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HK1045998B - 呼吸道合胞病毒複製抑制劑 - Google Patents

呼吸道合胞病毒複製抑制劑

Info

Publication number
HK1045998B
HK1045998B HK02107623.8A HK02107623A HK1045998B HK 1045998 B HK1045998 B HK 1045998B HK 02107623 A HK02107623 A HK 02107623A HK 1045998 B HK1045998 B HK 1045998B
Authority
HK
Hong Kong
Prior art keywords
respiratory syncytial
syncytial virus
virus replication
replication inhibitors
inhibitors
Prior art date
Application number
HK02107623.8A
Other languages
English (en)
Other versions
HK1045998A1 (en
Inventor
Eduard Janssens Frans
Fernand Armand Lacrampe Jean
Emile Georges Guillemont Jerome
Gaston Venet Marc
Jozef Lodenwijk Marcel Andries Koenraad
Original Assignee
詹森葯業有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 詹森葯業有限公司 filed Critical 詹森葯業有限公司
Publication of HK1045998A1 publication Critical patent/HK1045998A1/xx
Publication of HK1045998B publication Critical patent/HK1045998B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK02107623.8A 1999-06-28 2002-10-21 呼吸道合胞病毒複製抑制劑 HK1045998B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28
PCT/EP2000/005677 WO2001000615A1 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (2)

Publication Number Publication Date
HK1045998A1 HK1045998A1 (en) 2002-12-20
HK1045998B true HK1045998B (zh) 2005-06-03

Family

ID=8240374

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107623.8A HK1045998B (zh) 1999-06-28 2002-10-21 呼吸道合胞病毒複製抑制劑

Country Status (34)

Country Link
US (2) US7071192B1 (zh)
EP (2) EP1196410B1 (zh)
JP (1) JP2003503403A (zh)
KR (1) KR100731273B1 (zh)
CN (1) CN1171887C (zh)
AR (1) AR024495A1 (zh)
AT (2) ATE259796T1 (zh)
AU (1) AU774829B2 (zh)
BG (1) BG65373B1 (zh)
BR (1) BR0011997A (zh)
CA (1) CA2376785A1 (zh)
CZ (1) CZ20014573A3 (zh)
DE (2) DE60033859T2 (zh)
DK (1) DK1196410T3 (zh)
EA (1) EA004746B1 (zh)
EE (1) EE04592B1 (zh)
ES (2) ES2283716T3 (zh)
HK (1) HK1045998B (zh)
HR (2) HRP20010934A2 (zh)
HU (1) HUP0201789A3 (zh)
IL (2) IL147328A0 (zh)
MX (1) MXPA02000117A (zh)
MY (1) MY129810A (zh)
NO (1) NO321599B1 (zh)
NZ (1) NZ515392A (zh)
PL (1) PL200694B1 (zh)
PT (1) PT1196410E (zh)
SI (1) SI1196410T1 (zh)
SK (1) SK18952001A3 (zh)
TR (2) TR200500707T2 (zh)
TW (1) TWI267513B (zh)
UA (1) UA75866C2 (zh)
WO (1) WO2001000615A1 (zh)
ZA (1) ZA200110473B (zh)

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US6495580B1 (en) 1998-01-29 2002-12-17 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US20040010004A1 (en) 2000-01-17 2004-01-15 Naoki Tsuchiya Benzimidazole derivatives
AU758789B2 (en) 1998-07-15 2003-03-27 Teijin Limited Thiobenzimidazole derivatives
CN100415723C (zh) * 2000-01-17 2008-09-03 帝人株式会社 苯并咪唑衍生物
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
ES2243579T3 (es) 2000-12-15 2005-12-01 Glaxo Group Ltd Derivados de pirazolopirideno.
US6919352B2 (en) 2000-12-15 2005-07-19 Smithkline Beecham Corporation Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
DE60201074T2 (de) 2001-03-08 2005-09-15 Smithkline Beecham Corp. Pyrazolopyridinderivate
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
WO2002083672A1 (en) 2001-04-10 2002-10-24 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
WO2002088124A2 (en) 2001-04-27 2002-11-07 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
HUP0400266A2 (hu) 2001-06-21 2004-08-30 Smithkline Beecham Corp. Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére
WO2003031446A1 (en) * 2001-10-05 2003-04-17 Smithkline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
DE60222465T2 (de) 2001-12-11 2008-06-05 Smithkline Beecham Corp. Pyrazolopyridin-derivate als antiherpesmittel
US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US8202896B2 (en) 2002-08-09 2012-06-19 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1546148A1 (en) 2002-10-03 2005-06-29 SmithKline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
JP4537407B2 (ja) 2003-10-30 2010-09-01 ベーリンガー インゲルハイム （カナダ） リミテッド Ｒｓｖポリメラーゼインヒビター
WO2005058870A1 (en) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
BRPI0417668A (pt) * 2003-12-18 2007-04-03 Tibotec Pharm Ltd derivados de piperidina-amino-benzimidazol como inibidores de replicação do vìrus sincicial respiratório
TWI378926B (en) * 2003-12-18 2012-12-11 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
TWI382981B (zh) * 2003-12-18 2013-01-21 Tibotec Pharm Ltd 作為呼吸道融合病毒複製抑制劑之５-或６-經取代的苯并咪唑衍生物
NZ547796A (en) 2003-12-18 2009-04-30 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
CA2600507C (en) * 2005-03-17 2013-10-22 Tibotec Pharmaceuticals Ltd. 1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
EP1896473B1 (en) * 2005-06-20 2011-10-19 Tibotec Pharmaceuticals 1-[[2-amino-3-(substituted alkyl)-3h-benzimidazolyl]methyl]-3-subtituted-1,3-dihydro-benzoimidazol-2-ones as inhibitors of respiratory syncytial virus replication
WO2006136562A1 (en) 2005-06-20 2006-12-28 Tibotec Pharmaceuticals Ltd Heterocyclylaminoalkyl substituted benzimidazoles
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
WO2010045276A2 (en) * 2008-10-16 2010-04-22 Cara Therapeutics, Inc. Azabenzimidazolones
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
AU2010266570A1 (en) * 2009-06-30 2012-01-19 Siga Technologies, Inc. Treatment and prevention of Dengue virus infections
CN103781786A (zh) 2011-07-15 2014-05-07 盐野义制药株式会社 具有ampk活化作用的氮杂苯并咪唑衍生物
SG11201501036RA (en) 2012-08-23 2015-03-30 Alios Biopharma Inc Compounds for the treatment of paramoxyvirus viral infections
JP2016079168A (ja) 2014-10-17 2016-05-16 塩野義製薬株式会社 ９員縮合環誘導体

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Also Published As

Publication number Publication date
JP2003503403A (ja) 2003-01-28
NO20016370L (no) 2001-12-27
TR200103805T2 (tr) 2002-06-21
IL147328A (en) 2007-06-03
ES2283716T3 (es) 2007-11-01
MXPA02000117A (es) 2002-07-02
BG65373B1 (bg) 2008-04-30
AU5222200A (en) 2001-01-31
DE60008382T2 (de) 2004-12-02
HUP0201789A3 (en) 2003-12-29
SI1196410T1 (en) 2004-08-31
PL200694B1 (pl) 2009-01-30
HK1045998A1 (en) 2002-12-20
ZA200110473B (en) 2003-03-20
NO20016370D0 (no) 2001-12-27
US20060058309A1 (en) 2006-03-16
PT1196410E (pt) 2004-07-30
EA004746B1 (ru) 2004-08-26
CA2376785A1 (en) 2001-01-04
CZ20014573A3 (cs) 2002-05-15
AR024495A1 (es) 2002-10-02
NZ515392A (en) 2004-03-26
ATE356121T1 (de) 2007-03-15
BR0011997A (pt) 2002-03-05
ES2215670T3 (es) 2004-10-16
DE60033859D1 (de) 2007-04-19
EE04592B1 (et) 2006-02-15
HRP20010934A2 (en) 2003-06-30
DE60008382D1 (en) 2004-03-25
TR200500707T2 (tr) 2005-04-21
MY129810A (en) 2007-05-31
HRP20080390A2 (en) 2008-12-31
CN1171887C (zh) 2004-10-20
US7407969B2 (en) 2008-08-05
BG106288A (en) 2002-10-31
ATE259796T1 (de) 2004-03-15
KR20020000815A (ko) 2002-01-05
TWI267513B (en) 2006-12-01
EP1400519A1 (en) 2004-03-24
HUP0201789A2 (hu) 2002-11-28
WO2001000615A8 (en) 2002-01-10
WO2001000615A1 (en) 2001-01-04
NO321599B1 (no) 2006-06-06
EP1196410A1 (en) 2002-04-17
DK1196410T3 (da) 2004-06-28
SK18952001A3 (sk) 2002-11-06
PL352385A1 (en) 2003-08-25
UA75866C2 (en) 2006-06-15
EA200200086A1 (ru) 2002-06-27
CN1358182A (zh) 2002-07-10
KR100731273B1 (ko) 2007-06-21
IL147328A0 (en) 2002-08-14
DE60033859T2 (de) 2007-11-08
US7071192B1 (en) 2006-07-04
EE200100694A (et) 2003-02-17
EP1196410B1 (en) 2004-02-18
EP1400519B1 (en) 2007-03-07
AU774829B2 (en) 2004-07-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090620