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ES2159491A1 - Base cristalina de citalopram - Google Patents

Base cristalina de citalopram

Info

Publication number
ES2159491A1
ES2159491A1 ES200100548A ES200100548A ES2159491A1 ES 2159491 A1 ES2159491 A1 ES 2159491A1 ES 200100548 A ES200100548 A ES 200100548A ES 200100548 A ES200100548 A ES 200100548A ES 2159491 A1 ES2159491 A1 ES 2159491A1
Authority
ES
Spain
Prior art keywords
citalopram
base
crystalline base
salts
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200100548A
Other languages
English (en)
Other versions
ES2159491B1 (es
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2159491(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2159491A1 publication Critical patent/ES2159491A1/es
Application granted granted Critical
Publication of ES2159491B1 publication Critical patent/ES2159491B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Base cristalina de citalopram, 1-[3-dimetilamino)propil]-1-(4- fluoro-fenil)-1,3-dihidro-5-isobenzofurano-carbonitrilo, un bien conocido fármaco antidepresivo, formulaciones de dicha fase, un procedimiento para la preparación de sales purificadas de citalopram, tales como el hidrobromuro, por uso de la base, las sales obtenidas por dicho procedimiento y formulaciones que contienen dichas sales.
ES200100548A 2000-03-13 2001-03-09 Base cristalina de citalopram Expired - Fee Related ES2159491B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000402 2000-03-13
DKPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
ES2159491A1 true ES2159491A1 (es) 2001-10-01
ES2159491B1 ES2159491B1 (es) 2002-05-01

Family

ID=8159320

Family Applications (3)

Application Number Title Priority Date Filing Date
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.

Country Status (41)

Country Link
US (7) US20010031784A1 (es)
EP (2) EP1169314B2 (es)
JP (1) JP2003527383A (es)
KR (1) KR20020080486A (es)
CN (2) CN1258530C (es)
AR (1) AR029811A1 (es)
AT (3) ATE223396T1 (es)
AU (2) AU746664B2 (es)
BE (1) BE1013210A3 (es)
BG (1) BG107065A (es)
BR (1) BR0109373A (es)
CA (2) CA2360287C (es)
CH (2) CH691537A5 (es)
CZ (1) CZ292077B6 (es)
DE (7) DE20007303U1 (es)
DK (3) DK173903B1 (es)
EA (1) EA200200972A1 (es)
ES (3) ES2173054T3 (es)
FI (2) FI20010156A0 (es)
FR (1) FR2806086B1 (es)
GB (2) GB2357762B (es)
GR (1) GR1003796B (es)
HR (1) HRP20020756A2 (es)
HU (3) HU0001581D0 (es)
IE (1) IES20010109A2 (es)
IL (2) IL147339A (es)
IS (1) IS5841A (es)
IT (2) IT1319645B1 (es)
MX (1) MXPA02008793A (es)
NL (2) NL1016435C1 (es)
NO (2) NO312031B1 (es)
PL (1) PL360158A1 (es)
PT (2) PT1169314E (es)
SE (2) SE517136C2 (es)
SI (2) SI1227088T1 (es)
SK (1) SK285528B6 (es)
TR (1) TR200202185T2 (es)
UA (1) UA74360C2 (es)
WO (1) WO2001068627A1 (es)
YU (1) YU68802A (es)
ZA (1) ZA200207148B (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1173431T2 (sl) * 1999-04-14 2009-12-31 Lundbeck & Co As H Postopek za pripravo citaloprama
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US6977306B2 (en) * 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
IS6021A (is) * 2000-08-10 2001-10-20 H. Lundbeck A/S Lyfjasamsetningar sem innihalda sítalópram
AU2002231074A1 (en) 2000-12-20 2002-07-01 Fox Hollow Technologies, Inc. Debulking catheter
ES2228824T3 (es) * 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
HRP20030744A2 (en) * 2001-05-01 2005-06-30 H. Lundbeck A/S The use of enantiomeric pure escitalopram
EA006213B1 (ru) 2001-07-31 2005-10-27 Х. Лундбекк А/С Кристаллическая композиция, содержащая эсциталопрам
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
GB2387596B (en) * 2002-02-27 2004-02-11 Matrix Lab Ltd Process
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
AU2003238676A1 (en) * 2003-04-21 2004-11-19 Podile Khadgapathi An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
EP1901714A2 (en) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
RU2408368C2 (ru) 2005-06-27 2011-01-10 Биовэйл Лэборэториз Интернэшнл С.Р.Л. Препараты соли бупропиона с модифицированным высвобождением
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
JP5555242B2 (ja) 2008-10-13 2014-07-23 コヴィディエン リミテッド パートナーシップ カテーテルシャフトを操作するデバイスおよび方法
CA2760449A1 (en) 2009-04-29 2010-11-04 Tyco Healthcare Group Lp Methods and devices for cutting and abrading tissue
JP5281195B2 (ja) 2009-05-14 2013-09-04 コヴィディエン リミテッド パートナーシップ 簡単に清掃され得るアテレクトミー用カテーテルおよび使用の方法
EP2913013B1 (en) 2009-12-02 2016-11-09 Covidien LP Methods and devices for cutting tissue
CA2783301C (en) 2009-12-11 2015-02-24 Tyco Healthcare Group Lp Material removal device having improved material capture efficiency and methods of use
EP2579791B1 (en) 2010-06-14 2014-04-23 Covidien LP Material removal device
BR112013009835A2 (pt) 2010-10-28 2016-07-26 Covidien Lp dispositivo para a remoção de material e método de uso
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US8992717B2 (en) 2011-09-01 2015-03-31 Covidien Lp Catheter with helical drive shaft and methods of manufacture
US9532844B2 (en) 2012-09-13 2017-01-03 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
EP3999058A4 (en) 2019-07-19 2023-05-03 Bioxcel Therapeutics, Inc. NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

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US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO1999030548A2 (en) * 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
WO2000011926A2 (en) * 1999-06-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram

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CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) * 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
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GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4136193A (en) * 1976-01-14 1979-01-23 Kefalas A/S Anti-depressive substituted 1-dimethylaminopropyl-1-phenyl phthalans
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
WO1999030548A2 (en) * 1999-04-14 1999-06-24 H. Lundbeck A/S Method for the preparation of citalopram
WO2000011926A2 (en) * 1999-06-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
SK13132002A3 (sk) 2003-01-09
AR029811A1 (es) 2003-07-16
CH691537A5 (de) 2001-08-15
GB0105982D0 (en) 2001-05-02
ITMI20002425A1 (it) 2002-05-09
BR0109373A (pt) 2002-12-24
GB0102797D0 (en) 2001-03-21
AU2001100197B4 (en) 2001-12-06
EP1169314B1 (en) 2002-09-04
CZ292077B6 (cs) 2003-07-16
SE0103046D0 (sv) 2001-09-14
SE0200730L (sv) 2002-08-29
ES2159491B1 (es) 2002-05-01
DE60100022D1 (de) 2002-10-10
CA2360287A1 (en) 2001-09-20
KR20020080486A (ko) 2002-10-23
NL1017413C1 (nl) 2001-09-13
ZA200207148B (en) 2003-04-23
EP1169314A1 (en) 2002-01-09
HK1054750A1 (en) 2003-12-12
SI1169314T1 (en) 2002-12-31
US20060247451A1 (en) 2006-11-02
IL147339A0 (en) 2002-08-14
FR2806086B1 (fr) 2003-05-09
EP1227088A1 (en) 2002-07-31
DE10164687B4 (de) 2006-04-27
SK285528B6 (sk) 2007-03-01
US20050165244A1 (en) 2005-07-28
SE526022C2 (sv) 2005-06-14
MXPA02008793A (es) 2003-02-12
DK1169314T3 (da) 2002-10-14
CA2360287C (en) 2003-09-09
DE20007303U1 (de) 2000-07-27
US20040132808A1 (en) 2004-07-08
US20010031784A1 (en) 2001-10-18
DE60100022T2 (de) 2003-03-06
CN1680350A (zh) 2005-10-12
FI20010225L (fi) 2001-09-14
ES2173054T3 (es) 2002-12-16
NO312031B1 (no) 2002-03-04
SE517136C2 (sv) 2002-04-16
BG107065A (bg) 2003-05-30
GB2357762A (en) 2001-07-04
EA200200972A1 (ru) 2003-02-27
JP2003527383A (ja) 2003-09-16
EP1169314B2 (en) 2011-06-01
AT4364U1 (de) 2001-06-25
DE60100786T2 (de) 2004-07-15
FI109022B (fi) 2002-05-15
CH691477A5 (de) 2001-07-31
FR2806086A1 (fr) 2001-09-14
PL360158A1 (en) 2004-09-06
YU68802A (sh) 2005-11-28
NO20010619D0 (no) 2001-02-06
GR1003796B (el) 2002-02-08
IS5841A (is) 2001-09-14
HRP20020756A2 (en) 2004-12-31
NL1016435C1 (nl) 2000-11-06
ES2180471T3 (es) 2004-05-01
ES2180471T1 (es) 2003-02-16
SI1227088T1 (en) 2003-12-31
IES20010109A2 (en) 2002-02-20
NO20020356D0 (no) 2002-01-23
BE1013210A3 (fr) 2001-10-02
CZ2001808A3 (cs) 2002-01-16
NO315851B1 (no) 2003-11-03
WO2001068627A1 (en) 2001-09-20
DE1227088T1 (de) 2003-02-06
DK173903B1 (da) 2002-02-11
NO20020356L (no) 2001-09-14
DE60100022T3 (de) 2011-11-17
DE20121240U1 (de) 2002-07-04
US20040167210A1 (en) 2004-08-26
FI20010156A0 (fi) 2001-01-25
HUP0100531A3 (en) 2004-04-28
AU746664B2 (en) 2002-05-02
ITMI20010406A1 (it) 2002-08-28
DK1227088T3 (da) 2003-12-22
DE10108042A1 (de) 2001-10-18
NO20010619L (no) 2001-09-14
CN1258530C (zh) 2006-06-07
AU2001100197A4 (en) 2001-09-20
ATE223396T1 (de) 2002-09-15
IT1319645B1 (it) 2003-10-23
SE0103046L (sv) 2001-11-14
DE60100786D1 (de) 2003-10-23
PT1227088E (pt) 2003-12-31
HUP0100531A2 (hu) 2002-01-28
AU3725201A (en) 2001-09-13
PT1169314E (pt) 2002-11-29
IL158072A0 (en) 2004-03-28
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
ATE250050T1 (de) 2003-10-15
HU0100531D0 (en) 2001-03-28
HU0100450D0 (en) 2001-04-28
CN1429220A (zh) 2003-07-09
HU0001581D0 (en) 2000-06-28
EP1227088B1 (en) 2003-09-17
SI1169314T2 (sl) 2011-08-31
GB2357762B (en) 2002-01-30
FI20010225A0 (fi) 2001-02-07
TR200202185T2 (tr) 2002-12-23
US20030078442A1 (en) 2003-04-24
SE0200730D0 (sv) 2002-03-12
ES2173054T1 (es) 2002-10-16
IL147339A (en) 2004-09-27
CA2411732A1 (en) 2001-09-20

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