EA201890360A1 - Соединение, нацеленное на ил-23a и фактор активации в-лимфоцитов (baff), и его применение - Google Patents
Соединение, нацеленное на ил-23a и фактор активации в-лимфоцитов (baff), и его применениеInfo
- Publication number
- EA201890360A1 EA201890360A1 EA201890360A EA201890360A EA201890360A1 EA 201890360 A1 EA201890360 A1 EA 201890360A1 EA 201890360 A EA201890360 A EA 201890360A EA 201890360 A EA201890360 A EA 201890360A EA 201890360 A1 EA201890360 A1 EA 201890360A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- baff
- lymphocytes
- application
- activation factor
- compound targeting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 title abstract 2
- 102100036705 Interleukin-23 subunit alpha Human genes 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12P21/00—Preparation of peptides or proteins
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- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
Изобретение относится к соединениям, специфичным к ИЛ-23А и ФАВЛ (BAFF), композициям, содержащим указанные соединения, и способам их применения. Также раскрыты нуклеиновые кислоты, клетки и способы получения, связанные с указанными соединениями и композициями.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562196170P | 2015-07-23 | 2015-07-23 | |
US201562201067P | 2015-08-04 | 2015-08-04 | |
US201662355302P | 2016-06-27 | 2016-06-27 | |
PCT/US2016/043267 WO2017015433A2 (en) | 2015-07-23 | 2016-07-21 | Compound targeting il-23a and b-cell activating factor (baff) and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201890360A1 true EA201890360A1 (ru) | 2018-06-29 |
Family
ID=57835236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890360A EA201890360A1 (ru) | 2015-07-23 | 2016-07-21 | Соединение, нацеленное на ил-23a и фактор активации в-лимфоцитов (baff), и его применение |
Country Status (22)
Country | Link |
---|---|
US (3) | US10280231B2 (ru) |
EP (1) | EP3322436A4 (ru) |
JP (1) | JP6866345B2 (ru) |
KR (1) | KR102644875B1 (ru) |
CN (1) | CN108135976B (ru) |
AU (1) | AU2016297575B2 (ru) |
BR (1) | BR112018001255A2 (ru) |
CA (1) | CA2993329A1 (ru) |
CL (1) | CL2018000182A1 (ru) |
CO (1) | CO2018001264A2 (ru) |
EA (1) | EA201890360A1 (ru) |
IL (1) | IL256665B2 (ru) |
MX (1) | MX2018000959A (ru) |
MY (1) | MY191081A (ru) |
NZ (2) | NZ778160A (ru) |
PE (1) | PE20180774A1 (ru) |
PH (2) | PH12021552628A1 (ru) |
SA (1) | SA518390788B1 (ru) |
SG (1) | SG10201912593VA (ru) |
TW (2) | TWI861413B (ru) |
UA (1) | UA125433C2 (ru) |
WO (1) | WO2017015433A2 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
CA2816950C (en) | 2010-11-04 | 2018-11-27 | Boehringer Ingelheim International Gmbh | Anti-il-23 antibodies |
MX368653B (es) | 2012-05-03 | 2019-10-10 | Boehringer Ingelheim Int | Anticuerpos anti-il-23p19. |
US10507241B2 (en) | 2014-07-24 | 2019-12-17 | Boehringer Ingelheim International Gmbh | Biomarkers useful in the treatment of IL-23A related diseases |
MX2018000959A (es) * | 2015-07-23 | 2018-06-06 | Boehringer Ingelheim Int | Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos. |
EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
TW202323304A (zh) * | 2021-09-30 | 2023-06-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗il23抗體融合蛋白及用途 |
TW202442678A (zh) * | 2022-12-28 | 2024-11-01 | 大陸商蘇州創勝醫藥集團有限公司 | 包含抗-baff抗體的雙特異性結合蛋白及其用途 |
WO2025007943A1 (zh) * | 2023-07-06 | 2025-01-09 | 荣昌生物制药(烟台)股份有限公司 | 用taci-fc融合蛋白治疗anca相关性血管炎的方法 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
EP2281842A1 (en) | 2000-06-16 | 2011-02-09 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
DE60143544D1 (de) | 2000-12-12 | 2011-01-05 | Medimmune Llc | Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung |
AU2006236439B2 (en) | 2005-04-15 | 2012-05-03 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
EP2097452A1 (en) * | 2006-12-14 | 2009-09-09 | Actogenix N.V. | Delivery of binding molecules to induce immunomodulation |
EP2158221B1 (en) | 2007-06-21 | 2018-08-29 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
CN104788563A (zh) | 2007-12-21 | 2015-07-22 | 米迪缪尼有限公司 | 白介素-4受体α(IL-4Rα)-173的结合成员 |
KR101603917B1 (ko) | 2008-05-09 | 2016-03-17 | 애브비 인코포레이티드 | 최종 당화 산물의 수용체(rage)에 대한 항체 및 이의 용도 |
PL2786762T3 (pl) | 2008-12-19 | 2019-09-30 | Macrogenics, Inc. | Kowalencyjne diabody i ich zastosowania |
US20130129723A1 (en) * | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
GB201002238D0 (en) * | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
PL3053932T3 (pl) * | 2010-02-19 | 2021-03-08 | Xencor, Inc. | Nowe immunoadhezyny CTLA4-IG |
WO2011119484A1 (en) | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
TWI426920B (zh) * | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
BR112013002533A2 (pt) * | 2010-08-02 | 2021-09-08 | Macrogenics, Inc | Polipeptídeo de ligação de proteína sérica e diacorpo complexado ao polipeptídeo de ligação de proteína sérica |
CA2816950C (en) * | 2010-11-04 | 2018-11-27 | Boehringer Ingelheim International Gmbh | Anti-il-23 antibodies |
GB201020738D0 (en) | 2010-12-07 | 2011-01-19 | Affitech Res As | Antibodies |
KR101941514B1 (ko) | 2010-12-22 | 2019-01-23 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 개선된 반감기를 가지는 변형된 항체 |
CA2830254C (en) * | 2011-03-16 | 2019-09-10 | Amgen Inc. | Fc variants |
TWI622597B (zh) | 2011-03-28 | 2018-05-01 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
ES2676031T3 (es) | 2012-02-15 | 2018-07-16 | F. Hoffmann-La Roche Ag | Cromatografía de afinidad basada en el receptor Fc |
GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
AR090626A1 (es) * | 2012-04-20 | 2014-11-26 | Lilly Co Eli | Anticuerpos anti-baff-anti-il-17 biespecificos |
US9708401B2 (en) * | 2012-05-22 | 2017-07-18 | Bristol-Myers Squibb Company | IL-17A/F cross-reactive monoclonal antibodies and methods of using the same |
KR102181776B1 (ko) * | 2012-06-05 | 2020-11-24 | 삼성전자주식회사 | 범용 디바이스에서의 파일 송/수신 장치 및 방법 |
WO2014100490A1 (en) * | 2012-12-19 | 2014-06-26 | Adimab, Llc | Multivalent antibody analogs, and methods of their preparation and use |
JP2015088330A (ja) * | 2013-10-30 | 2015-05-07 | トヨタ自動車株式会社 | 硫黄含有全固体電池 |
US10435474B2 (en) * | 2013-12-24 | 2019-10-08 | Ossianix, Inc. | Baff selective binding compounds and related methods |
AU2015315834B2 (en) * | 2014-01-31 | 2019-12-12 | Boehringer Ingelheim International Gmbh | Novel anti-BAFF antibodies |
MX2018000959A (es) * | 2015-07-23 | 2018-06-06 | Boehringer Ingelheim Int | Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos. |
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2016
- 2016-07-21 MX MX2018000959A patent/MX2018000959A/es unknown
- 2016-07-21 MY MYPI2018000034A patent/MY191081A/en unknown
- 2016-07-21 UA UAA201801854A patent/UA125433C2/uk unknown
- 2016-07-21 NZ NZ778160A patent/NZ778160A/en unknown
- 2016-07-21 TW TW110122529A patent/TWI861413B/zh active
- 2016-07-21 TW TW105123026A patent/TWI733685B/zh active
- 2016-07-21 US US15/215,690 patent/US10280231B2/en active Active
- 2016-07-21 WO PCT/US2016/043267 patent/WO2017015433A2/en active Application Filing
- 2016-07-21 KR KR1020187004892A patent/KR102644875B1/ko active Active
- 2016-07-21 PE PE2018000111A patent/PE20180774A1/es unknown
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