[go: up one dir, main page]

ES2090836T3 - Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas. - Google Patents

Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.

Info

Publication number
ES2090836T3
ES2090836T3 ES93200438T ES93200438T ES2090836T3 ES 2090836 T3 ES2090836 T3 ES 2090836T3 ES 93200438 T ES93200438 T ES 93200438T ES 93200438 T ES93200438 T ES 93200438T ES 2090836 T3 ES2090836 T3 ES 2090836T3
Authority
ES
Spain
Prior art keywords
preparation
biologically active
procedure
microcapsules containing
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93200438T
Other languages
English (en)
Inventor
Cardina Anna Maria Chris Dirix
Hendrikus Johannes Maria Kamp
Anthonius Paulus Sam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2090836T3 publication Critical patent/ES2090836T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION DE MICROCAPSULAS QUE CONTIENEN UN MATERIAL BIOLOGICAMENTE ACTIVO. EL PROCESO COMPRENDE LA DISOLUCION DE UN POLIMERO EN UN SOLVENTE DENTRO DEL CUAL SE INTRODUCE EL MATERIAL ACTIVO; LA ATOMIZACION DE LA SUSPENSION O SOLUCION RESULTANTE Y LA RECOGIDA DE LAS GOTITAS EN UN MATERIAL NO SOLVENTE PARA LAS GOTITAS POLIMERICAS QUE CONTIENEN EL MATERIAL ACTIVO, DANDO COMO RESULTANDO LA COAGULACION. SUBSECUENTEMENTE, LAS GOTITAS COAGULADAS SE ENDURECEN EN UN SEGUNDO MATERIAL NO SOLVENTE.
ES93200438T 1992-02-18 1993-02-16 Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas. Expired - Lifetime ES2090836T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92200466 1992-02-18

Publications (1)

Publication Number Publication Date
ES2090836T3 true ES2090836T3 (es) 1996-10-16

Family

ID=8210436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93200438T Expired - Lifetime ES2090836T3 (es) 1992-02-18 1993-02-16 Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.

Country Status (16)

Country Link
US (1) US5389379A (es)
EP (1) EP0556917B1 (es)
JP (1) JPH05337360A (es)
KR (1) KR930017574A (es)
AT (1) ATE138263T1 (es)
AU (1) AU658715B2 (es)
CA (1) CA2089354A1 (es)
DE (1) DE69302721T2 (es)
DK (1) DK0556917T3 (es)
ES (1) ES2090836T3 (es)
FI (1) FI930672L (es)
GR (1) GR3020417T3 (es)
MX (1) MX9300851A (es)
NO (1) NO930557L (es)
NZ (1) NZ245914A (es)
ZA (1) ZA93929B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6383470B1 (en) 1992-09-26 2002-05-07 Thomas Fritzsch Microparticle preparations made of biodegradable copolymers
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
CA2160693C (en) 1993-04-22 2010-03-16 Sam J. Milstein Oral drug delivery compositions and methods
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20010003001A1 (en) * 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CN1151836C (zh) 1995-03-31 2004-06-02 艾米斯菲尔技术有限公司 用作传送活性剂的化合物和组合物
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
CN1055417C (zh) * 1995-09-05 2000-08-16 中国科学院成都有机化学研究所 一种核-壳结构的蛋白高分子微球及其制法
US6084112A (en) 1995-09-11 2000-07-04 Emisphere Technologies, Inc. Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones
SI9720025A (sl) * 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
US6375983B1 (en) 1996-06-14 2002-04-23 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
CA2243643A1 (en) 1996-11-18 1998-05-28 Susan Haas Methods and compositions for inducing oral tolerance in mammals
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
ES2343124T3 (es) * 1999-10-29 2010-07-23 Novartis Ag Composiciones de polvo seco con dispersabilidad mejorada.
US6767637B2 (en) * 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
WO2007070957A1 (en) * 2005-12-21 2007-06-28 Monash University Process and apparatus for generating particles
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
FR2618674B1 (fr) * 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
WO1990013361A1 (en) * 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs

Also Published As

Publication number Publication date
CA2089354A1 (en) 1993-08-19
NO930557L (no) 1993-08-19
NO930557D0 (no) 1993-02-17
FI930672A7 (fi) 1993-08-19
FI930672A0 (fi) 1993-02-16
EP0556917A1 (en) 1993-08-25
ATE138263T1 (de) 1996-06-15
AU658715B2 (en) 1995-04-27
DK0556917T3 (da) 1996-09-16
ZA93929B (en) 1993-09-10
DE69302721D1 (de) 1996-06-27
NZ245914A (en) 1995-02-24
KR930017574A (ko) 1993-09-20
EP0556917B1 (en) 1996-05-22
DE69302721T2 (de) 1996-09-19
FI930672L (fi) 1993-08-19
US5389379A (en) 1995-02-14
JPH05337360A (ja) 1993-12-21
AU3313493A (en) 1993-08-19
MX9300851A (es) 1994-08-31
GR3020417T3 (en) 1996-10-31

Similar Documents

Publication Publication Date Title
ES2090836T3 (es) Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.
BR9908893A (pt) Composição polimérica lìquida para a liberação controlada de substâncias bioativas hidrofóbicas, e, processo para a liberação controlada de uma substância bioativa hidrofóbica em um animal, incluindo o ser humano
ES555277A0 (es) Procedimiento de obtencion de una composicion de injerto para la liberacion controlada de macromoleculas
MX160019A (es) Un proceso para la produccion de particulas de polimero,redispersable en un liquido para formar una dispersion y capaz de unirse covalentemente a substancias bilogicas por si mismo
DK0720471T3 (da) Hydrofobe polymere mikropartikler
DE3789956D1 (de) Polymere trägerzubereitungen, herstellung und verwendung.
NO931809L (no) Hemofilter
ES2010960T3 (es) Polimeros con elevada velocidad de absorcion de liquidos acuosos.
DE69526787D1 (de) Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln
KR880002927A (ko) 폐색된 미소공 막
SE8501111D0 (sv) Process for spinning hollow fiber membranes
ES2116308T3 (es) Dispositivo implantable a base de un material polimero, que contiene principios activos farmaceuticos, asi como procedimiento para su produccion.
IL82197A0 (en) Wettable dry material in the form of an aqueous gel containing dispersed polymeric particles,process for preparation thereof and biological application thereof
ATE173578T1 (de) Implantierbare formkörper zur verabreichung von wirkstoffen an pflanzen
ES2060715T3 (es) Medicamentos escasamente solubles inmovilizados en substancias polimericas de una manera adecuada para incrementar su grado de disolucion.
ATE78263T1 (de) Verfahren zur herstellung eines produkts von geliertem cellulosetriacetat und das so hergestellte produkt.
ATE103976T1 (de) Verfahren zur verkapselung.
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
ES2177258T3 (es) Procedimiento parra la extraccion de particulas de poliamida 6.
ATE50586T1 (de) Absorbierendes polymeres material und dessen herstellung.
ATE499069T1 (de) Flüssige polymerlosung zur kontrollierten freisetzung von bioaktiven substanzen
JPS57136513A (en) Material for controlling release of physiologically active substance
DE50113104D1 (de) Mit Blut und Gewebe verträgliche Membranen aus P(AN/NVP)-Misch-polymeren und deren Anwendung im medizinischen Bereich
ES2031470T3 (es) Envase con un vehiculo de substancia activa contenido en el, cargado con una substancia activa no esterilizable y procedimiento para su fabricacion.
JP3378392B2 (ja) ミクロ多孔体及びその製造方法

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 556917

Country of ref document: ES

FG2A Definitive protection

Ref document number: 556917

Country of ref document: ES