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EP2319835A4 - Agoniste des récepteurs de glucocorticoïdes composé de dérivé de 2,2,4-triméthyl-6-phényl-1,2-dihydroquinoléine ayant un groupe oxy substitué - Google Patents

Agoniste des récepteurs de glucocorticoïdes composé de dérivé de 2,2,4-triméthyl-6-phényl-1,2-dihydroquinoléine ayant un groupe oxy substitué

Info

Publication number
EP2319835A4
EP2319835A4 EP09746568A EP09746568A EP2319835A4 EP 2319835 A4 EP2319835 A4 EP 2319835A4 EP 09746568 A EP09746568 A EP 09746568A EP 09746568 A EP09746568 A EP 09746568A EP 2319835 A4 EP2319835 A4 EP 2319835A4
Authority
EP
European Patent Office
Prior art keywords
trimethyl
phenyl
receptor agonist
oxy group
glucocorticoid receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09746568A
Other languages
German (de)
English (en)
Other versions
EP2319835A1 (fr
EP2319835B1 (fr
Inventor
Masatomo Kato
Miwa Takai
Takahiro Matsuyama
Tatsuji Kurose
Yumi Hagiwara
Mamoru Matsuda
Toshiyuki Mori
Kenji Imoto
Atsuyoshi Dota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ayumi Pharmaceutical Corp
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of EP2319835A1 publication Critical patent/EP2319835A1/fr
Publication of EP2319835A4 publication Critical patent/EP2319835A4/fr
Application granted granted Critical
Publication of EP2319835B1 publication Critical patent/EP2319835B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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EP09746568.6A 2008-05-12 2009-05-12 Agoniste des récepteurs de glucocorticoïdes composé de dérivé de 2,2,4-triméthyl-6-phényl-1,2-dihydroquinoléine ayant un groupe oxy substitué Active EP2319835B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008124714 2008-05-12
PCT/JP2009/058801 WO2009139361A1 (fr) 2008-05-12 2009-05-12 Agoniste des récepteurs de glucocorticoïdes composé de dérivé de 2,2,4-triméthyl-6-phényl-1,2-dihydroquinoléine ayant un groupe oxy substitué

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EP2319835A1 EP2319835A1 (fr) 2011-05-11
EP2319835A4 true EP2319835A4 (fr) 2011-12-28
EP2319835B1 EP2319835B1 (fr) 2016-04-13

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US (1) US8426406B2 (fr)
EP (1) EP2319835B1 (fr)
JP (1) JP5635743B2 (fr)
KR (1) KR20110010634A (fr)
CN (2) CN102089283B (fr)
AU (1) AU2009247250B2 (fr)
BR (1) BRPI0912171B8 (fr)
CA (1) CA2724055C (fr)
EA (1) EA019091B1 (fr)
ES (1) ES2574987T3 (fr)
GE (1) GEP20146061B (fr)
MX (1) MX2010012303A (fr)
MY (1) MY158747A (fr)
TW (1) TWI510240B (fr)
UA (1) UA102101C2 (fr)
WO (1) WO2009139361A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059866A1 (fr) 2006-11-14 2008-05-22 Santen Pharmaceutical Co., Ltd. Nouveau dérivé 1,2-dihydroquinoline comprenant un groupe alkyle inférieur à substitution phénylamino et un groupe phényle dans lequel est introduit un ester en tant que substituants
CA2826871A1 (fr) * 2011-02-09 2012-08-16 Santen Pharmaceutical Co., Ltd. Derive du 3-hydroxy-6h-benzo[c]chromen-6-one et son procede de production
CN104136432A (zh) * 2012-01-20 2014-11-05 参天制药株式会社 1,2-二氢喹啉衍生物或其盐的工业制备方法及其制备中间体
JP6060910B2 (ja) * 2013-03-28 2017-01-18 アイシン精機株式会社 周辺監視装置、及びプログラム
CN107922356A (zh) 2015-08-25 2018-04-17 参天制药株式会社 [4‑(1,3,3‑三甲基‑2‑氧代‑3,4‑二氢‑1h‑喹喔啉‑7‑基)苯氧基]乙基氧基化合物或其盐
KR102619458B1 (ko) 2017-06-16 2023-12-29 학교법인 도시샤 mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용
JPWO2018230713A1 (ja) 2017-06-16 2020-04-16 学校法人同志社 カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用
KR101933217B1 (ko) 2017-12-28 2018-12-27 (주) 에빅스젠 피부 염증 억제용 펩티드 및 이를 포함하는 피부 염증 예방 또는 치료용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1944290A1 (fr) * 2005-09-14 2008-07-16 Santen Pharmaceutical Co., Ltd. Nouveau dérivé de 1-2-dihydroquinoline présentant une activité de liaison aux récepteurs glucocorticoïdes
EP2085388A1 (fr) * 2006-11-14 2009-08-05 Santen Pharmaceutical Co., Ltd Nouveau dérivé 1,2-dihydroquinoline comprenant un groupe alkyle inférieur à substitution phénylamino et un groupe phényle dans lequel est introduit un ester en tant que substituants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696127A (en) * 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
PT800519E (pt) * 1994-12-22 2004-03-31 Ligand Pharm Inc Compostos moduladores de receptores de esteroides e metodos
US6696459B1 (en) * 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
ATE303369T1 (de) * 2000-10-30 2005-09-15 Pfizer Prod Inc Glucocorticoid rezeptor modulatoren
DE60318839T2 (de) * 2002-04-30 2009-01-22 Ucb Pharma, S.A. 2,6-chinolinyl- und 2,6-naphthylderivate und deren verwendungen zur behandlung von vla-4 bezogenen krankheiten
CA2496175A1 (fr) * 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Composes mimetiques de glucocorticoide, leurs procedes de fabrication, compositions pharmaceutiques, et leurs utilisations
MX2007000449A (es) * 2004-07-14 2007-03-28 Ligand Pharm Inc Compuestos moduladores de receptor intracelular y metodos.
US20070072908A1 (en) * 2005-06-08 2007-03-29 Japan Tobacco Inc. Heterocyclic compounds
RU2383539C2 (ru) 2005-06-08 2010-03-10 Джапан Тобакко Инк. Гетероциклические соединения
WO2008111632A1 (fr) * 2007-03-13 2008-09-18 Santen Pharmaceutical Co., Ltd. Agoniste de récepteur de glucocorticoïde constitué d'un dérivé de 2,2,4-triméthyl-6-phényl-1,2-dihydroquinoléine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1944290A1 (fr) * 2005-09-14 2008-07-16 Santen Pharmaceutical Co., Ltd. Nouveau dérivé de 1-2-dihydroquinoline présentant une activité de liaison aux récepteurs glucocorticoïdes
EP2085388A1 (fr) * 2006-11-14 2009-08-05 Santen Pharmaceutical Co., Ltd Nouveau dérivé 1,2-dihydroquinoline comprenant un groupe alkyle inférieur à substitution phénylamino et un groupe phényle dans lequel est introduit un ester en tant que substituants
EP2085389A1 (fr) * 2006-11-14 2009-08-05 Santen Pharmaceutical Co., Ltd Nouveau dérivé de 1,2-dihydroquinoline comprenant en tant que substituants un groupe alkyle inférieur-carbonyloxy (à substitution phényle ou substitution hétérocyclique) et un groupe phényle lié par un ester
EP2085387A1 (fr) * 2006-11-14 2009-08-05 Santen Pharmaceutical Co., Ltd Nouveau dérivé 1,2-dihydroquinoline comprenant un groupe alkyle inférieur phénylchalcogéno substitué et un groupe phényle introduit par un ester en tant que substituants

Also Published As

Publication number Publication date
EP2319835A1 (fr) 2011-05-11
MX2010012303A (es) 2011-03-30
KR20110010634A (ko) 2011-02-01
BRPI0912171B8 (pt) 2021-05-25
MY158747A (en) 2016-11-15
BRPI0912171B1 (pt) 2020-11-03
CN105395550A (zh) 2016-03-16
UA102101C2 (ru) 2013-06-10
CN102089283A (zh) 2011-06-08
US20110118260A1 (en) 2011-05-19
CN102089283B (zh) 2015-11-25
GEP20146061B (en) 2014-03-25
EA201071296A1 (ru) 2011-06-30
TWI510240B (zh) 2015-12-01
BRPI0912171A2 (pt) 2017-10-31
AU2009247250A1 (en) 2009-11-19
JP2009298775A (ja) 2009-12-24
CA2724055A1 (fr) 2009-11-19
AU2009247250B2 (en) 2014-04-10
TW200950781A (en) 2009-12-16
CN105395550B (zh) 2018-07-17
EP2319835B1 (fr) 2016-04-13
EA019091B1 (ru) 2014-01-30
CA2724055C (fr) 2016-08-02
BRPI0912171A8 (pt) 2017-12-12
WO2009139361A1 (fr) 2009-11-19
JP5635743B2 (ja) 2014-12-03
ES2574987T3 (es) 2016-06-23
US8426406B2 (en) 2013-04-23

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