EA201790234A1 - 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды - Google Patents
2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозидыInfo
- Publication number
- EA201790234A1 EA201790234A1 EA201790234A EA201790234A EA201790234A1 EA 201790234 A1 EA201790234 A1 EA 201790234A1 EA 201790234 A EA201790234 A EA 201790234A EA 201790234 A EA201790234 A EA 201790234A EA 201790234 A1 EA201790234 A1 EA 201790234A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- synthesis
- methods
- compounds
- intermediate compounds
- Prior art date
Links
- -1 PYRIMIDINDIONE NUCLEOSIDE Chemical class 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 241000700605 Viruses Species 0.000 abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 238000003786 synthesis reaction Methods 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 241000711904 Pneumoviridae Species 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000008512 pyrimidinediones Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Предложены составы, способы и замещенные 2'-хлораминопиримидиноновые и пиримидиндионовые соединения формулы (I) для лечения инфекции, вызванной вирусом подсемейства Pneumovirinae, включая инфекции, вызванные респираторно-синцитиальным вирусом, а также способы и промежуточные соединения для синтеза замещенных 2'-хлораминопиримидиноновых и пиримидиндионовых соединений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462040349P | 2014-08-21 | 2014-08-21 | |
PCT/US2015/045849 WO2016028866A1 (en) | 2014-08-21 | 2015-08-19 | 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201790234A1 true EA201790234A1 (ru) | 2017-07-31 |
Family
ID=54066190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790234A EA201790234A1 (ru) | 2014-08-21 | 2015-08-19 | 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды |
Country Status (17)
Country | Link |
---|---|
US (6) | US9617295B2 (ru) |
EP (2) | EP3738969A1 (ru) |
JP (2) | JP6765364B2 (ru) |
KR (1) | KR102528928B1 (ru) |
CN (1) | CN106573954A (ru) |
AR (1) | AR101561A1 (ru) |
AU (1) | AU2015305593C1 (ru) |
BR (1) | BR112017003242A2 (ru) |
CA (1) | CA2958546C (ru) |
EA (1) | EA201790234A1 (ru) |
ES (1) | ES2808868T3 (ru) |
IL (1) | IL250426A0 (ru) |
MX (1) | MX2017002288A (ru) |
NZ (1) | NZ728707A (ru) |
SG (1) | SG11201700810SA (ru) |
TW (1) | TWI673283B (ru) |
WO (1) | WO2016028866A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3107640A1 (en) | 2011-12-22 | 2013-06-27 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
MA40149A1 (fr) * | 2014-09-26 | 2019-04-30 | Riboscience Llc | Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial |
SG10202105371YA (en) | 2014-12-26 | 2021-07-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
WO2018009623A1 (en) * | 2016-07-08 | 2018-01-11 | Atea Pharmaceuticals, Inc. | β-D-2'-DEOXY-2'-SUBSTITUTED-4'-SUBSTITUTED-2-SUBSTITUTED-N6-SUBSTITUTED-6-AMINOPURINE NUCLEOTIDES FOR THE TREATMENT OF PARAMYXOVIRUS AND ORTHOMYXOVIRUS INFECTIONS |
CA3082191C (en) | 2017-12-07 | 2021-09-21 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
EP4431100A4 (en) * | 2021-11-12 | 2025-01-15 | National University Corporation Hokkaido University | ANTIVIRAL AGENT |
CN119546620A (zh) | 2022-03-15 | 2025-02-28 | 罗梅治疗股份有限公司 | 用于治疗疾病的化合物和方法 |
WO2024016639A1 (zh) * | 2022-07-21 | 2024-01-25 | 华创合成制药股份有限公司 | 一种抗病毒感染的化合物及其制备方法和用途 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3361306A (en) | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
US3565070A (en) | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
FR2224175B1 (ru) | 1973-04-04 | 1978-04-14 | Isf Spa | |
US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
IT1017153B (it) | 1974-07-15 | 1977-07-20 | Isf Spa | Apparecchio per inalazioni |
SE438261B (sv) | 1981-07-08 | 1985-04-15 | Draco Ab | Anvendning i dosinhalator av ett perforerat membran |
US4805811A (en) | 1985-03-29 | 1989-02-21 | Aktiebolaget Draco | Dosage device |
SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
US4955371A (en) | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
DE69230613T2 (de) | 1991-07-02 | 2000-12-28 | Inhale Inc | Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform |
US5261538A (en) | 1992-04-21 | 1993-11-16 | Glaxo Inc. | Aerosol testing method |
US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US5388572A (en) | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
US5622163A (en) | 1994-11-29 | 1997-04-22 | Iep Group, Inc. | Counter for fluid dispensers |
US6116234A (en) | 1999-02-01 | 2000-09-12 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler agitator |
EP2251015B1 (en) * | 2000-10-18 | 2013-02-20 | Gilead Pharmasset LLC | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation |
SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
PT2155758E (pt) | 2007-05-10 | 2012-11-12 | Biocryst Pharm Inc | Compostos de tetrahidrofuro[3,4-d]dioxolano para utilização no tratamento de infecções virais e do cancro |
WO2009132135A1 (en) | 2008-04-23 | 2009-10-29 | Gilead Sciences, Inc. | 1' -substituted carba-nucleoside analogs for antiviral treatment |
EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
BR122021012877B8 (pt) | 2009-09-21 | 2021-12-14 | Gilead Sciences Inc | Compostos análogos de 2'-flúor substituído carbanucleosídeo, uso dos mesmos e composição farmacêutica que os compreende |
US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
CA2773773C (en) | 2009-09-21 | 2019-04-23 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
KR20200052384A (ko) | 2010-07-19 | 2020-05-14 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
ME01924B (me) | 2010-07-22 | 2015-05-20 | Gilead Sciences Inc | Metode i jedinjenja za lečenje infekcija izazvanih Paramyxoviridae virusom |
TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
CA2812962C (en) * | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
NZ613370A (en) | 2010-12-20 | 2015-05-29 | Gilead Sciences Inc | Combinations for treating hcv |
WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
CA3107640A1 (en) * | 2011-12-22 | 2013-06-27 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections |
PL2827875T3 (pl) * | 2012-03-21 | 2019-07-31 | Janssen Biopharma, Inc. | Podstawione nukleozydy, nukleotydy i ich analogi |
GB201220843D0 (en) * | 2012-11-20 | 2013-01-02 | Univ College Cork Nat Univ Ie | Compound |
US10034893B2 (en) * | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
CA2913206C (en) * | 2013-06-26 | 2022-08-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
AU2014331863C1 (en) * | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
-
2015
- 2015-08-07 TW TW104125796A patent/TWI673283B/zh active
- 2015-08-14 AR ARP150102625A patent/AR101561A1/es unknown
- 2015-08-19 US US14/830,121 patent/US9617295B2/en active Active
- 2015-08-19 WO PCT/US2015/045849 patent/WO2016028866A1/en active Application Filing
- 2015-08-19 EA EA201790234A patent/EA201790234A1/ru unknown
- 2015-08-19 CN CN201580044979.5A patent/CN106573954A/zh active Pending
- 2015-08-19 SG SG11201700810SA patent/SG11201700810SA/en unknown
- 2015-08-19 BR BR112017003242A patent/BR112017003242A2/pt not_active Application Discontinuation
- 2015-08-19 EP EP20180058.8A patent/EP3738969A1/en active Pending
- 2015-08-19 EP EP15760544.5A patent/EP3183261B1/en active Active
- 2015-08-19 NZ NZ728707A patent/NZ728707A/en unknown
- 2015-08-19 ES ES15760544T patent/ES2808868T3/es active Active
- 2015-08-19 AU AU2015305593A patent/AU2015305593C1/en active Active
- 2015-08-19 MX MX2017002288A patent/MX2017002288A/es unknown
- 2015-08-19 CA CA2958546A patent/CA2958546C/en active Active
- 2015-08-19 JP JP2017508531A patent/JP6765364B2/ja active Active
- 2015-08-19 KR KR1020177006312A patent/KR102528928B1/ko active Active
-
2017
- 2017-02-02 IL IL250426A patent/IL250426A0/en unknown
- 2017-02-24 US US15/441,561 patent/US9982006B2/en active Active
-
2018
- 2018-04-11 US US15/950,442 patent/US20180340004A1/en not_active Abandoned
- 2018-12-06 US US16/212,374 patent/US20190202852A1/en not_active Abandoned
-
2019
- 2019-06-27 US US16/454,536 patent/US20200157137A1/en not_active Abandoned
- 2019-09-10 US US16/565,888 patent/US20200087337A1/en not_active Abandoned
-
2020
- 2020-04-10 JP JP2020070958A patent/JP2020111608A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2958546A1 (en) | 2016-02-25 |
US20200157137A1 (en) | 2020-05-21 |
EP3183261A1 (en) | 2017-06-28 |
JP2017525699A (ja) | 2017-09-07 |
US20160052953A1 (en) | 2016-02-25 |
AU2015305593A1 (en) | 2017-02-23 |
EP3738969A1 (en) | 2020-11-18 |
WO2016028866A1 (en) | 2016-02-25 |
CN106573954A (zh) | 2017-04-19 |
EP3183261B1 (en) | 2020-06-17 |
US20200087337A1 (en) | 2020-03-19 |
TW201619178A (zh) | 2016-06-01 |
US20190202852A1 (en) | 2019-07-04 |
US20170327526A1 (en) | 2017-11-16 |
AU2015305593C1 (en) | 2018-11-15 |
JP6765364B2 (ja) | 2020-10-07 |
US9617295B2 (en) | 2017-04-11 |
JP2020111608A (ja) | 2020-07-27 |
IL250426A0 (en) | 2017-03-30 |
AR101561A1 (es) | 2016-12-28 |
ES2808868T3 (es) | 2021-03-02 |
US20180340004A1 (en) | 2018-11-29 |
KR20170042643A (ko) | 2017-04-19 |
AU2015305593B2 (en) | 2018-05-17 |
MX2017002288A (es) | 2017-05-22 |
US9982006B2 (en) | 2018-05-29 |
NZ728707A (en) | 2018-06-29 |
KR102528928B1 (ko) | 2023-05-08 |
CA2958546C (en) | 2020-06-23 |
SG11201700810SA (en) | 2017-03-30 |
BR112017003242A2 (pt) | 2017-11-28 |
TWI673283B (zh) | 2019-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201790234A1 (ru) | 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды | |
EA201792639A1 (ru) | ПИРРОЛО[1.2-f][1.2.4]ТРИАЗИНЫ, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНО-СИНЦИТИАЛЬНЫХ ВИРУСНЫХ ИНФЕКЦИЙ | |
EA201791886A1 (ru) | Антивирусные соединения | |
EA201590197A1 (ru) | Соединения для лечения парамиксовирусных вирусных инфекций | |
EA201690224A1 (ru) | Противовирусные соединения | |
NZ729150A (en) | Antiretroviral agents | |
HK1257628A1 (zh) | 治療沙粒病毒科和冠狀病毒科病毒感染的方法 | |
EA201891000A1 (ru) | Вакцина против респираторно-синцитиального вируса | |
EA201790630A1 (ru) | Способы получения рибозидов | |
EA201790146A1 (ru) | ТИЕНО[3,2-d]ПИРИМИДИН, ФУРО[3,2-d]ПИРИМИДИН И ПИРРОЛО[3,2-d]ПИРИМИДИНЫ, ПОДХОДЯЩИЕ ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИЙ, ВЫЗВАННЫХ РЕСПИРАТОРНО-СИНЦИТИАЛЬНЫМ ВИРУСОМ | |
PH12015501881A1 (en) | Amide compounds for the treatment of hiv | |
EA201690526A1 (ru) | Замещенные нуклеозиды, нуклеотиды и их аналоги | |
EA201691261A1 (ru) | Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b | |
EA201592126A1 (ru) | 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b | |
EA201891666A1 (ru) | Арилзамещенные пиримидины для применения при инфекции, вызванной вирусом гриппа | |
EA201300604A1 (ru) | Соединения, предназначенные для лечения респираторно-синцитиальных вирусных инфекций | |
EA201500383A1 (ru) | Производные 1,2,4-триазина для лечения вирусных инфекций | |
EA201592184A1 (ru) | 4'-фтор-2'-метилзамещенные нуклеозидные производные | |
MX347692B (es) | Inhibidores del virus de la hepatitis c. | |
EA201692034A1 (ru) | Новые макроциклические соединения | |
EA201692063A1 (ru) | Спиросоединения мочевины в качестве противовирусных соединений против rsv | |
EA201490213A1 (ru) | Бензофурановые соединения для лечения инфекций вирусом гепатита с | |
MX2016001855A (es) | Nuevos aza-oxo-indoles para el tratamiento y profilaxis de la infeccion por virus sincitial respiratorio. | |
EA201790632A1 (ru) | 4'-винилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк респираторно-синцитиального вируса | |
EA201690300A1 (ru) | Замещенные аналоги пиридина-пиперазинила в качестве противовирусных соединений против rsv |