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ES2160675T3 - Dispositivo implantable debajo de la dermis. - Google Patents

Dispositivo implantable debajo de la dermis.

Info

Publication number
ES2160675T3
ES2160675T3 ES95307809T ES95307809T ES2160675T3 ES 2160675 T3 ES2160675 T3 ES 2160675T3 ES 95307809 T ES95307809 T ES 95307809T ES 95307809 T ES95307809 T ES 95307809T ES 2160675 T3 ES2160675 T3 ES 2160675T3
Authority
ES
Spain
Prior art keywords
layer
drug
central core
polymeric
intermediate layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95307809T
Other languages
English (en)
Inventor
Alfred J Moo-Young
Horacio B Croxatto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Population Council Inc
Original Assignee
Population Council Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Population Council Inc filed Critical Population Council Inc
Application granted granted Critical
Publication of ES2160675T3 publication Critical patent/ES2160675T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)

Abstract

LO DESCRITO ES UN DISPOSITIVO DE ADMINISTRACION DE FARMACOS SUBDERMICAMENTE IMPLANTABLE (10), QUE CONTIENE: UN NUCLEO CENTRAL (11) QUE SE EXTIENDE EN UNA DIRECCION AXIAL Y QUE TIENE UNA SUPERFICIE EXTERIOR (12) Y EXTREMOS OPUESTOS (13 Y 13''), DICHO NUCLEO INCLUYENDO UNA MATRIZ DE UNA CANTIDAD FARMACEUTICAMENTE EFECTIVA DE UN FARMACO SUBDERMICAMENTE ADMINISTRABLE (14) SUSTANCIALMENTE UNIFORMEMENTE DISPERSADO EN UN MATERIAL DE BASE POLIMERICA (15); UNA CAPA INTERMEDIA POLIMERICA (16) QUE YACE SOBRE LA SUPERFICIE EXTERIOR DEL NUCLEO CENTRAL; Y UNA CAPA POLIMERICA EXTERIOR (17) QUE YACE POR ENCIMA DE LA CAPA INTERMEDIA, CARACTERIZADA ADEMAS EN QUE LA CAPA INTERMEDIA CONTROLA LA FRECUENCIA DE DIFUSION DEL FARMACO DESDE EL NUCLEO CENTRAL A LA CAPA EXTERIOR. EN REALIZACIONES PREFERIDAS, EL FARMACO SUBDERMICAMENTE ADMINISTRABLE (14) ES UN AGENTE CONTRACEPTIVO COMO PROGESTINA NESTORONE{SUB,TM}; EL MATERIAL DE BASE POLIMERICA (15) Y LA CAPA POLIMERICA EXTERIOR (17) CONTIENE UN POLIDIMETISILOXANO COMOSILASTIC{SUB,R}; LA CAPA INTERMEDIA (16) CONTIENE UN MATERIAL POROSO COMO CELULOSA, Y EL DISPOSITIVO (10) CONTIENE ADEMAS ELEMENTOS DE SELLADO COMO UNA CAPA DE PLASTICO (21 Y 22) Y ADHESIVO (18, 18'') QUE COOPERAN CON LA CAPA BIOCOMPATIBLE PARA ENCAPSULAR COMPLETAMENTE EL NUCLEO CENTRAL Y LA CAPA INTERMEDIA. LOS DISPOSITIVOS PROPORCIONAN LA LIBERACION SUSTANCIALMENTE DE ORDEN CERO DEL FARMACO PARA SU DURACION ESTIMADA SIN SOBREDOSIFICACION INICIAL DEL FARMACO. TAMBIEN SE DESCRIBEN METODOS DE TRATAMIENTO DE SUJETOS CON LOS DISPOSITIVOS DE ADMINISTRACION DE FARMACO IMPLANTABLE DE LA INVENCION, Y METODOS DE CONTRACEPCION.
ES95307809T 1994-11-02 1995-11-01 Dispositivo implantable debajo de la dermis. Expired - Lifetime ES2160675T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/333,279 US5660848A (en) 1994-11-02 1994-11-02 Subdermally implantable device

Publications (1)

Publication Number Publication Date
ES2160675T3 true ES2160675T3 (es) 2001-11-16

Family

ID=23302115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95307809T Expired - Lifetime ES2160675T3 (es) 1994-11-02 1995-11-01 Dispositivo implantable debajo de la dermis.

Country Status (8)

Country Link
US (2) US5660848A (es)
EP (1) EP0710491B1 (es)
AT (1) ATE204773T1 (es)
CA (1) CA2161950C (es)
DE (1) DE69522409T2 (es)
DK (1) DK0710491T3 (es)
ES (1) ES2160675T3 (es)
PT (1) PT710491E (es)

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US6309843B1 (en) 1994-10-25 2001-10-30 The Curators Of The University Of Missouri Glycoprotein for use in determining endometrial receptivity
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US6472367B1 (en) 1998-05-05 2002-10-29 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin mediated cell adhesion
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
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Also Published As

Publication number Publication date
CA2161950A1 (en) 1996-05-03
EP0710491B1 (en) 2001-08-29
DE69522409T2 (de) 2001-12-13
EP0710491A1 (en) 1996-05-08
ATE204773T1 (de) 2001-09-15
PT710491E (pt) 2001-12-28
DK0710491T3 (da) 2001-10-08
DE69522409D1 (de) 2001-10-04
US5660848A (en) 1997-08-26
US5756115A (en) 1998-05-26
CA2161950C (en) 2000-10-24

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