EP2185560A4 - Heteroarylamidanaloge - Google Patents

Heteroarylamidanaloge

Info

Publication number: EP2185560A4
Authority: EP; European Patent Office
Prior art keywords: heteroarylamidanaloge
Prior art date: 2007-08-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP08797591A

Other languages

English (en)

French (fr)

Other versions

EP2185560A1 (de

Inventor

Rajagopal Bakthavatchalam

David C Ihle

Scott M Capitosti

David J Wustrow

Jun Yuan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

H Lundbeck AS

Original Assignee

H Lundbeck AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-10

Filing date

2008-08-11

Publication date

2011-10-05

2008-08-11 Application filed by H Lundbeck AS filed Critical H Lundbeck AS

2010-05-19 Publication of EP2185560A1 publication Critical patent/EP2185560A1/de

2011-10-05 Publication of EP2185560A4 publication Critical patent/EP2185560A4/de

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP08797591A 2007-08-10 2008-08-11 Heteroarylamidanaloge Withdrawn EP2185560A4 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95525007P	2007-08-10	2007-08-10
PCT/US2008/072760 WO2009023623A1 (en)	2007-08-10	2008-08-11	Heteroaryl amide analogues

Publications (2)

Publication Number	Publication Date
EP2185560A1 EP2185560A1 (de)	2010-05-19
EP2185560A4 true EP2185560A4 (de)	2011-10-05

Family

ID=40351102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08797591A Withdrawn EP2185560A4 (de)	2007-08-10	2008-08-11	Heteroarylamidanaloge

Country Status (14)

Country	Link
EP (1)	EP2185560A4 (de)
JP (2)	JP2010535816A (de)
KR (1)	KR20100066422A (de)
CN (1)	CN101778850A (de)
AU (1)	AU2008286946B2 (de)
BR (1)	BRPI0812594A2 (de)
CA (1)	CA2691512A1 (de)
CO (1)	CO6251319A2 (de)
EA (1)	EA020332B1 (de)
IL (1)	IL202550A0 (de)
NZ (1)	NZ582056A (de)
SG (1)	SG183699A1 (de)
UA (1)	UA99729C2 (de)
WO (1)	WO2009023623A1 (de)

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CN102395562A (zh) *	2009-04-14	2012-03-28	阿费克蒂斯制药股份公司	新的p2x7r拮抗剂及其用途
WO2012110190A1 (en) *	2011-02-17	2012-08-23	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
LT2707101T (lt)	2011-05-12	2019-05-27	Proteostasis Therapeutics, Inc.	Proteostazę reguliuojantys agentai
WO2012163456A1 (en) *	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
WO2012163792A1 (en) *	2011-05-27	2012-12-06	Affectis Pharmaceuticals Ag	Novel p2x7r antagonists and their use
MX2014000894A (es)	2011-07-22	2014-02-27	Actelion Pharmaceuticals Ltd	Derivados de amidas heterociclicas como antagonistas de receptores p2x7.
EA024204B1 (ru) *	2012-01-20	2016-08-31	Актелион Фармасьютиклз Лтд.	Производные гетероциклических амидов в качестве антагонистов p2xрецептора
JOP20130213B1 (ar) *	2012-07-17	2021-08-17	Takeda Pharmaceuticals Co	معارضات لمستقبلht3-5
WO2014091415A1 (en) *	2012-12-12	2014-06-19	Actelion Pharmaceuticals Ltd	Indole carboxamide derivatives as p2x7 receptor antagonists
AR094053A1 (es)	2012-12-18	2015-07-08	Actelion Pharmaceuticals Ltd	Derivados de indol carboxamida como antagonistas del receptor p2x₇
EP2956457B1 (de)	2013-01-22	2016-11-23	Actelion Pharmaceuticals Ltd	Heterocyclische amidderivate als p2x7-rezeptorantagonisten
CN104918617B (zh)	2013-01-22	2017-05-10	埃科特莱茵药品有限公司	作为p2x7受体拮抗剂的杂环酰胺衍生物
EA201591360A1 (ru)	2013-02-19	2016-03-31	Пфайзер Инк.	Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств
TWI644671B (zh) *	2013-03-14	2018-12-21	比利時商健生藥品公司	Ｐ２ｘ７調節劑
EP3321266A1 (de)	2013-03-14	2018-05-16	Janssen Pharmaceutica NV	P2x7-modulatoren
ES2689526T3 (es)	2013-03-14	2018-11-14	Janssen Pharmaceutica Nv	Moduladores de P2X7
JO3509B1 (ar)	2013-03-14	2020-07-05	Janssen Pharmaceutica Nv	معدلات p2x7
CA2918487C (en) *	2013-07-17	2021-08-03	Global Alliance For Tb Drug Development	Azaindole compounds, synthesis thereof, and methods of using the same
GB201317363D0 (en)	2013-10-01	2013-11-13	Eisai Ltd	Novel compounds
WO2015073528A1 (en)	2013-11-12	2015-05-21	Proteostasis Therapeutics, Inc.	Proteasome activity enhancing compounds
EP3172210B1 (de)	2014-07-24	2020-01-15	Pfizer Inc	Pyrazolopyrimidin verbindungen
AU2015298378B2 (en)	2014-08-06	2018-08-02	Pfizer Inc.	Imidazopyridazine compounds
ES2714048T3 (es)	2014-09-12	2019-05-24	Janssen Pharmaceutica Nv	Moduladores de P2X7
EP3201203B1 (de)	2014-09-29	2021-05-19	Takeda Pharmaceutical Company Limited	Kristalline form von 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indol-3-carboxamid
WO2016100281A1 (en)	2014-12-15	2016-06-23	Merck Patent Gmbh	Indole and azaindoles derivatives and their use in neurodegenerative diseases
JP6462493B2 (ja)	2015-05-29	2019-01-30	株式会社デンソー	進入判定装置、進入判定方法
CN108602775B (zh)	2016-01-14	2022-04-29	贝思以色列女会吏医学中心公司	肥大细胞调节剂及其用途
TW201819361A (zh)	2016-09-03	2018-06-01	印度商托仁特生技有限公司	新穎吲唑化合物
US20200102311A1 (en)	2018-09-28	2020-04-02	Janssen Pharmaceutica Nv	Monoacylglycerol Lipase Modulators
BR112021005896A2 (pt)	2018-09-28	2021-07-27	Janssen Pharmaceutica Nv	moduladores da monoacilglicerol lipase
CA3156100A1 (en)	2019-09-30	2021-04-08	Janssen Pharmaceutica Nv	Radiolabelled mgl pet ligands
KR20220157999A (ko)	2020-03-26	2022-11-29	얀센 파마슈티카 엔.브이.	모노아실글리세롤 리파아제 조절제
WO2022062991A1 (zh) *	2020-09-22	2022-03-31	苏州恩华生物医药科技有限公司	吲哚衍生物及其应用
WO2023198199A1 (zh) *	2022-04-15	2023-10-19	先声再明医药有限公司	膜缔合酪氨酸和苏氨酸激酶抑制剂

Citations (13)

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US4374846A (en) *	1979-08-02	1983-02-22	Kali-Chemie Pharma Gmbh	N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility
US4803198A (en) *	1981-08-08	1989-02-07	Kali-Chemie Pharma Gmbh	1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) *	1992-06-05	1995-03-21	Shell Research Limited	Fungicidal indole derivatives
US5424329A (en) *	1993-08-18	1995-06-13	Warner-Lambert Company	Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (de) *	2000-08-09	2003-05-14	Mitsubishi Pharma Corporation	Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
US20030199689A1 (en) *	2001-11-22	2003-10-23	Marc Nazare	New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) *	2002-12-20	2004-07-08	Bayer Healthcare Ag	Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (fr) *	2003-07-24	2005-02-03	Aventis Pharma S.A.	Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005014529A1 (en) *	2003-08-08	2005-02-17	Astrazeneca Ab	2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) *	2004-01-23	2005-07-28	Christopher Hulme	Vanilloid receptor ligands and their use in treatments
WO2006072736A1 (fr) *	2005-01-07	2006-07-13	Sanofi-Aventis	DERIVES DE N- (HETEROARYL) -1H-IND0LE-2-CARB0XAMIDΞS ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR VANILLOIDE TRPVl
WO2006100208A1 (en) *	2005-03-21	2006-09-28	N.V. Organon	1-benzylindole-2-carboxamide derivatives
US20070149602A1 (en) *	2004-08-05	2007-06-28	Sanofi-Aventis	N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their therapeutic use

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2008
- 2008-08-11 CN CN200880021498A patent/CN101778850A/zh active Pending
- 2008-08-11 WO PCT/US2008/072760 patent/WO2009023623A1/en active Application Filing
- 2008-08-11 NZ NZ582056A patent/NZ582056A/xx not_active IP Right Cessation
- 2008-08-11 UA UAA200913336A patent/UA99729C2/ru unknown
- 2008-08-11 KR KR1020097026704A patent/KR20100066422A/ko not_active Application Discontinuation
- 2008-08-11 AU AU2008286946A patent/AU2008286946B2/en not_active Ceased
- 2008-08-11 BR BRPI0812594-5A patent/BRPI0812594A2/pt not_active IP Right Cessation
- 2008-08-11 CA CA002691512A patent/CA2691512A1/en not_active Abandoned
- 2008-08-11 EP EP08797591A patent/EP2185560A4/de not_active Withdrawn
- 2008-08-11 SG SG2012058533A patent/SG183699A1/en unknown
- 2008-08-11 EA EA200971085A patent/EA020332B1/ru not_active IP Right Cessation
- 2008-08-11 JP JP2010520343A patent/JP2010535816A/ja not_active Ceased
2009
- 2009-12-06 IL IL202550A patent/IL202550A0/en unknown
- 2009-12-22 CO CO09146587A patent/CO6251319A2/es not_active Application Discontinuation
2014
- 2014-11-25 JP JP2014238138A patent/JP2015110566A/ja active Pending

Patent Citations (13)

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Publication number	Priority date	Publication date	Assignee	Title
US4374846A (en) *	1979-08-02	1983-02-22	Kali-Chemie Pharma Gmbh	N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility
US4803198A (en) *	1981-08-08	1989-02-07	Kali-Chemie Pharma Gmbh	1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) *	1992-06-05	1995-03-21	Shell Research Limited	Fungicidal indole derivatives
US5424329A (en) *	1993-08-18	1995-06-13	Warner-Lambert Company	Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (de) *	2000-08-09	2003-05-14	Mitsubishi Pharma Corporation	Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
US20030199689A1 (en) *	2001-11-22	2003-10-23	Marc Nazare	New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) *	2002-12-20	2004-07-08	Bayer Healthcare Ag	Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (fr) *	2003-07-24	2005-02-03	Aventis Pharma S.A.	Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005014529A1 (en) *	2003-08-08	2005-02-17	Astrazeneca Ab	2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) *	2004-01-23	2005-07-28	Christopher Hulme	Vanilloid receptor ligands and their use in treatments
US20070149602A1 (en) *	2004-08-05	2007-06-28	Sanofi-Aventis	N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their therapeutic use
WO2006072736A1 (fr) *	2005-01-07	2006-07-13	Sanofi-Aventis	DERIVES DE N- (HETEROARYL) -1H-IND0LE-2-CARB0XAMIDΞS ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR VANILLOIDE TRPVl
WO2006100208A1 (en) *	2005-03-21	2006-09-28	N.V. Organon	1-benzylindole-2-carboxamide derivatives

Non-Patent Citations (6)

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Title
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