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EA201890027A1 - Новые пептиды и комбинации пептидов для применения в иммунотерапии эпителиального рака яичника и других видов рака - Google Patents

Новые пептиды и комбинации пептидов для применения в иммунотерапии эпителиального рака яичника и других видов рака

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Publication number
EA201890027A1
EA201890027A1 EA201890027A EA201890027A EA201890027A1 EA 201890027 A1 EA201890027 A1 EA 201890027A1 EA 201890027 A EA201890027 A EA 201890027A EA 201890027 A EA201890027 A EA 201890027A EA 201890027 A1 EA201890027 A1 EA 201890027A1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptides
cancer
present
epitelial
combinations
Prior art date
Application number
EA201890027A
Other languages
English (en)
Inventor
Хайко Шустер
Джанет Пепер
Филипп Вагнер
Ханс-Георг Раммензее
Original Assignee
Имматикс Байотекнолоджиз Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Имматикс Байотекнолоджиз Гмбх filed Critical Имматикс Байотекнолоджиз Гмбх
Publication of EA201890027A1 publication Critical patent/EA201890027A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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Abstract

Настоящее изобретение относится к пептидам, белкам, нуклеиновым кислотам и клеткам для применения в иммунотерапевтических методах. В частности, настоящее изобретение относится к иммунотерапии рака. Настоящее изобретение относится далее к опухолеассоциированным пептидным эпитопам Т-клеток, в отдельности или в комбинации с другими опухолеассоциированными пептидами, которые могут, например, служить в качестве активных фармацевтических ингредиентов вакцинных композиций, стимулирующих противоопухолевые иммунные ответы, или стимулировать Т-клетки ex vivo с их перенесением в организм пациента. Пептиды, связанные с молекулами главного комплекса гистосовместимости (МНС), или пептиды в отдельности могут быть также мишенями антител, растворимых Т-клеточных рецепторов и других связывающих молекул.
EA201890027A 2015-07-15 2016-07-14 Новые пептиды и комбинации пептидов для применения в иммунотерапии эпителиального рака яичника и других видов рака EA201890027A1 (ru)

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