[go: up one dir, main page]

MA40149A1 - Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial - Google Patents

Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Info

Publication number
MA40149A1
MA40149A1 MA40149A MA40149A MA40149A1 MA 40149 A1 MA40149 A1 MA 40149A1 MA 40149 A MA40149 A MA 40149A MA 40149 A MA40149 A MA 40149A MA 40149 A1 MA40149 A1 MA 40149A1
Authority
MA
Morocco
Prior art keywords
respiratory syncytial
syncytial virus
inhibitors
substituted
derivatives useful
Prior art date
Application number
MA40149A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of MA40149A1 publication Critical patent/MA40149A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'application concerne des composés de formule (i), dans laquelle les substituants variables sont tels que définis dans la description. Les composés de formule (i) et des compositions pharmaceutiques comprenant des composés de formule i sont utiles pour le traitement de maladies médiées par le virus respiratoire syncytial.
MA40149A 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial MA40149A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26
PCT/US2015/052144 WO2016049415A1 (fr) 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Publications (1)

Publication Number Publication Date
MA40149A1 true MA40149A1 (fr) 2019-04-30

Family

ID=55582038

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40149A MA40149A1 (fr) 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Country Status (20)

Country Link
US (1) US10358458B2 (fr)
EP (1) EP3197457B1 (fr)
JP (1) JP6671355B2 (fr)
KR (1) KR102573609B1 (fr)
CN (1) CN107073002B (fr)
AU (1) AU2015320511B2 (fr)
BR (1) BR112017006264A2 (fr)
CA (1) CA2962770C (fr)
CL (1) CL2017000707A1 (fr)
CO (1) CO2017003994A2 (fr)
CR (1) CR20170157A (fr)
EA (1) EA031726B1 (fr)
IL (1) IL251368B (fr)
MA (1) MA40149A1 (fr)
MX (1) MX2017003788A (fr)
PE (1) PE20170698A1 (fr)
PH (1) PH12017500558A1 (fr)
SG (2) SG10201810361TA (fr)
WO (1) WO2016049415A1 (fr)
ZA (1) ZA201702858B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102573609B1 (ko) 2014-09-26 2023-08-31 리보사이언스 엘엘씨 호흡기 세포융합 바이러스 rna 복제 억제제로서의 4'-비닐 치환된 뉴클레오시드 유도체
CN114072407A (zh) * 2019-04-02 2022-02-18 阿里戈斯治疗公司 靶向prmt5的化合物
US20230123911A1 (en) * 2020-01-31 2023-04-20 Octagon Therapeutics, Inc. Modulation of immune cells
CN112194694B (zh) * 2020-09-29 2022-03-25 佛山科学技术学院 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用
TW202400134A (zh) 2022-03-15 2024-01-01 美商羅米醫療公司 用於治療疾病之化合物及方法
WO2024103016A1 (fr) * 2022-11-11 2024-05-16 Rome Therapeutics, Inc. 4'-halométhyl-cytidine phosphoramidates et composés apparentés et leur utilisation dans le traitement d'affections médicales

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0001186A3 (en) 1996-10-16 2002-04-29 Icn Pharmaceuticals Inc Costa Purine l-nucleosides,analogs and pharmaceutical compositions thereof
EP1103559A1 (fr) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Nucléosides auto-immunes
CN1253504A (zh) * 1997-01-17 2000-05-17 Icn药品公司 细胞因子相关的疾病治疗法
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
JP2005536440A (ja) 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2005011709A1 (fr) * 2003-02-19 2005-02-10 Yale University Analogues de nucleosides antiviraux et methodes de traitement d'infections virales, notamment d'infections a vih
WO2005020885A2 (fr) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions et methodes pour le traitement du syndrome respiratoire aigu severe (sras)
EP1928475B1 (fr) * 2005-08-15 2018-05-23 Riboscience LLC Dérivés anitivraux de phosphoramidates de pronucléotides 4'-c-azido-substitués
WO2007145593A1 (fr) 2006-06-15 2007-12-21 Jyoti Chattopadhyaya Thymidine à pont 2'-n,4'-c-éthylène (aza-ena-t) à contrainte conformationnelle
WO2009064387A2 (fr) 2007-11-09 2009-05-22 Gov't Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services Analogues de la c4'-substituée-2-désoxyadénosine et procédés de traitement du vih
US8445669B2 (en) 2008-04-10 2013-05-21 Hamari Chemicals, Ltd. Production process of ethynylthymidine compounds from 5-methyluridine as a starting material
US8163707B2 (en) 2008-09-15 2012-04-24 Enanta Pharmaceuticals, Inc. 4′-allene-substituted nucleoside derivatives
WO2011005860A2 (fr) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Mimétiques de 5' phosphate
WO2011133868A2 (fr) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. Monomères de dinucléotide et oligonucléotides à conformation restreinte
US20130018011A1 (en) 2011-06-10 2013-01-17 Hassan Javanbakht Method of treating dengue fever
LT2794627T (lt) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai
JP6242378B2 (ja) 2012-03-13 2017-12-06 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG10201804571TA (en) 2012-03-21 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
KR20150090894A (ko) * 2012-10-29 2015-08-06 코크리스탈 파마, 아이엔씨. 바이러스 감염 및 암 치료용 피리미딘 뉴클레오티드 및 그들의 모노포스페이트 프로드럭
AU2014302711A1 (en) 2013-06-26 2015-12-10 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MX2016004558A (es) * 2013-10-11 2016-07-06 Alios Biopharma Inc Nucleosidos sustituidos, nucleotidos y analogos de los mismos.
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
SG11201610597QA (en) 2014-06-24 2017-01-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
LT3160476T (lt) 2014-06-24 2021-04-12 Janssen Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme
TWI673283B (zh) * 2014-08-21 2019-10-01 美商基利科學股份有限公司 ２’－氯胺基嘧啶酮及嘧啶二酮核苷類
KR102573609B1 (ko) 2014-09-26 2023-08-31 리보사이언스 엘엘씨 호흡기 세포융합 바이러스 rna 복제 억제제로서의 4'-비닐 치환된 뉴클레오시드 유도체

Also Published As

Publication number Publication date
BR112017006264A2 (pt) 2017-12-12
JP2017529375A (ja) 2017-10-05
EP3197457B1 (fr) 2022-11-09
CR20170157A (es) 2017-07-03
JP6671355B2 (ja) 2020-03-25
NZ730923A (en) 2020-09-25
CN107073002A (zh) 2017-08-18
KR102573609B1 (ko) 2023-08-31
KR20170062499A (ko) 2017-06-07
CO2017003994A2 (es) 2017-07-11
EP3197457A4 (fr) 2018-08-01
CL2017000707A1 (es) 2017-12-15
SG11201702430WA (en) 2017-04-27
CN107073002B (zh) 2019-10-15
CA2962770C (fr) 2023-08-22
SG10201810361TA (en) 2018-12-28
WO2016049415A1 (fr) 2016-03-31
ZA201702858B (en) 2018-08-29
AU2015320511B2 (en) 2020-11-12
US20160264611A1 (en) 2016-09-15
EA201790632A1 (ru) 2017-09-29
AU2015320511A1 (en) 2017-05-04
PH12017500558A1 (en) 2017-08-30
PE20170698A1 (es) 2017-06-05
US10358458B2 (en) 2019-07-23
MX2017003788A (es) 2017-08-07
EP3197457A1 (fr) 2017-08-02
CA2962770A1 (fr) 2016-03-31
IL251368B (en) 2020-05-31
EA031726B1 (ru) 2019-02-28
IL251368A0 (en) 2017-05-29

Similar Documents

Publication Publication Date Title
MA35750B1 (fr) Dérivés de nucléoside substitué 2',4'-difluoro-2'-méthyle en tant qu'inhibiteurs de la réplication de l'arn du vhc (virus de l'hépatite c)
MA39783B1 (fr) Dérivés de quinoxaline utiles en tant que modulateurs de la fgfr kinase
MA40149A1 (fr) Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial
GEP20217248B (en) 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh
MA53399B1 (fr) Pyrazoles substitués en tant qu`inhibiteurs de la kallicréine plasmatique humaine
PH12018502747A1 (en) Boronic acid derivatives and therapeutic uses thereof
EA201991399A1 (ru) Аминотриазолопиридиновые соединения и их применение в лечении рака
UA122528C2 (uk) Сполуки, які модулюють fxr (nr1h4)
MA40111A1 (fr) Dérivés du tétrahydronaphtalène inhibant la protéine mcl-1
MA37213B1 (fr) Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MA38398A1 (fr) Composés biaryle amides en tant qu'inhibiteurs de kinase
MA47356B1 (fr) Dérivés d'isochromène utiles en tant qu'inhibiteurs des phosphoinositide 3-kinases
MA45598B1 (fr) Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda
EA201891063A1 (ru) Производные дигидроимидазопиразинона, применимые в лечении рака
EA201500953A1 (ru) 3-ацетиламино-1-(фенилгетероариламинокарбонил или фенилгетероарилкарбониламино)бензольные производные для лечения гиперпролиферативных нарушений
MA39317A1 (fr) Dérivés de nucléosides à substitution 4'-difluorométhyle utilisés en tant qu'inhibiteurs de la réplication de l'arn du virus de la grippe
MA46490A1 (fr) Dérivés de nucléosides 4'- fluoro-2' - méthyle substitués
EA202191188A1 (ru) Бензамиды производных пиразолил-амино-пиримидинила, композиции на их основе и способы применения
CY1122689T1 (el) Παραγωγα πυραζολιου χρησιμα ως αναστολεις της πρωτεϊνης ενεργοποιησης της 5-λιποξυγενασης (flap)
EA201790519A1 (ru) Терапевтические соединения в качестве ингибиторов рецептора орексина-1
MA40875A (fr) 2,4-diamino-quinoléine substituée servant de nouveaux agents anticancéreux
MA39171A1 (fr) Dérivés d'hydroxy formamide et leur utilisation
MA40886B1 (fr) Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
MA38678A1 (fr) Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués
BR112017021583A2 (pt) métodos para o tratamento de transtornos inflamatórios