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MX2007010716A - Purificacion de rapamicina. - Google Patents

Purificacion de rapamicina.

Info

Publication number
MX2007010716A
MX2007010716A MX2007010716A MX2007010716A MX2007010716A MX 2007010716 A MX2007010716 A MX 2007010716A MX 2007010716 A MX2007010716 A MX 2007010716A MX 2007010716 A MX2007010716 A MX 2007010716A MX 2007010716 A MX2007010716 A MX 2007010716A
Authority
MX
Mexico
Prior art keywords
rapamycin
purification
purified rapamycin
obtaining
chemical process
Prior art date
Application number
MX2007010716A
Other languages
English (en)
Inventor
Warren Chew
Chia-Cheng Shaw
Bogdan Kazimierz Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2007010716A publication Critical patent/MX2007010716A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe rapamicina purificada y un procedimiento quimico para obtener la rapamicina purificada.
MX2007010716A 2005-03-02 2006-02-22 Purificacion de rapamicina. MX2007010716A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65791005P 2005-03-02 2005-03-02
PCT/US2006/006212 WO2006093745A1 (en) 2005-03-02 2006-02-22 Purification of rapamycin

Publications (1)

Publication Number Publication Date
MX2007010716A true MX2007010716A (es) 2008-01-16

Family

ID=36568679

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010716A MX2007010716A (es) 2005-03-02 2006-02-22 Purificacion de rapamicina.

Country Status (15)

Country Link
US (1) US7384953B2 (es)
EP (1) EP1853612A1 (es)
JP (1) JP2008531686A (es)
KR (1) KR20070107087A (es)
CN (1) CN101133065A (es)
AU (1) AU2006218918A1 (es)
CA (1) CA2599582A1 (es)
CR (1) CR9297A (es)
IL (1) IL185077A0 (es)
MX (1) MX2007010716A (es)
NI (1) NI200700225A (es)
NO (1) NO20074102L (es)
RU (1) RU2007130406A (es)
WO (1) WO2006093745A1 (es)
ZA (1) ZA200707523B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040693A1 (es) 2002-07-30 2005-04-13 Wyeth Corp Formulaciones parenterales
EP2079748A4 (en) * 2006-11-10 2011-05-04 Biocon Ltd PURE FORM OF RAPAMYCIN AND ITS RECOVERY AND PURIFICATION PROCESS
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
EP2453874A2 (en) 2009-07-14 2012-05-23 Biogen Idec MA Inc. Methods for inhibiting yellow color and peroxide formation in a composition
CN102443012B (zh) * 2010-10-13 2016-03-02 鲁南制药集团股份有限公司 一种从发酵液中提纯雷帕霉素的方法
CN103705925B (zh) 2012-09-29 2018-03-30 段磊 抑制PI3K/AKT/mTOR信号通路的药物组合
US9750728B2 (en) 2012-09-29 2017-09-05 Targeted Therapeutics, Llc Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
WO2014145780A1 (en) * 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
KR102256576B1 (ko) 2013-10-08 2021-05-27 에이아이 테라퓨틱스, 인코포레이티드 림프관평활근종증의 치료를 위한 라파마이신
CA2944075C (en) * 2014-04-04 2022-06-28 Lam Therapeutics, Inc. An inhalable rapamycin formulation for treating age-related conditions
CA2963085C (en) 2014-10-07 2023-02-21 Lam Therapeutics, Inc. An inhalable rapamycin formulation for the treatment of pulmonary hypertension
WO2016130645A1 (en) 2015-02-10 2016-08-18 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
CA3032473A1 (en) 2016-08-10 2018-02-15 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
CN109369680A (zh) * 2018-12-24 2019-02-22 江苏卓和药业有限公司 一种依维莫司的纯化方法
CN109485657A (zh) * 2018-12-24 2019-03-19 江苏卓和药业有限公司 一种替西罗莫司的纯化方法
CN109369679A (zh) * 2018-12-24 2019-02-22 江苏卓和药业有限公司 一种雷帕霉素的精制方法
MX2021010058A (es) 2019-02-20 2021-11-12 Ai Therapeutics Inc Formulaciones de rapamicina tópicas y su uso en el tratamiento de angiofibromas faciales y otros trastornos de la piel.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
CA2528173A1 (en) * 2003-07-16 2005-02-03 Wyeth Cci-779 isomer c
KR20060057605A (ko) * 2003-08-07 2006-05-26 와이어쓰 Ｃｃｉ-779의 위치선택적 합성 방법

Also Published As

Publication number Publication date
NO20074102L (no) 2007-09-26
US20060199954A1 (en) 2006-09-07
CN101133065A (zh) 2008-02-27
JP2008531686A (ja) 2008-08-14
NI200700225A (es) 2008-07-03
CA2599582A1 (en) 2006-09-08
AU2006218918A1 (en) 2006-09-08
EP1853612A1 (en) 2007-11-14
IL185077A0 (en) 2007-12-03
KR20070107087A (ko) 2007-11-06
CR9297A (es) 2008-01-21
RU2007130406A (ru) 2009-04-10
ZA200707523B (en) 2010-02-24
US7384953B2 (en) 2008-06-10
WO2006093745A1 (en) 2006-09-08

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