[go: up one dir, main page]

ES2084151T3 - Compuestos de piperidina y una composicion farmaceutica. - Google Patents

Compuestos de piperidina y una composicion farmaceutica.

Info

Publication number
ES2084151T3
ES2084151T3 ES91901483T ES91901483T ES2084151T3 ES 2084151 T3 ES2084151 T3 ES 2084151T3 ES 91901483 T ES91901483 T ES 91901483T ES 91901483 T ES91901483 T ES 91901483T ES 2084151 T3 ES2084151 T3 ES 2084151T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
piperidine compounds
pharmaceutical composition
alquilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901483T
Other languages
English (en)
Inventor
Palle Jakobsen
Ursula Sonnewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2084151T3 publication Critical patent/ES2084151T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPUESTOS DE PIPERIDINA Y UNA COMPOSICION FARMACEUTICA. COMPUESTOS NUEVOS DE PIPERIDINA CON LA FORMULA, EN DONDE R3 ES 3.4-METILENEDIOXIFENILO, FENILO, NAFTILO, QUE SE SUSTITUYEN, OPCIONALMENTE, POR UNO O DOS HALOGENO, AMINO, GRUPO MONO C1-6-ALQUILO O AMINO DISUSTITUIDO, GRUPOS C1-6-ALCOXI, CIANO, MONO-, C1-6-ALQUILO DIQUILENO, C1-6-ALQUILO, C3-5-ALQUILENO, TRIFLUOROMETOXI, O TRIFLUOROMETILO, R1 ES HIDROGENO, C1-8-ALQUILO RECTO O RAMIFICADO, C1-8-ALQUILO, C1-8-ALCOXI -CICLOALQUILALQUILO, C2-6-ALQUENILO, Z ES HIDROGENO, C1-8-ALQUILO RECTO O RAMIFICADO, Y ES O O S, X ES O, S O NR, EN DONDE R ES HIDROGENO O C1-4-ALQUILO O UNA SAL DEL MISMO CON UN ACIDO FARMACEUTICAMENTE ACEPTABLE. LOS COMPUESTOS NUEVOS SON UTILES EN EL TRATAMIENTO DE ANOXIA, HERIDAS TRAUMATICAS, ISQUEMIA, MIGRAÑA Y EPILEPSIA.
ES91901483T 1989-12-18 1990-12-11 Compuestos de piperidina y una composicion farmaceutica. Expired - Lifetime ES2084151T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK640289A DK640289D0 (da) 1989-12-18 1989-12-18 Ny heterocyklisk kemi

Publications (1)

Publication Number Publication Date
ES2084151T3 true ES2084151T3 (es) 1996-05-01

Family

ID=8148694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901483T Expired - Lifetime ES2084151T3 (es) 1989-12-18 1990-12-11 Compuestos de piperidina y una composicion farmaceutica.

Country Status (18)

Country Link
US (1) US5102894A (es)
EP (1) EP0505465B1 (es)
JP (1) JPH05502867A (es)
CN (1) CN1052674A (es)
AT (1) ATE135704T1 (es)
AU (1) AU645722B2 (es)
CA (1) CA2071480A1 (es)
DE (1) DE69026110T2 (es)
DK (2) DK640289D0 (es)
ES (1) ES2084151T3 (es)
FI (1) FI922826L (es)
IE (1) IE904435A1 (es)
IL (2) IL96592A (es)
NO (2) NO922313D0 (es)
PT (1) PT96235B (es)
WO (1) WO1991009032A1 (es)
ZA (1) ZA9010183B (es)
ZW (1) ZW19190A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763589B1 (fr) 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
AU2001290873B2 (en) * 2000-09-11 2006-07-27 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
WO2005032479A2 (en) 2003-10-01 2005-04-14 Unviversity Of Florida Research Foundation, Inc. Compositions and methods for selective inhibition of nicotine acetylcholine receptors
JP5199678B2 (ja) 2005-02-23 2013-05-15 プレクサ ファーマシューティカルズ， インコーポレイテッド 運動障害および他のｃｎｓ適応症の処置に使用することにおけるドーパミントランスポータ阻害剤
US20090054489A1 (en) * 2005-02-23 2009-02-26 Prexa Pharmaceuticals, Inc. Multimediator Dopamine Transport Inhibitors, and Uses Related Thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895965A (en) * 1959-07-21 Process for the production of
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi

Also Published As

Publication number Publication date
IE904435A1 (en) 1991-06-19
EP0505465B1 (en) 1996-03-20
CA2071480A1 (en) 1991-06-19
PT96235B (pt) 1998-06-30
FI922826A0 (fi) 1992-06-17
NO922313L (no) 1992-06-12
DK0505465T3 (da) 1996-08-05
PT96235A (pt) 1991-09-30
NO1994003I1 (no) 1994-07-01
WO1991009032A1 (en) 1991-06-27
CN1052674A (zh) 1991-07-03
AU645722B2 (en) 1994-01-20
AU6971691A (en) 1991-07-18
IL96592A0 (en) 1991-09-16
US5102894A (en) 1992-04-07
DK640289D0 (da) 1989-12-18
IL96592A (en) 1995-06-29
DE69026110D1 (de) 1996-04-25
EP0505465A1 (en) 1992-09-30
NO922313D0 (no) 1992-06-12
FI922826L (fi) 1992-06-17
DE69026110T2 (de) 1996-10-02
ZA9010183B (en) 1991-10-30
ATE135704T1 (de) 1996-04-15
JPH05502867A (ja) 1993-05-20
ZW19190A1 (en) 1991-06-05

Similar Documents

Publication Publication Date Title
ES2096673T3 (es) Uso de sulfonamidas como medicamentos y nuevas sulfonamidas.
ATE133418T1 (de) Zusammensetzungen zum erreichen eines lasereffektes und methoden zu deren gebrauch
GT199600100A (es) Procedimientos para hacer compuestos heterociclicos.
ES2031876T3 (es) Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas.
ES2174989T3 (es) Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion.
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
ZA902633B (en) New sulphonamides derived from benzo-cyclic or benzo heterocyclic acids,their preparation and their application in therapy
ES2051479T3 (es) Uso de imidazoles substituidos en 4 para disminuir la presion intraocular.
ES2084151T3 (es) Compuestos de piperidina y una composicion farmaceutica.
ES8801806A1 (es) Procedimientopara la preparacion de derivados de 2-oxi-4h-3, 1-ebzoxazin-4-ona
ES2109229T3 (es) Sulfonamidas sustituidas y compuestos relacionados para el tratamiento del asma, la artritis y enfermedades relacionadas.
ATE174588T1 (de) 4-arylisoindol-analgetika
ES2174669B1 (es) Trisresorciniltriazinas.
FR2756826B1 (fr) Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1274997B (it) Procedimento per la produzione di spazzole nonche' macchina per la produzione di spazzole per l'esecuzione del procedimento
ES2058264T3 (es) Sulfonildecahidro-8h-isoquino(2,1-g)(1,6)naftiridinas, isomeros opticos de las mismas y compuestos afines.
AR014738A1 (es) Nuevo procedimiento de preparacion de la fexofenadina y compuestos intermediarios
PT81621B (pt) Processo para a preparacao de derivados da glicerilfosforilcolina possuindo actividade terapeutica e de suas composicoes farmaceuticas
IT8548442A0 (it) Composti tetraalchilpiridinici n-sostituiti agenti come stabilizzanti agli effetti della luce per materiali polimerici
PT89492A (pt) Processo de preparacao de novos derivados de tioformamida terapeuticamente activos
UA26443A (uk) Похідhі 20,21-диhоребурhамеhіhу, їх рацемати або оптичhі ізомери, або їх адитивhі солі з оргаhічhими кислотами, що мають hоотропhі та аhтидепресивhі властивості
ES2096931T3 (es) Derivados de 4-oxa-1-azabiciclo(3,2,0)heptan-7-ona utilizados como agentes antitumorales.
ECSP951499A (es) Compuestos ariltios
ES2061667T3 (es) Agente hipotensivo para el tratamiento o prevencion de la hipertension.
NO20004685D0 (no) Nye forbindelser

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 505465

Country of ref document: ES