ECSP024267A - Imidazotriazinonas sustituidas por 2-fenilo - Google Patents
Imidazotriazinonas sustituidas por 2-feniloInfo
- Publication number
- ECSP024267A ECSP024267A EC2002004267A ECSP024267A ECSP024267A EC SP024267 A ECSP024267 A EC SP024267A EC 2002004267 A EC2002004267 A EC 2002004267A EC SP024267 A ECSP024267 A EC SP024267A EC SP024267 A ECSP024267 A EC SP024267A
- Authority
- EC
- Ecuador
- Prior art keywords
- phenyl
- imidazotriazinones
- replaced
- treatment
- diseases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2-Phenyl-substituted imidazotriazinones Chemical class 0.000 abstract 1
- YQQHMYAEQTYRKO-UHFFFAOYSA-N 2-phenyl-3h-imidazo[4,5-d]triazin-4-one Chemical class N1=C2N=CN=C2C(=O)NN1C1=CC=CC=C1 YQQHMYAEQTYRKO-UHFFFAOYSA-N 0.000 abstract 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 210000002229 urogenital system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las imidazotriazinonas 2-fenil-sustituidas que tienen radicales de alquilo lineales cortas, en la posición 9 se preparan de las correspondientes imidazotriazinonas 2-fenil por clorosulfonación y la reacción subsecuente con las aminas. Los compuestos que inhiben las fosfodiesterasas que metabolizan el GMPc y son apropiadas para utilizarse como compuestos activos en los medicamentos, para el tratamiento de enfermedades cardiovasculares y cerebrovasculares y/o enfermedades del sistema urogenital, en particular el tratamiento de la disfunción eréctil
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19750085A DE19750085A1 (de) | 1997-11-12 | 1997-11-12 | 2-Phenyl-substituierte Imidazotriazinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP024267A true ECSP024267A (es) | 2002-06-26 |
Family
ID=7848473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2002004267A ECSP024267A (es) | 1997-11-12 | 2002-05-28 | Imidazotriazinonas sustituidas por 2-fenilo |
Country Status (6)
| Country | Link |
|---|---|
| DE (1) | DE19750085A1 (es) |
| EC (1) | ECSP024267A (es) |
| GT (1) | GT199800183A (es) |
| RU (1) | RU2260593C2 (es) |
| SV (1) | SV1998000135A (es) |
| ZA (1) | ZA9810297B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0113343D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel Heterocycles 2 |
| MX2013003093A (es) * | 2010-09-20 | 2013-10-28 | Envivo Pharmaceuticals Inc | Compuestos de imidazotriazinona. |
| CN102134242B (zh) * | 2011-01-21 | 2013-08-28 | 浙江大德药业集团有限公司 | 一种用于治疗阳痿的快速长效的化合物 |
-
1997
- 1997-11-12 DE DE19750085A patent/DE19750085A1/de not_active Withdrawn
-
1998
- 1998-10-31 RU RU2000115281/04A patent/RU2260593C2/ru active
- 1998-11-11 GT GT199800183A patent/GT199800183A/es unknown
- 1998-11-11 ZA ZA9810297A patent/ZA9810297B/xx unknown
- 1998-11-12 SV SV1998000135A patent/SV1998000135A/es active IP Right Grant
-
2002
- 2002-05-28 EC EC2002004267A patent/ECSP024267A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE19750085A1 (de) | 1999-05-20 |
| RU2260593C2 (ru) | 2005-09-20 |
| SV1998000135A (es) | 1999-03-09 |
| GT199800183A (es) | 2000-05-04 |
| ZA9810297B (en) | 1999-05-20 |
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