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EA201071296A1 - Агонист глюкокортикоидного рецептора, включающий 2,2,4-триметил-6-фенил-1,2-дигидрохинолиновые производные, содержащие замещенную оксигруппу - Google Patents

Агонист глюкокортикоидного рецептора, включающий 2,2,4-триметил-6-фенил-1,2-дигидрохинолиновые производные, содержащие замещенную оксигруппу

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Publication number
EA201071296A1
EA201071296A1 EA201071296A EA201071296A EA201071296A1 EA 201071296 A1 EA201071296 A1 EA 201071296A1 EA 201071296 A EA201071296 A EA 201071296A EA 201071296 A EA201071296 A EA 201071296A EA 201071296 A1 EA201071296 A1 EA 201071296A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trimethyl
phenyl
oxype
glucocorticide
dihydrochinoline
Prior art date
Application number
EA201071296A
Other languages
English (en)
Other versions
EA019091B1 (ru
Inventor
Масатомо Като
Мива Такаи
Такахиро Мацуяма
Тацудзи Куросе
Юми Хагивара
Мамору Мацуда
Тосиюки Мори
Кендзи Имото
Ацуеси Дота
Original Assignee
Сантен Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантен Фармасьютикал Ко., Лтд. filed Critical Сантен Фармасьютикал Ко., Лтд.
Publication of EA201071296A1 publication Critical patent/EA201071296A1/ru
Publication of EA019091B1 publication Critical patent/EA019091B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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Abstract

Настоящее изобретение относится к агонистам глюкокортикоидного рецептора, представляющим собой соединение формулы (1), которое представляет собой 2,2,4-триметил-6-фенил-1,2-дигидрохинолиновое производное или его соль, и новым фармакологическим эффектам агонистов глюкокортикоидного рецептора. В формуле (1) Rпредставляет собой формулу (2а) , (3а), (4а) или (5а); Rпредставляет собой -(СО)-R, -(CO)O-Rили т.п.; R-O- замещен в 4 или 5 положении бензольного кольца А; Rпредставляет собой низшую алкильную группу; R, R, Rили Rпредставляют собой атом галогена, низшую алкильную группу, которая может содержать заместитель, или т.п.; m, n, p или q имеют значение 0, 1 или т.п.; R, Rили подобные представляют собой низшую алкильную группу, которая может содержать заместитель, низшую алкенильную группу или т.п.
EA201071296A 2008-05-12 2009-05-12 Агонист глюкокортикоидного рецептора, включающий 2,2,4-триметил-6-фенил-1,2-дигидрохинолиновые производные, содержащие замещенную оксигруппу EA019091B1 (ru)

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JP2013166752A (ja) * 2012-01-20 2013-08-29 Santen Pharmaceut Co Ltd １，２−ジヒドロキノリン誘導体またはその塩の工業的製造方法およびその製造中間体
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