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ES2046195T3 - Un procedimiento para la preparacion de los derivados de prolinal. - Google Patents

Un procedimiento para la preparacion de los derivados de prolinal.

Info

Publication number
ES2046195T3
ES2046195T3 ES198787118566T ES87118566T ES2046195T3 ES 2046195 T3 ES2046195 T3 ES 2046195T3 ES 198787118566 T ES198787118566 T ES 198787118566T ES 87118566 T ES87118566 T ES 87118566T ES 2046195 T3 ES2046195 T3 ES 2046195T3
Authority
ES
Spain
Prior art keywords
group
chem
general formula
carbon atoms
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787118566T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashidanchi 19-103 Ohuchida
Hiroyuki Ohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2046195T3 publication Critical patent/ES2046195T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO DERIVADO DE PROLINAL DE FORMULA GENERAL (I), DONDE A REPRESENTA UN GRUPO DE FORMULA GENERAL (II) EN LA QUE UNO DE LOS SUSTITUYENTES R1 Y R2 REPRESENTA UN ATOMO DE HIDROGENO Y EL OTRO UN GRUPO ALQUILO DE 2 A 5 ATOMOS DE CARBONO, UN GRUPO ALCOXI DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO FENILO, UN GRUPO BENCILO, UN GRUPO CICLOALQUILO DE 4 A 6 ATOMOS DE CARBONO O UN GRUPO (CICLOALQUIL DE 4 A 6 ATOMOS DE CARBONO)-METILO, O BIEN R1 Y R2 REPRESENTAN CADA UNO UN GRUPO ALQUILO DE 1 A 4 ATOMOS DE CARBONO IGUALES O DISTINTOS.
ES198787118566T 1986-12-29 1987-12-15 Un procedimiento para la preparacion de los derivados de prolinal. Expired - Lifetime ES2046195T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31015186 1986-12-29

Publications (1)

Publication Number Publication Date
ES2046195T3 true ES2046195T3 (es) 1994-02-01

Family

ID=18001775

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787118566T Expired - Lifetime ES2046195T3 (es) 1986-12-29 1987-12-15 Un procedimiento para la preparacion de los derivados de prolinal.

Country Status (6)

Country Link
US (2) US4983624A (es)
EP (1) EP0275482B1 (es)
KR (1) KR950009359B1 (es)
AT (1) ATE84787T1 (es)
DE (1) DE3783754T2 (es)
ES (1) ES2046195T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277588B1 (en) * 1987-02-04 1993-03-24 Ono Pharmaceutical Co., Ltd. Prolinal derivatives
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
WO1990012005A1 (en) * 1989-04-13 1990-10-18 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
ATE462432T1 (de) 2003-05-05 2010-04-15 Probiodrug Ag Glutaminylcyclase-hemmer
WO2005049027A2 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
AU2005210004B2 (en) 2004-02-05 2010-10-28 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
WO2008144748A1 (en) * 2007-05-21 2008-11-27 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
CA1298033C (en) * 1985-04-16 1992-03-24 Takaharu Tanaka Dipeptide derivative of fatty acid
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
ES2058089T3 (es) * 1986-11-20 1994-11-01 Ono Pharmaceutical Co Un procedimiento para la preparacion de un nuevo derivado de prolinal.

Also Published As

Publication number Publication date
EP0275482A2 (en) 1988-07-27
KR950009359B1 (ko) 1995-08-21
EP0275482A3 (en) 1988-12-28
EP0275482B1 (en) 1993-01-20
KR880007457A (ko) 1988-08-27
ATE84787T1 (de) 1993-02-15
US5112847A (en) 1992-05-12
DE3783754T2 (de) 1993-08-05
DE3783754D1 (de) 1993-03-04
US4983624A (en) 1991-01-08

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