EP2187893A4 - SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES - Google Patents

SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES

Info

Publication number: EP2187893A4
Authority: EP; European Patent Office
Prior art keywords: boronous; molecules; small; active substances; inflammatory active
Prior art date: 2008-03-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP09700012A

Other languages

German (de)

French (fr)

Other versions

EP2187893A2 (en

Inventor

Tsutomu Akama

Yong-Kang Zhang

Charles Z Ding

Jacob J Plattner

Kirk R Maples

Yvonne Freund

Virginia Sanders

Yi Xia

Stephen J Baker

James A Niemann

Xiaosong Lu

Marcelo Sales

Rashmi Sharma

Rajeshwar Singh

Robert Jacobs

Daitao Chen

Michael Richard Kevin Alley

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Anacor Pharmaceuticals LLC

Original Assignee

Anacor Pharmaceuticals LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-03-06

Filing date

2009-03-05

Publication date

2012-02-22

2009-03-05 Application filed by Anacor Pharmaceuticals LLC filed Critical Anacor Pharmaceuticals LLC

2009-03-05 Priority to EP17158536.7A priority Critical patent/EP3246034A1/en

2009-03-05 Priority to EP12178640.4A priority patent/EP2564857B1/en

2010-05-26 Publication of EP2187893A2 publication Critical patent/EP2187893A2/en

2012-02-22 Publication of EP2187893A4 publication Critical patent/EP2187893A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP09700012A 2008-03-06 2009-03-05 SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES Withdrawn EP2187893A4 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
EP17158536.7A EP3246034A1 (en)	2008-03-06	2009-03-05	Boron-containing small molecules as anti-inflammatory agents
EP12178640.4A EP2564857B1 (en)	2008-03-06	2009-03-05	Boron-containing small molecules as anti-inflammatory agents

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US3437108P	2008-03-06	2008-03-06
US5263708P	2008-05-12	2008-05-12
US9440608P	2008-09-04	2008-09-04
US10599008P	2008-10-16	2008-10-16
US11090308P	2008-11-03	2008-11-03
US14370009P	2009-01-09	2009-01-09
US14873109P	2009-01-30	2009-01-30
PCT/US2009/036250 WO2009111676A2 (en)	2008-03-06	2009-03-05	Boron-containing small molecules as anti-inflammatory agents

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
EP12178640.4A Division EP2564857B1 (en)	2008-03-06	2009-03-05	Boron-containing small molecules as anti-inflammatory agents
EP17158536.7A Division EP3246034A1 (en)	2008-03-06	2009-03-05	Boron-containing small molecules as anti-inflammatory agents

Publications (2)

Publication Number	Publication Date
EP2187893A2 EP2187893A2 (en)	2010-05-26
EP2187893A4 true EP2187893A4 (en)	2012-02-22

Family

ID=41056660

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP09700012A Withdrawn EP2187893A4 (en)	2008-03-06	2009-03-05	SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES

Country Status (2)

Country	Link
EP (1)	EP2187893A4 (en)
WO (1)	WO2009111676A2 (en)

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JP2009526751A (en)	2005-12-30	2009-07-23	アナコールファーマシューティカルズ，インコーポレイテッド	Boron-containing small molecule
RU2508113C2 (en)	2006-02-16	2014-02-27	Анакор Фармасьютикалз, Инк.	Boron-based small molecules as anti-inflammatory drugs
KR20150065941A (en)	2008-03-06	2015-06-15	아나코르 파마슈티칼스 인코포레이티드	Boron-containing small molecules as anti-inflammatory agents
WO2010028005A1 (en)	2008-09-04	2010-03-11	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
EP2348863A4 (en)	2008-09-04	2012-03-07	Anacor Pharmaceuticals Inc	SMALL MOLECULES CONTAINING BORON
US9493489B2 (en)	2008-10-15	2016-11-15	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as anti-protozoal agents
PE20120052A1 (en)	2008-12-17	2012-02-13	Anacor Pharmaceuticals Inc	(S) -3-AMINO-METHYL-7- (3-HYDROXY-PROPOXY) -3H-BENZO- [C] [1,2] -OXABOROL-1-OL POLYMORPHES
US8343944B2 (en)	2009-07-28	2013-01-01	Anacor Pharmaceuticals, Inc.	Trisubstituted boron-containing molecules
WO2011019618A1 (en)	2009-08-14	2011-02-17	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
US20110207701A1 (en)	2009-08-19	2011-08-25	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
WO2011049971A1 (en)	2009-10-20	2011-04-28	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antiprotozoal agents
US20110212918A1 (en)	2009-11-11	2011-09-01	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
WO2011063293A1 (en) *	2009-11-20	2011-05-26	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as antihelminth agents
US8716478B2 (en) *	2010-01-27	2014-05-06	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
US8623911B2 (en)	2010-03-19	2014-01-07	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as anti-protozoal agent
CN108610356B (en)	2010-09-07	2021-02-26	阿纳科制药公司	Benzoxaborole Derivatives for the Treatment of Bacterial Infections
EP3199531A1 (en)	2011-08-19	2017-08-02	Glaxo Group Limited	Benzofuran compounds for the treatment of hepatitis c virus infections
US10070649B2 (en)	2013-01-30	2018-09-11	Agrofresh Inc.	Volatile applications against pathogens
US9585396B2 (en)	2013-01-30	2017-03-07	Agrofresh Inc.	Volatile applications against pathogens
US8669207B1 (en)	2013-01-30	2014-03-11	Dow Agrosciences, Llc.	Compounds and compositions
NZ710723A (en)	2013-01-30	2019-12-20	Agrofresh Inc	Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts
US11039617B2 (en)	2013-01-30	2021-06-22	Agrofresh Inc.	Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
WO2016001834A1 (en)	2014-07-01	2016-01-07	Daiichi Sankyo Company, Limited	Tricyclic benzoxaboroles as antibacterial agents
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
RU2724053C2 (en)	2015-11-30	2020-06-19	Анакор Фармасьютикалз, Инк.	Pharmaceutical compositions for topical application for treating inflammation-related conditions
TW201735792A (en)	2016-03-07	2017-10-16	農業保鮮股份有限公司	Synergistic method using a benzoxaborole compound and an antiseptic gas as an antimicrobial agent for crops
US11447506B2 (en)	2016-05-09	2022-09-20	Anacor Pharmaceuticals, Inc.	Crystal forms of crisaborole in free form and preparation method and use thereof
WO2017203514A1 (en) *	2016-05-26	2017-11-30	Perrigo Api Ltd	Polymorphs of crisaborole and production processes therefor
US10961261B2 (en)	2017-03-01	2021-03-30	Anacor Pharmaceuticals, Inc.	Oxaborole analogs and uses thereof
WO2018207216A1 (en) *	2017-05-12	2018-11-15	Biophore India Pharmaceuticals Pvt. Ltd.	Novel process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (crisaborole)
US10865217B2 (en)	2017-05-23	2020-12-15	Msn Laboratories Private Limited, R & D Center	Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
AU2018375795A1 (en)	2017-11-30	2020-07-02	Boragen, Inc.	Benzoxaborole compounds and formulations thereof
WO2020041200A1 (en)	2018-08-18	2020-02-27	Boragen Inc.	Solid forms of substituted benzoxaborole and compositions thereof
BR112021005870B1 (en)	2018-10-05	2024-01-09	Pfizer Inc	PDE4 INHIBITORS CONTAINING BORON
TW202100526A (en)	2019-03-06	2021-01-01	日商第一三共股份有限公司	Pyrrolopyrazole derivatives
CN112174989B (en) *	2019-07-02	2023-06-20	江西同和药业股份有限公司	A kind of preparation method of crisborole
US20230340530A1 (en)	2020-08-31	2023-10-26	Pfizer Inc.	Methods of Protecting RNA
CN119894518A (en) *	2022-08-18	2025-04-25	米托迪治愈有限责任公司	Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or fatigue intolerance
CN116239498B (en) *	2023-05-11	2023-07-21	北京元延医药科技股份有限公司	The method for preparing crisborole intermediate

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US20060234981A1 (en) *	2005-02-16	2006-10-19	Anacor Pharmaceuticals	Boron-containing small molecules

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US6596985B2 (en) *	2000-02-22	2003-07-22	Rioch Company, Ltd.	Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
TW200722087A (en) *	2005-03-30	2007-06-16	Astion Dev As	Treatment of dermatological diseases and pruritus
RU2508113C2 (en) *	2006-02-16	2014-02-27	Анакор Фармасьютикалз, Инк.	Boron-based small molecules as anti-inflammatory drugs

2009
- 2009-03-05 WO PCT/US2009/036250 patent/WO2009111676A2/en not_active Ceased
- 2009-03-05 EP EP09700012A patent/EP2187893A4/en not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060234981A1 (en) *	2005-02-16	2006-10-19	Anacor Pharmaceuticals	Boron-containing small molecules

Also Published As

Publication number	Publication date
EP2187893A2 (en)	2010-05-26
WO2009111676A3 (en)	2010-04-01
WO2009111676A2 (en)	2009-09-11
WO2009111676A8 (en)	2010-09-30

Publication	Publication Date	Title
EP2187893A4 (en)	2012-02-22	SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES
DK2719388T3 (en)	2019-05-13	Boron-containing small molecules as anti-inflammatory agents
BRPI0919295A2 (en)	2015-12-15	1h-benzimidazole-5-carboxamides as anti-inflammatory agents.
EP2164331A4 (en)	2011-09-07	BORN SMALL MOLECULES
BRPI0913945A2 (en)	2016-09-27	anti-inflammatory agents
BRPI0917888A2 (en)	2014-02-25	STABLE NET ANTIBODY FORMULATION
BRPI0922845A2 (en)	2015-12-29	pyrazol-4-n-alkoxycarboxamides as microbiocides
NO20081639L (en)	2009-10-05	Device by chair
IL213353A (en)	2017-04-30	Anti-1l – pd antibodies and their use to enhance t cell function
EP3064512C0 (en)	2023-08-30	ANTIBODIES TO CLDN6
IL207955A0 (en)	2010-12-30	Boron - containing small molecules as anti - inflammatory agents
DK3750552T5 (en)	2024-08-26	GDF TRAPS
DOP2010000260A (en)	2010-10-15	FUSIONED HETEROCICLIC DERIVATIVE AND ITS USE
HRP20180718T1 (en)	2018-07-13	OLIGOPEPTID COMPOUNDS AND THEIR USE
SMT201500218B (en)	2015-10-30	Aryl-phenylsulfonamido-cycloalkyl compounds and their use
BRPI0908116A2 (en)	2015-10-06	spray
EP2321062A4 (en)	2014-10-29	sprayer
BRPI0914781A2 (en)	2015-08-04	Microbiocides
BRPI0908118A2 (en)	2015-10-06	fragrance dispenser
EP2340271A4 (en)	2014-11-19	CONJUGATES POLYMER-BIOACTIVE AGENT
BRPI0821498A2 (en)	2015-06-16	Burner structure
BRPI0923550A2 (en)	2016-01-26	potty
EP2310699A4 (en)	2012-08-22	WASHER
BRPI0911199A2 (en)	2016-04-26	microbiocides
BRPI0921483A2 (en)	2019-09-24	improved ethanol fermentation using biodigested

Legal Events

Date	Code	Title	Description
2010-04-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2010-05-26	17P	Request for examination filed	Effective date: 20090327
2010-05-26	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
2010-05-26	AX	Request for extension of the european patent	Extension state: AL BA RS
2011-02-11	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1144260 Country of ref document: HK
2011-03-16	RIN1	Information on inventor provided before grant (corrected)	Inventor name: ALLEY, MICHAEL RICHARD KEVIN Inventor name: CHEN, DAITAO Inventor name: JACOBS, ROBERT Inventor name: SINGH, RAJESHWAR Inventor name: SHARMA, RASHMI Inventor name: SALES, MARCELO Inventor name: LU, XIAOSONG Inventor name: NIEMANN, JAMES A. Inventor name: BAKER, STEPHEN J. Inventor name: XIA, YI Inventor name: SANDERS, VIRGINIA Inventor name: FREUND, YVONNE Inventor name: MAPLES, KIRK R. Inventor name: PLATTNER, JACOB J. Inventor name: DING, CHARLES Z. Inventor name: ZHANG, YONG-KANG Inventor name: AKAMA, TSUTOMU
2012-02-22	A4	Supplementary search report drawn up and despatched	Effective date: 20120125
2012-02-22	RIC1	Information provided on ipc code assigned before grant	Ipc: C07F 5/02 20060101ALI20120119BHEP Ipc: A61K 31/69 20060101AFI20120119BHEP
2013-01-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2013-02-27	18D	Application deemed to be withdrawn	Effective date: 20120824
2016-09-30	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1144260 Country of ref document: HK