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DK0505465T3 - 4-Heterocyclylpiperidin, deres fremstilling samt deres anvendelse som inhibitorer af calciumoverfyldning i hjerneceller - Google Patents

4-Heterocyclylpiperidin, deres fremstilling samt deres anvendelse som inhibitorer af calciumoverfyldning i hjerneceller

Info

Publication number
DK0505465T3
DK0505465T3 DK91901483.7T DK91901483T DK0505465T3 DK 0505465 T3 DK0505465 T3 DK 0505465T3 DK 91901483 T DK91901483 T DK 91901483T DK 0505465 T3 DK0505465 T3 DK 0505465T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
heterocyclylpiperidine
overflow
inhibitors
Prior art date
Application number
DK91901483.7T
Other languages
English (en)
Inventor
Palle Jakobsen
Ursula Sonnewald
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0505465T3 publication Critical patent/DK0505465T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DK91901483.7T 1989-12-18 1990-12-11 4-Heterocyclylpiperidin, deres fremstilling samt deres anvendelse som inhibitorer af calciumoverfyldning i hjerneceller DK0505465T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK640289A DK640289D0 (da) 1989-12-18 1989-12-18 Ny heterocyklisk kemi

Publications (1)

Publication Number Publication Date
DK0505465T3 true DK0505465T3 (da) 1996-08-05

Family

ID=8148694

Family Applications (2)

Application Number Title Priority Date Filing Date
DK640289A DK640289D0 (da) 1989-12-18 1989-12-18 Ny heterocyklisk kemi
DK91901483.7T DK0505465T3 (da) 1989-12-18 1990-12-11 4-Heterocyclylpiperidin, deres fremstilling samt deres anvendelse som inhibitorer af calciumoverfyldning i hjerneceller

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK640289A DK640289D0 (da) 1989-12-18 1989-12-18 Ny heterocyklisk kemi

Country Status (18)

Country Link
US (1) US5102894A (da)
EP (1) EP0505465B1 (da)
JP (1) JPH05502867A (da)
CN (1) CN1052674A (da)
AT (1) ATE135704T1 (da)
AU (1) AU645722B2 (da)
CA (1) CA2071480A1 (da)
DE (1) DE69026110T2 (da)
DK (2) DK640289D0 (da)
ES (1) ES2084151T3 (da)
FI (1) FI922826L (da)
IE (1) IE904435A1 (da)
IL (2) IL96592A (da)
NO (2) NO922313D0 (da)
PT (1) PT96235B (da)
WO (1) WO1991009032A1 (da)
ZA (1) ZA9010183B (da)
ZW (1) ZW19190A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763589B1 (fr) 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
AU2001290873B2 (en) * 2000-09-11 2006-07-27 Sepracor Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
WO2005032479A2 (en) 2003-10-01 2005-04-14 Unviversity Of Florida Research Foundation, Inc. Compositions and methods for selective inhibition of nicotine acetylcholine receptors
JP5199678B2 (ja) 2005-02-23 2013-05-15 プレクサ ファーマシューティカルズ, インコーポレイテッド 運動障害および他のcns適応症の処置に使用することにおけるドーパミントランスポータ阻害剤
US20090054489A1 (en) * 2005-02-23 2009-02-26 Prexa Pharmaceuticals, Inc. Multimediator Dopamine Transport Inhibitors, and Uses Related Thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895965A (en) * 1959-07-21 Process for the production of
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi

Also Published As

Publication number Publication date
IE904435A1 (en) 1991-06-19
EP0505465B1 (en) 1996-03-20
CA2071480A1 (en) 1991-06-19
PT96235B (pt) 1998-06-30
FI922826A0 (fi) 1992-06-17
NO922313L (no) 1992-06-12
PT96235A (pt) 1991-09-30
NO1994003I1 (no) 1994-07-01
WO1991009032A1 (en) 1991-06-27
CN1052674A (zh) 1991-07-03
AU645722B2 (en) 1994-01-20
ES2084151T3 (es) 1996-05-01
AU6971691A (en) 1991-07-18
IL96592A0 (en) 1991-09-16
US5102894A (en) 1992-04-07
DK640289D0 (da) 1989-12-18
IL96592A (en) 1995-06-29
DE69026110D1 (de) 1996-04-25
EP0505465A1 (en) 1992-09-30
NO922313D0 (no) 1992-06-12
FI922826L (fi) 1992-06-17
DE69026110T2 (de) 1996-10-02
ZA9010183B (en) 1991-10-30
ATE135704T1 (de) 1996-04-15
JPH05502867A (ja) 1993-05-20
ZW19190A1 (en) 1991-06-05

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