EE04592B1 - Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt - Google Patents

Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Info

Publication number: EE04592B1
Authority: EE; Estonia
Prior art keywords: preparation; intermediates; product; pharmaceutical composition; respiratory syncytial
Prior art date: 1999-06-28

Application number

EEP200100694A

Other languages

English (en)

Estonian (et)

Inventor

Eduard Janssens Frans

Fernand Armand Lacrampe Jean

Emile Georges Guillemont J�r�me

Gaston Venet Marc

Jozef Lodewijk Marcel Andries Koenraad

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-28

Filing date

2000-06-20

Publication date

2006-02-15

2000-06-20 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2003-02-17 Publication of EE200100694A publication Critical patent/EE200100694A/xx

2006-02-15 Publication of EE04592B1 publication Critical patent/EE04592B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

EEP200100694A 1999-06-28 2000-06-20 Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt EE04592B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99202089		1999-06-28
PCT/EP2000/005677 WO2001000615A1 (en)	1999-06-28	2000-06-20	Respiratory syncytial virus replication inhibitors

Publications (2)

Publication Number	Publication Date
EE200100694A EE200100694A (et)	2003-02-17
EE04592B1 true EE04592B1 (et)	2006-02-15

Family

ID=8240374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100694A EE04592B1 (et)	1999-06-28	2000-06-20	Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Country Status (34)

Country	Link
US (2)	US7071192B1 (de)
EP (2)	EP1400519B1 (de)
JP (1)	JP2003503403A (de)
KR (1)	KR100731273B1 (de)
CN (1)	CN1171887C (de)
AR (1)	AR024495A1 (de)
AT (2)	ATE259796T1 (de)
AU (1)	AU774829B2 (de)
BG (1)	BG65373B1 (de)
BR (1)	BR0011997A (de)
CA (1)	CA2376785A1 (de)
CZ (1)	CZ20014573A3 (de)
DE (2)	DE60008382T2 (de)
DK (1)	DK1196410T3 (de)
EA (1)	EA004746B1 (de)
EE (1)	EE04592B1 (de)
ES (2)	ES2215670T3 (de)
HK (1)	HK1045998B (de)
HR (2)	HRP20010934A2 (de)
HU (1)	HUP0201789A3 (de)
IL (2)	IL147328A0 (de)
MX (1)	MXPA02000117A (de)
MY (1)	MY129810A (de)
NO (1)	NO321599B1 (de)
NZ (1)	NZ515392A (de)
PL (1)	PL200694B1 (de)
PT (1)	PT1196410E (de)
SI (1)	SI1196410T1 (de)
SK (1)	SK18952001A3 (de)
TR (2)	TR200103805T2 (de)
TW (1)	TWI267513B (de)
UA (1)	UA75866C2 (de)
WO (1)	WO2001000615A1 (de)
ZA (1)	ZA200110473B (de)

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RU2263674C2 (ru) *	2000-01-17	2005-11-10	Тейдзин Лимитед	Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе
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ATE301653T1 (de)	2000-12-15	2005-08-15	Glaxo Group Ltd	Pyrazolopyridine
WO2002048148A2 (en)	2000-12-15	2002-06-20	Glaxo Group Limited	Pyrazolopyridine derivatives
US6774134B2 (en)	2000-12-20	2004-08-10	Bristol-Myers Squibb Company	Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
JP2004529119A (ja)	2001-03-08	2004-09-24	スミスクラインビーチャムコーポレーション	ピラゾロピリジン誘導体
WO2002078700A1 (en)	2001-03-30	2002-10-10	Smithkline Beecham Corporation	Pyralopyridines, process for their preparation and use as therapteutic compounds
US7141569B2 (en)	2001-04-10	2006-11-28	Smithkline Beecham Corporation	Antiviral pyrazolopyridine compounds
ATE296826T1 (de)	2001-04-27	2005-06-15	Smithkline Beecham Corp	Pyrazolo(1,5)pyridinderivate
US7030150B2 (en)	2001-05-11	2006-04-18	Trimeris, Inc.	Benzimidazole compounds and antiviral uses thereof
JP2005500315A (ja)	2001-06-21	2005-01-06	スミスクラインビーチャムコーポレーション	ヘルペスウイルス感染の予防および治療用イミダゾ［１，２−ａ］ピリジン誘導体
EP1432712B1 (de)	2001-10-05	2006-05-17	SmithKline Beecham Corporation	Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
US6919331B2 (en)	2001-12-10	2005-07-19	Bristol-Myers Squibb Company	Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2003050120A1 (en)	2001-12-11	2003-06-19	Smithkline Beecham Corporation	Pyrazolo-pyridine derivatives as antiherpes agents
US7244847B2 (en) *	2002-02-06	2007-07-17	Isis Pharmaceuticals, Inc.	Benzimidazole compounds
WO2004014316A2 (en)	2002-08-09	2004-02-19	Viropharma Incorporated	Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
CA2495245A1 (en)	2002-08-09	2004-02-19	Viropharma Incorporated	Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
JP2006504728A (ja)	2002-10-03	2006-02-09	スミスクラインビーチャムコーポレーション	ピラソロピリジン誘導体系治療用化合物
US7323567B2 (en)	2003-10-30	2008-01-29	Boehringer Ingelheim (Canada) Ltd.	RSV polymerase inhibitors
CN1914196B (zh) *	2003-12-18	2012-01-25	泰博特克药品有限公司	作为呼吸道合胞病毒复制抑制剂的5-或6-取代的苯并咪唑衍生物
US7355051B2 (en) *	2003-12-18	2008-04-08	Tibotec Pharmaceuticals	Piperdine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
RU2332414C2 (ru) *	2003-12-18	2008-08-27	Тиботек Фармасьютикалз Лтд.	Производные аминобензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
CN1894236B (zh) *	2003-12-18	2011-08-17	泰博特克药品有限公司	作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物
AR046959A1 (es) *	2003-12-18	2006-01-04	Tibotec Pharm Ltd	Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
NZ547796A (en) *	2003-12-18	2009-04-30	Tibotec Pharm Ltd	Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
AU2006224533B9 (en) *	2005-03-17	2012-06-21	Janssen Sciences Ireland Uc	1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
ES2444690T3 (es) *	2005-06-20	2014-02-26	Janssen R&D Ireland	Bencimidazoles sustituidos con heterociclilaminoalquilo.
BRPI0612628B8 (pt)	2005-06-20	2021-05-25	Janssen R & D Ireland	1-(2-amina-3-(alquil substituído)-3h-benzimidazolil)metil]-3-substituído-1,3-diidro-benzoimidazol-2-onas com atividade sobre vírus sincicial respiratório, seu processo de preparação e composição farmacêutica que os compreende
CL2008001003A1 (es)	2007-04-11	2008-10-17	Actelion Pharmaceuticals Ltd	Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
US20110190336A1 (en) *	2008-10-16	2011-08-04	Cara Therapeutics, Inc.	Azabenzimidazolones
JP5487692B2 (ja)	2009-04-10	2014-05-07	国立大学法人京都大学	複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en)	2009-06-30	2015-03-31	Siga Technologies, Inc.	Treatment and prevention of dengue virus infections
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2000
- 2000-06-20 EP EP03102464A patent/EP1400519B1/de not_active Expired - Lifetime
- 2000-06-20 ES ES00936899T patent/ES2215670T3/es not_active Expired - Lifetime
- 2000-06-20 EA EA200200086A patent/EA004746B1/ru not_active IP Right Cessation
- 2000-06-20 DE DE60008382T patent/DE60008382T2/de not_active Expired - Fee Related
- 2000-06-20 DE DE60033859T patent/DE60033859T2/de not_active Expired - Fee Related
- 2000-06-20 AT AT00936899T patent/ATE259796T1/de not_active IP Right Cessation
- 2000-06-20 SI SI200030358T patent/SI1196410T1/xx unknown
- 2000-06-20 TR TR2001/03805T patent/TR200103805T2/xx unknown
- 2000-06-20 CA CA002376785A patent/CA2376785A1/en not_active Abandoned
- 2000-06-20 BR BR0011997-0A patent/BR0011997A/pt not_active Application Discontinuation
- 2000-06-20 PL PL352385A patent/PL200694B1/pl not_active IP Right Cessation
- 2000-06-20 NZ NZ515392A patent/NZ515392A/xx unknown
- 2000-06-20 EP EP00936899A patent/EP1196410B1/de not_active Expired - Lifetime
- 2000-06-20 CZ CZ20014573A patent/CZ20014573A3/cs unknown
- 2000-06-20 CN CNB008095302A patent/CN1171887C/zh not_active Expired - Fee Related
- 2000-06-20 MX MXPA02000117A patent/MXPA02000117A/es active IP Right Grant
- 2000-06-20 EE EEP200100694A patent/EE04592B1/xx not_active IP Right Cessation
- 2000-06-20 AT AT03102464T patent/ATE356121T1/de not_active IP Right Cessation
- 2000-06-20 KR KR1020017015284A patent/KR100731273B1/ko not_active IP Right Cessation
- 2000-06-20 ES ES03102464T patent/ES2283716T3/es not_active Expired - Lifetime
- 2000-06-20 PT PT00936899T patent/PT1196410E/pt unknown
- 2000-06-20 IL IL14732800A patent/IL147328A0/xx active IP Right Grant
- 2000-06-20 SK SK1895-2001A patent/SK18952001A3/sk unknown
- 2000-06-20 HU HU0201789A patent/HUP0201789A3/hu unknown
- 2000-06-20 US US10/019,376 patent/US7071192B1/en not_active Expired - Fee Related
- 2000-06-20 AU AU52222/00A patent/AU774829B2/en not_active Ceased
- 2000-06-20 JP JP2001507023A patent/JP2003503403A/ja not_active Withdrawn
- 2000-06-20 TR TR2005/00707T patent/TR200500707T2/xx unknown
- 2000-06-20 UA UA2002010361A patent/UA75866C2/uk unknown
- 2000-06-20 DK DK00936899T patent/DK1196410T3/da active
- 2000-06-20 WO PCT/EP2000/005677 patent/WO2001000615A1/en active Application Filing
- 2000-06-26 TW TW089112479A patent/TWI267513B/zh not_active IP Right Cessation
- 2000-06-27 MY MYPI20002914A patent/MY129810A/en unknown
- 2000-06-27 AR ARP000103222A patent/AR024495A1/es unknown
2001
- 2001-12-19 HR HR20010934A patent/HRP20010934A2/hr not_active Application Discontinuation
- 2001-12-20 ZA ZA200110473A patent/ZA200110473B/xx unknown
- 2001-12-26 IL IL147328A patent/IL147328A/en not_active IP Right Cessation
- 2001-12-27 NO NO20016370A patent/NO321599B1/no unknown
2002
- 2002-01-08 BG BG106288A patent/BG65373B1/bg unknown
- 2002-10-21 HK HK02107623.8A patent/HK1045998B/zh not_active IP Right Cessation
2005
- 2005-10-11 US US11/247,392 patent/US7407969B2/en not_active Expired - Fee Related
2008
- 2008-08-12 HR HR20080390A patent/HRP20080390A2/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE356121T1 (de)	2007-03-15
BR0011997A (pt)	2002-03-05
ATE259796T1 (de)	2004-03-15
HRP20080390A2 (en)	2008-12-31
EP1400519A1 (de)	2004-03-24
KR100731273B1 (ko)	2007-06-21
AU774829B2 (en)	2004-07-08
KR20020000815A (ko)	2002-01-05
ES2283716T3 (es)	2007-11-01
UA75866C2 (en)	2006-06-15
PL200694B1 (pl)	2009-01-30
EE200100694A (et)	2003-02-17
TR200103805T2 (tr)	2002-06-21
DK1196410T3 (da)	2004-06-28
AU5222200A (en)	2001-01-31
TR200500707T2 (tr)	2005-04-21
US7071192B1 (en)	2006-07-04
CN1358182A (zh)	2002-07-10
WO2001000615A1 (en)	2001-01-04
HUP0201789A3 (en)	2003-12-29
MY129810A (en)	2007-05-31
HUP0201789A2 (hu)	2002-11-28
US7407969B2 (en)	2008-08-05
US20060058309A1 (en)	2006-03-16
CZ20014573A3 (cs)	2002-05-15
AR024495A1 (es)	2002-10-02
NO20016370L (no)	2001-12-27
TWI267513B (en)	2006-12-01
NZ515392A (en)	2004-03-26
DE60008382T2 (de)	2004-12-02
EP1196410B1 (de)	2004-02-18
HK1045998A1 (en)	2002-12-20
PL352385A1 (en)	2003-08-25
SI1196410T1 (en)	2004-08-31
DE60008382D1 (en)	2004-03-25
BG106288A (en)	2002-10-31
CN1171887C (zh)	2004-10-20
JP2003503403A (ja)	2003-01-28
NO20016370D0 (no)	2001-12-27
MXPA02000117A (es)	2002-07-02
CA2376785A1 (en)	2001-01-04
DE60033859T2 (de)	2007-11-08
ES2215670T3 (es)	2004-10-16
DE60033859D1 (de)	2007-04-19
EA200200086A1 (ru)	2002-06-27
EP1196410A1 (de)	2002-04-17
NO321599B1 (no)	2006-06-06
EP1400519B1 (de)	2007-03-07
ZA200110473B (en)	2003-03-20
HK1045998B (zh)	2005-06-03
BG65373B1 (bg)	2008-04-30
SK18952001A3 (sk)	2002-11-06
IL147328A (en)	2007-06-03
WO2001000615A8 (en)	2002-01-10
HRP20010934A2 (en)	2003-06-30
IL147328A0 (en)	2002-08-14
EA004746B1 (ru)	2004-08-26
PT1196410E (pt)	2004-07-30

Publication	Publication Date	Title
EE04591B1 (et)	2006-02-15	Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt
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EE200100692A (et)	2003-02-17	Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende kasutamine ja valmistamismeetod, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt
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IL208891A0 (en)	2011-01-31	Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
EE200200017A (et)	2003-04-15	Kinuklidiinderivaadid, nende valmistamismeetod, vaheühendid, farmatseutiline kompositsioon ja nendekasutamine
EE200100684A (et)	2003-04-15	Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200300327A (et)	2003-10-15	Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon
NO329884B1 (no)	2011-01-17	Indolderivater, farmasoytisk formulering, anvendelse av forbindelsene, fremgangsmate for fremstilling derav samt mellomprodukter for anvendelse i fremgangsmaten
EE05217B1 (et)	2009-10-15	Atslitud indanlamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat
NO20040282L (no)	2004-01-21	Hepatit C virus-polymerase-inhibitorer, samt anvendelse og fremgangsmåte for fremstilling derav og farmasøytisk preparat
AU2003299790A8 (en)	2004-07-22	Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
EE200000620A (et)	2002-04-15	3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
HUP0301683A3 (en)	2004-11-29	Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral indopeptidase, their intermediates, process for their preparation, pharmaceutical compositions containing them and their use
EE200200655A (et)	2004-08-16	5-kloro-3-(4-metaansulfonüülfenüül)-6'-metüül[2,3']bipüridinüüli polümorfne vorm, selle valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE04917B1 (et)	2007-10-15	Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine
EE200100653A (et)	2003-02-17	Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
HUP0204563A3 (en)	2004-12-28	Process for preparation of 3,3-diarylpropylamine derivatives and their intermediates and their use for preparation of pharmaceutical compositions
EE04812B1 (et)	2007-04-16	2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon
FR2872164B1 (fr)	2006-11-17	Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
EE04718B1 (et)	2006-10-16	PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod
EE200200637A (et)	2004-04-15	Torasemiidi uudne polümorf V, selle valmistamismeetod, kasutamine ja ravimvorm
NO20031108D0 (no)	2003-03-11	Farmasöytisk preparat for behandling av hodepine, og fremgangsmåte for fremstilling av preparatet
EE200000752A (et)	2002-04-15	Alfa-D-ksüloosiühendid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon

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