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ES2139662T3 - Soluciones solidas y liquidas de sustancias medicamentosas dificilmente solubles en agua. - Google Patents

Soluciones solidas y liquidas de sustancias medicamentosas dificilmente solubles en agua.

Info

Publication number
ES2139662T3
ES2139662T3 ES93914598T ES93914598T ES2139662T3 ES 2139662 T3 ES2139662 T3 ES 2139662T3 ES 93914598 T ES93914598 T ES 93914598T ES 93914598 T ES93914598 T ES 93914598T ES 2139662 T3 ES2139662 T3 ES 2139662T3
Authority
ES
Spain
Prior art keywords
pct
water
solid
liquid solutions
hardly soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914598T
Other languages
English (en)
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Alfatec Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6462411&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2139662(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alfatec Pharma GmbH filed Critical Alfatec Pharma GmbH
Application granted granted Critical
Publication of ES2139662T3 publication Critical patent/ES2139662T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Colloid Chemistry (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A SUSTANCIAS ACTIVAS, POR EJEMPLO MEDICAMENTOS, DIFICILMENTE SOLUBLES EN AGUA, QUE SE CONVIERTEN EN UN ESTADO DISUELTO (DISPERSION MOLECULAR) DE TAL MODO QUE SE CONSIGUE MEDIANTE DISOLUCION EN UN PEPTIDO HIDROFILICO CON UN PESO MOLECULAR DE MAS DE 100 D, POR EJEMPLO GELATINA. CON ELLO SE GARANTIZA LA SOLUBILIDAD TANTO DURANTE LA CONSERVACION, COMO TAMBIEN EN LA UTILIZACION DE LA PREPARACION POR UN UTILIZADOR O EL PACIENTE, SIN QUE SEA NECESARIO DISOLVENTES ORGANICOS O POLISOLUBILIZADORES QUE ORIGINAN EFECTOS SECUNDARIOS NO DESEADOS.
ES93914598T 1992-07-03 1993-07-05 Soluciones solidas y liquidas de sustancias medicamentosas dificilmente solubles en agua. Expired - Lifetime ES2139662T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4221880A DE4221880A1 (de) 1992-07-03 1992-07-03 Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen

Publications (1)

Publication Number Publication Date
ES2139662T3 true ES2139662T3 (es) 2000-02-16

Family

ID=6462411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914598T Expired - Lifetime ES2139662T3 (es) 1992-07-03 1993-07-05 Soluciones solidas y liquidas de sustancias medicamentosas dificilmente solubles en agua.

Country Status (12)

Country Link
US (1) US5902606A (es)
EP (1) EP0650354B1 (es)
JP (1) JP2975112B2 (es)
AT (1) ATE187639T1 (es)
AU (1) AU688263B2 (es)
CA (1) CA2139133C (es)
DE (2) DE4221880A1 (es)
DK (1) DK0650354T3 (es)
ES (1) ES2139662T3 (es)
GR (1) GR3032113T3 (es)
PT (1) PT650354E (es)
WO (1) WO1994001090A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0701815B1 (de) * 1992-01-17 1999-06-30 ALFATEC-PHARMA GmbH Verfahren zur Herstellung von Wirkstoff enthaltenden Pulvern, Granulaten oder Pellets mit einem Gerüst aus hydrophilen Makromolekülen und ihre Verwendung
US5449519C1 (en) * 1994-08-09 2001-05-01 Revlon Consumer Prod Corp Cosmetic compositions having keratolytic and anti-acne activity
US6118080A (en) * 1998-01-13 2000-09-12 Micron Technology, Inc. Z-axis electrical contact for microelectronic devices
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
EP1216059B1 (en) 1999-09-16 2005-10-19 Novo Nordisk A/S Composition for ivf
US20030149288A1 (en) * 2000-04-18 2003-08-07 Natural Asa Conjugated linoleic acid powder
WO2002030466A2 (en) * 2000-10-11 2002-04-18 Purdue Research Foundation Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
DE10058771A1 (de) * 2000-11-27 2002-06-06 Falk Pharma Gmbh Coazervierungsverfahren zur Herstellung von verzögert feisetzenden Arzneimitteln
DE10058772A1 (de) * 2000-11-27 2002-06-06 Falk Pharma Gmbh Verfahren zur Herstellung leicht löslicher Arzneimittelformulierungen und entsprechende Formulierungen
US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
US20040013732A1 (en) * 2001-09-25 2004-01-22 Michael Farber Starch-based delivery system for creatine
JP2003221335A (ja) 2001-10-26 2003-08-05 Dey Lp 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法
US6702997B2 (en) 2001-10-26 2004-03-09 Dey, L.P. Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
US20030191151A1 (en) * 2001-10-26 2003-10-09 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030203930A1 (en) * 2001-10-26 2003-10-30 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030140920A1 (en) * 2001-10-26 2003-07-31 Dey L.P. Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma
DE10205362A1 (de) * 2002-02-08 2003-08-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
EP1661556A4 (en) * 2003-08-20 2010-05-19 Ajinomoto Kk MEDICAL PREPARATION WITH IMPROVED RESOLUTION CHARACTERISTICS
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
US20080160086A1 (en) * 2004-02-19 2008-07-03 Scepter Holdings, Inc. Delivery Systems For Calcium
SG177132A1 (en) 2005-02-14 2012-01-30 Johnson & Johnson Vision Care A comfortable ophthalmic device and methods of its production
US9052529B2 (en) 2006-02-10 2015-06-09 Johnson & Johnson Vision Care, Inc. Comfortable ophthalmic device and methods of its production
US9347947B2 (en) 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
WO2014022195A1 (en) * 2012-08-01 2014-02-06 Tavakoli Zahra Free flowing, frozen compositions comprising a therapeutic agent
DE102013207083A1 (de) 2013-04-19 2014-10-23 Leibniz-Institut Für Polymerforschung Dresden E.V. Verwendung von Chitosan und/oder dessen Derivaten in Baumaterialien
WO2017137992A1 (en) 2016-02-11 2017-08-17 Gelpell Ag Oral solid cannabinoid formulations, methods for producing and using thereof
US20190083629A1 (en) 2016-04-29 2019-03-21 Rousselot B.V. Protein based excipient for active pharmaceutical ingredients

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887901A (es) * 1960-04-13 1900-01-01
US3435110A (en) * 1966-03-21 1969-03-25 Ethicon Inc Collagen fibril matrix pharmaceuticals
US3959472A (en) * 1972-04-10 1976-05-25 Hoffmann-La Roche Inc. Free-flowing, high density, agglomerated riboflavin powders
IE45770B1 (en) * 1976-10-06 1982-11-17 Wyeth John & Brother Ltd Pharmaceutical dosage forms
US4670247A (en) * 1983-07-05 1987-06-02 Hoffman-Laroche Inc. Process for preparing fat-soluble vitamin active beadlets
DE3484584D1 (de) * 1983-10-14 1991-06-20 Sumitomo Pharma Injektionen mit verzoegerter abgabe.
JPS6144825A (ja) * 1984-08-09 1986-03-04 Unitika Ltd 止血剤
CA1324083C (en) * 1987-03-09 1993-11-09 Tetsu Miyoshi Pharmaceutical preparations containing non-steroidal anti-inflammatory agents
DE3770940D1 (de) * 1987-04-06 1991-07-25 Hoffmann La Roche Verfahren zur herstellung von vitaminpraeparaten.
MC2034A1 (fr) * 1988-06-23 1990-05-30 Hoffmann La Roche Preparations
CH677141A5 (es) * 1988-09-16 1991-04-15 Rosenmund Ag
US4948580A (en) * 1988-12-08 1990-08-14 E. R. Squibb & Sons, Inc. Muco-bioadhesive composition
FR2650502B1 (fr) * 1989-08-07 1994-05-27 Delagrange Laboratoires Nouvelle forme galenique orale ameliorant la biodisponibilite
EP0499619B1 (en) * 1989-11-06 1996-02-07 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres

Also Published As

Publication number Publication date
ATE187639T1 (de) 2000-01-15
AU688263B2 (en) 1998-03-12
DE4221880A1 (de) 1994-01-05
JP2975112B2 (ja) 1999-11-10
EP0650354B1 (de) 1999-12-15
WO1994001090A1 (de) 1994-01-20
DK0650354T3 (da) 2000-05-29
AU4415293A (en) 1994-01-31
JPH07508525A (ja) 1995-09-21
EP0650354A1 (de) 1995-05-03
US5902606A (en) 1999-05-11
PT650354E (pt) 2000-05-31
CA2139133A1 (en) 1994-01-20
GR3032113T3 (en) 2000-03-31
CA2139133C (en) 2001-09-18
DE59309907D1 (de) 2000-01-20

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