their production and pharmaceutical formulations containing them
US4688610A (en) * 1985-03-19 1987-08-25 Spiral Systems Inc. Apparatus for dispensing particulate agglomerating solids
US4940556A (en) * 1986-01-30 1990-07-10 Syntex (U.S.A.) Inc. Method of preparing long acting formulation
GB8606762D0 (en) * 1986-03-19 1986-04-23 Boots Co Plc Therapeutic agents
JPS63116732A (ja) * 1986-11-06 1988-05-21 Fukae Kogyo Kk 粉粒体処理装置
GB8711005D0 (en) * 1987-05-09 1987-06-10 British Petroleum Co Plc Chemical process
ATE94801T1 (de) * 1990-01-29 1993-10-15 Ciba Geigy Ag Verfahren und vorrichtung zur dosierung eines feinkoernigen pulvers.
GB9027018D0 (en) * 1990-12-12 1991-01-30 Ici Plc Heterocyclic compounds
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments

Also Published As

Publication number Publication date
HU9600821D0 (en) 1996-05-28
PL313765A1 (en) 1996-07-22
DK0721331T3 (da) 2002-02-11
US5551489A (en) 1996-09-03
PT721331E (pt) 2002-05-31
FI116364B (fi) 2005-11-15
SG48049A1 (en) 1998-04-17
WO1995009615A1 (en) 1995-04-13
CZ289214B6 (cs) 2001-12-12
AU679789B2 (en) 1997-07-10
EG20677A (en) 1999-11-30
SK283569B6 (sk) 2003-09-11
EP0721331B1 (en) 2001-12-05
NZ274277A (en) 1998-01-26
FI961430A0 (fi) 1996-03-29
NO961290D0 (no) 1996-03-29
RU2170082C2 (ru) 2001-07-10
HU222355B1 (hu) 2003-06-28
DE69429357T2 (de) 2002-08-14
CN1132476A (zh) 1996-10-02
PL175564B1 (pl) 1999-01-29
DE69429357D1 (de) 2002-01-17
FI961430L (fi) 1996-03-29
HUT74519A (en) 1997-01-28
EP0721331A1 (en) 1996-07-17
IL111080A (en) 1999-08-17
JPH09504224A (ja) 1997-04-28
NO314836B1 (no) 2003-06-02
AU7826194A (en) 1995-05-01
NO961290L (no) 1996-03-29
CZ94296A3 (en) 1996-06-12
CN1110300C (zh) 2003-06-04
JP3732508B2 (ja) 2006-01-05
BR9407686A (pt) 1997-02-04
SK39196A3 (en) 1997-06-04
ATE209903T1 (de) 2001-12-15
IL111080A0 (en) 1994-11-28

Similar Documents

Publication Publication Date Title
ES2166786T3 (es) Procedimiento i.
ES2178655T3 (es) Proceso ii.
GEP20063979B (en) Expanded perlite products with controlled particle size distribution
NZ271082A (en) Cooker-extruder; apparatus for producing thermally treated biopolymers; comprises a feeding hopper, screws and a nozzle, there being at least one spatula pump between the screw and nozzle
MY109813A (en) Process of preparing large dimension emulsion polymer particles, polymer product and uses thereof
ES2150158T3 (es) Proceso para producir microesferas inorganicas y microbalones de vidrio.
ZA95933B (en) Expanded articles of biodegradable plastic material and a process for the preparation thereof
FR2679450B1 (fr) Procede pour la preparation de microspheres en matiere polymere biodegradable, pour la liberation controlee de substances medicamenteuses peptidiques.
MY125269A (en) Wiring-connecting material and process for producing circuit board with the same
FR2768151B1 (fr) Matiere de base en poudre traitee avec des composes organiques de silicium, son procede de production et cosmetique la contenant
TW349839B (en) Uniform mixtures of pesticidal granules
ES8303941A1 (es) Procedimiento para la fabricacion de un material fibroso o granulado a partir de desperdicios domesticos, agricolas, fo-restales, organicos industriales y-o artesanales.
FI962675A0 (fi) Menetelmä talkkijauheen käsittelemiseksi kestomuoviainekseen yhdistämistä varten
IT1265473B1 (it) Procedimento per la produzione di polveri a granulometria controllata e prodotto in polvere cosi' ottenuto
YU68400A (sh) Postupak vlažnog granulisanja za obrazovanje granula
PL1628813T3 (pl) Urządzenie do przeróbki tworzywa sztucznego w celach recyklingu
BR9916604A (pt) Granulado, método e equipamento para a suaprodução
ATE159045T1 (de) Schaumregulatorgranulat und verfahren zu seiner herstellung
EP0509494A3 (en) Process for the production of polyurethane, and true spherical, fine polyurethane particles
ES8406032A1 (es) Equipo para seleccionar productos granulares
GB2292880B (en) Size reduction apparatus for the production of prismatical and particularly cubical particles from cuttable materials.
IT1256184B (it) Procedimento ed impianto pewr il raffreddamento rapido di un prodotto lavorato in un laminatoio a caldo.
BR9508240A (pt) Filme polimérico e processo de produção do mesmo
ES2113962T3 (es) Fertilizante de sustancias naturales de tres fases biologicamente puro y procedimiento para la fabricacion del mismo.
DK0973509T3 (da) Multipartikulær farmaceutisk form, de udgörende partikler, fremgangsmåde og indretning til fremstilling heraf