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EA201790234A1 - 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды - Google Patents

2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды

Info

Publication number
EA201790234A1
EA201790234A1 EA201790234A EA201790234A EA201790234A1 EA 201790234 A1 EA201790234 A1 EA 201790234A1 EA 201790234 A EA201790234 A EA 201790234A EA 201790234 A EA201790234 A EA 201790234A EA 201790234 A1 EA201790234 A1 EA 201790234A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
synthesis
methods
compounds
intermediate compounds
Prior art date
Application number
EA201790234A
Other languages
English (en)
Inventor
Майкл О'Нил Ханрахан Кларк
Ричард Л. Макман
Дастин Сигель
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201790234A1 publication Critical patent/EA201790234A1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/073Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Предложены составы, способы и замещенные 2'-хлораминопиримидиноновые и пиримидиндионовые соединения формулы (I) для лечения инфекции, вызванной вирусом подсемейства Pneumovirinae, включая инфекции, вызванные респираторно-синцитиальным вирусом, а также способы и промежуточные соединения для синтеза замещенных 2'-хлораминопиримидиноновых и пиримидиндионовых соединений.
EA201790234A 2014-08-21 2015-08-19 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды EA201790234A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462040349P 2014-08-21 2014-08-21
PCT/US2015/045849 WO2016028866A1 (en) 2014-08-21 2015-08-19 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides

Publications (1)

Publication Number Publication Date
EA201790234A1 true EA201790234A1 (ru) 2017-07-31

Family

ID=54066190

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790234A EA201790234A1 (ru) 2014-08-21 2015-08-19 2'-хлораминопиримидиноновые и пиримидиндионовые нуклеозиды

Country Status (17)

Country Link
US (6) US9617295B2 (ru)
EP (2) EP3738969A1 (ru)
JP (2) JP6765364B2 (ru)
KR (1) KR102528928B1 (ru)
CN (1) CN106573954A (ru)
AR (1) AR101561A1 (ru)
AU (1) AU2015305593C1 (ru)
BR (1) BR112017003242A2 (ru)
CA (1) CA2958546C (ru)
EA (1) EA201790234A1 (ru)
ES (1) ES2808868T3 (ru)
IL (1) IL250426A0 (ru)
MX (1) MX2017002288A (ru)
NZ (1) NZ728707A (ru)
SG (1) SG11201700810SA (ru)
TW (1) TWI673283B (ru)
WO (1) WO2016028866A1 (ru)

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Also Published As

Publication number Publication date
CA2958546A1 (en) 2016-02-25
US20200157137A1 (en) 2020-05-21
EP3183261A1 (en) 2017-06-28
JP2017525699A (ja) 2017-09-07
US20160052953A1 (en) 2016-02-25
AU2015305593A1 (en) 2017-02-23
EP3738969A1 (en) 2020-11-18
WO2016028866A1 (en) 2016-02-25
CN106573954A (zh) 2017-04-19
EP3183261B1 (en) 2020-06-17
US20200087337A1 (en) 2020-03-19
TW201619178A (zh) 2016-06-01
US20190202852A1 (en) 2019-07-04
US20170327526A1 (en) 2017-11-16
AU2015305593C1 (en) 2018-11-15
JP6765364B2 (ja) 2020-10-07
US9617295B2 (en) 2017-04-11
JP2020111608A (ja) 2020-07-27
IL250426A0 (en) 2017-03-30
AR101561A1 (es) 2016-12-28
ES2808868T3 (es) 2021-03-02
US20180340004A1 (en) 2018-11-29
KR20170042643A (ko) 2017-04-19
AU2015305593B2 (en) 2018-05-17
MX2017002288A (es) 2017-05-22
US9982006B2 (en) 2018-05-29
NZ728707A (en) 2018-06-29
KR102528928B1 (ko) 2023-05-08
CA2958546C (en) 2020-06-23
SG11201700810SA (en) 2017-03-30
BR112017003242A2 (pt) 2017-11-28
TWI673283B (zh) 2019-10-01

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