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ES2098752T3 - Uso de analogos de acido nucleico en la inhibicion de la multiplicacion de acidos nucleicos. - Google Patents

Uso de analogos de acido nucleico en la inhibicion de la multiplicacion de acidos nucleicos.

Info

Publication number
ES2098752T3
ES2098752T3 ES93912907T ES93912907T ES2098752T3 ES 2098752 T3 ES2098752 T3 ES 2098752T3 ES 93912907 T ES93912907 T ES 93912907T ES 93912907 T ES93912907 T ES 93912907T ES 2098752 T3 ES2098752 T3 ES 2098752T3
Authority
ES
Spain
Prior art keywords
pcr
pna
nucleic acid
amplification
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912907T
Other languages
English (en)
Inventor
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Rolf Henrik Berg
Christopher John Stanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2098752T3 publication Critical patent/ES2098752T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ANALOGOS DE ACIDO NUCLEICO DEL TIPO DESCRITO EN PCT/EP92/01220(PNA''S) QUE SE HIBRIDIZAN FUERTEMENTE A LOS ACIDO NUCLEICOS SE USAN PARA INHIBIR PROCESOS DE AMPLIFICACION DE ACIDO NUCLEICO TAL COMO PCR. SE EVITAN FALSOS POSITIVOS EN SUBSIGUIENTES ENSAYOS DE PCR HIBRIDIZANDO UN PNA A PRODUCTOS DE AMPLIFICACION DE PCR. LOS ENSAYOS CAPACES DE DISCRIMINAR ENTRE MUTANTES DE PAR DE BASE SENCILLA SON CONDUCIDOS USANDO UN PNA QUE HIBRIDIZA A UNA DE LAS DOS FORMAS ALELICAS PARA INHIBIR UNA AMPLIFICACION DE ESTA FORMA SELECTIVAMENTE. SE LLEVAN A CABO AMPLIFICACIONES DE PCR ASIMETRICAS CEBANDO UN PCR QUE USA SIMETRICAMENTE CANTIDADES DE CEBOS DELANTEROS E INVERSOS Y UNA VEZ QUE SE ESTABLECE LA AMPLIFICACION SE INCAPACITA UN CEBO HIBRIDIZANDO UN PNA.
ES93912907T 1992-06-05 1993-06-07 Uso de analogos de acido nucleico en la inhibicion de la multiplicacion de acidos nucleicos. Expired - Lifetime ES2098752T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929211979A GB9211979D0 (en) 1992-06-05 1992-06-05 Uses of nucleic acid analogues

Publications (1)

Publication Number Publication Date
ES2098752T3 true ES2098752T3 (es) 1997-05-01

Family

ID=10716635

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912907T Expired - Lifetime ES2098752T3 (es) 1992-06-05 1993-06-07 Uso de analogos de acido nucleico en la inhibicion de la multiplicacion de acidos nucleicos.

Country Status (17)

Country Link
US (2) US5891625A (es)
EP (1) EP0646181B1 (es)
JP (1) JP3061064B2 (es)
KR (2) KR0140836B1 (es)
AT (1) ATE147441T1 (es)
AU (1) AU674520B2 (es)
CA (1) CA2136831C (es)
CZ (1) CZ282786B6 (es)
DE (1) DE69307317T2 (es)
DK (1) DK0646181T3 (es)
ES (1) ES2098752T3 (es)
FI (1) FI110694B (es)
GB (1) GB9211979D0 (es)
HU (1) HU219371B (es)
NO (1) NO317111B1 (es)
SK (1) SK149394A3 (es)
WO (1) WO1993025706A1 (es)

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EP0646181A1 (en) 1995-04-05
JPH08501681A (ja) 1996-02-27
CA2136831A1 (en) 1993-12-23
CZ295194A3 (en) 1995-09-13
DE69307317T2 (de) 1997-05-22
AU4323593A (en) 1994-01-04
KR950702252A (ko) 1995-06-19
EP0646181B1 (en) 1997-01-08
US5891625A (en) 1999-04-06
AU674520B2 (en) 1997-01-02
JP3061064B2 (ja) 2000-07-10
ATE147441T1 (de) 1997-01-15
FI945725A0 (fi) 1994-12-05
CA2136831C (en) 2002-11-05
HU219371B (en) 2001-03-28
NO944655L (no) 1995-02-03
HU9403463D0 (en) 1995-02-28
KR0140836B1 (ko) 1998-06-15
DK0646181T3 (da) 1997-10-13
HUT71931A (en) 1996-02-28
SK149394A3 (en) 1996-01-10
NO944655D0 (no) 1994-12-02
WO1993025706A1 (en) 1993-12-23
DE69307317D1 (de) 1997-02-20
FI945725L (fi) 1994-12-05
CZ282786B6 (cs) 1997-10-15
FI110694B (fi) 2003-03-14
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US5972610A (en) 1999-10-26
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