CO6290668A2 - Derivados de 1-oxo-1,2-dihidroisoquinolein-5-carboxamidas y de 4-oxo-3,4-dihifroquinazolina -8-carboxamidas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de 1-oxo-1,2-dihidroisoquinolein-5-carboxamidas y de 4-oxo-3,4-dihifroquinazolina -8-carboxamidas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6290668A2 CO6290668A2 CO10007694A CO10007694A CO6290668A2 CO 6290668 A2 CO6290668 A2 CO 6290668A2 CO 10007694 A CO10007694 A CO 10007694A CO 10007694 A CO10007694 A CO 10007694A CO 6290668 A2 CO6290668 A2 CO 6290668A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- group
- oxo
- cycloalkyl
- carboxamids
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 nitro, cyano, amino Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
- KTKPEWJLAITGMW-UHFFFAOYSA-N 1-oxo-2h-isoquinoline-5-carboxamide Chemical class C1=CNC(=O)C2=C1C(C(=O)N)=CC=C2 KTKPEWJLAITGMW-UHFFFAOYSA-N 0.000 abstract 1
- ODYHMCPYNKFVHM-UHFFFAOYSA-N 4-oxo-1h-quinazoline-8-carboxamide Chemical class N1C=NC(=O)C2=C1C(C(=O)N)=CC=C2 ODYHMCPYNKFVHM-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a los derivados de 1-oxo-1,2-dihidroisoquinoleín-5-carboxamidas y de 4-oxo-3,4-dihidroquinazolin-8-carboxamidas, de fórmula general (I)en la que: R1 representa un átomo de hidrógeno, un grupo alquilo(C1-C10), cicloalquilo(C3-C7), (CH2)n-alquenilo(C1-C6), (CH2)n-alquinilo(C1-C6), alquilo(C1-C6)-Z-alquilo(C1-C6), en el que Z representa un heteroátomo elegido entre O, N y S(O)m, o bien R1 representa un grupo COOR, S(O)mR, un arilo o un aralquilo, los grupos alquilo(C1-C10), cicloalquilo(C3-C7), (CH2)n-alquenilo(C1-C6), (CH2)n-alquinilo(C1-C6), alquilo(C1-C6)-Z-alquiIo(C1-C6), arilo o aralquilo; R2 representa uno o varios grupos elegidos entre un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo(C1-C6), cicloalquilo(C3-C7), alquenilo(C1-C6), alquinilo(C1-C6), alquilo(C1-C6)-Z-alquilo(C1-C6), en el que Z representa un heteroátomo elegido entre O, N y S(O)m, o bien R2 representa un grupo haloalquilo(C1-C6), haloalcoxi(C1-C6), hidroxi, alcoxi(C1-C6), nitro, ciano, amino, un grupo NR7R8, COOR, CONR7R8, O-COalquilo(C1-C6), S(O)mNR7R8, un grupo arilo; R4 y R5 representan, independientemente uno del otro, un átomo de hidrógeno, o bien R4 y R5 forman con el átomo de carbono que les lleva un ciclo saturado que contiene de 3 a 6 átomos de carbono y que contienen opcionalmente de 0 a 1 heteroátomo elegido entre O, N o S; R6 representa un grupo elegido entre un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo(C1-C6), cicloalquilo(C3-C7), cicloalquilo(C3-C7)alquilo(C1-C6), un grupo haloalquilo(C1-C6), nitro, amino, un grupo NR7R8, COOR, un grupo NR7(SO2)R8, CONR7R8, un grupo arilo; X representa un átomo de carbono o un átomo de nitrógeno; m representa un número entero comprendido entre 0 y 2 y n representa un número entero comprendido entre 1 y 6. Procedimiento de preparación y aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705500A FR2919286A1 (fr) | 2007-07-27 | 2007-07-27 | Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6290668A2 true CO6290668A2 (es) | 2011-06-20 |
Family
ID=39106736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10007694A CO6290668A2 (es) | 2007-07-27 | 2010-01-26 | Derivados de 1-oxo-1,2-dihidroisoquinolein-5-carboxamidas y de 4-oxo-3,4-dihifroquinazolina -8-carboxamidas su preparacion y su aplicacion en terapeutica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8030320B2 (es) |
| EP (1) | EP2185523A2 (es) |
| JP (1) | JP2010534640A (es) |
| KR (1) | KR20100047294A (es) |
| CN (1) | CN101790518A (es) |
| AU (1) | AU2008306762A1 (es) |
| BR (1) | BRPI0814177A2 (es) |
| CA (1) | CA2694313A1 (es) |
| CO (1) | CO6290668A2 (es) |
| EA (1) | EA201070196A1 (es) |
| FR (1) | FR2919286A1 (es) |
| MA (1) | MA31629B1 (es) |
| MX (1) | MX2010001081A (es) |
| NZ (1) | NZ582995A (es) |
| WO (1) | WO2009044018A2 (es) |
| ZA (1) | ZA201000583B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2164834A2 (en) * | 2007-07-06 | 2010-03-24 | Boehringer Ingelheim International GmbH | Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture |
| FR2919285B1 (fr) * | 2007-07-27 | 2012-08-31 | Sanofi Aventis | Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. |
| US9193689B2 (en) | 2012-03-07 | 2015-11-24 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| CN103087047B (zh) * | 2012-12-10 | 2016-12-21 | 南京农业大学 | 一种含二氢异喹啉基团的吡咯烷‑2,4‑二酮类化合物、制备方法及其应用 |
| CN105722835B (zh) | 2013-09-11 | 2018-07-31 | 癌症研究协会:皇家癌症医院 | 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 |
| US11845737B2 (en) * | 2020-04-02 | 2023-12-19 | Gilead Sciences, Inc. | Process for preparing a Cot inhibitor compound |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005520791A (ja) * | 2001-11-08 | 2005-07-14 | イーラン ファーマスーティカルズ、インコーポレイテッド | Ｎ，ｎ’−置換−１，３−ジアミノ−２−ヒドロキシプロパン誘導体 |
| BR0307588A (pt) | 2002-02-22 | 2005-02-01 | Teijin Ltd | Composto, inibidor de gsk-3, composição farmacêutica, e, agente terapêutico ou preventivo para uma doença |
| GB0309221D0 (en) | 2003-04-23 | 2003-06-04 | Glaxo Group Ltd | Novel compounds |
| GB0328900D0 (en) | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
| US7745470B2 (en) | 2005-03-10 | 2010-06-29 | Bristol-Myers Squibb Company | Isophthalates as beta-secretase inhibitors |
| GB0506562D0 (en) | 2005-03-31 | 2005-05-04 | Glaxo Group Ltd | Novel compounds |
-
2007
- 2007-07-27 FR FR0705500A patent/FR2919286A1/fr active Pending
-
2008
- 2008-07-25 CA CA2694313A patent/CA2694313A1/fr not_active Abandoned
- 2008-07-25 NZ NZ582995A patent/NZ582995A/en not_active IP Right Cessation
- 2008-07-25 BR BRPI0814177-0A2A patent/BRPI0814177A2/pt not_active IP Right Cessation
- 2008-07-25 EA EA201070196A patent/EA201070196A1/ru unknown
- 2008-07-25 MX MX2010001081A patent/MX2010001081A/es not_active Application Discontinuation
- 2008-07-25 EP EP08835688A patent/EP2185523A2/fr not_active Withdrawn
- 2008-07-25 JP JP2010517452A patent/JP2010534640A/ja not_active Withdrawn
- 2008-07-25 WO PCT/FR2008/001109 patent/WO2009044018A2/fr active Application Filing
- 2008-07-25 AU AU2008306762A patent/AU2008306762A1/en not_active Abandoned
- 2008-07-25 CN CN200880104537A patent/CN101790518A/zh active Pending
- 2008-07-25 KR KR1020107004332A patent/KR20100047294A/ko not_active Application Discontinuation
-
2010
- 2010-01-26 CO CO10007694A patent/CO6290668A2/es not_active Application Discontinuation
- 2010-01-26 ZA ZA2010/00583A patent/ZA201000583B/en unknown
- 2010-01-26 US US12/693,598 patent/US8030320B2/en not_active Expired - Fee Related
- 2010-02-24 MA MA32646A patent/MA31629B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0814177A2 (pt) | 2015-01-20 |
| CA2694313A1 (fr) | 2009-04-09 |
| ZA201000583B (en) | 2011-04-28 |
| MX2010001081A (es) | 2010-03-24 |
| WO2009044018A2 (fr) | 2009-04-09 |
| WO2009044018A9 (fr) | 2010-10-14 |
| CN101790518A (zh) | 2010-07-28 |
| FR2919286A1 (fr) | 2009-01-30 |
| US20100197706A1 (en) | 2010-08-05 |
| US8030320B2 (en) | 2011-10-04 |
| EP2185523A2 (fr) | 2010-05-19 |
| NZ582995A (en) | 2012-04-27 |
| AU2008306762A1 (en) | 2009-04-09 |
| JP2010534640A (ja) | 2010-11-11 |
| EA201070196A1 (ru) | 2010-08-30 |
| MA31629B1 (fr) | 2010-08-02 |
| WO2009044018A3 (fr) | 2009-06-18 |
| KR20100047294A (ko) | 2010-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |