EP2079748A4 - Forme pure de rapamycine et son procédé de récupération et de purification - Google Patents
Forme pure de rapamycine et son procédé de récupération et de purificationInfo
- Publication number
- EP2079748A4 EP2079748A4 EP06842776A EP06842776A EP2079748A4 EP 2079748 A4 EP2079748 A4 EP 2079748A4 EP 06842776 A EP06842776 A EP 06842776A EP 06842776 A EP06842776 A EP 06842776A EP 2079748 A4 EP2079748 A4 EP 2079748A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- rapamycin
- purification
- recovery
- pure form
- pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2079CH2006 | 2006-11-10 | ||
| PCT/IN2006/000502 WO2008056372A1 (fr) | 2006-11-10 | 2006-12-26 | Forme pure de rapamycine et son procédé de récupération et de purification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2079748A1 EP2079748A1 (fr) | 2009-07-22 |
| EP2079748A4 true EP2079748A4 (fr) | 2011-05-04 |
Family
ID=39364224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06842776A Withdrawn EP2079748A4 (fr) | 2006-11-10 | 2006-12-26 | Forme pure de rapamycine et son procédé de récupération et de purification |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100029933A1 (fr) |
| EP (1) | EP2079748A4 (fr) |
| JP (1) | JP2010509317A (fr) |
| KR (1) | KR20090080110A (fr) |
| AU (1) | AU2006350684B2 (fr) |
| BR (1) | BRPI0621967A2 (fr) |
| CA (1) | CA2669714A1 (fr) |
| MX (1) | MX2009005012A (fr) |
| RU (1) | RU2009122202A (fr) |
| WO (1) | WO2008056372A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7146409B1 (en) * | 2001-07-24 | 2006-12-05 | Brightplanet Corporation | System and method for efficient control and capture of dynamic database content |
| EP2090580B1 (fr) * | 2006-11-27 | 2014-06-04 | Terumo Kabushiki Kaisha | Procédé de fabrication d'un dérivé de rapamycine o-alkylé, et dérivé de rapamycine o-alkylée |
| JP5643770B2 (ja) * | 2009-01-21 | 2014-12-17 | バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ | シロリムスの安定性の決定方法およびその安定形態の調製方法 |
| CN102443012B (zh) * | 2010-10-13 | 2016-03-02 | 鲁南制药集团股份有限公司 | 一种从发酵液中提纯雷帕霉素的方法 |
| CN102464668B (zh) * | 2010-11-17 | 2015-04-29 | 浙江海正药业股份有限公司 | 雷帕霉素或其衍生物的制备色谱纯化方法 |
| CN102372726B (zh) * | 2011-11-08 | 2014-02-19 | 福建省微生物研究所 | 西罗莫司粗晶的制备方法 |
| WO2014072984A1 (fr) * | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Processus amélioré d'isolation et de purification de rapamycine à partir d'un bouillon de fermentation |
| WO2014145780A1 (fr) | 2013-03-15 | 2014-09-18 | Biosensors International Group, Ltd. | Purification de dérivés de rapamycine |
| KR102256576B1 (ko) | 2013-10-08 | 2021-05-27 | 에이아이 테라퓨틱스, 인코포레이티드 | 림프관평활근종증의 치료를 위한 라파마이신 |
| CA2944075C (fr) | 2014-04-04 | 2022-06-28 | Lam Therapeutics, Inc. | Preparation a inhaler contenant de la rapamycine pour traiter les pathologies liees a l'age |
| CA2963085C (fr) | 2014-10-07 | 2023-02-21 | Lam Therapeutics, Inc. | Formulation de rapamycine inhalable pour le traitement de l'hypertension pulmonaire |
| CN105585578B (zh) * | 2014-10-23 | 2017-12-05 | 重庆乾泰生物医药有限公司 | 一种雷帕霉素的制备方法 |
| CN104844620B (zh) * | 2015-04-10 | 2018-06-19 | 鲁南新时代生物技术有限公司 | 一种雷帕霉素的分离纯化方法 |
| CN105301159B (zh) * | 2015-10-29 | 2017-01-18 | 无锡福祈制药有限公司 | 一种西罗莫司的高效液相色谱分析方法 |
| CN108976245B (zh) * | 2017-11-09 | 2020-08-07 | 北大方正集团有限公司 | 一种雷帕霉素的提取方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| GB9125660D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compound |
| UA41884C2 (uk) * | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| US7232486B2 (en) * | 2003-03-31 | 2007-06-19 | TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság | Crystallization and purification of macrolides |
| AU2003269473A1 (en) * | 2003-08-26 | 2005-03-10 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| MX2007010716A (es) * | 2005-03-02 | 2008-01-16 | Wyeth Corp | Purificacion de rapamicina. |
-
2006
- 2006-12-26 EP EP06842776A patent/EP2079748A4/fr not_active Withdrawn
- 2006-12-26 WO PCT/IN2006/000502 patent/WO2008056372A1/fr active Application Filing
- 2006-12-26 US US12/514,356 patent/US20100029933A1/en not_active Abandoned
- 2006-12-26 JP JP2009535883A patent/JP2010509317A/ja active Pending
- 2006-12-26 CA CA002669714A patent/CA2669714A1/fr not_active Abandoned
- 2006-12-26 BR BRPI0621967-5A patent/BRPI0621967A2/pt not_active IP Right Cessation
- 2006-12-26 MX MX2009005012A patent/MX2009005012A/es not_active Application Discontinuation
- 2006-12-26 AU AU2006350684A patent/AU2006350684B2/en not_active Ceased
- 2006-12-26 KR KR1020097011577A patent/KR20090080110A/ko not_active Application Discontinuation
- 2006-12-26 RU RU2009122202/04A patent/RU2009122202A/ru not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009005012A (es) | 2009-09-07 |
| AU2006350684B2 (en) | 2012-07-05 |
| EP2079748A1 (fr) | 2009-07-22 |
| KR20090080110A (ko) | 2009-07-23 |
| BRPI0621967A2 (pt) | 2011-12-27 |
| US20100029933A1 (en) | 2010-02-04 |
| CA2669714A1 (fr) | 2008-05-15 |
| RU2009122202A (ru) | 2010-12-20 |
| JP2010509317A (ja) | 2010-03-25 |
| AU2006350684A1 (en) | 2008-05-15 |
| WO2008056372A1 (fr) | 2008-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2079748A4 (fr) | Forme pure de rapamycine et son procédé de récupération et de purification | |
| ZA200908605B (en) | Method for the purification of a gas containing co2 | |
| ZA200707523B (en) | Purification of rapamycin | |
| GB0608520D0 (en) | Method of separation | |
| IL207429A0 (en) | A method of purifying a peptide | |
| EP1996533A4 (fr) | Processus et système de purification de l'hydrogène | |
| GB0608190D0 (en) | Method of purification | |
| EP2233492A4 (fr) | Procédé de synthèse et de purification du sucralose | |
| GB0616004D0 (en) | Method of treating a gas stream | |
| EP2167429A4 (fr) | Procédé de purification d'hydrocarbures | |
| PL2032236T3 (pl) | Sposób obróbki strumienia gazu | |
| ZA200610740B (en) | Process for fine purification of 1-butenic streams | |
| PL1950176T3 (pl) | Sposób usuwania zanieczyszczeń ze strumieni gazu | |
| EP1968728A4 (fr) | Procede servant a extraire des impuretes d'un gaz | |
| GB0909588D0 (en) | Purification method | |
| HK1183286A1 (zh) | 從燃燒氣流中移除 的方法 | |
| ZA200810504B (en) | Process to prepare a synthesis gas | |
| EP2025662A4 (fr) | Procédé servant à purifier un coenzyme q10 réduit | |
| WO2007117760A3 (fr) | Préparation de gemcitabine | |
| HK1134295A1 (en) | Compounds and methods for synthesis and purification of oligonucleotides | |
| ZA200904863B (en) | Method of treating a gas stream | |
| EP2241566A4 (fr) | Procédé de séparation et de purification d'épothilones | |
| ZA200807897B (en) | Recovery process for precious metals | |
| GB0505852D0 (en) | Method of treating a gas stream | |
| EP1767565A4 (fr) | Oligoanilines et procédé de purification desdites oligoanilines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20090508 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20110331 |
|
| DAX | Request for extension of the european patent (deleted) | ||
| 17Q | First examination report despatched |
Effective date: 20121205 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20130416 |