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ES2155827T3 - 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico. - Google Patents

4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico.

Info

Publication number
ES2155827T3
ES2155827T3 ES93304131T ES93304131T ES2155827T3 ES 2155827 T3 ES2155827 T3 ES 2155827T3 ES 93304131 T ES93304131 T ES 93304131T ES 93304131 T ES93304131 T ES 93304131T ES 2155827 T3 ES2155827 T3 ES 2155827T3
Authority
ES
Spain
Prior art keywords
rent
antagonists
carboxiimidazoles
angiotensin
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304131T
Other languages
English (en)
Inventor
Hiroaki Yanagisawa
Yasuo Shimoji
Yoshiya Amomiya
Takuro Kanazaki
Hiroyuki Koike
Toshio Sada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2155827T3 publication Critical patent/ES2155827T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN LOS COMPONENTES DE FORMULA (I),EN LOS QUE: R1 ES HIDROGENO,ALQUILO,CICLOALQUILO O ALCANOIL; R2 ES UN ENLACE SIMPLE UN ALQUILENO O UN ALQUILIDENO; R3 Y R4 SON CADA UNO, HIDROGENO O ALQUILO; R6 ES CARBOXI O TETRAZOL-5-IL; Y X ES OXIGENO O AZUFRE.SE DESCRIBEN TAMBIEN,SUS SALES ACEPTABLES FARMACEUTICAMENTE Y ESTERES DERIVADOS COMO ANTAGONISTAS, ASI COMO SU USO EN EL TRATAMIENTO Y PROFILAXIS DE HIPERTENSION Y ENFERMEDADES VASCULARES.
ES93304131T 1992-06-02 1993-05-27 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico. Expired - Lifetime ES2155827T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14116092 1992-06-02

Publications (1)

Publication Number Publication Date
ES2155827T3 true ES2155827T3 (es) 2001-06-01

Family

ID=15285532

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304131T Expired - Lifetime ES2155827T3 (es) 1992-06-02 1993-05-27 4-carboxiimidazoles como antagonistas de la angiotensina ii y su uso terapeutico.

Country Status (22)

Country Link
EP (1) EP0573218B1 (es)
JP (1) JP3461863B2 (es)
KR (1) KR100300473B1 (es)
CN (1) CN1051766C (es)
AT (1) ATE199548T1 (es)
AU (1) AU661153B2 (es)
CA (1) CA2097444C (es)
CZ (1) CZ287764B6 (es)
DE (1) DE69329982T2 (es)
DK (1) DK0573218T3 (es)
ES (1) ES2155827T3 (es)
FI (1) FI112476B (es)
GR (1) GR3035624T3 (es)
HK (1) HK1011983A1 (es)
HU (1) HUT64329A (es)
IL (1) IL105825A (es)
NO (1) NO303872B1 (es)
NZ (1) NZ247750A (es)
PT (1) PT573218E (es)
RU (1) RU2086541C1 (es)
TW (1) TW228521B (es)
ZA (1) ZA933824B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
AU684916B2 (en) * 1994-03-16 1998-01-08 Sankyo Company Limited Ocular tension depressant
KR100428725B1 (ko) * 1996-03-30 2004-07-07 주식회사 현대시스콤 디지탈이동통신교환기녹음안내장치의2단계자체루프백시험장치및방법
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
CN1197866C (zh) * 2003-03-21 2005-04-20 上海医药工业研究院 4，6－二氢呋喃并[3,4－d]咪唑－6－酮衍生物及其盐和制备方法
CA2522318C (en) * 2003-04-15 2011-09-13 Sankyo Company Limited Drug for preventing or treating angiogenic eye diseases
WO2005077941A2 (en) 2004-02-11 2005-08-25 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
JP2010535743A (ja) * 2007-08-08 2010-11-25 レツク・フアーマシユーテイカルズ・デー・デー オルメサルタンメドキソミルの調製のための方法
CN101481374B (zh) * 2008-01-09 2013-01-09 浙江华海药业股份有限公司 1-三苯甲基-5-(1，1｀-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104356069B (zh) * 2014-11-18 2016-09-14 黄冈鲁班药业有限公司 奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
SG52709A1 (en) * 1989-06-30 1998-09-28 Du Pont Substituted imidazoles
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
CA2229000C (en) * 1991-02-21 2002-04-09 Sankyo Company, Limited 1-biphenylimidazole derivatives, their preparation and their therapeutic use
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
CZ105093A3 (en) 1993-12-15
KR100300473B1 (ko) 2002-01-09
IL105825A (en) 1998-01-04
EP0573218A3 (en) 1994-06-01
EP0573218B1 (en) 2001-03-07
GR3035624T3 (en) 2001-06-29
AU3988093A (en) 1993-12-09
DE69329982D1 (de) 2001-04-12
FI932492A0 (fi) 1993-06-01
JPH0649036A (ja) 1994-02-22
CA2097444C (en) 2005-03-29
KR940000455A (ko) 1994-01-03
NO931980L (no) 1993-12-03
NO931980D0 (no) 1993-06-01
TW228521B (es) 1994-08-21
CN1085896A (zh) 1994-04-27
NO303872B1 (no) 1998-09-14
RU2086541C1 (ru) 1997-08-10
HK1011983A1 (en) 1999-07-23
PT573218E (pt) 2001-06-29
DE69329982T2 (de) 2001-09-27
CA2097444A1 (en) 1993-12-03
ZA933824B (en) 1993-12-27
FI932492L (fi) 1993-12-03
EP0573218A2 (en) 1993-12-08
IL105825A0 (en) 1993-09-22
ATE199548T1 (de) 2001-03-15
HU9301600D0 (en) 1993-09-28
JP3461863B2 (ja) 2003-10-27
DK0573218T3 (da) 2001-06-18
HUT64329A (en) 1993-12-28
CN1051766C (zh) 2000-04-26
AU661153B2 (en) 1995-07-13
FI112476B (fi) 2003-12-15
NZ247750A (en) 1995-05-26
CZ287764B6 (en) 2001-01-17

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