ES2068908T3 - Compuestos de poliaza macrociclicos que contienen anillos de 5 o 6 eslabones, procedimiento para su preparacion y agentes farmaceuticos que los contienen. - Google Patents
Compuestos de poliaza macrociclicos que contienen anillos de 5 o 6 eslabones, procedimiento para su preparacion y agentes farmaceuticos que los contienen.Info
- Publication number
- ES2068908T3 ES2068908T3 ES89730165T ES89730165T ES2068908T3 ES 2068908 T3 ES2068908 T3 ES 2068908T3 ES 89730165 T ES89730165 T ES 89730165T ES 89730165 T ES89730165 T ES 89730165T ES 2068908 T3 ES2068908 T3 ES 2068908T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- rest
- meaning
- atom
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
Abstract
CONEXIONES MACROCICLICAS SEGUN LA FORMULA GENERAL I DE LA QUE ... PARA UNA UNION SENCILLA O DOBLE; Q PARA LA CIFRA 0-5, A Y B QUE SON IGUALES O DIFERENTES, EN CADA CASO PARA UN GRUPO DE ALKILES DE CADENA RECTA O RAMIFICADA, CON 2 A 6 ATOMOS DE CARBONO; D PARA UN ATOMO DE NITROGENO OXIGENO, EL GRUPO = C = O = NR2 CON R2 EN EL SIGNIFICADO DE UN ATOMO DE HIDROGENO O ATOMO DE HALOGENO DE UN GRUPO DE FENIL DE UN C1-C6 DE ALKIL QUE EN CASO DADO PUEDE SER SUSTITUIDO POR UN GRUPO DE FENIL O HIDROXIDO, DEL RESTO OR5, PARA LO QUE R5 PUEDE SER SUSTITUIDO POR UN GRUPO DE 1 A 3 HIDROXIDOS C1-C6-RESTO DE ALKIL DEL SUSTITUIDO -(C) INR6R7, PARA LO QUE I PARA LA CIFRA 0 Y 1 Y RE Y R7 INDEPENDIENTES ENTRE SI PARA ATOMO DE HIDROGENO, PARA EL RESTO R5, PARA CASO DADO SER SUSTITUIDO POR 1 A 3 GRUPOS DE HIDROXIDO RESTOS DE FENIL O BENZIL O R6 Y R7 CONJUNTAMENTE CON EL ATOMO DE NITROGENO PARA UN ATOMO SATURADO O NO SATURADO CON Y EN CASO DADO OTRO ATOMO MAS DE NITROGENO, OXIGENO, SULFURO Y GRUPO CARBONIL CONTENIENDO 5 O 6 ANILLOS QUE EN CASO DADO PUEDE SER SUSTITUIDO POR 1 A 3 RESTOS R5 O UN SUSTITUIDO R6 O R7 PARA EL RESTO -C-R5 ESTAN O SISTITUYEN G PARA LO QUE G CONTIENE A TRAVES DE UNA UNION DIRECTA UN GRUPO BIS(CARBONILAMONIO) (NH-CO-CO-NH) O UN GRUPO SOBRE C1-C20-ALKILES QUE EN CASO DADO CONTIENEN EN LOS EXTREMOS CARBONIL -(>CO) O CARBONILAMINO (-NH-CO) GRUPOS O ATOMOS DE NITROGENO Y CASO DADO UNO A VARIOS ATOMOS DE NITROGENO Z-, ALCYL, O HIDROXIALCYL SUSTITUIDO INMUNOGRUPOS O UNO A DOS C-C-DOBLE- Y/O C-C-TRIUNIONES, UNIDAS EN UN SEGUNDO MACROCICLO DE LA FORMULA GENERAL (II) EN DONDE: D1 TIENE EL MISMO SIGNIFICADO QUE D CON LA EXCEPCION DE QUE D1 NO CONTIENE LA G SUSTITUIDA, O EL RESTO -CH-, =C- O -N- ESTAN Y F1 TIENE EL MISMO SIGNIFICADO QUE F CON LA EXCEPCION DE QUE F1 NO CONTIENE LA G SUSTITUIDO O PARA EL RESTO -CH- O =C- ESTA E PARA UN ATOMO DE NITROGENO-SULFURO-OXIGENO O NR4-GRUPO CON R4 ENEL SIGNIFICADO DE UN GRUPO HIDROXIDO, DE R2 O CADO DADO HIDROXILADO O CARBOSILADO GRUPO ALKIL C1-C8 F PARA (-CHR8-) N CON EL SIGNIFICFADO DE LAS CIFRAS 0 O 1 Y R8 EN EL SIGNIFICADO DE R1 O G, R1 PARA UN ATOMO DE HIDROGENO O HALOGENO O UN C1-C8-ALKILGRUPO. Z PARA UN ATOMO DE HIDROGENO O EL GRUPO -CH2COOY CON Y EN EL SIGNIFICADO DE UN ATOMO DE HIDROGENO Y/O UN EQUIVALENCIA DE IONES METALICOS DE UN ELEMENTO DE LAS CIFRAS ORDINALES 21-29, 31. 32. 37-39, 42-44, 49 O 57-83, CON LA MEDICION DE QUE COMO MINIMO HAY DOS Z SUSTITUIDAS PARA EL RESTO =CH2COOY Y QUE LA UNION MACROCICLICA DE LA FORMULA GENERAL I NO CONTIENE MAS DE UN RESTO G ASI COMO SUS SALES CON BASES ORGANICAS Y/O INORGANICAS O AMINOACIDOSAMIDA SON MEDIOS MUY VALIOSOS EN DIAGNOSTICAR Y TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3825040A DE3825040A1 (de) | 1988-07-20 | 1988-07-20 | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2068908T3 true ES2068908T3 (es) | 1995-05-01 |
Family
ID=6359368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89730165T Expired - Lifetime ES2068908T3 (es) | 1988-07-20 | 1989-07-18 | Compuestos de poliaza macrociclicos que contienen anillos de 5 o 6 eslabones, procedimiento para su preparacion y agentes farmaceuticos que los contienen. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0352218B1 (es) |
| JP (1) | JP2877844B2 (es) |
| AT (1) | ATE118775T1 (es) |
| CA (1) | CA1341035C (es) |
| DE (2) | DE3825040A1 (es) |
| DK (1) | DK171097B1 (es) |
| ES (1) | ES2068908T3 (es) |
| FI (1) | FI893509A7 (es) |
| GR (1) | GR3015162T3 (es) |
| IE (1) | IE66693B1 (es) |
| IL (1) | IL91046A (es) |
| NO (1) | NO179104C (es) |
| NZ (1) | NZ229996A (es) |
| PT (1) | PT91211B (es) |
| ZA (1) | ZA895543B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| BR9007009A (pt) * | 1989-01-17 | 1991-11-12 | Xyrofin Oy | Processo para producao de xilitol a partir de solucao de xilose aquosa |
| FR2652589B1 (fr) * | 1989-10-04 | 1995-02-17 | Roquette Freres | Procede de fabrication de xylitol et de produits riches en xylitol. |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| WO1991010669A1 (en) * | 1990-01-19 | 1991-07-25 | Cockbain, Julian, Roderick, Michaelson | Chelating compounds |
| US5330737A (en) * | 1991-12-06 | 1994-07-19 | Mallinckrodt Medical, Inc. | Nitrogen-sulfur ligands as opiate receptor drug mimics |
| EP0735040A3 (en) * | 1991-12-10 | 1997-02-26 | Dow Chemical Co | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, and their preparation |
| WO1994026313A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| WO1993011800A1 (en) * | 1991-12-10 | 1993-06-24 | The Dow Chemical Company | Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents |
| HU9302308D0 (en) * | 1991-12-10 | 1993-12-28 | Dow Chemical Co | Process for production lof biciclo-polyaza-macrocyclyc-carbonic acid-complexes and their conjugates and of medical preparatives containing them |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5480990A (en) * | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
| US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| WO1994026315A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals |
| US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| AU719002B2 (en) * | 1996-04-19 | 2000-05-04 | Dow Chemical Company, The | Fluorescent chelates as visual tissue specific imaging agents |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| CA2419629A1 (en) * | 2000-09-25 | 2002-04-04 | The Procter & Gamble Company | Mri image enhancement compositions |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| EP3728168B1 (en) * | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2478456A (en) | 1946-03-15 | 1949-08-09 | Socony Vaeuum Oil Company Inc | Solvent dewaxing |
| US3194818A (en) | 1963-08-14 | 1965-07-13 | Sterling Drug Inc | Alpha-aryl or aralkyl furfurylamines |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| DE3150917A1 (de) | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| EP0232751B1 (en) | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
-
1988
- 1988-07-20 DE DE3825040A patent/DE3825040A1/de not_active Withdrawn
-
1989
- 1989-07-18 ES ES89730165T patent/ES2068908T3/es not_active Expired - Lifetime
- 1989-07-18 AT AT89730165T patent/ATE118775T1/de active
- 1989-07-18 DE DE58909022T patent/DE58909022D1/de not_active Expired - Lifetime
- 1989-07-18 EP EP89730165A patent/EP0352218B1/de not_active Expired - Lifetime
- 1989-07-19 IE IE233589A patent/IE66693B1/en not_active IP Right Cessation
- 1989-07-19 CA CA000606159A patent/CA1341035C/en not_active Expired - Fee Related
- 1989-07-19 NZ NZ229996A patent/NZ229996A/en unknown
- 1989-07-19 IL IL9104689A patent/IL91046A/en not_active IP Right Cessation
- 1989-07-19 PT PT91211A patent/PT91211B/pt not_active IP Right Cessation
- 1989-07-19 DK DK358889A patent/DK171097B1/da not_active IP Right Cessation
- 1989-07-19 NO NO892959A patent/NO179104C/no not_active IP Right Cessation
- 1989-07-20 JP JP1186190A patent/JP2877844B2/ja not_active Expired - Lifetime
- 1989-07-20 FI FI893509A patent/FI893509A7/fi not_active Application Discontinuation
- 1989-07-20 ZA ZA895543A patent/ZA895543B/xx unknown
-
1995
- 1995-02-23 GR GR950400281T patent/GR3015162T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE66693B1 (en) | 1996-01-24 |
| NO179104B (no) | 1996-04-29 |
| ATE118775T1 (de) | 1995-03-15 |
| DE3825040A1 (de) | 1990-01-25 |
| FI893509A7 (fi) | 1990-01-21 |
| ZA895543B (en) | 1990-05-30 |
| NO892959D0 (no) | 1989-07-19 |
| CA1341035C (en) | 2000-06-20 |
| DE58909022D1 (de) | 1995-04-06 |
| AU3827589A (en) | 1990-02-01 |
| GR3015162T3 (en) | 1995-05-31 |
| AU637052B2 (en) | 1993-05-20 |
| NO892959L (no) | 1990-01-22 |
| NZ229996A (en) | 1992-05-26 |
| EP0352218A2 (de) | 1990-01-24 |
| IL91046A0 (en) | 1990-02-09 |
| NO179104C (no) | 1996-08-07 |
| IE892335L (en) | 1990-01-20 |
| DK358889D0 (da) | 1989-07-19 |
| PT91211B (pt) | 1995-03-01 |
| JPH02104588A (ja) | 1990-04-17 |
| FI893509A0 (fi) | 1989-07-20 |
| DK171097B1 (da) | 1996-06-03 |
| PT91211A (pt) | 1990-02-08 |
| EP0352218B1 (de) | 1995-02-22 |
| DK358889A (da) | 1990-01-21 |
| JP2877844B2 (ja) | 1999-04-05 |
| EP0352218A3 (de) | 1991-01-16 |
| IL91046A (en) | 1995-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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