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NI200700225A - Purificación de rapamicina - Google Patents

Purificación de rapamicina

Info

Publication number
NI200700225A
NI200700225A NI200700225A NI200700225A NI200700225A NI 200700225 A NI200700225 A NI 200700225A NI 200700225 A NI200700225 A NI 200700225A NI 200700225 A NI200700225 A NI 200700225A NI 200700225 A NI200700225 A NI 200700225A
Authority
NI
Nicaragua
Prior art keywords
rapamycin
purification
purified rapamycin
chemical method
obtaining
Prior art date
Application number
NI200700225A
Other languages
English (en)
Inventor
Chia-Cheng Shaw
Warren Chew
Bogdan Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NI200700225A publication Critical patent/NI200700225A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe rapamicina purificada y un procedimiento químico para obtener la rapamicina purificada.
NI200700225A 2005-03-02 2007-08-30 Purificación de rapamicina NI200700225A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65791005P 2005-03-02 2005-03-02

Publications (1)

Publication Number Publication Date
NI200700225A true NI200700225A (es) 2008-07-03

Family

ID=36568679

Family Applications (1)

Application Number Title Priority Date Filing Date
NI200700225A NI200700225A (es) 2005-03-02 2007-08-30 Purificación de rapamicina

Country Status (15)

Country Link
US (1) US7384953B2 (es)
EP (1) EP1853612A1 (es)
JP (1) JP2008531686A (es)
KR (1) KR20070107087A (es)
CN (1) CN101133065A (es)
AU (1) AU2006218918A1 (es)
CA (1) CA2599582A1 (es)
CR (1) CR9297A (es)
IL (1) IL185077A0 (es)
MX (1) MX2007010716A (es)
NI (1) NI200700225A (es)
NO (1) NO20074102L (es)
RU (1) RU2007130406A (es)
WO (1) WO2006093745A1 (es)
ZA (1) ZA200707523B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2493878C (en) 2002-07-30 2013-07-23 Wyeth Parenteral formulations containing a rapamycin hydroxyester
US20100029933A1 (en) * 2006-11-10 2010-02-04 Biocon Limited Pure form of rapamycin and a process for recovery and purification thereof
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20120183531A1 (en) 2009-07-14 2012-07-19 Biogen Idee Ma Inc Methods for Inhibiting Yellow Color Formation in a Composition
CN102443012B (zh) * 2010-10-13 2016-03-02 鲁南制药集团股份有限公司 一种从发酵液中提纯雷帕霉素的方法
CN103705925B (zh) 2012-09-29 2018-03-30 段磊 抑制PI3K/AKT/mTOR信号通路的药物组合
US9750728B2 (en) 2012-09-29 2017-09-05 Targeted Therapeutics, Llc Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
SG11201507406YA (en) 2013-03-15 2015-10-29 Biosensors Int Group Ltd Purification of rapamycin derivatives
CA2926719C (en) 2013-10-08 2020-11-24 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
HRP20230863T1 (hr) 2014-04-04 2023-11-10 AI Therapeutics, Inc. Inhalacijska formulacija rapamicina, namijenjena liječenju stanja povezanih sa starenjem
US20170304276A1 (en) 2014-10-07 2017-10-26 Lam Therapeutics, Inc. An inhalable rapamycin formulation for the treatment of pulmonary hypertension
WO2016130645A1 (en) 2015-02-10 2016-08-18 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
CA3032473A1 (en) 2016-08-10 2018-02-15 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
CN109369679A (zh) * 2018-12-24 2019-02-22 江苏卓和药业有限公司 一种雷帕霉素的精制方法
CN109485657A (zh) * 2018-12-24 2019-03-19 江苏卓和药业有限公司 一种替西罗莫司的纯化方法
CN109369680A (zh) * 2018-12-24 2019-02-22 江苏卓和药业有限公司 一种依维莫司的纯化方法
CN113710232A (zh) 2019-02-20 2021-11-26 人工智能治疗公司 局部雷帕霉素制剂及其在治疗面部血管纤维瘤和其他皮肤病中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
EP1646635A1 (en) 2003-07-16 2006-04-19 Wyeth Cci-779 isomer c
KR20060057605A (ko) 2003-08-07 2006-05-26 와이어쓰 Ｃｃｉ-779의 위치선택적 합성 방법

Also Published As

Publication number Publication date
EP1853612A1 (en) 2007-11-14
CA2599582A1 (en) 2006-09-08
AU2006218918A1 (en) 2006-09-08
NO20074102L (no) 2007-09-26
CN101133065A (zh) 2008-02-27
US20060199954A1 (en) 2006-09-07
MX2007010716A (es) 2008-01-16
RU2007130406A (ru) 2009-04-10
CR9297A (es) 2008-01-21
US7384953B2 (en) 2008-06-10
KR20070107087A (ko) 2007-11-06
WO2006093745A1 (en) 2006-09-08
JP2008531686A (ja) 2008-08-14
IL185077A0 (en) 2007-12-03
ZA200707523B (en) 2010-02-24

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