BR9908545A - Derivado de piperidina, processo para a preparação do mesmo, composto, processo para a preparação do mesmo, e, composição farmacêutica - Google Patents
Derivado de piperidina, processo para a preparação do mesmo, composto, processo para a preparação do mesmo, e, composição farmacêuticaInfo
- Publication number
- BR9908545A BR9908545A BR9908545-3A BR9908545A BR9908545A BR 9908545 A BR9908545 A BR 9908545A BR 9908545 A BR9908545 A BR 9908545A BR 9908545 A BR9908545 A BR 9908545A
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- compound
- pharmaceutical composition
- formula
- piperidine derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"DERIVADO DE PIPERIDINA, PROCESSO PARA A PREPARAçãO DO MESMO, COMPOSTO, PROCESSO PARA A PREPARAçãO DO MESMO, E, COMPOSIçãO FARMACêUTICA" A presente invenção diz respeito a um novo derivado de piperidina representado pela fórmula (1), que mostra uma atividade inibitória contra a farnesil transferase ou seus sais farmaceuticamente aceitáveis, em que A, E e G são como definidos no relatório descritivo; a um processo para a preparação do composto de fórmula (1); a um intermediário que é usado na preparação do composto de fórmula (1); e a uma composição farmacêutica que compreende o composto de fórmula (1) como um ingrediente ativo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019980002777A KR100388789B1 (ko) | 1998-02-02 | 1998-02-02 | 피롤구조를갖는파네실전이효소억제제및그의제조방법 |
| KR19980002776 | 1998-02-02 | ||
| KR1019980028340A KR100388792B1 (ko) | 1998-02-02 | 1998-07-14 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
| KR10-1998-0032150A KR100388794B1 (ko) | 1998-08-07 | 1998-08-07 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
| PCT/KR1999/000051 WO1999038862A1 (en) | 1998-02-02 | 1999-02-01 | Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908545A true BR9908545A (pt) | 2001-10-02 |
Family
ID=27483262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908545-3A BR9908545A (pt) | 1998-02-02 | 1999-02-01 | Derivado de piperidina, processo para a preparação do mesmo, composto, processo para a preparação do mesmo, e, composição farmacêutica |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6436960B1 (pt) |
| EP (1) | EP1058683B1 (pt) |
| JP (1) | JP3283032B2 (pt) |
| CN (1) | CN1158277C (pt) |
| AT (1) | ATE229017T1 (pt) |
| AU (1) | AU745855B2 (pt) |
| BR (1) | BR9908545A (pt) |
| CA (1) | CA2320233C (pt) |
| DE (1) | DE69904302T2 (pt) |
| ES (1) | ES2185307T3 (pt) |
| PT (1) | PT1058683E (pt) |
| WO (1) | WO1999038862A1 (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100388792B1 (ko) * | 1998-02-02 | 2003-09-22 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
| KR100388794B1 (ko) * | 1998-08-07 | 2003-10-10 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
| CN1151148C (zh) * | 1999-04-13 | 2004-05-26 | Lgci株式会社 | 具有吡咯结构的法尼转移酶抑制剂及其制备方法 |
| KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물 |
| US7035932B1 (en) * | 2000-10-27 | 2006-04-25 | Eric Morgan Dowling | Federated multiprotocol communication |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| AU2003294909B2 (en) | 2002-12-20 | 2007-05-17 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
| KR20120035234A (ko) | 2003-04-11 | 2012-04-13 | 메디뮨 엘엘씨 | 재조합 ｉｌ?９ 항체 및 그의 용도 |
| AU2004286198C1 (en) | 2003-08-18 | 2011-02-24 | Medimmune, Llc | Humanization of antibodies |
| MXPA06004191A (es) * | 2003-10-17 | 2007-01-19 | Incyte Corp | Hidroxamatos ciclicos sustituidos en la forma inhibidores de metaloproteinasas de matriz. |
| US20060121042A1 (en) | 2004-10-27 | 2006-06-08 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| CA2602035C (en) | 2005-03-18 | 2015-06-16 | Medimmune, Inc. | Framework-shuffling of antibodies |
| AU2006261920A1 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Llc | Antibody formulations having optimized aggregation and fragmentation profiles |
| JP5209625B2 (ja) | 2006-08-28 | 2013-06-12 | 協和発酵キリン株式会社 | アンタゴニストのヒトｌｉｇｈｔ特異的ヒトモノクローナル抗体 |
| EP2068923A4 (en) | 2007-03-30 | 2010-11-24 | Medimmune Llc | ANTIBODIES HAVING REDUCED DEAMIDATION PROFILES |
| DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
| GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| NZ630363A (en) | 2012-07-25 | 2018-09-28 | Celldex Therapeutics Inc | Anti-kit antibodies and uses thereof |
| EP2906598A1 (en) | 2012-10-09 | 2015-08-19 | Igenica Biotherapeutics, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| JP6824735B2 (ja) | 2013-06-06 | 2021-02-03 | ピエール、ファーブル、メディカマン | 抗Ｃ１０ｏｒｆ５４抗体およびその使用方法 |
| WO2015053871A2 (en) | 2013-08-26 | 2015-04-16 | MabVax Therapeutics, Inc. | NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| KR102614642B1 (ko) | 2014-06-04 | 2023-12-19 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 강글리오사이드 ｇｄ２에 대한 사람 단클론 항체 |
| CN108064167A (zh) | 2014-12-11 | 2018-05-22 | 皮埃尔法布雷医药公司 | 抗c10orf54抗体及其用途 |
| KR20250005465A (ko) | 2015-03-03 | 2025-01-09 | 키맵 리미티드 | 항체, 용도 및 방법 |
| WO2017096017A1 (en) | 2015-12-02 | 2017-06-08 | Stsciences, Inc. | Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator) |
| CN109415437B (zh) | 2015-12-02 | 2022-02-01 | 斯特库伯株式会社 | 与btn1a1免疫特异性结合的抗体和分子及其治疗用途 |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN111051346A (zh) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法 |
| JP7369038B2 (ja) | 2017-05-31 | 2023-10-25 | ストキューブ アンド シーオー．， インコーポレイテッド | Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子並びにその治療的使用 |
| CN110997724A (zh) | 2017-06-06 | 2020-04-10 | 斯特库伯株式会社 | 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 |
| EP3694889A1 (en) | 2017-10-13 | 2020-08-19 | Boehringer Ingelheim International GmbH | Human antibodies to thomsen-nouvelle (tn) antigen |
| CA3106418A1 (en) | 2018-07-20 | 2020-01-23 | Pierre Fabre Medicament | Receptor for vista |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| SK114094A3 (en) * | 1992-03-25 | 1995-04-12 | Pfizer | Peptides, method of their producing, their using and pharmaceutical preparation on their base |
| GB9312806D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
| AU716153B2 (en) * | 1996-04-03 | 2000-02-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU727939B2 (en) * | 1996-04-03 | 2001-01-04 | Merck & Co., Inc. | A method of treating cancer |
| WO1997038665A2 (en) * | 1996-04-03 | 1997-10-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1997036890A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0891360A4 (en) * | 1996-04-03 | 2002-05-15 | Merck & Co Inc | FARNESYL PROTEIN TRANSFERASE INHIBITORS |
| ATE239014T1 (de) * | 1997-11-28 | 2003-05-15 | Lg Chemical Ltd | Imidazolderivate mit farnesyltransferase hemmenden eigenschaften und verfahren zu ihrer herstellung |
-
1999
- 1999-02-01 ES ES99901979T patent/ES2185307T3/es not_active Expired - Lifetime
- 1999-02-01 US US09/601,426 patent/US6436960B1/en not_active Expired - Fee Related
- 1999-02-01 BR BR9908545-3A patent/BR9908545A/pt not_active Application Discontinuation
- 1999-02-01 CN CNB99802581XA patent/CN1158277C/zh not_active Expired - Fee Related
- 1999-02-01 AU AU21886/99A patent/AU745855B2/en not_active Ceased
- 1999-02-01 AT AT99901979T patent/ATE229017T1/de not_active IP Right Cessation
- 1999-02-01 DE DE69904302T patent/DE69904302T2/de not_active Expired - Fee Related
- 1999-02-01 WO PCT/KR1999/000051 patent/WO1999038862A1/en active IP Right Grant
- 1999-02-01 JP JP2000529330A patent/JP3283032B2/ja not_active Expired - Fee Related
- 1999-02-01 CA CA002320233A patent/CA2320233C/en not_active Expired - Fee Related
- 1999-02-01 PT PT99901979T patent/PT1058683E/pt unknown
- 1999-02-01 EP EP99901979A patent/EP1058683B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1058683A1 (en) | 2000-12-13 |
| US6436960B1 (en) | 2002-08-20 |
| DE69904302T2 (de) | 2003-08-14 |
| PT1058683E (pt) | 2003-04-30 |
| AU2188699A (en) | 1999-08-16 |
| CA2320233C (en) | 2004-07-27 |
| ES2185307T3 (es) | 2003-04-16 |
| AU745855B2 (en) | 2002-04-11 |
| JP2002501918A (ja) | 2002-01-22 |
| EP1058683B1 (en) | 2002-12-04 |
| CA2320233A1 (en) | 1999-08-05 |
| CN1289331A (zh) | 2001-03-28 |
| DE69904302D1 (de) | 2003-01-16 |
| CN1158277C (zh) | 2004-07-21 |
| WO1999038862A1 (en) | 1999-08-05 |
| ATE229017T1 (de) | 2002-12-15 |
| JP3283032B2 (ja) | 2002-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O, 24 E 25 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |