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ES2133428T3 - Fabricacion de amidas y peptidos, exenta de racemizacion, en presencia de cantidades cataliticas de un compuesto n-hidroxi. - Google Patents

Fabricacion de amidas y peptidos, exenta de racemizacion, en presencia de cantidades cataliticas de un compuesto n-hidroxi.

Info

Publication number
ES2133428T3
ES2133428T3 ES94101784T ES94101784T ES2133428T3 ES 2133428 T3 ES2133428 T3 ES 2133428T3 ES 94101784 T ES94101784 T ES 94101784T ES 94101784 T ES94101784 T ES 94101784T ES 2133428 T3 ES2133428 T3 ES 2133428T3
Authority
ES
Spain
Prior art keywords
amides
peptides
racemization
exempt
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94101784T
Other languages
English (en)
Inventor
Markus Hohler
Peter Vogt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Original Assignee
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4188840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2133428(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by HOFFMANN LA ROCHE, F Hoffmann La Roche AG filed Critical HOFFMANN LA ROCHE
Application granted granted Critical
Publication of ES2133428T3 publication Critical patent/ES2133428T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/084—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCESO PARA LA OBTENCION DE AMIDAS Y DE PEPTIDOS POR TRANSFORMACION DE UN ACIDO CARBOXILICO CON UNA AMINA PRIMARIA O SECUNDARIA EN PRESENCIA DE UNA CARBODIIMIDA Y DE UNA CANTIDAD CATALITICA DE UN COMPUESTO DE HIDROXI-N.
ES94101784T 1993-02-19 1994-02-07 Fabricacion de amidas y peptidos, exenta de racemizacion, en presencia de cantidades cataliticas de un compuesto n-hidroxi. Expired - Lifetime ES2133428T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH51893 1993-02-19

Publications (1)

Publication Number Publication Date
ES2133428T3 true ES2133428T3 (es) 1999-09-16

Family

ID=4188840

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94101784T Expired - Lifetime ES2133428T3 (es) 1993-02-19 1994-02-07 Fabricacion de amidas y peptidos, exenta de racemizacion, en presencia de cantidades cataliticas de un compuesto n-hidroxi.

Country Status (8)

Country Link
US (2) US5536816A (es)
EP (1) EP0611774B1 (es)
JP (1) JP2524685B2 (es)
CN (1) CN1035873C (es)
AT (1) ATE180491T1 (es)
DE (1) DE59408292D1 (es)
DK (1) DK0611774T3 (es)
ES (1) ES2133428T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611774B1 (de) * 1993-02-19 1999-05-26 F. Hoffmann-La Roche Ag Racemisierungsfreie Herstellung von Amiden und Peptiden in Gegenwart katalytischer Mengen einer N-Hydroxy-Verbindung
GB9424842D0 (en) * 1994-12-09 1995-02-08 British Tech Group Pharmaceutical compositions
US5914404A (en) * 1996-08-09 1999-06-22 Hoffmann-La Roche Inc. Process for the preparation of quinargine
EP0823424A1 (de) * 1996-08-09 1998-02-11 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Chinargin
ATE236880T1 (de) 1996-12-11 2003-04-15 Hoffmann La Roche Verfahren zur herstellung gemischter anhydride
WO1999065931A1 (en) * 1998-06-17 1999-12-23 Magainin Pharmaceuticals, Inc. Non-enzymatic chemical amidation process
JP4949557B2 (ja) * 1999-03-17 2012-06-13 ノヴォ ノルディスク アー／エス ペプチドのアシル化方法及び新規アシル化剤
US6719080B1 (en) 2000-01-10 2004-04-13 The United States Of America As Represented By The Administrator Of The Environmental Protection Agency Hydraulic hybrid vehicle
DE60237757D1 (de) * 2001-03-19 2010-11-04 Fujimori Kogyo Co Anhydrothrombinderivate und verfahren zu deren herstellung, die blutplättchenagglutination induzierende zusammensetzungen, verfahren zur induktion der blutplättchenagglutination, klinische testreagenzien, klinisches testverfahren, thromboseinhibitoren, adsorbens und verfahren
US7423166B2 (en) * 2001-12-13 2008-09-09 Advanced Technology Materials, Inc. Stabilized cyclosiloxanes for use as CVD precursors for low-dielectric constant thin films
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
CN103113177B (zh) * 2013-02-06 2015-02-04 济南志合医药科技有限公司 一种酰胺的制备方法
ES2624961T3 (es) 2013-03-21 2017-07-18 Sanofi-Aventis Deutschland Gmbh Síntesis de productos de péptido que contienen imida cíclica
MX363522B (es) 2013-03-21 2019-03-26 Sanofi Aventis Deutschland Síntesis de productos peptídicos que contienen hidantoína.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2202613C3 (de) * 1972-01-20 1974-06-20 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Peptiden
WO1994007910A1 (en) * 1992-09-28 1994-04-14 Research Corporation Technologies, Inc. New reagents for peptide couplings
EP0611774B1 (de) * 1993-02-19 1999-05-26 F. Hoffmann-La Roche Ag Racemisierungsfreie Herstellung von Amiden und Peptiden in Gegenwart katalytischer Mengen einer N-Hydroxy-Verbindung

Also Published As

Publication number Publication date
JPH06256225A (ja) 1994-09-13
DK0611774T3 (da) 1999-11-15
CN1035873C (zh) 1997-09-17
EP0611774A1 (de) 1994-08-24
US5536816A (en) 1996-07-16
JP2524685B2 (ja) 1996-08-14
CN1111237A (zh) 1995-11-08
US5750649A (en) 1998-05-12
DE59408292D1 (de) 1999-07-01
EP0611774B1 (de) 1999-05-26
ATE180491T1 (de) 1999-06-15

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