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ES2047458A6 - P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos. - Google Patents

P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos.

Info

Publication number
ES2047458A6
ES2047458A6 ES9050004A ES9050004A ES2047458A6 ES 2047458 A6 ES2047458 A6 ES 2047458A6 ES 9050004 A ES9050004 A ES 9050004A ES 9050004 A ES9050004 A ES 9050004A ES 2047458 A6 ES2047458 A6 ES 2047458A6
Authority
ES
Spain
Prior art keywords
lys
ile
leu
gly
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9050004A
Other languages
English (en)
Inventor
Marco Baggiolini
Kenneth John Clemetson
Alfred Walz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kocher Theodor Institut
Sandoz AG
Original Assignee
Kocher Theodor Institut
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828728A external-priority patent/GB8828728D0/en
Priority claimed from GB898909681A external-priority patent/GB8909681D0/en
Application filed by Kocher Theodor Institut, Sandoz AG filed Critical Kocher Theodor Institut
Publication of ES2047458A6 publication Critical patent/ES2047458A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Procedimiento para la preparación de péptido-2 activador de neutrófilos (NSA-1/NAP-2) o una variante, fragmento o derivado funcional del mismo, que tiene la siguiente secuencia de 70 aminoácidos: Ala-Glu-Leu-Arg-Cys-Met-Cys-Ile-Lys-Thr- Thr-Ser-Gly-Ile-His-Pro-Lys-Asn-Ile-Gln- Ser-Leu-Glu-Val-Ile-Gly-Lys-Gly-Thr-His- Cys-Asn-Gln-Val-Glu-Val-Ile-Ala-Thr-Leu- Lys-Asp-Gly-Arg-Lys-Ile-Cys-Leu-Asp-Pro- Asp-Ala-Pro-Arg-Ile-Lys-Lys-Ile-Val-Gln- Lys-Lys-Leu-Ala-Gly-Asp-Glu-Ser-Ala-Asp caracterizado porque comprende purificar uidos de cultivo de leucocitos sanguíneos estimulados por cromatografía con fosfocelulosa y cromatografía de fase inversa.
ES9050004A 1988-12-08 1989-11-17 P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos. Expired - Lifetime ES2047458A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888828728A GB8828728D0 (en) 1988-12-08 1988-12-08 Neutrophil-stimulating activity i
GB898909681A GB8909681D0 (en) 1989-04-27 1989-04-27 Neutrophil-stimulating activity 1

Publications (1)

Publication Number Publication Date
ES2047458A6 true ES2047458A6 (es) 1994-02-16

Family

ID=26294713

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9050004A Expired - Lifetime ES2047458A6 (es) 1988-12-08 1989-11-17 P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos.

Country Status (19)

Country Link
US (1) US5759533A (es)
JP (1) JP3051160B2 (es)
KR (1) KR910700260A (es)
AU (1) AU634508B2 (es)
BE (1) BE1003636A4 (es)
CA (1) CA2004685A1 (es)
CH (1) CH681625A5 (es)
DK (1) DK188690A (es)
ES (1) ES2047458A6 (es)
FI (1) FI903931A7 (es)
FR (1) FR2640142B1 (es)
GB (1) GB2231872B (es)
GR (1) GR1000455B (es)
IL (1) IL92557A0 (es)
NL (1) NL8921262A (es)
NZ (1) NZ231652A (es)
PT (1) PT92509A (es)
SE (1) SE9002589D0 (es)
WO (1) WO1990006321A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2047458A6 (es) * 1988-12-08 1994-02-16 Sandoz Ag P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos.
US6673893B1 (en) * 1990-02-01 2004-01-06 University Of South Florida Leukocyte derived growth factor 2
EP0513201A1 (en) * 1990-02-01 1992-11-19 University Of South Florida Leukocyte-derived growth factor
WO1993001826A1 (en) * 1991-07-19 1993-02-04 East Carolina University Method of treating asthma
AU3071492A (en) * 1991-11-15 1993-06-15 University Of Pennsylvania Suppression of megakaryocytopoiesis by neutrophil activating peptide-2
EP0677106A4 (en) * 1993-01-07 1998-12-09 Univ South Florida GROWTH FACTORS MADE OF LEUKOCYTEN.
US5786327A (en) 1993-03-12 1998-07-28 Gensci Regeneration Sciences Inc. Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
US5578569A (en) * 1993-03-12 1996-11-26 Tam; Cherk S. Method of increasing bone growth
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US5912232A (en) * 1994-09-23 1999-06-15 Board Of Regents Of The University Of Nebraska Anti-inflammatory polypeptide antagonists of human I1-8
US6117839A (en) * 1995-06-07 2000-09-12 Gensci Regeneration Sciences, Inc. Bone stimulating factor
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US5880094A (en) * 1995-06-07 1999-03-09 Osteopharm Limited Polypeptides that stimulate bone growth
US6693081B2 (en) * 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
AU9747698A (en) 1997-09-25 1999-04-12 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Isolated and recombinant antimicrobial peptides thrombocidin-1 (tc-1) and thrombocidin-2 (tc-2) or variants thereof
GB9807721D0 (en) 1998-04-08 1998-06-10 Chiron Spa Antigen
JP5500749B2 (ja) 2000-03-07 2014-05-21 日本たばこ産業株式会社 好中球刺激活性を有するポリペプチド
US6815421B1 (en) 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
US7375192B2 (en) 2002-05-01 2008-05-20 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
US7177246B2 (en) * 2003-09-12 2007-02-13 Hewlett-Packard Development Company, L.P. Optical disk drive focusing apparatus using sum signal
BR112013012396A2 (pt) 2010-11-19 2020-11-10 Toshio Imai anticorpos anti-ccl20 de neutralização

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897348A (en) * 1983-08-25 1990-01-30 Sri International Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof
DE3737703A1 (de) * 1987-11-06 1989-05-18 Ferring Arzneimittel Gmbh Neutrophilen aktivierendes polypeptid, verfahren zu dessen herstellung sowie dessen verwendung als arzneimittel und diagnostikum
US5026639A (en) * 1988-01-14 1991-06-25 Nippon Mining Company, Limited Method to improve mRNA translation and use thereof for production of platelet factor-4
ES2047458A6 (es) * 1988-12-08 1994-02-16 Sandoz Ag P\rocedimiento para la preparacion de peptido-2 activador de neutrofilos.

Also Published As

Publication number Publication date
DK188690D0 (da) 1990-08-07
FI903931A0 (fi) 1990-08-08
GR890100810A (en) 1991-03-15
GB2231872B (en) 1992-07-22
SE9002589L (sv) 1990-08-07
AU634508B2 (en) 1993-02-25
FR2640142B1 (fr) 1994-09-23
NZ231652A (en) 1993-02-25
AU4655689A (en) 1990-06-26
BE1003636A4 (fr) 1992-05-12
CH681625A5 (es) 1993-04-30
KR910700260A (ko) 1991-03-14
IL92557A0 (en) 1990-08-31
NL8921262A (nl) 1990-11-01
SE9002589D0 (sv) 1990-08-07
GR1000455B (el) 1992-07-30
CA2004685A1 (en) 1990-06-08
DK188690A (da) 1990-08-07
PT92509A (pt) 1990-06-29
JPH03503767A (ja) 1991-08-22
JP3051160B2 (ja) 2000-06-12
GB9011468D0 (en) 1990-08-29
US5759533A (en) 1998-06-02
WO1990006321A1 (en) 1990-06-14
FR2640142A1 (fr) 1990-06-15
FI903931A7 (fi) 1990-08-08
GB2231872A (en) 1990-11-28

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Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19930818