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ES2164889T3 - Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas. - Google Patents

Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas.

Info

Publication number
ES2164889T3
ES2164889T3 ES96917304T ES96917304T ES2164889T3 ES 2164889 T3 ES2164889 T3 ES 2164889T3 ES 96917304 T ES96917304 T ES 96917304T ES 96917304 T ES96917304 T ES 96917304T ES 2164889 T3 ES2164889 T3 ES 2164889T3
Authority
ES
Spain
Prior art keywords
sub
sup
semicarbazonas
snc
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917304T
Other languages
English (en)
Inventor
Jonathan Richard Dimmock
Ramanan Narayan Puthucode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Saskatchewan
Saskatchewan University of Technologies Inc
Original Assignee
University of Saskatchewan
Saskatchewan University of Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Saskatchewan, Saskatchewan University of Technologies Inc filed Critical University of Saskatchewan
Application granted granted Critical
Publication of ES2164889T3 publication Critical patent/ES2164889T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/14—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

COMPUESTO DE FORMULA GENERAL (I) UTIL COMO ANTICONVULSIVANTE PARA LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL EN EL QUE: R SUP,1}, R SUP,2}, R SUP,3} Y R SUP,4} PUEDEN SER IGUALES O DIFERENTES, REPRESENTANDO CADA UNO UN ATOMO DE HIDROGENO O DE HALOGENO, O UN GRUPO ALQUILO C SUB,1-9}, C SUB,3-9}CICLOALQUILO, CIANO, C SUB,1-9}ALQUIOXILO O C SUB,6-10}ARILOXILO; R SUP,5} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO C SUB,1-9}ALQUILO, C SUB,3-9}CICLOALQUILO O C SUB,6-10}ARILO; Y X ES OXIGENO O AZUFRE; O UNA SAL FARMACEUTICAMENTE ACEPTABLE. EL COMPUESTO PUEDE ADMINISTRARSE POR VIA ORAL PARA EL TRATAMIENTO DE LAS CONVULSIONES EN EL HOMBRE O EN ANIMALES.
ES96917304T 1995-06-07 1996-06-07 Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas. Expired - Lifetime ES2164889T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/475,313 US5741818A (en) 1995-06-07 1995-06-07 Semicarbazones having CNS activity and pharmaceutical preparations containing same

Publications (1)

Publication Number Publication Date
ES2164889T3 true ES2164889T3 (es) 2002-03-01

Family

ID=23887035

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917304T Expired - Lifetime ES2164889T3 (es) 1995-06-07 1996-06-07 Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas.

Country Status (24)

Country Link
US (2) US5741818A (es)
EP (1) EP0836591B1 (es)
JP (1) JPH11506109A (es)
KR (1) KR19990022408A (es)
CN (1) CN1062263C (es)
AT (1) ATE206110T1 (es)
AU (1) AU715897B2 (es)
BR (1) BR9609408A (es)
CA (1) CA2223935A1 (es)
CZ (1) CZ387497A3 (es)
DE (1) DE69615558T2 (es)
DK (1) DK0836591T3 (es)
ES (1) ES2164889T3 (es)
FI (1) FI974447L (es)
GE (1) GEP20012414B (es)
HU (1) HUP9802637A3 (es)
IL (1) IL122350A0 (es)
NO (1) NO310655B1 (es)
NZ (1) NZ309707A (es)
PL (1) PL184048B1 (es)
PT (1) PT836591E (es)
RU (1) RU2174115C2 (es)
UA (1) UA62915C2 (es)
WO (1) WO1996040628A1 (es)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
EP1568690A1 (en) * 1997-04-22 2005-08-31 Euro-Celtique S.A. The use of carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones as sodium channel blockers
CA2287255A1 (en) 1997-04-22 1998-10-29 Cocensys, Inc. Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
ES2352739T3 (es) 1997-11-21 2011-02-22 Purdue Neuroscience Company 2-aminoacetamidas sustituidas y el uso de las mismas.
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
CA2319484A1 (en) * 1998-02-04 1999-08-12 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
JP4832647B2 (ja) 1999-03-26 2011-12-07 ユーロ−セルティック エス． ア． アリール置換ピラゾール、イミダゾール、オキサゾール、チアゾールおよびピロール、ならびにそれらの使用
DE60022333T2 (de) * 1999-04-09 2006-07-06 Euro-Celtique S.A. Natrium kanalblocker zusammensetzungen und deren verwendung
US8771740B2 (en) 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
US7078057B2 (en) 1999-12-20 2006-07-18 Kerkhof Nicholas J Process for producing nanometer particles by fluid bed spray-drying
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
PL214230B1 (pl) * 2000-03-24 2013-07-31 Euro Celtique Sa Podstawione arylem pirazole i triazole, kompozycja farmaceutyczna je zawierajaca oraz ich zastosowanie
GB0025208D0 (en) 2000-10-13 2000-11-29 Euro Celtique Sa Delayed release pharmaceutical formulations
EP1392219A4 (en) * 2001-05-10 2007-01-24 Cytovia Inc SUBSTITUTED N '- (ARYLCARBONYL) -BENZYLIDENE-HYDRAZIDE N' - (ARYLCARBONYL) -BENZHYDRAZIDES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS AND USE THEREOF
EP1399159A4 (en) * 2001-06-01 2007-02-14 Cytovia Inc 4-SUBSTITUTE-1- (ARYLMETHYLIDENE) THIOSEMICARBAZIDE, 4-SUBSTITUTE-1- (ARYLCARBONYL) THIOSEMICARBAZIDE AND ANALOGUES AS ACTIVATORS OF APOPTOSIS CAPSASES AND TRIGS, AND USE THEREOF
WO2003006426A1 (en) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Aromatic guanylhydrazones as effective compounds against neurodiseases
RU2295337C2 (ru) * 2001-09-03 2007-03-20 Ньюрон Фармасьютикалс Спа Фармацевтическая композиция, содержащая габапентин или его аналог и альфа-аминоамид, и ее применение в качестве анальгетика
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
US7528164B2 (en) * 2002-05-16 2009-05-05 Cytovia, Inc. Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2003096982A2 (en) * 2002-05-16 2003-11-27 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
PT1809271E (pt) * 2004-09-10 2010-08-30 Newron Pharm Spa Utilização de (halogenobenziloxi)benzilamino-propanamidas para o fabrico de medicamentos activos como moduladores selectivos dos canais de sódio e/ou de cálcio
EP2155643B1 (en) * 2007-06-08 2016-08-10 MannKind Corporation Ire-1a inhibitors
US9630275B2 (en) * 2008-12-10 2017-04-25 Boston Scientific Limited Methods and designs for forming joints between metallic members
CN104402771B (zh) * 2014-11-26 2016-09-28 玉林师范学院 对羟基苯甲醛缩氨基脲的合成及在防治植物病害中的应用
CN104974053B (zh) * 2015-06-24 2017-04-26 天津久日新材料股份有限公司 一种新的氨基酮类光引发剂及在uv‑led光固化体系的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE667022A (es)
US3255241A (en) 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
NL129087C (es) 1961-01-19
BE622079A (es) 1961-09-11
US3251064A (en) 1962-11-13 1966-05-10 Everett M Schultz beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids
BE639727A (es) 1962-11-13
BE643709A (es) * 1963-02-12 1900-01-01
DE1288086B (es) * 1963-12-26 1969-01-30
US3304323A (en) * 1964-03-20 1967-02-14 Upjohn Co Oxygenated dicycloalkyl sulfones
US3392171A (en) * 1964-03-20 1968-07-09 Upjohn Co 4-morpholino-4'-hydroxy bicyclohexyls
US3303214A (en) * 1964-05-13 1967-02-07 Wallace & Tiernan Inc Nitrososemicarbazides
GB1164608A (en) * 1966-08-23 1969-09-17 May & Baker Ltd Semicarbazone and Thiosemicarbazone Quaternary Salts
US3712914A (en) * 1970-05-14 1973-01-23 Stauffer Chemical Co Arylidene semicarbizides
DE2420618C2 (de) * 1974-04-27 1982-09-16 C.H. Boehringer Sohn, 6507 Ingelheim Aminoalkylanilide, Verfahren zu ihrer Herstellung sowie pharmazeutische Zubereitungen, die diese Aminoalkylanilide enthalten
US4394514A (en) * 1981-04-30 1983-07-19 Smithkline Beckman Corporation Processes for preparing 4-substituted indoles
US5266585A (en) 1981-05-12 1993-11-30 Ciba-Geigy Corporation Arylphenyl ether derivatives, compositions containing these compounds and use thereof
FI77458C (fi) * 1981-05-12 1989-03-10 Ciba Geigy Ag Nya mikrobicida arylfenyleterderivat, foerfarande foer deras framstaellning och deras anvaendning.
US4454337A (en) * 1981-06-29 1984-06-12 Smithkline Beckman Corporation Semicarbazide intermediates for preparing 4-substituted indoles
US5665673A (en) 1988-12-29 1997-09-09 Anderson; Richard J. Potentiating herbicidal compositions
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
WO1994006758A1 (en) * 1992-09-21 1994-03-31 University Of Saskatchewan Aryl semicarbazone anticonvulsants
AU2641295A (en) 1994-05-17 1995-12-05 Dowelanco N-(5-isothiazolyl)amide pesticides
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
JP2000500742A (ja) 1995-10-30 2000-01-25 スミスクライン・ビーチャム・コーポレイション プロテアーゼ阻害剤

Also Published As

Publication number Publication date
US5741818A (en) 1998-04-21
NO310655B1 (no) 2001-08-06
UA62915C2 (en) 2004-01-15
HUP9802637A2 (hu) 1999-02-01
AU715897B2 (en) 2000-02-10
CN1062263C (zh) 2001-02-21
PT836591E (pt) 2002-03-28
FI974447A0 (fi) 1997-12-05
HUP9802637A3 (en) 2000-09-28
BR9609408A (pt) 1999-07-27
NZ309707A (en) 1998-11-25
ATE206110T1 (de) 2001-10-15
DK0836591T3 (da) 2001-11-26
IL122350A0 (en) 1998-04-05
JPH11506109A (ja) 1999-06-02
KR19990022408A (ko) 1999-03-25
EP0836591B1 (en) 2001-09-26
PL323666A1 (en) 1998-04-14
RU2174115C2 (ru) 2001-09-27
FI974447L (fi) 1997-12-05
DE69615558T2 (de) 2002-07-11
USRE38425E1 (en) 2004-02-10
CN1190388A (zh) 1998-08-12
WO1996040628A1 (en) 1996-12-19
CZ387497A3 (cs) 1998-07-15
DE69615558D1 (de) 2001-10-31
GEP20012414B (en) 2001-04-25
NO975663D0 (no) 1997-12-05
CA2223935A1 (en) 1996-12-19
EP0836591A1 (en) 1998-04-22
AU5993896A (en) 1996-12-30
NO975663L (no) 1998-02-09
PL184048B1 (pl) 2002-08-30

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