[go: up one dir, main page]

ES2038163T3 - Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4. - Google Patents

Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4.

Info

Publication number
ES2038163T3
ES2038163T3 ES198787119077T ES87119077T ES2038163T3 ES 2038163 T3 ES2038163 T3 ES 2038163T3 ES 198787119077 T ES198787119077 T ES 198787119077T ES 87119077 T ES87119077 T ES 87119077T ES 2038163 T3 ES2038163 T3 ES 2038163T3
Authority
ES
Spain
Prior art keywords
tetrasustituted
trisustituted
dioxolanes
prepare
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787119077T
Other languages
English (en)
Inventor
Anil Kumar Saksena
Alan Bruce Cooper
Henry Guzik
Viyyoor Moopil Girijavallabhan
Ashit Kumar Ganguly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2038163T3 publication Critical patent/ES2038163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
    • A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
    • A45C11/005—Contact lens cases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0011—Moulds or cores; Details thereof or accessories therefor thin-walled moulds
    • B29C33/0016—Lost moulds, e.g. staying on the moulded object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0038—Moulds or cores; Details thereof or accessories therefor with sealing means or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/005—Moulds or cores; Details thereof or accessories therefor characterised by the location of the parting line of the mould parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C37/00—Component parts, details, accessories or auxiliary operations, not covered by group B29C33/00 or B29C35/00
    • B29C37/005—Compensating volume or shape change during moulding, in general
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/00038—Production of contact lenses
    • B29D11/00057—Production of contact lenses characterised by the shape or surface condition of the edge, e.g. flashless, burrless, smooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/0048—Moulds for lenses
    • B29D11/00567—Moulds for lenses wherein the mould forms part of the final package for lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/00009—Production of simple or compound lenses
    • B29D11/0048—Moulds for lenses
    • B29D11/00576—Moulds for lenses with means to engage flash, e.g. HEMA ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE 1,3-DIOXOLANO 2,4,4-TRI- Y 2,2,4,4-TETRASUSTITUIDOS Y A A SUS SALES Y SOLVATOS FARMACEUTICAMENTE ACEPTABLES, QUE POSEEN ACTIVIDAD ANTIFUNCICA, ANTIALERGICA, ANTI-INFLAMATORIA Y/O DE INMUNO-MODULACION. TAMBIEN SE DESCRIBEN METODOS PARA PREPARAR Y USAR ESTOS COMPUESTOS.
ES198787119077T 1986-12-24 1987-12-22 Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4. Expired - Lifetime ES2038163T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/946,352 US4788190A (en) 1986-12-24 1986-12-24 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds

Publications (1)

Publication Number Publication Date
ES2038163T3 true ES2038163T3 (es) 1993-07-16

Family

ID=25484358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787119077T Expired - Lifetime ES2038163T3 (es) 1986-12-24 1987-12-22 Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4.

Country Status (8)

Country Link
US (1) US4788190A (es)
EP (2) EP0329711A1 (es)
JP (2) JPH07616B2 (es)
AT (1) ATE75742T1 (es)
DE (1) DE3778870D1 (es)
ES (1) ES2038163T3 (es)
GR (1) GR3005363T3 (es)
WO (1) WO1988005048A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK167878B1 (da) * 1985-04-19 1993-12-27 Sankyo Co Griseolsyrederivater
TW211006B (es) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
WO1996002664A1 (fr) * 1994-07-18 1996-02-01 Daicel Chemical Industries, Ltd. Procede pour produire et racemiser un compose triazole optiquement actif
TW593312B (en) * 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
JP4473350B2 (ja) * 1997-07-11 2010-06-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ２，４，４−三置換−１，３−ジオキソラン抗菌・抗カビ剤
KR100458866B1 (ko) * 1999-05-21 2004-12-03 한국화학연구원 1,3-디옥솔란-2-일리덴 유도체 및 그의 제조 방법
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
JP2012502028A (ja) * 2008-09-08 2012-01-26 ウ，ニアン トリアゾール抗真菌剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575999A (en) * 1968-08-19 1971-04-20 Janssen Pharmaceutica Nv Ketal derivatives of imidazole
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4338453A (en) * 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
US4490530A (en) * 1981-01-14 1984-12-25 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4456605A (en) * 1981-05-07 1984-06-26 Janssen Pharmaceutica N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
JPS58128383A (ja) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd トリアゾ−ル系化合物、その製造法およびこれを有効成分として含有する農園芸用殺菌剤、植物生長調節剤または除草剤
EP0094167A3 (en) * 1982-05-12 1984-07-04 Fbc Limited Azolyl fungicide and plant growth regulators and compositions containing them
DE3305769A1 (de) * 1982-06-04 1983-12-08 Bayer Ag, 5090 Leverkusen Schaedlingsbekaempfungsmittel
US4577020A (en) * 1983-01-25 1986-03-18 The Upjohn Company Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents
JPS59212491A (ja) * 1983-05-17 1984-12-01 Sumitomo Chem Co Ltd トリアゾ−ル系化合物、その製造法およびそれを有効成分とする農園芸用殺菌剤
JPS6025990A (ja) * 1983-07-20 1985-02-08 Shionogi & Co Ltd トリアゾ−ル系ジオキソラン誘導体
DK354185A (da) * 1984-08-31 1986-03-01 Hoffmann La Roche 1,3-dioxolanderivater

Also Published As

Publication number Publication date
DE3778870D1 (de) 1992-06-11
EP0329711A1 (en) 1989-08-30
US4788190A (en) 1988-11-29
GR3005363T3 (es) 1993-05-24
ATE75742T1 (de) 1992-05-15
JPH07616B2 (ja) 1995-01-11
WO1988005048A1 (en) 1988-07-14
JPH02501733A (ja) 1990-06-14
EP0278105B1 (en) 1992-05-06
JPH05310707A (ja) 1993-11-22
EP0278105A1 (en) 1988-08-17

Similar Documents

Publication Publication Date Title
ES2068179T3 (es) Benzo(5,6)-ciclohepta-piridinas, composiciones y metodo de uso.
ES2104946T3 (es) Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica.
SE8602723L (sv) Tiazoler, deras framstellning och farmaceutiska kompositioner innehallande dem
ES552627A0 (es) Procedimiento para la preparacion de carbamatos de fenilo
IT8024658A0 (it) Placca per giunzioni di porzioni d'osso separate da frattura.
DE69004731D1 (de) Hilfsmittel enthaltende verdünnbare Formulierungen von Nachlaufherbiziden.
IT8421343A0 (it) Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti.
PT758248E (pt) Formulacoes para o factor ix
ES8707974A1 (es) Procedimiento para la obtencion de un peptido
ES2037013T3 (es) Procedimiento para preparar tieno-1,4-diazepinas.
IT1119380B (it) Trinciatrice per la distruzione di documenti
ATE26115T1 (de) Substituierte 8-phenylxanthine.
FI875411L (fi) Foerfarande och anordning foer inriktning och laengsriktad foerskjutning av avrundade burkars kanter i foerhaollande till en svetsanordning.
ES2139024T3 (es) Produccion de xilitol por recombinacion y huesped utilizado para este procedimiento.
ES2084831T3 (es) Nuevo procedimiento para preparar formoterol y compuestos relacionados.
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
ES2038163T3 (es) Procedimiento para preparar 1,3-dioxolanos trisustituidos en 2,4,4 y tetrasustituidos en 2,2,4,4.
BG45552A3 (bg) Метод за получаване на 2-фенил-хексахидро-1,2,4- триазин-3,5-диони
AR228161A1 (es) Procedimiento para desintegrar derivados de 2,4-dihidroxi-6-amino-s-triazina
AR228586A1 (es) Procedimiento para preparar derivados de 2,3-dihidrobenzofuran-2-ona o croman-2-ona y sus sales farmaceuticamente aceptables
BG40803A3 (en) Method for preparing arylcyclobutylalkylaminic derivatives
ES545004A0 (es) Un procedimiento para producir un acetileno.
IT8921894A0 (it) Procedimento per la produzione di impiallacciatura di radica artificiale mediante fogli di legno rigati.
ES2059396T3 (es) Derivados de indeno y metodos.
IT8422245A0 (it) Procedimento per la preparazione di derivati del lisergolo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 278105

Country of ref document: ES