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ES2127699A1 - Nuevos derivados de 2,3-benzodiazepina. - Google Patents

Nuevos derivados de 2,3-benzodiazepina.

Info

Publication number
ES2127699A1
ES2127699A1 ES09700703A ES9700703A ES2127699A1 ES 2127699 A1 ES2127699 A1 ES 2127699A1 ES 09700703 A ES09700703 A ES 09700703A ES 9700703 A ES9700703 A ES 9700703A ES 2127699 A1 ES2127699 A1 ES 2127699A1
Authority
ES
Spain
Prior art keywords
sup
group
sub
translation
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700703A
Other languages
English (en)
Other versions
ES2127699B1 (es
Inventor
Istvan Ling
Gizella Abraham
Pal Berzsenyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9600871A external-priority patent/HU9600871D0/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2127699A1 publication Critical patent/ES2127699A1/es
Application granted granted Critical
Publication of ES2127699B1 publication Critical patent/ES2127699B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevos derivados de 2,3-benzodiazepina La invención se refiere a compuestos antagonistas AMPA no competitivos de fórmula I, en la que R{sup,1 y R{sup,2 representan, independientemente, un hidrógeno, un halógeno, un grupo C{sub,1-4 -alquilo, un grupo C{sub,1-4 -alcoxilo, un grupo nitro, un grupo trifluoro-metilo o un grupo de amina secundaria R{sup,3 representa un grupo C{sub,1-4 -alquilo, un grupo C{sub,3-5 -cicloalquilo o un grupo cetocarbonilo R{sup,4 y R{sup,5 significan, independientemente, un hidrógeno o un grupo C{sub,1-3 alquilo, R{sup,6 y R{sup,7 son, independientemente, un hidrógeno, un cloro o un bromo. así como a los isómeros y las sales de adición de ácido de los compuestos o los isómeros, y a las composiciones farmacéuticas preparadas a partir de cualquiera de ellos. La invención se refiere también a los compuestos de partida de fórmula II, en, la que R{sup,1 , R{sup,2 , R{sup,4 , R{sup,5 , R{sup,6 y R{sup,7 tienen el significado indicado en relación con la fórmula I.
ES009700703A 1996-04-04 1997-04-04 Nuevos derivados de 2,3-benzodiazepina. Expired - Fee Related ES2127699B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9600871A HU9600871D0 (en) 1996-04-04 1996-04-04 New 2,3-benzodiazepine derivatives

Publications (2)

Publication Number Publication Date
ES2127699A1 true ES2127699A1 (es) 1999-04-16
ES2127699B1 ES2127699B1 (es) 2000-01-16

Family

ID=89993864

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009700703A Expired - Fee Related ES2127699B1 (es) 1996-04-04 1997-04-04 Nuevos derivados de 2,3-benzodiazepina.

Country Status (11)

Country Link
KR (1) KR970069997A (es)
AT (1) ATE254608T1 (es)
AU (1) AU720745B2 (es)
BE (1) BE1010962A4 (es)
DE (1) DE59711013D1 (es)
ES (1) ES2127699B1 (es)
IT (1) IT1290453B1 (es)
NZ (1) NZ314517A (es)
UA (1) UA45358C2 (es)
YU (1) YU13197A (es)
ZA (1) ZA972746B (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2034706A (en) * 1978-10-19 1980-06-11 Egyt Gyogyszervegyeszeti Gyar Benzodiazepines
US4423044A (en) * 1981-03-12 1983-12-27 Egyt Gyogyszervegyeszeti Gyar 3,4-Dihydro-5H-2,3-benzodiazepine derivatives and pharmaceutical use thereof
EP0492485A1 (en) * 1990-12-21 1992-07-01 Gyogyszerkutato Intezet N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
WO1996006606A1 (en) * 1994-08-31 1996-03-07 Eli Lilly And Company Dihydro-2,3-benzodiazepine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2034706A (en) * 1978-10-19 1980-06-11 Egyt Gyogyszervegyeszeti Gyar Benzodiazepines
US4423044A (en) * 1981-03-12 1983-12-27 Egyt Gyogyszervegyeszeti Gyar 3,4-Dihydro-5H-2,3-benzodiazepine derivatives and pharmaceutical use thereof
EP0492485A1 (en) * 1990-12-21 1992-07-01 Gyogyszerkutato Intezet N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
WO1996006606A1 (en) * 1994-08-31 1996-03-07 Eli Lilly And Company Dihydro-2,3-benzodiazepine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VIZI, E.S. y TARNAWA, I.: "2,3 benzodiazepines (GYKI 52466 and analogs): Negative allosteric Modulators of AMPA receptors. CNS DRUG Reviews, 1996, Vol. 2, No 1, paginas 91-126 *

Also Published As

Publication number Publication date
DE59711013D1 (de) 2003-12-24
UA45358C2 (uk) 2002-04-15
BE1010962A4 (fr) 1999-03-02
ATE254608T1 (de) 2003-12-15
ES2127699B1 (es) 2000-01-16
AU720745B2 (en) 2000-06-08
YU13197A (sh) 1999-09-27
AU1773497A (en) 1997-10-09
ITMI970776A1 (it) 1998-10-04
IT1290453B1 (it) 1998-12-03
ZA972746B (en) 1998-10-09
KR970069997A (ko) 1997-11-07
NZ314517A (en) 2000-03-27

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