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ES2086026T3 - Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion. - Google Patents

Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion.

Info

Publication number
ES2086026T3
ES2086026T3 ES92110347T ES92110347T ES2086026T3 ES 2086026 T3 ES2086026 T3 ES 2086026T3 ES 92110347 T ES92110347 T ES 92110347T ES 92110347 T ES92110347 T ES 92110347T ES 2086026 T3 ES2086026 T3 ES 2086026T3
Authority
ES
Spain
Prior art keywords
octadecil
phosphate
piperidine
pharmaceutical
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92110347T
Other languages
English (en)
Inventor
Wolfgang Dr Schumacher
Jurgen Prof Engel
Gerhard Dr Nossner
Bernhard Dr Kutscher
Jurij Dr Stekar
Peter Dr Hilgard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2086026T3 publication Critical patent/ES2086026T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

FOSFATO OCTADECIL OPLASTICO, ASI COMO PROCESO PARA SU FABRICACION.
ES92110347T 1991-07-04 1992-06-19 Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion. Expired - Lifetime ES2086026T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4122140 1991-07-04
DE4129364 1991-09-04

Publications (1)

Publication Number Publication Date
ES2086026T3 true ES2086026T3 (es) 1996-06-16

Family

ID=25905206

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92110347T Expired - Lifetime ES2086026T3 (es) 1991-07-04 1992-06-19 Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion.

Country Status (19)

Country Link
US (1) US5219866A (es)
EP (1) EP0521353B1 (es)
JP (1) JP3176720B2 (es)
KR (1) KR100255436B1 (es)
CN (1) CN1030658C (es)
AT (1) ATE136783T1 (es)
AU (1) AU651224B2 (es)
CA (1) CA2073146C (es)
DE (2) DE59205998D1 (es)
DK (1) DK0521353T3 (es)
EG (1) EG20082A (es)
ES (1) ES2086026T3 (es)
FI (1) FI108035B (es)
GR (1) GR3019776T3 (es)
HU (2) HUT61561A (es)
IE (1) IE73200B1 (es)
IL (1) IL102380A (es)
NO (1) NO303939B1 (es)
PL (3) PL173905B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130016413A (ko) 2002-07-30 2013-02-14 아에테르나 젠타리스 게엠베하 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품
US8383605B2 (en) * 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
RU2469727C2 (ru) * 2005-12-19 2012-12-20 Этерна Центарис ГмбХ Способ лечения или профилактики заболеваний и/или патофизиологических состояний, вызванных микроорганизмами, посредством производных алкилфосфолипидов
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
JP5068630B2 (ja) * 2007-11-15 2012-11-07 オルガノ株式会社 アルコール含有溶液中のアルデヒド化合物の除去方法及び該方法により精製された醸造酒
WO2011123691A1 (en) 2010-03-31 2011-10-06 Keryx Biopharmaceuticals, Inc. Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU301951A1 (ru) * 1970-06-01 1973-04-05 В. А. Чернов, Т. С. Сафонова, Н. В. Сазонов, А. А. Кропачева, Лекарственное средство
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
ATE158295T1 (de) * 1991-07-04 1997-10-15 Asta Medica Ag Verfahren zur herstellung von alkylphosphocholinen und reinherstellung derselben

Also Published As

Publication number Publication date
EG20082A (en) 1997-05-31
CN1068119A (zh) 1993-01-20
AU651224B2 (en) 1994-07-14
CA2073146A1 (en) 1993-01-05
EP0521353B1 (de) 1996-04-17
NO922642D0 (no) 1992-07-03
FI923088A0 (fi) 1992-07-03
GR3019776T3 (en) 1996-07-31
IE73200B1 (en) 1997-05-07
IL102380A0 (en) 1993-01-14
FI108035B (fi) 2001-11-15
PL173794B1 (pl) 1998-05-29
ATE136783T1 (de) 1996-05-15
CN1030658C (zh) 1996-01-10
FI923088L (fi) 1993-01-05
DE4219972A1 (de) 1993-01-07
HU9202232D0 (en) 1992-10-28
DK0521353T3 (da) 1996-05-13
HUT61561A (en) 1993-01-28
US5219866A (en) 1993-06-15
IL102380A (en) 1996-10-16
IE922183A1 (en) 1993-01-13
JP3176720B2 (ja) 2001-06-18
AU1943592A (en) 1993-03-11
EP0521353A1 (de) 1993-01-07
DE59205998D1 (de) 1996-05-23
KR100255436B1 (ko) 2000-05-01
NO303939B1 (no) 1998-09-28
PL173869B1 (pl) 1998-05-29
JPH05213980A (ja) 1993-08-24
CA2073146C (en) 2002-05-28
PL173905B1 (pl) 1998-05-29
HU211483A9 (en) 1995-11-28
PL295128A1 (en) 1993-08-23
NO922642L (no) 1993-01-05
KR930001909A (ko) 1993-02-22

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