[go: up one dir, main page]

EP2906696A4 - Procédés pour moduler l'expression de c90rf72 - Google Patents

Procédés pour moduler l'expression de c90rf72

Info

Publication number
EP2906696A4
EP2906696A4 EP13846313.8A EP13846313A EP2906696A4 EP 2906696 A4 EP2906696 A4 EP 2906696A4 EP 13846313 A EP13846313 A EP 13846313A EP 2906696 A4 EP2906696 A4 EP 2906696A4
Authority
EP
European Patent Office
Prior art keywords
c90rf72
modulating
expression
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13846313.8A
Other languages
German (de)
English (en)
Other versions
EP2906696B1 (fr
EP2906696A1 (fr
EP2906696B2 (fr
Inventor
Frank Rigo
Don W Cleveland
Clotilde Lagier-Tourenne
John M Ravits
C Frank Bennett
Susan M Freier
Michael W Baughn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research Ltd
Ionis Pharmaceuticals Inc
University of California San Diego UCSD
Original Assignee
Ludwig Institute for Cancer Research Ltd
Ionis Pharmaceuticals Inc
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50488699&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2906696(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ludwig Institute for Cancer Research Ltd, Ionis Pharmaceuticals Inc, University of California Berkeley, University of California San Diego UCSD filed Critical Ludwig Institute for Cancer Research Ltd
Publication of EP2906696A1 publication Critical patent/EP2906696A1/fr
Publication of EP2906696A4 publication Critical patent/EP2906696A4/fr
Publication of EP2906696B1 publication Critical patent/EP2906696B1/fr
Application granted granted Critical
Publication of EP2906696B2 publication Critical patent/EP2906696B2/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Liquid Crystal Substances (AREA)
EP13846313.8A 2012-10-15 2013-10-15 Procédés pour moduler l'expression de c90rf72 Active EP2906696B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261714139P 2012-10-15 2012-10-15
PCT/US2013/065067 WO2014062686A1 (fr) 2012-10-15 2013-10-15 Procédés pour moduler l'expression de c90rf72

Publications (4)

Publication Number Publication Date
EP2906696A1 EP2906696A1 (fr) 2015-08-19
EP2906696A4 true EP2906696A4 (fr) 2016-06-08
EP2906696B1 EP2906696B1 (fr) 2019-10-09
EP2906696B2 EP2906696B2 (fr) 2022-12-14

Family

ID=50488699

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13846313.8A Active EP2906696B2 (fr) 2012-10-15 2013-10-15 Procédés pour moduler l'expression de c90rf72

Country Status (7)

Country Link
US (1) US9963699B2 (fr)
EP (1) EP2906696B2 (fr)
DK (1) DK2906696T4 (fr)
ES (1) ES2762326T5 (fr)
FI (1) FI2906696T4 (fr)
PT (1) PT2906696T (fr)
WO (1) WO2014062686A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2370451B1 (fr) 2008-12-02 2016-11-16 Wave Life Sciences Japan, Inc. Procédé pour la synthèse d'acides nucléiques modifiés au niveau de l'atome de phosphore
IN2012DN00720A (fr) 2009-07-06 2015-06-19 Ontorii Inc
WO2012039448A1 (fr) 2010-09-24 2012-03-29 株式会社キラルジェン Groupe auxiliaire asymétrique
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
EP2872485B1 (fr) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Groupe auxiliaire asymétrique
CN104968783B (zh) 2012-10-15 2019-12-10 Ionis制药公司 用于调节c9orf72表达的组合物
WO2014062736A1 (fr) 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Procédés permettant de surveiller l'expression de c9orf72
US9963699B2 (en) 2012-10-15 2018-05-08 Ionis Pharmaceuticals, Inc. Methods for modulating C9ORF72 expression
MX2016004651A (es) * 2013-10-11 2016-08-05 Ionis Pharmaceuticals Inc Composiciones para modular la expresion de c9orf72.
US11162096B2 (en) 2013-10-14 2021-11-02 Ionis Pharmaceuticals, Inc Methods for modulating expression of C9ORF72 antisense transcript
KR20240164968A (ko) 2014-01-16 2024-11-21 웨이브 라이프 사이언시스 리미티드 키랄 디자인
WO2016024205A1 (fr) * 2014-08-15 2016-02-18 Pfizer Inc. Oligomères ciblant l'expansion d'une répétition hexanucléotidique dans le gène c9orf72 humain
WO2016112132A1 (fr) 2015-01-06 2016-07-14 Ionis Pharmaceuticals, Inc. Compositions destinées à moduler l'expression du transcrit antisens c9orf72
HUE049233T2 (hu) * 2015-04-16 2020-09-28 Ionis Pharmaceuticals Inc C9ORF72-expresszió módosítására szolgáló készítmények
WO2016167780A1 (fr) 2015-04-16 2016-10-20 Ionis Pharmaceuticals, Inc. Compositions destinées à moduler l'expression du transcrit antisens c9orf72
ES2784360T3 (es) 2015-05-29 2020-09-24 Regeneron Pharma Animales no humanos que tienen una interrupción en un locus C9ORF72
EP4285912A3 (fr) 2015-09-25 2024-07-10 Ionis Pharmaceuticals, Inc. Compositions et méthodes de modulation de l'expression de l'ataxine 3
US10760076B2 (en) 2015-10-05 2020-09-01 Proqr Therapeutics Ii B.V. Use of single-stranded antisense oligonucleotide in prevention or treatment of genetic diseases involving a trinucleotide repeat expansion
WO2017079291A1 (fr) * 2015-11-02 2017-05-11 Ionis Pharmaceuticals, Inc. Composés et méthodes de modulation de c90rf72
EP3443094B1 (fr) * 2016-04-13 2022-10-19 Ionis Pharmaceuticals, Inc. Procédés de réduction de l'expression de c9orf72
RU2760877C2 (ru) 2016-09-30 2021-12-01 Регенерон Фармасьютикалс, Инк. Животные, отличные от человека, характеризующиеся экспансией гексануклеотидных повторов в локусе c9orf72
JOP20190104A1 (ar) 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
US20180193270A1 (en) 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
GB2579747B8 (en) 2017-08-04 2022-10-05 Skyhawk Therapeutics Inc Methods and compositions for modulating splicing
TW201920672A (zh) * 2017-08-08 2019-06-01 新加坡商波濤生命科學有限公司 寡核苷酸組合物及其使用方法
CA3079727A1 (fr) * 2017-10-24 2019-05-02 Sangamo Therapeutics, Inc. Methodes et compositions pour le traitement de maladies rares
US10905707B2 (en) 2017-11-10 2021-02-02 University Of Massachusetts Compositions and methods for the treatment of expanded repeat-associated disorders
CR20200604A (es) 2018-05-09 2021-02-09 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir de la expresión de atxn3
CN113365640A (zh) 2018-12-06 2021-09-07 比奥根Ma公司 引导肌萎缩侧索硬化症的治疗性干预的神经丝蛋白
EP3732291A1 (fr) 2018-12-20 2020-11-04 Regeneron Pharmaceuticals, Inc. Expansion de répétition à médiation par nucléase
WO2020163405A1 (fr) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Procédés et compositions pour moduler l'épissage
CN113677344A (zh) 2019-02-06 2021-11-19 斯基霍克疗法公司 用于调节剪接的方法和组合物
KR20210124374A (ko) 2019-02-08 2021-10-14 듀포인트 테라퓨틱스, 인크. 화합물의 응축물-연관된 특징을 특징규명하는 방법 및 그의 용도
JP2022532169A (ja) * 2019-05-09 2022-07-13 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物及びその使用方法
EP4031876A1 (fr) 2019-09-18 2022-07-27 Dewpoint Therapeutics, Inc. Procédés de criblage de spécificité associée à un condensat et leurs utilisations
EP4073251A1 (fr) * 2019-12-13 2022-10-19 Alnylam Pharmaceuticals, Inc. Agents et compositions d'arni ciblant c9orf72 - cadre de lecture ouvert 72 sur le chromosome 9 - humain et procédés d'utilisation
WO2021159008A2 (fr) 2020-02-07 2021-08-12 Maze Therapeutics, Inc. Compositions et méthodes de traitement de maladies neurodégénératives
US20250011773A1 (en) 2021-04-06 2025-01-09 Maze Therapeutics, Inc. Compositions and methods for treating tdp-43 proteinopathy
WO2023108071A2 (fr) * 2021-12-08 2023-06-15 Thomas Jefferson University Méthodes relatives à la sclérose latérale amyotrophique
WO2023220740A2 (fr) * 2022-05-12 2023-11-16 The Regents Of The University Of California Approches d'édition de gène crispr/cas9 thérapeutique pour une mutation de type expansion de répétition c9orf72 en ipscs
WO2024077109A1 (fr) 2022-10-05 2024-04-11 Maze Therapeutics, Inc. Oligonucléotides antisens unc13a et leurs utilisations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012092367A1 (fr) * 2010-12-28 2012-07-05 University Of Rochester Composés de liaison d'acide nucléique, procédés de fabrication, et utilisation de ceux-ci
US20120214865A1 (en) * 2001-06-21 2012-08-23 Isis Pharmaceuticals, Inc. Methods for slowing familial als disease progression
WO2013030588A1 (fr) * 2011-08-31 2013-03-07 The University Of Manchester Procédé de diagnostic d'une maladie neurodégénérative

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699808A (en) 1944-10-06 1955-01-18 Mark W Lowe Apparatus for peeling tomatoes
US2699508A (en) 1951-12-21 1955-01-11 Selectronics Inc Method of mounting and construction of mounting for low frequency piezoelectric crystals
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
RU95114435A (ru) 1992-12-14 1997-05-20 Ханивелл Инк. (Us) Система с бесщеточным двигателем постоянного тока
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5656408A (en) 1996-04-29 1997-08-12 Xerox Corporation Coated carrier particles
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
CA2303299C (fr) 1997-09-12 2016-02-23 Exiqon A/S Analogues d'oligonucleotides
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US20030228597A1 (en) 1998-04-13 2003-12-11 Cowsert Lex M. Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
KR100782896B1 (ko) 1999-05-04 2007-12-06 엑시콘 에이/에스 Ｌ-리보-ｌｎａ 유사체
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
USH2191H1 (en) 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
EP1499627A2 (fr) 2001-07-03 2005-01-26 ISIS Pharmaceuticals, Inc. Oligonucleotides chimeres resistants a la nuclease
WO2004044136A2 (fr) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Compositions comprenant des nucleosides modifies en 2' de substitution destinees a la modulation de gene
CA2504694C (fr) 2002-11-05 2013-10-01 Isis Pharmaceuticals, Inc. Composes oligomeres renfermant un substitut de sucre polycyclique et compositions intervenant dans la modulation genique
US8090542B2 (en) 2002-11-14 2012-01-03 Dharmacon Inc. Functional and hyperfunctional siRNA
WO2004106356A1 (fr) 2003-05-27 2004-12-09 Syddansk Universitet Derives de nucleotides fonctionnalises
ATE555118T1 (de) 2003-08-28 2012-05-15 Takeshi Imanishi Neue synthetische nukleidsäuren vom typ mit quervernetzter n-o-bindung
WO2005027962A1 (fr) 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides et composes d'oligomeres
AU2005248147A1 (en) 2004-05-11 2005-12-08 Alphagen Co., Ltd. Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
EP1984381B1 (fr) 2006-01-27 2010-09-29 Isis Pharmaceuticals, Inc. Analogues d'acides nucleiques bicycliques modifies en position 6
US7547684B2 (en) 2006-05-11 2009-06-16 Isis Pharmaceuticals, Inc. 5′-modified bicyclic nucleic acid analogs
JP2010505432A (ja) 2006-10-09 2010-02-25 サンタリス ファーマ アー／エス Ｐｃｓｋ９を調節するためのｒｎａアンタゴニスト化合物
EP2125852B1 (fr) 2007-02-15 2016-04-06 Ionis Pharmaceuticals, Inc. Nucléosides modifiés 5'-substitués-2'-f et composés oligomères préparés à partir de ceux-ci
AU2008260277C1 (en) 2007-05-30 2014-04-17 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
ES2386492T3 (es) 2007-06-08 2012-08-21 Isis Pharmaceuticals, Inc. Análogos de ácidos nucleicos bicíclicos carbocíclicos
EP2176280B2 (fr) 2007-07-05 2015-06-24 Isis Pharmaceuticals, Inc. Analogues d'acides nucléiques bicycliques disubstitués en position 6
WO2009067647A1 (fr) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Analogues d'acide nucléique alpha-l-bicyclique carbocyclique
US8530640B2 (en) 2008-02-07 2013-09-10 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
US8669102B2 (en) 2008-08-14 2014-03-11 Isis Pharmaceuticals, Inc. Modulation of prion expression
DK2356129T3 (da) 2008-09-24 2013-05-13 Isis Pharmaceuticals Inc Substituerede alpha-L-bicykliske nukleosider
AT507215B1 (de) 2009-01-14 2010-03-15 Boehler Edelstahl Gmbh & Co Kg Verschleissbeständiger werkstoff
WO2010120820A1 (fr) 2009-04-13 2010-10-21 Isis Pharmaceuticals, Inc. Compositions et procédés pour moduler l'épissage de smn2
WO2011017521A2 (fr) 2009-08-06 2011-02-10 Isis Pharmaceuticals, Inc. Analogues d'acides nucléiques cyclohexoses bicycliques
WO2011135396A1 (fr) 2010-04-30 2011-11-03 Cellectis Procédé de modulation de recombinaison homologue induite par les cassures double-brin
EP2595663A4 (fr) 2010-07-19 2014-03-05 Isis Pharmaceuticals Inc Modulation de l'expression de la protéine kinase de la dystrophie myotonique (dmpk)
EP3312189A1 (fr) 2011-04-21 2018-04-25 Ionis Pharmaceuticals, Inc. Modulation de l'expression du virus de l'hépatite b (vhb)
US20140255936A1 (en) 2011-09-09 2014-09-11 Mayo Foundation For Medical Education And Research Detecting frontotemporal dementia and amyotrophic lateral sclerosis
EP3858847A1 (fr) * 2011-11-30 2021-08-04 Sarepta Therapeutics, Inc. Oligonucléotides pour le traitement de maladies à répétition nucléotidique étendue
EP2788087A4 (fr) 2011-12-06 2015-08-26 Ohio State Innovation Foundation Agents de contraste non ioniques de faible osmolarité pour l'administration d'oligonucléotides antisens et le traitement de maladie
JP6174678B2 (ja) 2012-04-23 2017-08-02 バイオマリン テクノロジーズ ベー．フェー． 神経筋障害の治療のための改善された特徴を有するｒｎａ調節オリゴヌクレオチド
US9984408B1 (en) 2012-05-30 2018-05-29 Amazon Technologies, Inc. Method, medium, and system for live video cooperative shopping
WO2014062736A1 (fr) 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Procédés permettant de surveiller l'expression de c9orf72
US9963699B2 (en) 2012-10-15 2018-05-08 Ionis Pharmaceuticals, Inc. Methods for modulating C9ORF72 expression
CN104968783B (zh) 2012-10-15 2019-12-10 Ionis制药公司 用于调节c9orf72表达的组合物
EP2948777B1 (fr) 2013-01-22 2019-06-26 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Protéines à répétition dipeptidique en tant que cible thérapeutique dans des maladies neurodégénératives ayant une expansion de répétition hexanucléotidique
MX2016004651A (es) 2013-10-11 2016-08-05 Ionis Pharmaceuticals Inc Composiciones para modular la expresion de c9orf72.
EP2868746A1 (fr) 2013-10-29 2015-05-06 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Micro-ARN modulant l'effet de la signalisation des glucocorticoïdes
DE102014204360A1 (de) 2014-03-10 2015-09-10 Ford Global Technologies, Llc Verfahren sowie Vorrichtung zur Abschätzung des Abstandes eines in Bewegung befindlichen Fahrzeuges von einem Objekt
WO2016024205A1 (fr) 2014-08-15 2016-02-18 Pfizer Inc. Oligomères ciblant l'expansion d'une répétition hexanucléotidique dans le gène c9orf72 humain
WO2016060919A1 (fr) 2014-10-14 2016-04-21 The Board Of Regents Of The University Of Texas System Inhibition sélective d'allèle de l'expression de foci c9orf72 mutants par des arn duplexes ciblant la répétition étendue d'hexanucléotide
HUE049233T2 (hu) 2015-04-16 2020-09-28 Ionis Pharmaceuticals Inc C9ORF72-expresszió módosítására szolgáló készítmények
US9778708B1 (en) 2016-07-18 2017-10-03 Lenovo Enterprise Solutions (Singapore) Pte. Ltd. Dual sided latching retainer for computer modules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120214865A1 (en) * 2001-06-21 2012-08-23 Isis Pharmaceuticals, Inc. Methods for slowing familial als disease progression
WO2012092367A1 (fr) * 2010-12-28 2012-07-05 University Of Rochester Composés de liaison d'acide nucléique, procédés de fabrication, et utilisation de ceux-ci
WO2013030588A1 (fr) * 2011-08-31 2013-03-07 The University Of Manchester Procédé de diagnostic d'une maladie neurodégénérative

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A. MADSEN: "Antisense Against C90RF72", MDA/ALS NEWSMAGAZINE, 1 July 2012 (2012-07-01), pages 1 - 2, XP055251577, Retrieved from the Internet <URL:http://alsn.mda.org/article/antisense-against-c90rf72> [retrieved on 20160219] *
ALANE RENTON ET AL: "A Hexanucleotide Repeat Expansion inIs the Cause of Chromosome 9p21-Linked ALS-FTD", NEURON, CELL PRESS, US, vol. 72, no. 2, 14 September 2011 (2011-09-14), pages 257 - 268, XP028322561, ISSN: 0896-6273, [retrieved on 20110917], DOI: 10.1016/J.NEURON.2011.09.010 *
DONNELLY CHRISTOPHER J ET AL: "Development of C9orf72 ALS Biomarkers and Therapeutics", ANNALS OF NEUROLOGY & 137TH ANNUAL MEETING OF THE AMERICAN-NEUROLOGICAL-ASSOCIATION (ANA); BOSTON, MA, USA; OCTOBER 07 -10, 2012, vol. 72, no. Suppl. 16, M1415, 7 October 2012 (2012-10-07), pages S67 - S68, XP002757118 *
MARIELY DEJESUS-HERNANDEZ ET AL: "Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region ofCauses Chromosome 9p-Linked FTD and ALS", NEURON, CELL PRESS, US, vol. 72, no. 2, 14 September 2011 (2011-09-14), pages 245 - 256, XP028322560, ISSN: 0896-6273, [retrieved on 20110917], DOI: 10.1016/J.NEURON.2011.09.011 *
PETER K TODD ET AL: "RNA mediated neurodegeneration in repeat expansion disorders", ANNALS OF NEUROLOGY., vol. 67, no. 3, 23 December 2009 (2009-12-23), BOSTON, US, pages NA - NA, XP055269539, ISSN: 0364-5134, DOI: 10.1002/ana.21948 *
S. A. M. MULDERS ET AL: "Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 33, 18 August 2009 (2009-08-18), pages 13915 - 13920, XP055007026, ISSN: 0027-8424, DOI: 10.1073/pnas.0905780106 *
See also references of WO2014062686A1 *

Also Published As

Publication number Publication date
EP2906696B1 (fr) 2019-10-09
EP2906696A1 (fr) 2015-08-19
US20150267197A1 (en) 2015-09-24
DK2906696T4 (da) 2023-02-27
ES2762326T5 (es) 2023-04-27
DK2906696T3 (da) 2019-11-25
EP2906696B2 (fr) 2022-12-14
WO2014062686A1 (fr) 2014-04-24
ES2762326T3 (es) 2020-05-22
FI2906696T4 (fi) 2023-03-18
US9963699B2 (en) 2018-05-08
PT2906696T (pt) 2019-12-16

Similar Documents

Publication Publication Date Title
EP2906696A4 (fr) Procédés pour moduler l&#39;expression de c90rf72
EP2992009A4 (fr) Compositions et procédés de modulation de l&#39;expression de l&#39;apolipoprotéine (a)
EP3003049A4 (fr) Compositions et procédés pour l&#39;activation de la germination
EP2864479A4 (fr) Modulation de l&#39;expression d&#39;ube3a-ats
EP2855500A4 (fr) Procédés et compositions de modulation de l&#39;expression de l&#39;apolipoprotéine(a)
EP2538785A4 (fr) Procédés pour la synthèse de composés diarylthiohydantoïnes et diarylhydantoïnes
EP2851043A4 (fr) Compte-gouttes de gouttes pour les yeux
EP2895526A4 (fr) Polyamines ramifiées pour l&#39;administration de matières biologiquement
FR2988609B1 (fr) Formulation pour l&#39;hormonotherapie
EP2931327A4 (fr) Membrane à hydrogel pour la prévention de l&#39;adhérence
EP2868511A4 (fr) Appareil d&#39;affichage pour véhicule
EP2764006A4 (fr) Sophorolipides modifiés pour l&#39;inhibition de phytopathogènes
IL251897A0 (en) Liver x receptor modulators
EP2717923A4 (fr) Procédés pour moduler l&#39;expression de la kallicréine (klkb1)
EP2909231A4 (fr) Composés et procédés pour la production de suckérine et utilisations de ceux-ci
EP2776564A4 (fr) Modulation de l&#39;expression de tmprss6
EP2760887A4 (fr) Compositions et procédés pour moduler l&#39;homéostasie
EP2916837A4 (fr) Promédicament bipyridylaminopyridines en tant qu&#39;inhibiteurs de syk
EP2834046A4 (fr) Récipient d&#39;outils
EP2970037A4 (fr) Procédés de préparation d&#39;alkylfurannes
FR3000475B3 (fr) Capuchon pour l&#39;evacuation
BR112015003032A2 (pt) anticorpos anti-jagged e métodos de utilização&#39;.
CL2014003125A1 (es) Anticuerpos de anti-transglutaminasa 2
EP2879675A4 (fr) Composés et procédés pour le ciblage de hsp90
EP2844171A4 (fr) Distribution d&#39;attaches

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150514

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED

Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Owner name: IONIS PHARMACEUTICALS, INC.

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602013061601

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: C12N0015110000

Ipc: C12N0015113000

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20160511

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/28 20060101ALI20160504BHEP

Ipc: C12N 15/113 20100101AFI20160504BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20170426

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LUDWIG INSTITUTE FOR CANCER RESEARCH

Owner name: IONIS PHARMACEUTICALS, INC.

Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

INTG Intention to grant announced

Effective date: 20190415

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602013061601

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: E. BLUM AND CO. AG PATENT- UND MARKENANWAELTE , CH

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1188839

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191115

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20191122

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 2906696

Country of ref document: PT

Date of ref document: 20191216

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20191206

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: NO

Ref legal event code: T2

Effective date: 20191009

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200109

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200110

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2762326

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20200522

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200224

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 602013061601

Country of ref document: DE

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PG2D Information on lapse in contracting state deleted

Ref country code: IS

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191015

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200209

REG Reference to a national code

Ref country code: FI

Ref legal event code: MDE

Opponent name: STRAWMAN LIMITED

Ref country code: FI

Ref legal event code: MDE

Opponent name: RICHLY, ERIK

26 Opposition filed

Opponent name: RICHLY, ERIK

Effective date: 20200709

Opponent name: STRAWMAN LIMITED

Effective date: 20200708

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PLBP Opposition withdrawn

Free format text: ORIGINAL CODE: 0009264

REG Reference to a national code

Ref country code: FI

Ref legal event code: MDE

Opponent name: STRAWMAN LIMITED

Ref country code: FI

Ref legal event code: MDE

Opponent name: RICHLY, ERIK

REG Reference to a national code

Ref country code: FI

Ref legal event code: MDE

Opponent name: STRAWMAN LIMITED

Ref country code: FI

Ref legal event code: MDE

Opponent name: RICHLY, ERIK

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PLBP Opposition withdrawn

Free format text: ORIGINAL CODE: 0009264

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

REG Reference to a national code

Ref country code: AT

Ref legal event code: UEP

Ref document number: 1188839

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PLBC Reply to examination report in opposition received

Free format text: ORIGINAL CODE: EPIDOSNORE3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20131015

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

PLBC Reply to examination report in opposition received

Free format text: ORIGINAL CODE: EPIDOSNORE3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20221214

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R102

Ref document number: 602013061601

Country of ref document: DE

REG Reference to a national code

Ref country code: SE

Ref legal event code: RPEO

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: NO

Ref legal event code: TB2

Ref country code: DK

Ref legal event code: T4

Effective date: 20230223

REG Reference to a national code

Ref country code: ES

Ref legal event code: DC2A

Ref document number: 2762326

Country of ref document: ES

Kind code of ref document: T5

Effective date: 20230427

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230521

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20240910

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20240829

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20240917

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20240909

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240917

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20240910

Year of fee payment: 12

Ref country code: IT

Payment date: 20240910

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20240924

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20241014

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240904

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NO

Payment date: 20241009

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20241011

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FI

Payment date: 20241015

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20240925

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20241104

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20241101

Year of fee payment: 12